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irm_ch22 - Louisiana Tech University
irm_ch22 - Louisiana Tech University

... 22.99 A virus invades a cell by 1) attaching itself to the outside of a specific cell, 2) using an enzyme within its protein overcoat to catalyze the breakdown of the membrane and open a hole into it, and 3) injecting its DNA or RNA into the cell, whereupon the cell begins to synthesize the virus co ...
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Helicase



Helicases are a class of enzymes vital to all living organisms. Their main function is to unpackage an organism's genes. They are motor proteins that move directionally along a nucleic acid phosphodiester backbone, separating two annealed nucleic acid strands (i.e., DNA, RNA, or RNA-DNA hybrid) using energy derived from ATP hydrolysis. There are many helicases resulting from the great variety of processes in which strand separation must be catalyzed. Approximately 1% of eukaryotic genes code for helicases. The human genome codes for 95 non-redundant helicases: 64 RNA helicases and 31 DNA helicases. Many cellular processes, such as DNA replication, transcription, translation, recombination, DNA repair, and ribosome biogenesis involve the separation of nucleic acid strands that necessitates the use of helicases.
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