Measuring human-error probabilities in drug preparation: a pilot
... experience [15]. Unfortunately, HEP data are difficult to extract from these studies. Indeed, reported error rates often relate to an entire process or to some of its segments (e.g. prescribing, dispensing) but not to the different tasks it includes. For example, a rate of wrong-dose error—defined a ...
... experience [15]. Unfortunately, HEP data are difficult to extract from these studies. Indeed, reported error rates often relate to an entire process or to some of its segments (e.g. prescribing, dispensing) but not to the different tasks it includes. For example, a rate of wrong-dose error—defined a ...
Cocaine Addiction
... relapse to drug use, even after long periods of abstinence. and alcohol. Taken in combination, the two drugs are converted by the body to cocaethylene. Cocaethylene has a longer duration of action in the brain and is more toxic than either drug alone. While more research needs to be done, it is note ...
... relapse to drug use, even after long periods of abstinence. and alcohol. Taken in combination, the two drugs are converted by the body to cocaethylene. Cocaethylene has a longer duration of action in the brain and is more toxic than either drug alone. While more research needs to be done, it is note ...
Here - Dipartimento di Scienze Chimiche e Farmaceutiche
... assessment of nano-products. To recognize the therapeutic value of a medicinal nano-product and avoid potential risks associated with its use are two-side of a coin, aimed at the achievement of the same goal, i.e., the improvement of human life. Although it is prudent to investigate the adverse effe ...
... assessment of nano-products. To recognize the therapeutic value of a medicinal nano-product and avoid potential risks associated with its use are two-side of a coin, aimed at the achievement of the same goal, i.e., the improvement of human life. Although it is prudent to investigate the adverse effe ...
Formulation and Evaluation of Almotriptan Malate Nasal Drops
... E15 was added in different proportions from 2.57.5% w/v. The osmolarity was recorded on Osmomat 30. Viscosity of the solutions was recorded using a cone and plate viscometer. In vitro permeation studies were performed using a Franz diffusion cell with dialysis membrane. The receptor compartment cont ...
... E15 was added in different proportions from 2.57.5% w/v. The osmolarity was recorded on Osmomat 30. Viscosity of the solutions was recorded using a cone and plate viscometer. In vitro permeation studies were performed using a Franz diffusion cell with dialysis membrane. The receptor compartment cont ...
Coactifed® Preparations - GlaxoSmithKline
... bleeding or other symptoms of ischemic colitis develop. Respiratory Codeine, including COACTIFIED®, is not recommended for use in any patient in whom respiratory function might be compromised including neuromuscular disorders, severe cardiac or respiratory conditions, lung infections, multiple traum ...
... bleeding or other symptoms of ischemic colitis develop. Respiratory Codeine, including COACTIFIED®, is not recommended for use in any patient in whom respiratory function might be compromised including neuromuscular disorders, severe cardiac or respiratory conditions, lung infections, multiple traum ...
okf"kZd izfrosnu@Annual Report 2014-15
... students for all the success, in both professional and personal lives. The faculty members and students continued to be recognized with various honours and awards for their academic as well as research achievements. Close to 170 papers were published during this period. We were also successful in li ...
... students for all the success, in both professional and personal lives. The faculty members and students continued to be recognized with various honours and awards for their academic as well as research achievements. Close to 170 papers were published during this period. We were also successful in li ...
Full Text - Global Science Books
... Simple, accurate and precise reversed phase high-performance liquid chromatographic (RP-HPLC) methods for simultaneous estimation of aspirin (ASP), atorvastatin (ATO) and clopidogrel (CLO) in combined capsule dosage form have been developed and validated. The RP-HPLC method uses a Shimadzu LC 10 ATV ...
... Simple, accurate and precise reversed phase high-performance liquid chromatographic (RP-HPLC) methods for simultaneous estimation of aspirin (ASP), atorvastatin (ATO) and clopidogrel (CLO) in combined capsule dosage form have been developed and validated. The RP-HPLC method uses a Shimadzu LC 10 ATV ...
Standardization and toxicological satudies of Butea frondosa
... Freedom from insect infestation and contamination has become an important consideration in storage of grain and to maintain a high quality product. This is also an issue to herbal medicine, therefore, for the determination of pest in herbal medicine the classical method of analysis is used during ex ...
... Freedom from insect infestation and contamination has become an important consideration in storage of grain and to maintain a high quality product. This is also an issue to herbal medicine, therefore, for the determination of pest in herbal medicine the classical method of analysis is used during ex ...
Information on new drugs at market entry: retrospective
... “dossier” and “module” refer exclusively to documents submitted by companies to the Federal Joint Committee within the framework of AMNOG; they do not refer to documents submitted to regulatory authorities as part of the regulatory submission dossier, the common technical document.) The dossier is p ...
... “dossier” and “module” refer exclusively to documents submitted by companies to the Federal Joint Committee within the framework of AMNOG; they do not refer to documents submitted to regulatory authorities as part of the regulatory submission dossier, the common technical document.) The dossier is p ...
Reinforcing Effects of Benzodiazepines
... – anticonvulsant (to lesser extent) effects of benzodiazepines (expressed throughout the cerebral cortex). Majority of benzodiazepine receptors. Agents (ie zolpidem, zaleplon) that bind specifically to α1 subunits have no effects in animals in which the α1 subunit is made to be insensitive α2 su ...
... – anticonvulsant (to lesser extent) effects of benzodiazepines (expressed throughout the cerebral cortex). Majority of benzodiazepine receptors. Agents (ie zolpidem, zaleplon) that bind specifically to α1 subunits have no effects in animals in which the α1 subunit is made to be insensitive α2 su ...
Pharmacy Therapeutics Policies and Procedures
... The safety risk / benefit of a product will be compared with other treatments. We will minimize the potential for errors caused by product characteristics such as name, dosage form, and packaging that pose threats to patient safety or increase the potential for errors in the health care system. ...
... The safety risk / benefit of a product will be compared with other treatments. We will minimize the potential for errors caused by product characteristics such as name, dosage form, and packaging that pose threats to patient safety or increase the potential for errors in the health care system. ...
Electrical potential difference, sodium absorption and
... SUMMARY The transmucosal electrical potential difference (pd) and the sodium and potassium net fluxes were measured in the rectum of subjects taking carbenoxolone. There was a rise in transmucosal pd persisting throughout treatment in all subjects which was accompanied by an increase in sodium absor ...
... SUMMARY The transmucosal electrical potential difference (pd) and the sodium and potassium net fluxes were measured in the rectum of subjects taking carbenoxolone. There was a rise in transmucosal pd persisting throughout treatment in all subjects which was accompanied by an increase in sodium absor ...
Herbal Medication Pitfalls Question “Natural Product” or Drug
... medicines available. However, one must be aware of the power of herbs to heal and, if misused, to cause imbalance. Herbs produce no side effects when used in the amounts required to effect a cure. Negative effects occur only when one fails to observe the cautions that herbalists have recognized afte ...
... medicines available. However, one must be aware of the power of herbs to heal and, if misused, to cause imbalance. Herbs produce no side effects when used in the amounts required to effect a cure. Negative effects occur only when one fails to observe the cautions that herbalists have recognized afte ...
Translational Safety in Drug Development
... susceptibility factors for quantitative analysis of interactions between drugs and patients. This involves pharmacokinetics, toxicodynamics, pharmacodynamics and individual subject factors with a focus on populations and variability, Toxicometrics is defined as the science that quantifies drug, toxi ...
... susceptibility factors for quantitative analysis of interactions between drugs and patients. This involves pharmacokinetics, toxicodynamics, pharmacodynamics and individual subject factors with a focus on populations and variability, Toxicometrics is defined as the science that quantifies drug, toxi ...
ZYRTEC LEVOCABASTINE Eye Drops and Nasal Spray
... on performance and subjective test measures with ZYRTEC Levocabastine nasal spray used at normal doses. Pharmacokinetic interactions The decongestant oxymetazoline may transiently reduce the absorption of nasal levocabastine. ...
... on performance and subjective test measures with ZYRTEC Levocabastine nasal spray used at normal doses. Pharmacokinetic interactions The decongestant oxymetazoline may transiently reduce the absorption of nasal levocabastine. ...
TETRACYCLINE AND DOXYCYCLINE APPLICATIONS
... scheduled, unless the subsequent dose is due within the next 2 hours. In that case, the missed dose should not be taken to avoid double dosing, which increases the risk of toxic side effects, especially to the gastrointestinal tract.6 ...
... scheduled, unless the subsequent dose is due within the next 2 hours. In that case, the missed dose should not be taken to avoid double dosing, which increases the risk of toxic side effects, especially to the gastrointestinal tract.6 ...
Safe Handling of Hazardous Drugs
... A hazardous drug is any drug identified as hazardous or potentially hazardous by the National Institute for Occupational Safety and Health (NIOSH) on the basis of at least one of the following six criteria: carcinogenicity, teratogenicity or developmental toxicity, reproductive toxicity in humans, o ...
... A hazardous drug is any drug identified as hazardous or potentially hazardous by the National Institute for Occupational Safety and Health (NIOSH) on the basis of at least one of the following six criteria: carcinogenicity, teratogenicity or developmental toxicity, reproductive toxicity in humans, o ...
Best Nursing Practices in Care for Older Adults
... The older adult is exposed to fat soluble drugs for a longer time There is more blood concentration of water soluble drugs Albumin is main site for protein binding drugs to bind for transport prior to being distributed to body tissue ...
... The older adult is exposed to fat soluble drugs for a longer time There is more blood concentration of water soluble drugs Albumin is main site for protein binding drugs to bind for transport prior to being distributed to body tissue ...
Marijuana: Facts and Myths - livedrugfree.org
... especially executive function and processing speed. The study was thus able to rule out pre-existing differences in IQ between heavy marijuana users and others; it is also significant for including degree of cannabis exposure and age of onset as factors. ...
... especially executive function and processing speed. The study was thus able to rule out pre-existing differences in IQ between heavy marijuana users and others; it is also significant for including degree of cannabis exposure and age of onset as factors. ...
DESIGN AND DEVELOPMENT OF MUCOADHESIVE BUCCAL DELIVERY FOR PANTOPRAZOLE
... esophageal reflux disease. However, the bioavailability of Pantoprazole following oral administration is usually very low, since it degrades very rapidly in the acidic environment of stomach and undergoes hepatic first pass metabolism. To improve the bioavailability of Pantoprazole, in particular by ...
... esophageal reflux disease. However, the bioavailability of Pantoprazole following oral administration is usually very low, since it degrades very rapidly in the acidic environment of stomach and undergoes hepatic first pass metabolism. To improve the bioavailability of Pantoprazole, in particular by ...
LIVOSTIN Eye Drops and Nasal Spray - E
... were no reports of interaction with alcohol in clinical trials. In psychomotor performance studies there was no significant potentiation of the effects of alcohol on performance and subjective test measures with LIVOSTIN nasal spray used at normal doses. Pharmacokinetic interactions The decongestant ...
... were no reports of interaction with alcohol in clinical trials. In psychomotor performance studies there was no significant potentiation of the effects of alcohol on performance and subjective test measures with LIVOSTIN nasal spray used at normal doses. Pharmacokinetic interactions The decongestant ...
pharmaceuticals: restrictions in use and availability
... effective date on which the regulation came into force; a summary of regulatory measures taken by governments; brief explanatory comments where necessary; and legal and bibliographical references. While the information cannot be regarded as exhaustive, either in terms of products or regulatory measu ...
... effective date on which the regulation came into force; a summary of regulatory measures taken by governments; brief explanatory comments where necessary; and legal and bibliographical references. While the information cannot be regarded as exhaustive, either in terms of products or regulatory measu ...
Unique Postsynaptic Signaling at the Hair Cell Efferent Synapse
... (passband 100 –10,000 Hz). The resulting signal was digitized with a 30 msec sampling interval via a 12 bit A/D converter (National Instruments A2000), and the digital waveforms were averaged on-line using custom software in LabVIEW 2 (National Instruments) on a Macintosh computer. Each CAP data poi ...
... (passband 100 –10,000 Hz). The resulting signal was digitized with a 30 msec sampling interval via a 12 bit A/D converter (National Instruments A2000), and the digital waveforms were averaged on-line using custom software in LabVIEW 2 (National Instruments) on a Macintosh computer. Each CAP data poi ...
STUDYING G THE RELE
... Compendial dissolution protocol The compendial dissolution test for LNS and OMP is fully described in the United States Pharmacopoeia 30 (USP 30), and the dissolution test of ESOMP capsules is described in the FDA web site (as mentioned in the references). Table (1): summarize the pro ...
... Compendial dissolution protocol The compendial dissolution test for LNS and OMP is fully described in the United States Pharmacopoeia 30 (USP 30), and the dissolution test of ESOMP capsules is described in the FDA web site (as mentioned in the references). Table (1): summarize the pro ...
Biospectra Analysis: Model Proteome
... score of g0.80.3 Figure 1 highlights a section of this dendrogram containing dopamine 21. Shown are molecules sharing biospectra similarity with dopamine having CCS scores of greater than 0.608. The Supporting Information contains selected IC50 values for dopamine receptor ligands 1-24. Hierarchical ...
... score of g0.80.3 Figure 1 highlights a section of this dendrogram containing dopamine 21. Shown are molecules sharing biospectra similarity with dopamine having CCS scores of greater than 0.608. The Supporting Information contains selected IC50 values for dopamine receptor ligands 1-24. Hierarchical ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.