Fact Sheet (2002) Amphetamine and Ecstasy Use in the Caribbean
... stimulants that dramatically affect the central nervous system. Amphetamines are a class of drugs, that in chemical terms, are closely related to each other. This family of drugs includes amphetamines sulfate, dexamphetamines and methamphetamine. The principal active ingredient in Ecstasy is MDMA (3 ...
... stimulants that dramatically affect the central nervous system. Amphetamines are a class of drugs, that in chemical terms, are closely related to each other. This family of drugs includes amphetamines sulfate, dexamphetamines and methamphetamine. The principal active ingredient in Ecstasy is MDMA (3 ...
This Article As A Word Document
... impairs vigilance, impairs reaction time and decreases the ability to maintain a straight lane position. Heavy users of marijuana develop tolerance for it and require increasing doses. Other health affects—cancer decreased immune response, increased risk of heart attacks, etc. Psycho-social—aggressi ...
... impairs vigilance, impairs reaction time and decreases the ability to maintain a straight lane position. Heavy users of marijuana develop tolerance for it and require increasing doses. Other health affects—cancer decreased immune response, increased risk of heart attacks, etc. Psycho-social—aggressi ...
DRUGS AFFECTING THE RESPIRATORY SYSTEM
... 5. Kinetics – short biological half-life; ‘slow-release’ preparations 6. Side effects: narrow therapeutic window generally safe; nausea, cardiac arrhythmias and convulsions. ...
... 5. Kinetics – short biological half-life; ‘slow-release’ preparations 6. Side effects: narrow therapeutic window generally safe; nausea, cardiac arrhythmias and convulsions. ...
Combination therapy: Synergism between natural plant extracts and
... The increasing phenomenon of acquisition of resistance among microorganisms to antimicrobial drugs is attributed to the indiscriminate and improper use of current antimicrobial drugs [1]. Today, clinically important bacteria are characterized not only by single drug resistance, but also by multiple ...
... The increasing phenomenon of acquisition of resistance among microorganisms to antimicrobial drugs is attributed to the indiscriminate and improper use of current antimicrobial drugs [1]. Today, clinically important bacteria are characterized not only by single drug resistance, but also by multiple ...
Drug Metabolism Phcy 172 - UNC
... • Parkinson, A.: Biotransformation of xenobiotics. In: Casarett and Doull’s Toxicology. The Basic Science of Poisons. Sixth edition (edited by C.D. Klaassen). McGraw Hill, New York, 2001. • Wang, H. and Negishi, M. (2003) Transcriptional regulation of cytochrome p450 2B genes by nuclear receptors. C ...
... • Parkinson, A.: Biotransformation of xenobiotics. In: Casarett and Doull’s Toxicology. The Basic Science of Poisons. Sixth edition (edited by C.D. Klaassen). McGraw Hill, New York, 2001. • Wang, H. and Negishi, M. (2003) Transcriptional regulation of cytochrome p450 2B genes by nuclear receptors. C ...
CAR
... • Parkinson, A.: Biotransformation of xenobiotics. In: Casarett and Doull’s Toxicology. The Basic Science of Poisons. Sixth edition (edited by C.D. Klaassen). McGraw Hill, New York, 2001. • Wang, H. and Negishi, M. (2003) Transcriptional regulation of cytochrome p450 2B genes by nuclear receptors. C ...
... • Parkinson, A.: Biotransformation of xenobiotics. In: Casarett and Doull’s Toxicology. The Basic Science of Poisons. Sixth edition (edited by C.D. Klaassen). McGraw Hill, New York, 2001. • Wang, H. and Negishi, M. (2003) Transcriptional regulation of cytochrome p450 2B genes by nuclear receptors. C ...
Towards early inclusion of children in tuberculosis drugs trials: a
... generated from an international panel of opinion leaders on childhood tuberculosis and incorporating reviews of published literature from January, 2004, to May, 2014, addressed four key questions: what drugs or regimens should be prioritised for clinical trials in children? Which populations of chil ...
... generated from an international panel of opinion leaders on childhood tuberculosis and incorporating reviews of published literature from January, 2004, to May, 2014, addressed four key questions: what drugs or regimens should be prioritised for clinical trials in children? Which populations of chil ...
Movement Disorders Induced by Gastrointestinal Drugs: Two
... believed to penetrate the blood-brain barrier, and is thus considered to have fewer neurological adverse effects than metoclopramide. The cases mentioned in Table 1, as well as our case, show that adverse extrapyramidal drug reactions can occur with cisapride. Awareness of this side effect remains r ...
... believed to penetrate the blood-brain barrier, and is thus considered to have fewer neurological adverse effects than metoclopramide. The cases mentioned in Table 1, as well as our case, show that adverse extrapyramidal drug reactions can occur with cisapride. Awareness of this side effect remains r ...
Memorandum
... people; rather, the studies mostly appear to be designed to evaluate its short-term effect in persons suffering from serious diseases. Such efficacy studies have limited utility for determining whether the long-term use of a substance as an ingredient in dietary supplements is safe for healthy peopl ...
... people; rather, the studies mostly appear to be designed to evaluate its short-term effect in persons suffering from serious diseases. Such efficacy studies have limited utility for determining whether the long-term use of a substance as an ingredient in dietary supplements is safe for healthy peopl ...
Limitations of Use
... • CYP2C19 inhibitors (e.g. proton pump inhibitors, selective serotonin reuptake inhibitors, benzodiazepines, antifungals) may increase Addyi exposure, which may increase the risk of hypotension, syncope, and CNS depression. • Do not use Addyi with strong CYP3A4 inducers (e.g., rifampin, St. Johns Wo ...
... • CYP2C19 inhibitors (e.g. proton pump inhibitors, selective serotonin reuptake inhibitors, benzodiazepines, antifungals) may increase Addyi exposure, which may increase the risk of hypotension, syncope, and CNS depression. • Do not use Addyi with strong CYP3A4 inducers (e.g., rifampin, St. Johns Wo ...
Contained Chemistry - SafeBridge Consultants, Inc.
... pharmacologic potency, toxicity, and other effects. Although there's some disagreement about what is occupationally "potent," the drug industry typically uses that rating for compounds with OELs at or below 10 µg/m3; for those that are highly selective for a receptor or enzyme inhibition; and for th ...
... pharmacologic potency, toxicity, and other effects. Although there's some disagreement about what is occupationally "potent," the drug industry typically uses that rating for compounds with OELs at or below 10 µg/m3; for those that are highly selective for a receptor or enzyme inhibition; and for th ...
Cholinergics and Anticholinergics
... are antagonistic to each other When acetylcholine acts on body cells that respond to parasympathetic stimulation, it interacts with two types of cholinergic receptors: nicotinic and muscarinic ...
... are antagonistic to each other When acetylcholine acts on body cells that respond to parasympathetic stimulation, it interacts with two types of cholinergic receptors: nicotinic and muscarinic ...
Generic Name - UHN Research
... hyperlinks) to which references are made in the Handbook. In no event shall UHN be liable for direct, indirect, consequential, special, exemplary, or other damages related to your use of the Handbook, regardless of how arising or the theory of liability whether arising in contract, tort, negligence ...
... hyperlinks) to which references are made in the Handbook. In no event shall UHN be liable for direct, indirect, consequential, special, exemplary, or other damages related to your use of the Handbook, regardless of how arising or the theory of liability whether arising in contract, tort, negligence ...
GlucoNorm PM
... adequate blood glucose-lowering after an initial period of effectiveness). For patients with an increased risk of hypoglycemia, or at risk of losing blood glucose control (see Warnings and Precautions, Endocrine and Metabolism section), a closer glucose monitoring should be considered. Glycosylated ...
... adequate blood glucose-lowering after an initial period of effectiveness). For patients with an increased risk of hypoglycemia, or at risk of losing blood glucose control (see Warnings and Precautions, Endocrine and Metabolism section), a closer glucose monitoring should be considered. Glycosylated ...
Application Note LCMS-94 Native and Subunit Analysis of an
... and equipped with High Mass Option was used. This added capability enables the increase of the pressure in the first ion transfer stage resulting in an enhanced protein desolvation and higher ion transfer efficiency. This tuning improves the results when analyzing high molecular weight proteins and ...
... and equipped with High Mass Option was used. This added capability enables the increase of the pressure in the first ion transfer stage resulting in an enhanced protein desolvation and higher ion transfer efficiency. This tuning improves the results when analyzing high molecular weight proteins and ...
Foreign Pharmacy Graduate Equivalency Examination
... 1. Dose response relationships 2. Absorption, distribution, and elimination 3. Metabolism 4. Adverse reactions (toxicity, side effects, abuse, etc) B. Interaction of drugs with biological systems 1. Relationship of chemical structure to biochemical mechanism of action 2. Stereochemical factors 3. St ...
... 1. Dose response relationships 2. Absorption, distribution, and elimination 3. Metabolism 4. Adverse reactions (toxicity, side effects, abuse, etc) B. Interaction of drugs with biological systems 1. Relationship of chemical structure to biochemical mechanism of action 2. Stereochemical factors 3. St ...
Rocha RS, Bezerra SC, Lima JWO, Costa FS. Consumption of ... alcohol and smoking in pregnancy and assessment of teratogenic...
... been a decrease in the overall rate of infectious-related diseases and, in turn, an increase in the rate of deaths due to congenital malformations (1). Among the possible causes of these malformations, besides environmental factors, there are some medications and other drugs such as alcohol and toba ...
... been a decrease in the overall rate of infectious-related diseases and, in turn, an increase in the rate of deaths due to congenital malformations (1). Among the possible causes of these malformations, besides environmental factors, there are some medications and other drugs such as alcohol and toba ...
petit mal
... panic disorders, obsessive compulsive disorder (OCD). These are link to many neurotransmitters. But gama-aminobutyric acid (GABA), norepi, 5HT are consider as having major influence on these disorders. R ...
... panic disorders, obsessive compulsive disorder (OCD). These are link to many neurotransmitters. But gama-aminobutyric acid (GABA), norepi, 5HT are consider as having major influence on these disorders. R ...
APPLICATION OF NOVEL CONCEPT OF MIXED SOLVENCY IN THE DESIGN... DEVELOPMENT OF FLOATING MICROSPHERS OF FUROSEMIDE
... process. For many drug substances, conventional immediate-release formulations provide clinically effective therapy with an acceptable level of safety to the patient. However, the potential for oral dosage form development is sometimes limited for therapeutic agents that are poorly absorbed in the g ...
... process. For many drug substances, conventional immediate-release formulations provide clinically effective therapy with an acceptable level of safety to the patient. However, the potential for oral dosage form development is sometimes limited for therapeutic agents that are poorly absorbed in the g ...
Kionex - Perrigo
... be carefully controlled by frequent serum potassium determinations within each 24 hour period. Since intracellular potassium deficiency is not always reflected by serum potassium levels, the level at which treatment with Kionex® should be discontinued must be determined individually for each patient ...
... be carefully controlled by frequent serum potassium determinations within each 24 hour period. Since intracellular potassium deficiency is not always reflected by serum potassium levels, the level at which treatment with Kionex® should be discontinued must be determined individually for each patient ...
New Theories of Addiction_Day 2
... 2. These systems include those involved in the process of incentivesalience and reward. (focus on drug and related cues) 3. The changes render the brains’ reward systems hypersensitive (“sensitized”) to addictive substances (and substance-associated stimuli). (regular to compulsive transition) 4. Th ...
... 2. These systems include those involved in the process of incentivesalience and reward. (focus on drug and related cues) 3. The changes render the brains’ reward systems hypersensitive (“sensitized”) to addictive substances (and substance-associated stimuli). (regular to compulsive transition) 4. Th ...
2015 DRUGS TO WATCH
... This first-in-class agent represents a new treatment approach for heart failure by combining the enhancement of cardioprotective mechanisms via neprilysin inhibition, with the antihypertensive effects of angiotensin antagonism. It was filed for US and EU approval for chronic heart failure with reduc ...
... This first-in-class agent represents a new treatment approach for heart failure by combining the enhancement of cardioprotective mechanisms via neprilysin inhibition, with the antihypertensive effects of angiotensin antagonism. It was filed for US and EU approval for chronic heart failure with reduc ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.