Compressed q-gram Indexing for Highly Repetitive Biological
... of all humans. Less than one decade later, DNA sequencing technologies have become so fast and cost-effective that sequencing individual genomes will soon become a common task [1], [2], [3]. Huge DNA collections are at the next corner. The computational challenges posed by handling collections of th ...
... of all humans. Less than one decade later, DNA sequencing technologies have become so fast and cost-effective that sequencing individual genomes will soon become a common task [1], [2], [3]. Huge DNA collections are at the next corner. The computational challenges posed by handling collections of th ...
Genotyping BoLA-DRB3 alleles in Brazilian Dairy Gir cattle (Bos
... reaction and restriction fragment length polymorphism of the amplified fragments (PCR-RFLP) for assignment of alleles. This methodology cannot accurately determine differences between all current alleles, and this may have led to the different conclusions in disease association studies. Another tech ...
... reaction and restriction fragment length polymorphism of the amplified fragments (PCR-RFLP) for assignment of alleles. This methodology cannot accurately determine differences between all current alleles, and this may have led to the different conclusions in disease association studies. Another tech ...
Role for CCG-trinucleotide repeats in the pathogenesis of chronic
... reported in many solid tumors.22-27 These observations beg the question of why the distal portion of chromosome 11 is an unstable region, prone to breakage and rearrangement, in so many cancers. Genetic instability is a common feature of many human cancers. Microsatellite instability was first descr ...
... reported in many solid tumors.22-27 These observations beg the question of why the distal portion of chromosome 11 is an unstable region, prone to breakage and rearrangement, in so many cancers. Genetic instability is a common feature of many human cancers. Microsatellite instability was first descr ...
The Human Globin Genes
... repetitive DNA resulting from errors during replication or recombination About a third of this consists of duplication of long sequences of DNA from one location to another ...
... repetitive DNA resulting from errors during replication or recombination About a third of this consists of duplication of long sequences of DNA from one location to another ...
The National Institute of Justice and Advances in Forensic
... training, and developing certification programs for forensic examiners, OS&T is ensuring the accurate application of this advanced technology by crime labs across the Nation. This bulletin describes new methods of physical evidence analysis as well as recent developments in automation for such analy ...
... training, and developing certification programs for forensic examiners, OS&T is ensuring the accurate application of this advanced technology by crime labs across the Nation. This bulletin describes new methods of physical evidence analysis as well as recent developments in automation for such analy ...
Comprehensive Analysis of Chimpanzee and Human
... It is now clear that the genetic differences between humans and chimpanzees are far more extensive than previously thought; their genomes are not 98% or 99% identical (Preuss 2012, p. 10709). ...
... It is now clear that the genetic differences between humans and chimpanzees are far more extensive than previously thought; their genomes are not 98% or 99% identical (Preuss 2012, p. 10709). ...
Nucleotides. Nucleic Acid, and Heredity
... loops (Figure 8.6). In these regions, A pairs with U, and G pairs with C. The base pairing in RNA hairpins is frequently imperfect, G can also form a base pair with U, but it is less strong than the GC base pair. ...
... loops (Figure 8.6). In these regions, A pairs with U, and G pairs with C. The base pairing in RNA hairpins is frequently imperfect, G can also form a base pair with U, but it is less strong than the GC base pair. ...
Construction of PANM Database (Protostome DB) for rapid
... DB. It was also noted that PANM-DB show two times more significant hits with diverse annotation profiles as compared with Mollusks DB. Hence, the construction of PANM-DB is a significant step in the annotation of molluscan sequence information obtained from NGS platforms. The PANM-DB is freely downl ...
... DB. It was also noted that PANM-DB show two times more significant hits with diverse annotation profiles as compared with Mollusks DB. Hence, the construction of PANM-DB is a significant step in the annotation of molluscan sequence information obtained from NGS platforms. The PANM-DB is freely downl ...
Widespread RNA and DNA Sequence Differences in the Human
... analyses. First, we considered sites that are monomorphic in the human genome. A monomorphic site is one where there is no evidence for sequence variation at that locus in dbSNP, the HapMap, and the 1000 Genomes Project. Different studies have analyzed these 27 and hundreds of additional individuals ...
... analyses. First, we considered sites that are monomorphic in the human genome. A monomorphic site is one where there is no evidence for sequence variation at that locus in dbSNP, the HapMap, and the 1000 Genomes Project. Different studies have analyzed these 27 and hundreds of additional individuals ...
Point mutation of bacterial artificial chromosomes by ET recombination
... strategy used confers all of the advantages of other ET recombination applications, including the following. (i) A high degree of fidelity is preserved. As shown in Figure 2B, all of the clones examined contained the additional EcoRI site at the correct locus. (ii) Recombination occurs in a recA– ba ...
... strategy used confers all of the advantages of other ET recombination applications, including the following. (i) A high degree of fidelity is preserved. As shown in Figure 2B, all of the clones examined contained the additional EcoRI site at the correct locus. (ii) Recombination occurs in a recA– ba ...
Functional analysis of plastid DNA replication origins in tobacco by
... B, respectively, is shown on top of the plasmids; regions of homology are indicated by dotted lines. Genes are indicated as open arrows marking the direction of transcription. JSA and JSB denote the border between Inverted Repeat A or B, respectively, and the small single copy region of the plastome ...
... B, respectively, is shown on top of the plasmids; regions of homology are indicated by dotted lines. Genes are indicated as open arrows marking the direction of transcription. JSA and JSB denote the border between Inverted Repeat A or B, respectively, and the small single copy region of the plastome ...
crystal structure of the DNA-binding domain of vIRF
... Even though vIRF-1 shows sequence homology to the N-terminal DNA-binding domain (DBD) of human IRFs, a specific role for this domain in vIRF-1’s function has remained uncertain. To provide insights into the function of the vIRF-1 DBD, we have determined the crystal structure of it in complex with DN ...
... Even though vIRF-1 shows sequence homology to the N-terminal DNA-binding domain (DBD) of human IRFs, a specific role for this domain in vIRF-1’s function has remained uncertain. To provide insights into the function of the vIRF-1 DBD, we have determined the crystal structure of it in complex with DN ...
DNA-Directed Base Pair Opening
... transcription initiation, the detailed molecular mechanisms that lead to the initiation of DNA melting remain to be elucidated [1,2]. Similarly, DNA helicases unwind DNA and translocate by a variety of mechanisms that are now well characterized, however, the first steps that trigger strand separatio ...
... transcription initiation, the detailed molecular mechanisms that lead to the initiation of DNA melting remain to be elucidated [1,2]. Similarly, DNA helicases unwind DNA and translocate by a variety of mechanisms that are now well characterized, however, the first steps that trigger strand separatio ...
Comparison of DNA Sequences with Protein Sequences
... they can be more easily joined, and (b) to allow small overlaps (10 residues) between joined regions. Step 4 is changed to produce a band-limited DNA–protein local alignment score (Zhang et al., 1997) as outlined above. FASTX and FASTY use a full Smith–Waterman local DNA–protein alignment in linear ...
... they can be more easily joined, and (b) to allow small overlaps (10 residues) between joined regions. Step 4 is changed to produce a band-limited DNA–protein local alignment score (Zhang et al., 1997) as outlined above. FASTX and FASTY use a full Smith–Waterman local DNA–protein alignment in linear ...
Down syndrome, trisomy 21, parental origin, PCR, D21S11 and
... and cytogenetic analysis of patients with Down syndrome (DS) in Bahawalpur, Pakistan. Mongoloid slant, epicanthal folds, simian crease, flat nasal bridge, Retarded growth and development was observed in 90% cases of present research. The current research study showed that out of the total thirty pat ...
... and cytogenetic analysis of patients with Down syndrome (DS) in Bahawalpur, Pakistan. Mongoloid slant, epicanthal folds, simian crease, flat nasal bridge, Retarded growth and development was observed in 90% cases of present research. The current research study showed that out of the total thirty pat ...
Rapid detection of multidrug-resistant tuberculosis
... reliable, generating data that can be readily analysed by eye, and stored using any simple word-processing programme. Strain-typing itself does not provide direct information about drug susceptibility, but a register of spoligotypes from known MDR isolates may be particularly useful in providing ear ...
... reliable, generating data that can be readily analysed by eye, and stored using any simple word-processing programme. Strain-typing itself does not provide direct information about drug susceptibility, but a register of spoligotypes from known MDR isolates may be particularly useful in providing ear ...
The role of DNA shape in protein-DNA recognition
... the formation of hydrogen bonds with specific bases, primarily in the major groove, and one involving sequence-dependent deformations of the DNA helix. By comprehensively analysing the three-dimensional structures of protein–DNA complexes, here we show that the binding of arginine residues to narrow ...
... the formation of hydrogen bonds with specific bases, primarily in the major groove, and one involving sequence-dependent deformations of the DNA helix. By comprehensively analysing the three-dimensional structures of protein–DNA complexes, here we show that the binding of arginine residues to narrow ...
genetics laboratory manual
... substrate (such as the side of your bottle). The cuticle then transforms into a puparium, which is initially soft and white but soon hardens, turning tan and eventually brown and brittle. Shortly after the puparium forms, the larva detaches from the inside of the puparium by molting a fourth time. M ...
... substrate (such as the side of your bottle). The cuticle then transforms into a puparium, which is initially soft and white but soon hardens, turning tan and eventually brown and brittle. Shortly after the puparium forms, the larva detaches from the inside of the puparium by molting a fourth time. M ...
Linear DNA Low Efficiency Transfection by Liposome Can - if
... Delivery of DNA to the target cells could be mediated by different vehicles: viral vectors, liposomes, cationic lipids, and other reagents are used to overcome the membrane barrier. The DNA transfection methods must take into account the negative charge present on the cell membrane, the stability of ...
... Delivery of DNA to the target cells could be mediated by different vehicles: viral vectors, liposomes, cationic lipids, and other reagents are used to overcome the membrane barrier. The DNA transfection methods must take into account the negative charge present on the cell membrane, the stability of ...
A- DNA
... each other by the electrostatic repulsion of the negatively charged deoxyribose – phosphate backbone of each strand. The strands of the double helix must separate during replication and transcription of DNA. In vitro experiments denaturation can be induced by increasing the temperature of DNA solu ...
... each other by the electrostatic repulsion of the negatively charged deoxyribose – phosphate backbone of each strand. The strands of the double helix must separate during replication and transcription of DNA. In vitro experiments denaturation can be induced by increasing the temperature of DNA solu ...
Risk assessment of T-DNA borders from Agrobacterium tumefaciens
... plant breeders and researchers have replaced the crown gall inducing genes from A. tumefaciens by other genes. In case of transgenesis, foreign genes are used as genes of interest. In case of cisgenesis, genes are used from plants that are sexually compatible with the recipient plant.2 The DNA that ...
... plant breeders and researchers have replaced the crown gall inducing genes from A. tumefaciens by other genes. In case of transgenesis, foreign genes are used as genes of interest. In case of cisgenesis, genes are used from plants that are sexually compatible with the recipient plant.2 The DNA that ...
CHARACTERlZATION OF THE ~ 0 CHONDRIA . L DNA MOLECULE
... throuph oxidative phosphorylation. Oxidative phosphorylation is a cornplex biochemical mechanism that involves the conversion of potential energy from electron gradients into chernical energy. Each mitochondrion contains its own genetic code. However, the mitochondria do not encode al1 of the protei ...
... throuph oxidative phosphorylation. Oxidative phosphorylation is a cornplex biochemical mechanism that involves the conversion of potential energy from electron gradients into chernical energy. Each mitochondrion contains its own genetic code. However, the mitochondria do not encode al1 of the protei ...
11.1 How Did Scientists Discover That Genes Are Made of DNA?
... knowledge of genes – Heritable information is carried in discrete units called genes – Genes are parts of structures called chromosomes – Chromosomes are made of deoxyribonucleic acid (DNA) and protein ...
... knowledge of genes – Heritable information is carried in discrete units called genes – Genes are parts of structures called chromosomes – Chromosomes are made of deoxyribonucleic acid (DNA) and protein ...
template strand
... message must be three times the number of amino acids making up the protein product. – It would take at least 300 nucleotides to code for a polypeptide that is 100 amino acids long. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings ...
... message must be three times the number of amino acids making up the protein product. – It would take at least 300 nucleotides to code for a polypeptide that is 100 amino acids long. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings ...
A code controlling specific binding of regulatory proteins to DNA
... more specific. The first case to be studied was that when a ligand covers a definite number of DNA base pairs on binding, but does not react specifically with bases [13--15]. The second case under study was that when a ligand has one [ 13, 16] or several [17, 18] reaction centres responsible for the ...
... more specific. The first case to be studied was that when a ligand covers a definite number of DNA base pairs on binding, but does not react specifically with bases [13--15]. The second case under study was that when a ligand has one [ 13, 16] or several [17, 18] reaction centres responsible for the ...
Microsatellite
A microsatellite is a tract of repetitive DNA in which certain DNA motifs (ranging in length from 2–5 base pairs) are repeated, typically 5-50 times. Microsatellites occur at thousands of locations in the human genome and they are notable for their high mutation rate and high diversity in the population. Microsatellites and their longer cousins, the minisatellites, together are classified as VNTR (variable number of tandem repeats) DNA. The name ""satellite"" refers to the early observation that centrifugation of genomic DNA in a test tube separates a prominent layer of bulk DNA from accompanying ""satellite"" layers of repetitive DNA. Microsatellites are often referred to as short tandem repeats (STRs) by forensic geneticists, or as simple sequence repeats (SSRs) by plant geneticists.They are widely used for DNA profiling in kinship analysis and in forensic identification. They are also used in genetic linkage analysis/marker assisted selection to locate a gene or a mutation responsible for a given trait or disease.