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Prémio Artigo Destaque SPN_2011 Cellular and Molecular
Prémio Artigo Destaque SPN_2011 Cellular and Molecular

... NeuroCentre Magendie (Bordeaux, France) PhD programme in Experimental Biology and Biomedicine (PhD BEB) University of Coimbra About the work Neurons are capable of integrating information spatially and temporally. They can process electrical signals at specific locations called synapses, which can b ...
The Nervous System (PowerPoint)
The Nervous System (PowerPoint)

... Axon. Noradrenalin (speeds up activity) and acetylcholine (slows down activity) are examples of Neurotransmitters. When an impulse reaches the end of the axon like it usually would, not only does Na+ come into the axon, but Ca+2 as well. This calcium binds with contractile proteins that pull the Neu ...
Key Transmitters - Sinauer Associates
Key Transmitters - Sinauer Associates

... they have a much higher permeability to Ca+ ions than most AMPA channels (see Chapter 11). Their voltage-dependence means that they act as coincidence detectors, only allowing current to pass when the neuron is simultaneously depolarized by, for example, highfrequency activation of AMPA channels, on ...
Unit IV-D Outline
Unit IV-D Outline

... A. The Regulatory Process 1. Functions of Regulation a. regulation - responses to a wide variety of changes that take place both inside and outside the body of the organism must be controlled in amount and directed to the right place b. coordination – responses to a wide variety of changes that take ...
Topic 6.5 Neuron and Synapses
Topic 6.5 Neuron and Synapses

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Skeletal Muscle

... of visceral reflexes that require constant monitoring by the internal body systems. Reflexes like coughing, swallowing, sneezing, or vomiting are considered to autonomic, however, these reflexes require at least some participation of the skeletal muscles. Somatic reflexes refer to those that include ...
How Neurons Talk to Each Other
How Neurons Talk to Each Other

... The presynaptic nerve endings contain signal molecules known as neurotransmitters, which are stored in small membrane-enclosed vesicles. Each nerve ending in the central nervous system contains an average of several hundred synaptic vesicles. However, synapses vary significantly. For example, some s ...
Anatomy of the Somatosensory System
Anatomy of the Somatosensory System

... to noxious chemicals. These receptors respond to minute punctures of the epithelium, with a response magnitude that depends on the degree of tissue deformation. They also respond to temperatures in the range of 40–60°C, and change their response rates as a linear function of warming (in contrast wit ...
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A. What is a neuron? 1. A neuron is a type of cell that receives and

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Developmental plasticity: Pruning
Developmental plasticity: Pruning

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The Nervous System crossword

... 1. The peripheral nervous system connects everything to the brain and spinal cord. 3. The cells of the nervous system are called neurones. 4. What is the name of the membrane bound structure found in the body of the cell? [Nucleus] 6. The small space between two nerve cells is called the synaptic cl ...
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Chapter 17 Part A

... Ca++ ions that flood into the axon bulb - Ca++ ions cause microfilaments to pull synaptic vesicles to presynaptic (axon bulb) membrane - vesicles secrete neurotransmitter (exocytosis) into the synaptic cleft - neurotransmitter diffuses across cleft to bind (“lock-and key”) to receptor on postsynapti ...
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Synaptogenesis

... nuclei directly beneath the endplate express α,β,γ,δ and ε subunits; all other nuclei re-express the fetal subunit pattern of α2βγδ. Embryonic AChRs are found all over the surface of the myofiber, producing denervation supersensitivity. The adult form of the receptor is restricted to the end plate r ...
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Human Biology Human Body Systems Nervous System

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Nervous System - APBio
Nervous System - APBio

... (like dominoes) • Because of the refectory period, the impulse can only move in one direction ...
Document
Document

... Neurotransmitter release at excitatory synapse favors action potential generation in post-synaptic cell Neurotransmitter release at inhibitory synapse discourages action potential generation in post-synaptic cell ...
Study Guide
Study Guide

... postsynaptic neuron. The terms presynaptic and postsynaptic may also be applied to various parts of these neurons; for example, the end of the presynaptic neuron’s axon is called the presynaptic terminal. • Paragraph 4: Most of Kandel’s own work has been conducted on Aplysia, the lowly sea slug. Som ...
Nervous System
Nervous System

... • Some are transported back to synaptic knob that released them or into nearby neuroglial cells. ...
CONTROL OF MOVEMENT
CONTROL OF MOVEMENT

... 4.  Motor  neuron   –  Efferent,  peripheral;  leading  from  the  CNS   •  Soma/c  motor  neuron   •  Autonomic  motor  neuron   •  Sympathe7c  division   •  Parasympathe7c  division   ...
Synapses - JNCASR Desktop
Synapses - JNCASR Desktop

... Neurons are the basic data processing units of the brain. ...
File
File

`synapse`.
`synapse`.

... receiving neurons. ► It is the presence of the NT 'keys' opening the receptor 'locks' on the surface of the dendrites of the post-synaptic neurons (and not any electrical signal that jumps the synapse) that excites or inhibits the postsynaptic neurons into activating or not. ...
EXCITABLE TISSUES
EXCITABLE TISSUES

... membrane.  Some vesicles fuse with the neuronal surface membrane and  burst  releasing  their  neurotransmitter  content  into  the  cleft.    The  neurotransmitter  in  this  case  is  Acetylcholine  (ACh).  The  ACh  diffuses  rapidly  across  the  narrow  cleft  and  attaches  to  receptors  on  ...
Slide 1
Slide 1

... – Signal changes form across synapse – Electrical  chemical  electrical ...
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Neuromuscular junction



A neuromuscular junction (sometimes called a myoneural junction) is a junction between nerve and muscle; it is a chemical synapse formed by the contact between the presynaptic terminal of a motor neuron and the postsynaptic membrane of a muscle fiber. It is at the neuromuscular junction that a motor neuron is able to transmit a signal to the muscle fiber, causing muscle contraction.Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy. Synaptic transmission at the neuromuscular junction begins when an action potential reaches the presynaptic terminal of a motor neuron, which activates voltage-dependent calcium channels to allow calcium ions to enter the neuron. Calcium ions bind to sensor proteins (synaptotagmin) on synaptic vesicles, triggering vesicle fusion with the cell membrane and subsequent neurotransmitter release from the motor neuron into the synaptic cleft. In vertebrates, motor neurons release acetylcholine (ACh), a small molecule neurotransmitter, which diffuses across the synaptic cleft and binds to nicotinic acetylcholine receptors (nAChRs) on the cell membrane of the muscle fiber, also known as the sarcolemma. nAChRs are ionotropic receptors, meaning they serve as ligand-gated ion channels. The binding of ACh to the receptor can depolarize the muscle fiber, causing a cascade that eventually results in muscle contraction.Neuromuscular junction diseases can be of genetic and autoimmune origin. Genetic disorders, such as Duchenne muscular dystrophy, can arise from mutated structural proteins that comprise the neuromuscular junction, whereas autoimmune diseases, such as myasthenia gravis, occur when antibodies are produced against nicotinic acetylcholine receptors on the sarcolemma.
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