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sedation and analgesia in the icu
sedation and analgesia in the icu

... head injuries and raised intracranial pressures & in treatment of refractory status epilepticus. They cause severe cardiovascular depression and accumulate during infusions leading to ...


... et al., 1987; Morgan et al., 2002) and transporter sites (McKittrick et al., 2000; Isovich et al., 2001) and in the expression of neurotrophic factors in limbic brain regions (Pizarro et al., 2004; Berton et al., 2006). In addition, one key element which was correlated with the behavioural signs of ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)

... Keywords:Anti-anxiety, Diazepam, Elevated plus maze, SalixAegyptiaca, Sedative. ...
Document
Document

... However, decreases in dosage may lead to a reduction in the degree of pain control. ...
a review on sarpagandha
a review on sarpagandha

... Much smaller doses are required to obtain the same results. (4) According to some observers, it is a much more potent hypotensive agent. Those who report favourably on the whole extract in preference to alkaloids support their claims with the following arguments: (1) the whole extract of R. serpenti ...
Homework 1 - Emerson Statistics Home
Homework 1 - Emerson Statistics Home

... 3. To have a high positive predictive value PPV = (number of approved effective drugs) / (number of approved drugs). We can examine the interrelationships of these statistical design criteria in the context of a RCT where we let θ denote our treatment effect, and we presume that an ineffective drug ...
RIVOTRIL Product Monograph
RIVOTRIL Product Monograph

... dependence may occur (see ADVERSE REACTIONS). The risk of dependence increases with dose and duration of treatment; it is also greater in patients with a medical history of alcohol and/or drug abuse. Once physical dependence has developed, abrupt termination of treatment will be accompanied by withd ...
Antihistamines Breastfeeding an older baby whilst experiencing
Antihistamines Breastfeeding an older baby whilst experiencing

... Another name for Pyridoxine is vitamin B-6. The recommended daily allowance for nonpregnant women is 1.6 mg/day. Slightly more is needed during pregnancy and lactation and most prenatal vitamin supplements contain from 12-25 mg/day. Very high doses (600 mg/day) were reported to decrease production o ...
PDF (Injection of synthetic cathinones)
PDF (Injection of synthetic cathinones)

... drug market in 2005. These substances have effects similar to known stimulant drugs and are structurally related to cathinone, which is found in the Khat plant (Catha edulis). Mephedrone is the synthetic cathinone that has received particular attention, first appearing as a so-called ‘legal high’ on ...
PEC Pipeline: Looking into the Crystal Ball LCDR Joe Lawrence, MSC, USN
PEC Pipeline: Looking into the Crystal Ball LCDR Joe Lawrence, MSC, USN

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WHAT`S SMACK GOT TO DO WITH IT
WHAT`S SMACK GOT TO DO WITH IT

... between your brain and your body. They block physical, mental and emotional responses. Sudden withdrawal from heroin won’t kill you, unless you are using other drugs at the same time, or you are in poor health. It is much less dangerous than withdrawal from drugs like alcohol or benzodiazepines. ...
Over The Counter drugs during Pregnancy
Over The Counter drugs during Pregnancy

... the reported association between the use of pseudoephedrine in the first trimester and the development of gastroschisis.9 This theory is debatable; evidence suggests that this effect is negligible at typical dosages.11 Diphenhydramine is widely used in pregnancy as a sedative, an antihistamine, and ...
Antihypertensive Agents
Antihypertensive Agents

... * Want to start at lowest possible doses of meds. * Reduce risk factors, even while on meds. - lifestyle changes may allow the client to decrease medications. * suggested after 1 yr. of therapy to dec. dose to determine if less drug dose possible • Step care hypertensive approach to treatment develo ...
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... movement, coordination and sensory and time perception are affected by these endogenous cannabinoids. THC is able to take advantage of this similarity and attach to cannabinoid receptors on neurons in these brain areas, activating them and thus disrupting various mental and physical functions.1  Ac ...
Drugs and the kidney
Drugs and the kidney

... This article on drug nephrotoxicity is detailed, as it is important to be fully aware of renal side-effects of drugs with regard to prevention and early diagnosis in order to manage the condition correctly. Many therapeutic agents are nephrotoxic, particularly when the serum half-life is prolonged a ...
Perianesthetic Pharmacology
Perianesthetic Pharmacology

...  Respiratory depression which is enhanced by general anesthetics, sedatives   GI motility and nausea/vomiting  Urinary retention  Miosis  Histamine release that causes hypotension.  Altered thermoregulation  slightly lower body temperature ...
Methamphetamine - Department of Electrical Engineering
Methamphetamine - Department of Electrical Engineering

... Methamphetamine is also well absorbed following inhalation and following intranasal administration.[11] It is distributed to most parts of the body. Because methamphetamine has a high lipophilicity it is distributed across the blood brain barrier and crosses the placenta.[11] Methamphetamine is meta ...
Histamine and Antihistaminic Agents
Histamine and Antihistaminic Agents

... at H1-receptors rather than H2-receptors. The development of antihistamine drugs began more than 5 decades ago with the discovery that piperoxan was able to protect animals from the bronchial spasm induced by histamine. This finding was followed by the synthesis of a number of Nphenylethylenediamine ...
Absorption and distribution of drugs 7
Absorption and distribution of drugs 7

... molecular weight. Consequently, while large molecules diffuse more slowly than small ones, the variation with molecular weight is modest. Many drugs fall within the molecular weight range 200–1000, and variations in aqueous diffusion rate have only a small effect on their overall pharmacokinetic beh ...
The features and management of poisoning with drugs used to treat
The features and management of poisoning with drugs used to treat

... charcoal, forced diuresis, haemodialysis, peritoneal dialysis or haemoperfusion has not been fully assessed and therefore none of these is recommended.20 Apart from its adverse effects, arrhythmias are almost certainly the result of the direct cardiotoxicity of orphenadrine rather than its anticholi ...
DM235 (sunifiram): a novel nootropic with
DM235 (sunifiram): a novel nootropic with

... The so-called nootropic compounds are a group of pharmacologically active pyrrolidone derivatives that, in some respects, occupy a special position in the pharmacology of the central nervous system. The first pyrrolidone to come to the attention of clinicians was piracetam. This compound was develop ...
drugs used to relieve behavioural and psychological symptoms of
drugs used to relieve behavioural and psychological symptoms of

... irritability and rapid mood swings that often occur in dementia or following a stroke. Once started, the doctor will usually recommend taking antidepressant drugs for a period of at least six months. In order for them to be effective, it is important that they are taken regularly without missing any ...
Trends in methylamphetamine availability, use and treatment: 2003
Trends in methylamphetamine availability, use and treatment: 2003

... housing difficulties (NRHA 2012, Stafford & Burns 2015). In 2013, around 2.9 million people in Australia reported they had used illicit drugs in the previous 12 months (AIHW 2014). Both nationally and internationally, the proportion of people using illicit drugs has remained relatively stable over t ...
Opioid analgesics
Opioid analgesics

... of Straub ...
Antiplatelet Drugs : Is There a Surgical Risk?
Antiplatelet Drugs : Is There a Surgical Risk?

... inhibiting phosphodiesterase, an enzyme involved in the breakdown of cyclic adenosine monophosphate (cAMP). The resulting increase in cAMP inhibits platelet activation and aggregation.6 However, the antiplatelet activity of dipyridamole is less than that of ASA and the ADP receptor blockers. Moreove ...
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Stimulant



Stimulants (also referred to as psychostimulants) are psychoactive drugs that induce temporary improvements in either mental or physical functions or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others. Due to their rendering a characteristic ""up"" feeling, stimulants are also occasionally referred to as ""uppers"". Depressants or ""downers"", which decrease mental and/or physical function, are in stark contrast to stimulants and are considered to be their functional opposites. Stimulants are widely used throughout the world as prescription medicines and without prescription both as legal substances and illicit substances of recreational use or abuse.
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