The Safety of Citrus aurantium (Bitter Orange) and its
... repeatedly administering orally 2.5–20 mg/kg of two C. aurantium fruit extracts that had been standardized to 4% and 6% p‐synephrine. Animals were treated for 7 consecutive days and the various measurements were recorded for 15 consecutive days. Significant dose‐ dependent decreases in food intake as ...
... repeatedly administering orally 2.5–20 mg/kg of two C. aurantium fruit extracts that had been standardized to 4% and 6% p‐synephrine. Animals were treated for 7 consecutive days and the various measurements were recorded for 15 consecutive days. Significant dose‐ dependent decreases in food intake as ...
R.W. Moreadith, T.X. Viegas, M.D. Bentley, J.M. Harris, Z. Fang, K
... to that of the PEG-DSPE material after a single intravenous bolus injection of 500 nmol of liposomes. Comparatively, the PEOZ-DSPE composition was more hydrophobic and hence cleared the blood at a faster rate and was detected in relatively higher amounts in the liver and spleen. Kierstead et al. pre ...
... to that of the PEG-DSPE material after a single intravenous bolus injection of 500 nmol of liposomes. Comparatively, the PEOZ-DSPE composition was more hydrophobic and hence cleared the blood at a faster rate and was detected in relatively higher amounts in the liver and spleen. Kierstead et al. pre ...
Simultaneous Quantitative Determination of Candesartan cilexetil
... another portion was stored under refrigeration at approximately 48ºC, and the content of these solutions was regularly co mpared with that of a freshly prepared solution. Accuracy (% Recovery) The accuracy of the methods was determined by calculating recoveries of Hydrochlorthiazide and Candesartan ...
... another portion was stored under refrigeration at approximately 48ºC, and the content of these solutions was regularly co mpared with that of a freshly prepared solution. Accuracy (% Recovery) The accuracy of the methods was determined by calculating recoveries of Hydrochlorthiazide and Candesartan ...
PDF version of March 2015 PBAC Meeting Agenda
... Major: Submissions to list new medicines on the Schedule of Pharmaceutical Benefits or to make substantial changes to current listings are generally classified as major submissions. Major submissions require presentation of an economic evaluation. Minor: Submissions that relate to new forms of p ...
... Major: Submissions to list new medicines on the Schedule of Pharmaceutical Benefits or to make substantial changes to current listings are generally classified as major submissions. Major submissions require presentation of an economic evaluation. Minor: Submissions that relate to new forms of p ...
Evidence Based Review of Weight Loss Medicines
... University of Otago, nor the contributors involved can accept responsibility for any errors or omissions. The reader should always consult the original database from which each abstract is derived along with the original articles before making decisions based on a document or abstract. All responsib ...
... University of Otago, nor the contributors involved can accept responsibility for any errors or omissions. The reader should always consult the original database from which each abstract is derived along with the original articles before making decisions based on a document or abstract. All responsib ...
Therapeutic Drug Monitoring of Lithium Carbonate
... kd=elimination rate constant (hr–1) [calculated as ln(2)/lithium t½]. The Terao et al. method (Terao 1999) was given by the following formula: ...
... kd=elimination rate constant (hr–1) [calculated as ln(2)/lithium t½]. The Terao et al. method (Terao 1999) was given by the following formula: ...
Sildenafil Determination in Various Matrices: A
... Similarly, RP-LC HPLC system was used for quantitation of sildenafil citrate in pure and its pharmaceutical preparations [13] using piroxicam as internal standard. They showed that this technique [13] provided a precise and accurate method for its determination in pharmaceutical formulation. Their m ...
... Similarly, RP-LC HPLC system was used for quantitation of sildenafil citrate in pure and its pharmaceutical preparations [13] using piroxicam as internal standard. They showed that this technique [13] provided a precise and accurate method for its determination in pharmaceutical formulation. Their m ...
EFFECT OF VALERIAN ROOT EXTRACTS (VALERIANA
... (Cmax) and a decrease in time to reach the maximum plasma concentration (tmax), but did not affect the area under the plasma concentration-time curve (AUC) or half life. As these results were unexpected, human hepatocyte cultures were used to determine if enzyme induction potential of some component ...
... (Cmax) and a decrease in time to reach the maximum plasma concentration (tmax), but did not affect the area under the plasma concentration-time curve (AUC) or half life. As these results were unexpected, human hepatocyte cultures were used to determine if enzyme induction potential of some component ...
Conflict acts as an implicit cost in reinforcement
... from the Brown University undergraduate subject pool and Providence community to complete the experiment (mean age ¼ 20 years, range ¼ 18–30 years, 52 female). Samples of saliva (B4 cc) were obtained from each subject using the Oragene system (DNA Genotek). A novel task was created to elicit respons ...
... from the Brown University undergraduate subject pool and Providence community to complete the experiment (mean age ¼ 20 years, range ¼ 18–30 years, 52 female). Samples of saliva (B4 cc) were obtained from each subject using the Oragene system (DNA Genotek). A novel task was created to elicit respons ...
Extract from the Clinical Evaluation Report for Ceftobiprole
... Ceftobiprole has demonstrated in vitroactivity against daptomycin-nonsusceptible, tigecyclineresistant and linezolid-resistant S. aureus. Ceftobiprole’s potent activity against MRSA and PRSP extends the predominantly gram-negative spectrum of the well-established fourth-generation cephalopsorins (su ...
... Ceftobiprole has demonstrated in vitroactivity against daptomycin-nonsusceptible, tigecyclineresistant and linezolid-resistant S. aureus. Ceftobiprole’s potent activity against MRSA and PRSP extends the predominantly gram-negative spectrum of the well-established fourth-generation cephalopsorins (su ...
University of Groningen Human and rat organ slices de
... the various conditions variables can be carefully manipulated and controlled. Ideally, in vitro methods are easy to set up, often yield results quickly and are inexpensive as well as simple to run. In addition, in vitro systems can be a very efficient way to reduce the amount of experimental animals ...
... the various conditions variables can be carefully manipulated and controlled. Ideally, in vitro methods are easy to set up, often yield results quickly and are inexpensive as well as simple to run. In addition, in vitro systems can be a very efficient way to reduce the amount of experimental animals ...
Simultaneous Determination of Piracetam and its Four
... from interacting with amines in your sample. Acetonitrile–0.2 g/L solution of triethyl amine at pH 6.5 in the proportion 15:85 (v/v) was found to be a suitable solvent system. When 50:50 (v/v) was employed as the mobile phase, poor resolution was obtained between the drug and its degradation product ...
... from interacting with amines in your sample. Acetonitrile–0.2 g/L solution of triethyl amine at pH 6.5 in the proportion 15:85 (v/v) was found to be a suitable solvent system. When 50:50 (v/v) was employed as the mobile phase, poor resolution was obtained between the drug and its degradation product ...
preparation of diazepam rectal gel using cellulose polymers
... properties and it is the most widely used drug for treatment of insomnia, convulsions, and status epilepticus. Considering the advantages of rectal administration of diazepam, the objective of our study was to formulate and evaluate rectal hydrogels containing diazepam as a drug substance in combina ...
... properties and it is the most widely used drug for treatment of insomnia, convulsions, and status epilepticus. Considering the advantages of rectal administration of diazepam, the objective of our study was to formulate and evaluate rectal hydrogels containing diazepam as a drug substance in combina ...
Dow Corning Silicones in Pharmaceutical Applications
... This addition reaction requires very low levels of a platinum complex as catalyst (5 20 ppm as Pt) and does not generate any by-products, hence its advantages in pharmaceutical applications (3). Using a polymer carrying many SiH groups, many vinyl endblocked chains can be crosslinked together. A lar ...
... This addition reaction requires very low levels of a platinum complex as catalyst (5 20 ppm as Pt) and does not generate any by-products, hence its advantages in pharmaceutical applications (3). Using a polymer carrying many SiH groups, many vinyl endblocked chains can be crosslinked together. A lar ...
The role of drug metabolism in drug discovery and
... adequacy nonclinical animal exposure was evaluated. The major human cytochrome P450 enzymes involved in the formation of principal metabolites were also identified and the clinical consequences assessed. Finally, the interaction potential of ospemifene as a cytochrome P450 enzyme inducer or inhibito ...
... adequacy nonclinical animal exposure was evaluated. The major human cytochrome P450 enzymes involved in the formation of principal metabolites were also identified and the clinical consequences assessed. Finally, the interaction potential of ospemifene as a cytochrome P450 enzyme inducer or inhibito ...
An in vitro study on the compatibility and precipitation of a
... process, leading to a loss of antibiotic content up to about 74%. Meanwhile, the therapeutic level recommended gives an intravitreal level that is not too high and is at the ‘‘supraprecipitation’’ level.13 14 Further, in the dialysis experiments, the ciprofloxacin level was decreased from its initia ...
... process, leading to a loss of antibiotic content up to about 74%. Meanwhile, the therapeutic level recommended gives an intravitreal level that is not too high and is at the ‘‘supraprecipitation’’ level.13 14 Further, in the dialysis experiments, the ciprofloxacin level was decreased from its initia ...
