Antimicrobial Pharmacokinetics and Pharmacodynamics
... antimicrobial agent. In some circumstances, protein binding can have a detrimental effect, whereas in others it may enhance dosing efficacy. The antimicrobial activity of a drug is inversely related to the extent of protein binding. Protein binding of antimicrobials in serum can interfere with biolo ...
... antimicrobial agent. In some circumstances, protein binding can have a detrimental effect, whereas in others it may enhance dosing efficacy. The antimicrobial activity of a drug is inversely related to the extent of protein binding. Protein binding of antimicrobials in serum can interfere with biolo ...
Feline Dosing Chart
... after dexmedetomidine could lead to adverse cardiovascular effects (secondary tachycardia, prolonged hypertension, and cardiac arrhythmias1, 2, 3). However, an anticholinergic drug may be administered to dogs at least 10 minutes before dexmedetomidine for the prevention of the dexmedetomidine-induce ...
... after dexmedetomidine could lead to adverse cardiovascular effects (secondary tachycardia, prolonged hypertension, and cardiac arrhythmias1, 2, 3). However, an anticholinergic drug may be administered to dogs at least 10 minutes before dexmedetomidine for the prevention of the dexmedetomidine-induce ...
Model-based Analysis of the Effects of Thioridazine Enantiomers on the... Papillary Action Potential
... mg L-1 required more substantial inhibition of ICaL. Using the forward method, the determined inhibition of IKr was similar to the values of racemate induced IKr inhibition obtained from the literature. The model could describe the experimental data only moderately well using this approach, as the r ...
... mg L-1 required more substantial inhibition of ICaL. Using the forward method, the determined inhibition of IKr was similar to the values of racemate induced IKr inhibition obtained from the literature. The model could describe the experimental data only moderately well using this approach, as the r ...
VALIDATED HPLC METHOD FOR SIMULTANEOUS QUANTITATION OF TADALAFIL AND
... HPLC method has been described for simultaneous determination of Tadalafil and Dapoxetine Hydrochloride in formulation. This method is based on HPLC separation of the two drugs on the Thermo Hypersil BDS–C18 (250 mm × 4.6 mm, 5.0 µ) from Germany with isocratic conditions and simple mobile phase cont ...
... HPLC method has been described for simultaneous determination of Tadalafil and Dapoxetine Hydrochloride in formulation. This method is based on HPLC separation of the two drugs on the Thermo Hypersil BDS–C18 (250 mm × 4.6 mm, 5.0 µ) from Germany with isocratic conditions and simple mobile phase cont ...
The PBAC agenda primarily consists of applications relating
... Major: Submissions to list new medicines on the Schedule of Pharmaceutical Benefits or to make substantial changes to current listings are generally classified as major submissions. Major submissions require presentation of an economic evaluation. Minor: Submissions that relate to new forms of p ...
... Major: Submissions to list new medicines on the Schedule of Pharmaceutical Benefits or to make substantial changes to current listings are generally classified as major submissions. Major submissions require presentation of an economic evaluation. Minor: Submissions that relate to new forms of p ...
SALT SOLID DISPERSIONS
... Improving oral bioavailability of poorly water-soluble drugs remains one of the most challenging aspects of drug development. Pharmaceutical salt formation is a widely accepted approach to improve dissolution rate of poorly water-soluble ionic drugs. Nevertheless, the salt formation process is often ...
... Improving oral bioavailability of poorly water-soluble drugs remains one of the most challenging aspects of drug development. Pharmaceutical salt formation is a widely accepted approach to improve dissolution rate of poorly water-soluble ionic drugs. Nevertheless, the salt formation process is often ...
- Boehringer Ingelheim (Canada)
... should be warned to seek immediate medical advice if they experience chest pain or other symptoms of worsening heart disease. Attention should be paid to assessment of symptoms such as dyspnoea and chest pain, as they may be of either respiratory or cardiac origin. Fatalities, the exact cause of whi ...
... should be warned to seek immediate medical advice if they experience chest pain or other symptoms of worsening heart disease. Attention should be paid to assessment of symptoms such as dyspnoea and chest pain, as they may be of either respiratory or cardiac origin. Fatalities, the exact cause of whi ...
In vitro metabolism of sirolimus: role of CYP3A4 and - HAL
... genotype effect consistent with numerous clinical reports (3, 10-12). We found that CYP3A4 is a better catalyst of everolimus than CYP3A5, while the opposite was observed for tacrolimus. This provides a first explanation to the fact that CYP3A5 expression does not significantly influence everolimus ...
... genotype effect consistent with numerous clinical reports (3, 10-12). We found that CYP3A4 is a better catalyst of everolimus than CYP3A5, while the opposite was observed for tacrolimus. This provides a first explanation to the fact that CYP3A5 expression does not significantly influence everolimus ...
Application of Hepatocytes for In Vitro Uptake Studies
... Adapted from Zamek-Glisczynski et al., ITC Workshop, Clin Pharm Ther 92(5): 2012 ...
... Adapted from Zamek-Glisczynski et al., ITC Workshop, Clin Pharm Ther 92(5): 2012 ...
CASSIA ALATA Research Article MULHAM ALFATAMA, KAUSAR AHMAD, FARAHIDAH MOHAMED
... The polymeric matrixes employed in this study is the most commonly used biodegradable, biocompatible, poly-(D,L-lactide-coglycolide) (PLGA) co-polymer4. Its non-toxic degradation products permits its application in drug delivery systems and due to their established safety profile, the FDA (Food and ...
... The polymeric matrixes employed in this study is the most commonly used biodegradable, biocompatible, poly-(D,L-lactide-coglycolide) (PLGA) co-polymer4. Its non-toxic degradation products permits its application in drug delivery systems and due to their established safety profile, the FDA (Food and ...
COMPARATIVE EVALUATION OF NATURAL AND SYNTHETIC SUPERDISINTEGRANT FOR PROMOTING NIMESULIDE DISSOLUTION FOR FAST DISSOLVING TECHNOLOGY
... sativum seed was obtained from local market Mehsana. All other ingredients were used of analytical grade. METHODS Methodology for extraction of mucilage Lepidium sativum11 The seeds of Lepidium sativum contain the mucilage around the outer layer. The major problem in iso ...
... sativum seed was obtained from local market Mehsana. All other ingredients were used of analytical grade. METHODS Methodology for extraction of mucilage Lepidium sativum11 The seeds of Lepidium sativum contain the mucilage around the outer layer. The major problem in iso ...
Is the Role of the Small Intestine in First
... Recent clinical studies, however, have indicated that the small intestine contributes substantially to the overall first-pass metabolism of cyclosporine, nifedipine, midazolam, verapamil, and certain other drugs (Hebert et al., 1992; Wu et al., 1995; Paine et al., 1996; Holtbecker et al., 1996; From ...
... Recent clinical studies, however, have indicated that the small intestine contributes substantially to the overall first-pass metabolism of cyclosporine, nifedipine, midazolam, verapamil, and certain other drugs (Hebert et al., 1992; Wu et al., 1995; Paine et al., 1996; Holtbecker et al., 1996; From ...
this PDF file
... Since then, there has been a revolution in the medical device industry which has introduced several orthopaedic implants such as pins, screws, cranio-maxilla-facial plates and so on. After about two decades, in the 1990s, the pharmaceutical industry entered in to this new era of biodegradable polyme ...
... Since then, there has been a revolution in the medical device industry which has introduced several orthopaedic implants such as pins, screws, cranio-maxilla-facial plates and so on. After about two decades, in the 1990s, the pharmaceutical industry entered in to this new era of biodegradable polyme ...