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Practice Quizzes for Honors Biology Unit 3
Practice Quizzes for Honors Biology Unit 3

... For  fossils:   a. How  can  sedimentary  rock  be  used  to  date  fossils?   b. What  are  the  two  main  characteristics  of  the  fossil  record?   c. Describe  episodic  speciation.   Differentiate  between  relative  and  absolute  dat ...
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Lesson 1 DNA and proteins

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Molecular Methods
Molecular Methods

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Cloning the Progesterone 5 beta- reductase gene

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11060_2014_1398_MOESM3_ESM
11060_2014_1398_MOESM3_ESM

... used to quantify and determine the purity of the total RNA. One microgram of RNA extracted from each sample was synthesized into double-stranded cDNA using the SuperScript III Reverse Transcriptase Kit (Invitrogen, Carlsbad, CA, USA), according to the manufacturer´s instructions. ...
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Bisulfite sequencing



Bisulphite sequencing (also known as bisulfite sequencing) is the use of bisulphite treatment of DNA to determine its pattern of methylation. DNA methylation was the first discovered epigenetic mark, and remains the most studied. In animals it predominantly involves the addition of a methyl group to the carbon-5 position of cytosine residues of the dinucleotide CpG, and is implicated in repression of transcriptional activity.Treatment of DNA with bisulphite converts cytosine residues to uracil, but leaves 5-methylcytosine residues unaffected. Thus, bisulphite treatment introduces specific changes in the DNA sequence that depend on the methylation status of individual cytosine residues, yielding single- nucleotide resolution information about the methylation status of a segment of DNA. Various analyses can be performed on the altered sequence to retrieve this information. The objective of this analysis is therefore reduced to differentiating between single nucleotide polymorphisms (cytosines and thymidine) resulting from bisulphite conversion (Figure 1).
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