LOCAL DRUG DELIVERY IN PERIODONTICS: A STRATEGIC INTERVENTION Review Article
... results due to the fact that the active product could not achieve an adequate concentration at the site of action and/or due to the inability of the active product to be retained locally for a sufficient period of time. These drawbacks would be markedly reduced if antimicrobial agents applied locall ...
... results due to the fact that the active product could not achieve an adequate concentration at the site of action and/or due to the inability of the active product to be retained locally for a sufficient period of time. These drawbacks would be markedly reduced if antimicrobial agents applied locall ...
Research Report Series from the director:
... while there has been a significant decline in the 30day prevalence of powder cocaine use among 8th, 10th, and 12thgraders from its peak use in the late 1990s, there was no significant change in current cocaine use from 2001 to 2008; however, crack use declined signifi ...
... while there has been a significant decline in the 30day prevalence of powder cocaine use among 8th, 10th, and 12thgraders from its peak use in the late 1990s, there was no significant change in current cocaine use from 2001 to 2008; however, crack use declined signifi ...
Antiinfective Agents
... person will experience a mild form of a reaction that occurs with alcohol and disulfiram. Symptoms include nausea, abdominal cramps, flushing, vomiting, and headache. The reaction can happen if the patient ingests any form of alcohol including foods, drinks, and mouth rinses containing ...
... person will experience a mild form of a reaction that occurs with alcohol and disulfiram. Symptoms include nausea, abdominal cramps, flushing, vomiting, and headache. The reaction can happen if the patient ingests any form of alcohol including foods, drinks, and mouth rinses containing ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.
... Insomnia is a widespread health complaint and the most common sleep disorders that affect people of all ages around the world [1, 2]. About 10-15% of adult population suffers from chronic insomnia, and additional 25-35% has transient or occasional insomnia [3]. The most widely used drugs in the mana ...
... Insomnia is a widespread health complaint and the most common sleep disorders that affect people of all ages around the world [1, 2]. About 10-15% of adult population suffers from chronic insomnia, and additional 25-35% has transient or occasional insomnia [3]. The most widely used drugs in the mana ...
Follow the Script_ Spring 2015
... dosage can made a big difference to a patient. But a big thing was just learning to interact with patients who are taking methadone. You have to get to know the patients and recognize whether they should be taking it on a given day. For example, if you think they’ve had alcohol, they can’t take meth ...
... dosage can made a big difference to a patient. But a big thing was just learning to interact with patients who are taking methadone. You have to get to know the patients and recognize whether they should be taking it on a given day. For example, if you think they’ve had alcohol, they can’t take meth ...
nerisone - GlaxoSmithKline
... corticosteroids. Hyperglycemia and glucosuria can also be produced in some patients by systemic absorption of topical corticosteroids (see ADVERSE REACTIONS). Conditions which augment systemic absorption include the formulation and potency of the topical corticosteroid, the application of topical c ...
... corticosteroids. Hyperglycemia and glucosuria can also be produced in some patients by systemic absorption of topical corticosteroids (see ADVERSE REACTIONS). Conditions which augment systemic absorption include the formulation and potency of the topical corticosteroid, the application of topical c ...
Selective phosphodiesterase inhibitors for the treatment
... heart failure and depression. Currently, a variety of new substances are under investigation as alternative potential anti-inflammatory drugs and, if the theoretical concept holds true, agents with lower potential for side-effects are being discovered. In the meantime, eight PDE isoenzyme gene famil ...
... heart failure and depression. Currently, a variety of new substances are under investigation as alternative potential anti-inflammatory drugs and, if the theoretical concept holds true, agents with lower potential for side-effects are being discovered. In the meantime, eight PDE isoenzyme gene famil ...
Body System Adverse Effects
... Many cautions, contraindications, and interactions exist pertaining to the use of antidepressants Inform patients that it may take several weeks to see therapeutic effects Monitor patients closely during this time, assess for suicidal tendencies, and provide support Assist elderly or weakened patien ...
... Many cautions, contraindications, and interactions exist pertaining to the use of antidepressants Inform patients that it may take several weeks to see therapeutic effects Monitor patients closely during this time, assess for suicidal tendencies, and provide support Assist elderly or weakened patien ...
DENS 211 4th Lecture
... Partial agonist “Drug with intermediate level of efficacy, such that even when 100% of the receptors are occupied, the tissue response is submaximal” exhibits similar potency (EC50), but lower efficacy (Emax) produce concentration-effect curves that resemble those observed with full agonists i ...
... Partial agonist “Drug with intermediate level of efficacy, such that even when 100% of the receptors are occupied, the tissue response is submaximal” exhibits similar potency (EC50), but lower efficacy (Emax) produce concentration-effect curves that resemble those observed with full agonists i ...
The Antidepressants - Consumer Health Choices
... ■■ If you have five or more of the symptoms in Table 1, for most of the time almost everyday for two weeks or longer—and you are not functioning well in life—you are likely a candidate for an antidepressant. This is true even if your depression was triggered by a life event or trauma, and is especia ...
... ■■ If you have five or more of the symptoms in Table 1, for most of the time almost everyday for two weeks or longer—and you are not functioning well in life—you are likely a candidate for an antidepressant. This is true even if your depression was triggered by a life event or trauma, and is especia ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) ISSN: 2278-3008.
... epilepsy [5]. The strategies for the development of antiepileptic drugs have heavily relied on the basic premise that epilepsies are due to an imbalance between excitatory and inhibitory transmission in the brain [6]. Epileptic drug therapy in most patients is based on experimental seizure classific ...
... epilepsy [5]. The strategies for the development of antiepileptic drugs have heavily relied on the basic premise that epilepsies are due to an imbalance between excitatory and inhibitory transmission in the brain [6]. Epileptic drug therapy in most patients is based on experimental seizure classific ...
pptx
... Reliable data on performance-enhancing supplements are often limited. Many have side effects and are banned for use by professional athletes. Some supplements make promises of rapid weight loss. Such supplements are either ineffective in the long term or actively harmful! The most common “weight-los ...
... Reliable data on performance-enhancing supplements are often limited. Many have side effects and are banned for use by professional athletes. Some supplements make promises of rapid weight loss. Such supplements are either ineffective in the long term or actively harmful! The most common “weight-los ...
Definition of Hazardous Drugs
... be hazardous by the five previous criteria. This additional criterion to the definition of HDs was first published by NIOSH in 2004 and serves as a reminder that new drugs should be critically evaluated using existing information and extrapolating data from similar agents. ASHP (2006) recommends tha ...
... be hazardous by the five previous criteria. This additional criterion to the definition of HDs was first published by NIOSH in 2004 and serves as a reminder that new drugs should be critically evaluated using existing information and extrapolating data from similar agents. ASHP (2006) recommends tha ...
Geriatric Cardiology – You CAN treat Angina! Part 2
... and palpitations – RCA ischemia and atrial fibrillation • Converted to NSR, RCA revascularized • Referred for cardiac rehab – completely asymptomatic • 2 years later – recurrent angina then ACS – new RCA lesion. Angina 2012 ...
... and palpitations – RCA ischemia and atrial fibrillation • Converted to NSR, RCA revascularized • Referred for cardiac rehab – completely asymptomatic • 2 years later – recurrent angina then ACS – new RCA lesion. Angina 2012 ...
Bicompartmental model Kinetic disposition of a parent drug and its
... Visual inspection of these different fittings indicates severe misfits. It also suggests that none of the classical compartmental models will be able to fit these data and so we decided to carry out only an NCA of the metabolite plasma kinetics. Before proceeding to this NCA, add a time point to the ...
... Visual inspection of these different fittings indicates severe misfits. It also suggests that none of the classical compartmental models will be able to fit these data and so we decided to carry out only an NCA of the metabolite plasma kinetics. Before proceeding to this NCA, add a time point to the ...
annexure ii
... Need of study: The occurrence of gastrointestinal damage (bleeding, ulceration) is probably among the most prevalent and serious of the side-effects associated with the use of non-steroid antiinflammatory (NSAI) drugs. Ketoprofen is a potent anti-inflammatory drug. Chemically, it is propionic acid d ...
... Need of study: The occurrence of gastrointestinal damage (bleeding, ulceration) is probably among the most prevalent and serious of the side-effects associated with the use of non-steroid antiinflammatory (NSAI) drugs. Ketoprofen is a potent anti-inflammatory drug. Chemically, it is propionic acid d ...
metabolism, disposition, excretion, and pharmacokinetics of
... collection of urine and feces separately. At the end of 168 h the rats were sacrificed by cervical dislocation and the carcasses retained after removal of a limited number of organs/tissues. For a disposition study, 15 male and 15 female Sprague-Dawley rats received a single oral dose of [14C]levorm ...
... collection of urine and feces separately. At the end of 168 h the rats were sacrificed by cervical dislocation and the carcasses retained after removal of a limited number of organs/tissues. For a disposition study, 15 male and 15 female Sprague-Dawley rats received a single oral dose of [14C]levorm ...
- Boehringer Ingelheim (Canada)
... perforation, obstruction and gastrointestinal bleeding, can occur at any time, with or without warning symptoms in patients treated with NSAIDs, such as MOBICOX. Minor upper GI problems, such as dyspepsia, commonly occur at any time. Health care providers should remain alert for ulceration and bleed ...
... perforation, obstruction and gastrointestinal bleeding, can occur at any time, with or without warning symptoms in patients treated with NSAIDs, such as MOBICOX. Minor upper GI problems, such as dyspepsia, commonly occur at any time. Health care providers should remain alert for ulceration and bleed ...
Conversion of Racemic Ibuprofen to (S)
... • A molecule that is not identical to its mirror image is asymmetric and named chiral. The most common chiral compounds which exist are enantiomers. • Enantiomers are typically characterized by an asymmetric ...
... • A molecule that is not identical to its mirror image is asymmetric and named chiral. The most common chiral compounds which exist are enantiomers. • Enantiomers are typically characterized by an asymmetric ...
Subuphine sublingual tablet ENG
... brain. Its activity in opioid maintenance treatment is attributed to its slowly reversible binding to the -receptors which over a longer period reduces the adapted patients need for drugs. Buprenorphine has a wide therapeutic index due to its partial agonist/antagonist effect, which limits its supp ...
... brain. Its activity in opioid maintenance treatment is attributed to its slowly reversible binding to the -receptors which over a longer period reduces the adapted patients need for drugs. Buprenorphine has a wide therapeutic index due to its partial agonist/antagonist effect, which limits its supp ...
Understanding Stimulant Drugs
... circulation- an effect that historically has made cocaine the preferred local anesthetic agent for eye surgery and other delicate procedures. The local anesthetic effects of cocaine are most pronounced when it is applied to the skin or mucous membranes. Thus, when cocaine is “snorted” it temporarily ...
... circulation- an effect that historically has made cocaine the preferred local anesthetic agent for eye surgery and other delicate procedures. The local anesthetic effects of cocaine are most pronounced when it is applied to the skin or mucous membranes. Thus, when cocaine is “snorted” it temporarily ...
49. Ibuprofen - Educhimica.it
... response to physiological stimuli. It is responsible for the production of prostaglandins, which get their name because it was originally believed they were synthesized in the prostate gland. In fact, prostaglandins are synthesized throughout the body and act like hormones by stimulating action in t ...
... response to physiological stimuli. It is responsible for the production of prostaglandins, which get their name because it was originally believed they were synthesized in the prostate gland. In fact, prostaglandins are synthesized throughout the body and act like hormones by stimulating action in t ...
CE EN Evidence-based Pharmacy Practice (EBPP): DYSLIPIDAEMIA
... dietary and biliary cholesterol.19 At recommended intake of about 2–2.5 g/day (about 20 g of margarine) products enriched with plant sterol/sterol esters lower plasma LDL cholesterol levels by reducing intestinal absorption by 10 to 14% without any reported side-effects.20 They do not have an effect ...
... dietary and biliary cholesterol.19 At recommended intake of about 2–2.5 g/day (about 20 g of margarine) products enriched with plant sterol/sterol esters lower plasma LDL cholesterol levels by reducing intestinal absorption by 10 to 14% without any reported side-effects.20 They do not have an effect ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.