INSILICO DRUG DESIGN AND MOLECULAR DOCKING STUDIES OF SOME NOVEL
... bacterial infection in human beings. The Objective of the study is too carried out the docking studies of benzothiazole derivatives containing oxadiazole groups or amino groups with known anti-cancer and anti-inflammatory targets like estrogen receptor, cox1 and cox2 by using Argus lab and Auto dock ...
... bacterial infection in human beings. The Objective of the study is too carried out the docking studies of benzothiazole derivatives containing oxadiazole groups or amino groups with known anti-cancer and anti-inflammatory targets like estrogen receptor, cox1 and cox2 by using Argus lab and Auto dock ...
Read More - WuXi NextCODE
... 30 to 40 patients with advanced malignancies to evaluate the safety, pharmacokinetics and preliminary antitumor activities, with plans to expand quickly if all goes well. “This is a big accomplishment for a company like us – developing an antibody drug is much more complex, both preclinically and cl ...
... 30 to 40 patients with advanced malignancies to evaluate the safety, pharmacokinetics and preliminary antitumor activities, with plans to expand quickly if all goes well. “This is a big accomplishment for a company like us – developing an antibody drug is much more complex, both preclinically and cl ...
Asthma
... Are not bronchodilators Given as prophylactic medications, used alone or combined with beta-agonists ...
... Are not bronchodilators Given as prophylactic medications, used alone or combined with beta-agonists ...
Reflection Paper co-development of PG biomarkers and Assays in
... development consideration. The level of scientific stringency applied to the assay will depend on the knowledge accumulated about the PGBM and the drug(s) under consideration, as well as the implication of its use. ...
... development consideration. The level of scientific stringency applied to the assay will depend on the knowledge accumulated about the PGBM and the drug(s) under consideration, as well as the implication of its use. ...
20808 AlleRx PE.indd
... cardiovascular disease, and hyperactivity to sympathomimetic amines. Hypertensive patients should only use with medical advice, as they may experience a change in blood pressure due to added vasoconstriction. Antihistamines may cause drowsiness, and ambulatory patients who operate machinery or motor ...
... cardiovascular disease, and hyperactivity to sympathomimetic amines. Hypertensive patients should only use with medical advice, as they may experience a change in blood pressure due to added vasoconstriction. Antihistamines may cause drowsiness, and ambulatory patients who operate machinery or motor ...
7-02 - Clarkson University
... synthesis and properties of nanostructured materials that are made up of crystallites or particles of ~10 nm. They may be generated by various physical and chemical approaches with ultrahigh surface reactivity. Through controlled synthesis in reverse microemulsions, my laboratory has achieved polyme ...
... synthesis and properties of nanostructured materials that are made up of crystallites or particles of ~10 nm. They may be generated by various physical and chemical approaches with ultrahigh surface reactivity. Through controlled synthesis in reverse microemulsions, my laboratory has achieved polyme ...
Standardization of pharmacokinetic
... time – kill experiments and the estimated value is therefore dependent on a number of experimental (technical) factors. These include: (i) The time over which the maximum kill rate is measured. The time points included in the regression analysis to determine the MKR should include at least two point ...
... time – kill experiments and the estimated value is therefore dependent on a number of experimental (technical) factors. These include: (i) The time over which the maximum kill rate is measured. The time points included in the regression analysis to determine the MKR should include at least two point ...
CLIA-WAIVED One Step Multi-Drug, Multi
... Methamphetamine is an addictive stimulant drug that strongly activates certain systems in the brain. Methamphetamine is closely related chemically to amphetamine, but the central nervous system effects of Methamphetamine are greater. Methamphetamine is made in illegal laboratories and has a high pot ...
... Methamphetamine is an addictive stimulant drug that strongly activates certain systems in the brain. Methamphetamine is closely related chemically to amphetamine, but the central nervous system effects of Methamphetamine are greater. Methamphetamine is made in illegal laboratories and has a high pot ...
Antibiotic Resistance. Because of overuse and misuse, some
... difficult to combat is that drug-resistant microbes are everywhere. According to the WHO, in all regions of the world there are high proportions of antibiotic resistance in bacteria that cause common infections in the urinary tract, lungs, and bloodstream; and a high percentage of hospital-acquired ...
... difficult to combat is that drug-resistant microbes are everywhere. According to the WHO, in all regions of the world there are high proportions of antibiotic resistance in bacteria that cause common infections in the urinary tract, lungs, and bloodstream; and a high percentage of hospital-acquired ...
Development and in-vitro characterization of sustained release
... systemic circulation, Sustained release tablets come in handy as a solution. A sustained-release dosage form is defined as “any drug or dosage form modification that prolongs the therapeutic activity of the drug” [1]. The primary objectives of sustained drug delivery are to ensure safety and enhance ...
... systemic circulation, Sustained release tablets come in handy as a solution. A sustained-release dosage form is defined as “any drug or dosage form modification that prolongs the therapeutic activity of the drug” [1]. The primary objectives of sustained drug delivery are to ensure safety and enhance ...
IRTRA Combination Tablets LD/HD
... therapy from the viewpoints of synergistic antihypertensive effects as well as less side effects related to the electrolyte and glucose metabolism of diuretics. IRTRAⓇ Combination Tablets LD/HD is expected to decrease the elevation of serum urate level incidental to an ARB/diuretic combination drug ...
... therapy from the viewpoints of synergistic antihypertensive effects as well as less side effects related to the electrolyte and glucose metabolism of diuretics. IRTRAⓇ Combination Tablets LD/HD is expected to decrease the elevation of serum urate level incidental to an ARB/diuretic combination drug ...
Parkinson`s Disease - For Emergency Use Only.
... dopamine storage capacity all released at once. If at peak of dose: make doses smaller and more frequent or try modified slow release levodopa, add dopamine agonist, consider surgery If at beginning/end of dose: try soluble levodopa before meals, add COMT-I Adding in adjuvants ...
... dopamine storage capacity all released at once. If at peak of dose: make doses smaller and more frequent or try modified slow release levodopa, add dopamine agonist, consider surgery If at beginning/end of dose: try soluble levodopa before meals, add COMT-I Adding in adjuvants ...
opioids
... • higher concentration of the drug in the brain because of an immature blood-brain barrier • Newborns & young infants less than 4–6 months of age have increased free fraction of the drug in the blood because of decreased plasma protein (less alpha-1 acid glycoprotein and albumin) binding. ...
... • higher concentration of the drug in the brain because of an immature blood-brain barrier • Newborns & young infants less than 4–6 months of age have increased free fraction of the drug in the blood because of decreased plasma protein (less alpha-1 acid glycoprotein and albumin) binding. ...
Controlled Release of Naproxen Sodium from
... Özlem Biçen Ünlüer1, Lütfi Genç2, 3, Şennur Görgülü Kahyaoğlu3, 4 and Arzu Ersöz1 1. Faculty of Science, Anadolu University, Eskişehir 26470, Turkey 2. Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey 3. Plant, Drug and Scientific Research Center (BİBAM), Anadolu University, Eskişehi ...
... Özlem Biçen Ünlüer1, Lütfi Genç2, 3, Şennur Görgülü Kahyaoğlu3, 4 and Arzu Ersöz1 1. Faculty of Science, Anadolu University, Eskişehir 26470, Turkey 2. Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey 3. Plant, Drug and Scientific Research Center (BİBAM), Anadolu University, Eskişehi ...
a review on sarpagandha
... pagandha root is still in wide use. herb because of apparent benefits over the The authors suggest, it is prudent to use extract. The whole herb has many compothe whole herb for therapeutic applicanents which can tions, until and unless any chemical de(1) Help in biotransformation into pharmarivativ ...
... pagandha root is still in wide use. herb because of apparent benefits over the The authors suggest, it is prudent to use extract. The whole herb has many compothe whole herb for therapeutic applicanents which can tions, until and unless any chemical de(1) Help in biotransformation into pharmarivativ ...
Lecture 6 - Harper College
... common site is the joint of the big toe * Uric acid metabolism disorder = increase in urates (uric acid salts) & accumulation of uric acid or ineffective clearance by the kidneys * Gout may appear as Bumps (tophi) in hands, & base of large toe * Complications = gouty arthritis, urinary calculi, gout ...
... common site is the joint of the big toe * Uric acid metabolism disorder = increase in urates (uric acid salts) & accumulation of uric acid or ineffective clearance by the kidneys * Gout may appear as Bumps (tophi) in hands, & base of large toe * Complications = gouty arthritis, urinary calculi, gout ...
FORMULATION AND IN VITRO EVALUATION OF NIOSOMAL POVIDONE –IODINE CARRIERS
... Objective: Use of povidone-iodine (PVP-I) as a microbicidal agent is complicated by contact burns and other adverse reactions attributed to its sudden concentrated release from absorbent skin bandages. The current investigation examines the potential of niosomes or non–ionic surfactant vesicles to a ...
... Objective: Use of povidone-iodine (PVP-I) as a microbicidal agent is complicated by contact burns and other adverse reactions attributed to its sudden concentrated release from absorbent skin bandages. The current investigation examines the potential of niosomes or non–ionic surfactant vesicles to a ...
Perphenazine Fact Sheet - The Main Line Center for the Family
... sometimes referred to as conventional or typical antipsychotics. Perphenazine was sold under the brand Trilafon, but Trilafon has since been discontinued. Currently, only generic perphenazine is available. The first-generation antipsychotics represent an older class of antipsychotics that have been ...
... sometimes referred to as conventional or typical antipsychotics. Perphenazine was sold under the brand Trilafon, but Trilafon has since been discontinued. Currently, only generic perphenazine is available. The first-generation antipsychotics represent an older class of antipsychotics that have been ...
Lecture 6 - Harper College
... tendons & other tissues - most common site is the joint of the big toe * Uric acid metabolism disorder = increase in urates (uric acid salts) & accumulation of uric acid or ineffective clearance by the kidneys * Gout may appear as Bumps (tophi) in hands, & base of large toe * Complications = gouty a ...
... tendons & other tissues - most common site is the joint of the big toe * Uric acid metabolism disorder = increase in urates (uric acid salts) & accumulation of uric acid or ineffective clearance by the kidneys * Gout may appear as Bumps (tophi) in hands, & base of large toe * Complications = gouty a ...
CB064-4.19 - Workforce3One
... Used to suppress bothersome dry, hacking, nonproductive cough – ***NOT normally used to suppress productive cough*** ...
... Used to suppress bothersome dry, hacking, nonproductive cough – ***NOT normally used to suppress productive cough*** ...
Moving from Animal Models to the Clinic
... etc.)? Are there off-target effects and/or on-target adverse effects, etc.?] They may also use animal studies in lead optimization. In preclinical animal studies, researchers may obtain data in several different animal models relating to the drug’s efficacy and potency, its clearance, its bioavailab ...
... etc.)? Are there off-target effects and/or on-target adverse effects, etc.?] They may also use animal studies in lead optimization. In preclinical animal studies, researchers may obtain data in several different animal models relating to the drug’s efficacy and potency, its clearance, its bioavailab ...
Psychopharmacology for the Clinician
... and are then generalized to patient populations that can vary by numerous parameters, such as age, sex, race and disorder.9–11 A recently published study in a clinical setting examined switching from brand-name to generic olanzapine in patients with schizophrenia and found lower serum olanzapine con ...
... and are then generalized to patient populations that can vary by numerous parameters, such as age, sex, race and disorder.9–11 A recently published study in a clinical setting examined switching from brand-name to generic olanzapine in patients with schizophrenia and found lower serum olanzapine con ...
management of hepatic disorders
... prophylaxis as well as curative drug to any kind of disorder affecting the healthy functioning of the liver, one of the vital organs of the body. In our daily living we can not escape factors like consumption of rich and spicy food, polluted drinking water, toxic medicines or possible attack from he ...
... prophylaxis as well as curative drug to any kind of disorder affecting the healthy functioning of the liver, one of the vital organs of the body. In our daily living we can not escape factors like consumption of rich and spicy food, polluted drinking water, toxic medicines or possible attack from he ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.