• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Absorption
Absorption

Lecture 6 Classification of Interest Rate Models
Lecture 6 Classification of Interest Rate Models

... be as accurate as multiple factor models • General equilibrium models are useful for modeling term structure behavior over time • Arbitrage free models are useful for pricing interest rate contingent securities • How the model will be used determines which interest rate model would be most appropria ...
PRINCIPLES OF PHARMACOKINETICS Learning Objectives
PRINCIPLES OF PHARMACOKINETICS Learning Objectives

... B. Differences in tissue/blood ratios at equilibrium 1. Dissolution of lipid-soluble drugs in adipose tissue 2. Binding of drugs to intracellular sites 3. Plasma protein binding; many drugs reversibly bind to albumin, α1-acid glycoprotein or other proteins in plasma; extent of binding dependent on a ...
Absorption, distribution, metabolism and excretion
Absorption, distribution, metabolism and excretion

... If neither secreted nor reabsorbed then clearance = clearance of inulin = 120 ml/min If completely cleared by secretion then clearance = clearance of p-hippuric acid = renal blood flow = 700 ml/min ...
Title Methods for Constructing Statistical Model Associated with Movement and Neuron Data
Title Methods for Constructing Statistical Model Associated with Movement and Neuron Data

... This paper considers the problem of constructing statistical model that describes the relationship between the arm movement of monkey and its neuron firing rate. This estimation statistical model could be a cornerstone for the neurologists and medical professionals research on how the human body mov ...
1.63J/2.26J Advanced Fluid Dynamics Spring 2014 Problem Set No. 2
1.63J/2.26J Advanced Fluid Dynamics Spring 2014 Problem Set No. 2

... two pieces of glass from each other, is difficult. This is because of the slow flow in the very thin gap, that produces an adhesive force. Referring to the sketch below, consider a two-dimensional problem for simplicity. A plate of finite width L originally rests on top of a rigid and smooth plane z ...
Math review ppt
Math review ppt

... • What is the SA/V for this cell? Round your answer to the nearest hundredths. ...
Specific ADRs
Specific ADRs

Iloprost patient information
Iloprost patient information

... Sickness, vomiting or abdominal cramps Diarrhoea ...
KINETICS OF ELIMINATION
KINETICS OF ELIMINATION

... * k is the elimination rate constant of the drug. i.e. the fraction of the total amount of the drug in the body which is removed per unit time . Eg: 2g of drug present in the body & 0.1g is eliminated every hour then k =0.1/2=0.05 or 5% per hour . k=CL/v , therefore t1/2 =0.693xV/CL ...
Antibiotic PK/PD
Antibiotic PK/PD

Some Proof Techniques • Induction • Pigeonhole Principle
Some Proof Techniques • Induction • Pigeonhole Principle

Lecture22: Fast reaction kinetics
Lecture22: Fast reaction kinetics

RbeattieTalk1
RbeattieTalk1

... little mass a black hole can have. Any amount of mass at all can in principle be made to form a black hole if you compress it to a high enough density. • The Schwarzschild radius (the radius of the horizon) and the mass are directly proportional to one another: if one black hole weighs ten times as ...
Understanding the Basics of Pharmacology
Understanding the Basics of Pharmacology

...  Generic name: chemical name  Brand name /Trade name ...
Supplements and Ergogenic Aids - Mr-Corrente
Supplements and Ergogenic Aids - Mr-Corrente

... Protein and Amino Acid Supplements • Protein supplements are for athletes concerned about strength, building muscle and endurance. • There is a lot of contradictory research in this area. The effectiveness of oral or intravenous infusion has not yet been proven scientifically. • Any benefits from ...
pharmacokinetics-3
pharmacokinetics-3

... free D. Drugs with high lipid solubility are reabsorbed passively & therefore slowly excreted. Idea of ion trapping can be used to increase excretion rate---traps drug in filtrate. ...
Seminar ECON4620, 2 May 2016 Problem 1 Suppose that an
Seminar ECON4620, 2 May 2016 Problem 1 Suppose that an

Exploring the clinical applications of a multi‑infusion model
Exploring the clinical applications of a multi‑infusion model

Section 9A
Section 9A

... Thus for A to decrease from 2 M to 1 M will take just as much time as decrease from 0.1 M to 0.05 M. For other types of reactions the half-lives do depend on the initial concentration of reactant. In general the expression describing relationship between [reactant] and half-life is as follows: t ...
MIDW 125 Math Review and Equation Sheet
MIDW 125 Math Review and Equation Sheet

... - uses the base ‘e’ where e is an irrational constant equal to 2.718  - there are several (very complicated) ways to calculate ‘e’.  For your purposes what is important is that  you know the series of buttons to push on your calculator to get the 2.718 result.  This involves taking  the anti‐natural ...
High Rate Lithium Cell
High Rate Lithium Cell

... Wide operating temperature range as low as -55oC and up to +85oC Low self discharge rate (3% per year at 25oC) Restricted for transportation (Class 9) Custom terminations available ...
HW2 (Macro Theory)
HW2 (Macro Theory)

... (e) Suppose that the government marginally lowers t1 and raises t2 by the same amount, so that its expected total revenue, t1 y1 + t2 E[y2 ] is unchanged. Implicitly differentiate the first-order condition in part (a) to find an expression for how c1 responds to this change. (f) Show that c1 is unaf ...
A Sheepish Problem (NCTM-Cartoon Corner: Jan
A Sheepish Problem (NCTM-Cartoon Corner: Jan

... ...
2.3 Rate of Change
2.3 Rate of Change

... exists at a, we say the function is diffentiable at a. What would it mean for a function not to be differentiable? ...
< 1 ... 148 149 150 151 152 153 154 155 156 >

Plateau principle

The plateau principle is a mathematical model or scientific law originally developed to explain the time course of drug action The principle has wide applicability in pharmacology, physiology, nutrition, biochemistry and system dynamics. It applies whenever a drug or nutrient is infused or ingested at a relatively constant rate and when a constant fraction is eliminated during each time interval. Under these conditions, any change in the rate of infusion leads to an exponential increase or decrease until a new level is achieved. This behavior is also called an approach to steady state because rather than causing an indefinite increase or decrease, a natural balance is achieved when the rate of infusion or production is balanced by the rate of loss.An especially important use of the plateau principle is to study the renewal of tissue constituents in the human and animal body. In adults, daily synthesis of tissue constituents is nearly constant, and most constituents are removed with a first order reaction rate. Applicability of the plateau principle was recognized during radiotracer studies of protein turnover in the 1940s by Rudolph Schoenheimer and David Rittenberg. Unlike the case with drugs, the initial amount of tissue or tissue protein is not zero because daily synthesis offsets daily elimination. In this case, the model is also said to approach a steady state with exponential or logarithmic kinetics. Constituents that change in this manner are said to have a biological half-life.A practical application of the plateau principle is that most people have experienced ""plateauing"" during regimens for weight management or training for sports. After a few weeks of progress, one seems unable to continue gaining in ability or losing weight. This outcome results from the same underlying quantitative model. This entry will describe the popular concepts as well as development of the plateau principle as a scientific, mathematical model.In the sciences, the broadest application of the plateau principle is creating realistic time signatures for change in kinetic models (see Mathematical model). One example of this principle is the long time required to effectively change human body composition. Theoretical studies have shown that many months of consistent physical training and food restriction are needed to bring about permanent weight stability in people who were previously overweight.
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report