lecture 7
... 2- BER is initiated by DNA glycosylases, which recognize and remove specific damaged or inappropriate bases, forming AP sites. These are then cleaved by an AP endonuclease. The resulting single-strand break can then be processed by either short-patch (where a single nucleotide is replaced) or long-p ...
... 2- BER is initiated by DNA glycosylases, which recognize and remove specific damaged or inappropriate bases, forming AP sites. These are then cleaved by an AP endonuclease. The resulting single-strand break can then be processed by either short-patch (where a single nucleotide is replaced) or long-p ...
Cancer results from an accumulation of mutations which
... breaks. Cancer cells, however, may have defects in these systems which then allow for them to "escape" this surveillance and cause mutations to accumulate. In our lab, we have studied the levels of a protein called ATM, which is one of the main proteins activated when DNA damage occurs. Activated AT ...
... breaks. Cancer cells, however, may have defects in these systems which then allow for them to "escape" this surveillance and cause mutations to accumulate. In our lab, we have studied the levels of a protein called ATM, which is one of the main proteins activated when DNA damage occurs. Activated AT ...
Mighty Miniscule DNA
... cell contains a nucleus which is filled with the directions for cell function, called DNA. ...
... cell contains a nucleus which is filled with the directions for cell function, called DNA. ...
Transcription
... • Contains over 3 billion base pairs • One meter long when fully streched • Size of 6 billion genomes, one from each person on earth = 1 meter long human hair ...
... • Contains over 3 billion base pairs • One meter long when fully streched • Size of 6 billion genomes, one from each person on earth = 1 meter long human hair ...
gewone vergadering - Bataafsch Genootschap
... We are discovering how proteins work together in complex and dynamic assemblies that accomplish the work of living cells. We determine how proteins assemble into functional nanomachinery when and where they are needed. Understanding the details of normal molecular function, how this is disturbed in ...
... We are discovering how proteins work together in complex and dynamic assemblies that accomplish the work of living cells. We determine how proteins assemble into functional nanomachinery when and where they are needed. Understanding the details of normal molecular function, how this is disturbed in ...
Abstract
... suggesting that ATM is required for repairing DSBs arising within or close to heterochromatic DNA regions [Goodarzi et al., Biochem. Soc. Trans. (2009): 37, 569-576]. In order to study the impact of chromatin compaction on chromosomal instability in AT cells, the response to Trichostatin A (TSA), a ...
... suggesting that ATM is required for repairing DSBs arising within or close to heterochromatic DNA regions [Goodarzi et al., Biochem. Soc. Trans. (2009): 37, 569-576]. In order to study the impact of chromatin compaction on chromosomal instability in AT cells, the response to Trichostatin A (TSA), a ...
DOC
... 7. How do E. coli distinguish between parental and newly replicated strands when performing DNA mismatch repair? For instance, if a T was wrongly paired with a G, how does the cell know which base to replace? ...
... 7. How do E. coli distinguish between parental and newly replicated strands when performing DNA mismatch repair? For instance, if a T was wrongly paired with a G, how does the cell know which base to replace? ...
PARP inhibitors for cancer therapy Nicola Curtin Newcastle
... PARPi increase the persistence of DNA single and double strand breaks and enhance the cytotoxicity and antitumour activity of DNA methylating agents, topoisomerase I poisons and ionising radiation. However, it was the discovery that PARPi selectively killed cells and tumour xenografts defective in h ...
... PARPi increase the persistence of DNA single and double strand breaks and enhance the cytotoxicity and antitumour activity of DNA methylating agents, topoisomerase I poisons and ionising radiation. However, it was the discovery that PARPi selectively killed cells and tumour xenografts defective in h ...
Genome instability is a salient feature of carcinogenesis. In
... Multiple Ubiquitin ligases, such as BRCA1, RNF8, RNF168, TRIP12 and the Fanconi core complex have emerged as key regulators of the DNA damage response and their mutations result in hereditary diseases and cancer formation. There is much less known about which deubiquitylases (Dubs) are involved in D ...
... Multiple Ubiquitin ligases, such as BRCA1, RNF8, RNF168, TRIP12 and the Fanconi core complex have emerged as key regulators of the DNA damage response and their mutations result in hereditary diseases and cancer formation. There is much less known about which deubiquitylases (Dubs) are involved in D ...
A proto-filament superfamily evolutionally linking centrosomal
... the cartwheel structure and microtubule triples of centrosomes. A mutation in SAS6 gene causes microcephaly indicating that the protein is important for normal human development. XRCC4, XLF and PAXX work in a major DNA double-strand break (DSB) repair pathway, non-homologous end joining (NHEJ). XRCC ...
... the cartwheel structure and microtubule triples of centrosomes. A mutation in SAS6 gene causes microcephaly indicating that the protein is important for normal human development. XRCC4, XLF and PAXX work in a major DNA double-strand break (DSB) repair pathway, non-homologous end joining (NHEJ). XRCC ...