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The nuclear envelope in genome organization, expression and
The nuclear envelope in genome organization, expression and

... harbour replication fork-blocking sequences, which can stall replication forks and induce double strand breaks. The locations of the centromere (Cen), telomeres (Tel), Pol I transcription initiation region (TIR) and DNA replication origin (empty circle) are shown in the figure. ...
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DNA Structure - WordPress.com
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DNA Replication - Crestwood Local Schools
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... • He found that R strain could become virulent when it took in DNA from heat-killed S strain • Study suggested that DNA was probably the genetic material copyright cmassengale ...
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Telomere



A telomere is a region of repetitive nucleotide sequences at each end of a chromatid, which protects the end of the chromosome from deterioration or from fusion with neighboring chromosomes. Its name is derived from the Greek nouns telos (τέλος) 'end' and merοs (μέρος, root: μερ-) 'part.' For vertebrates, the sequence of nucleotides in telomeres is TTAGGG. This sequence of TTAGGG is repeated approximately 2,500 times in humans. During chromosome replication, the enzymes that duplicate DNA cannot continue their duplication all the way to the end of a chromosome, so in each duplication the end of the chromosome is shortened (this is because the synthesis of Okazaki fragments requires RNA primers attaching ahead on the lagging strand). The telomeres are disposable buffers at the ends of chromosomes which are truncated during cell division; their presence protects the genes before them on the chromosome from being truncated instead.Over time, due to each cell division, the telomere ends become shorter. They are replenished by an enzyme, telomerase reverse transcriptase.
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