Lecture 14
... in the absence of GABA) => increased inhibition of the CNS (also block glutamate receptors) High risk of dependence (severe withdrawal symptoms) Strong depressent activity on the CNS => anesthesia At higher doses respiratory (inhibit hypoxic and CO2 response of chemoreceptors) and cardiovascular dep ...
... in the absence of GABA) => increased inhibition of the CNS (also block glutamate receptors) High risk of dependence (severe withdrawal symptoms) Strong depressent activity on the CNS => anesthesia At higher doses respiratory (inhibit hypoxic and CO2 response of chemoreceptors) and cardiovascular dep ...
m5zn_ae5dc4b31314435
... ► 4. Uterus & fetus: Is it a good analgesic for labor pain? - Delay labor due to decrease pain sensation & spasm in uterine muscles -Pass placental barrier & BBB & suppress fetal respiration -Less conjugated in fetus higher blood level ► 5. Immune system: Suppress immune system infection ► 6. Skin ...
... ► 4. Uterus & fetus: Is it a good analgesic for labor pain? - Delay labor due to decrease pain sensation & spasm in uterine muscles -Pass placental barrier & BBB & suppress fetal respiration -Less conjugated in fetus higher blood level ► 5. Immune system: Suppress immune system infection ► 6. Skin ...
Psychoactive Plants
... Psychoactive plants produce their effects by acting on the nervous system. In general they mimic, block, or affect the normal metabolism of neurotransmitters. They can be classified as stimulants, depressants, or hallucinogens. Stimulants excite portions of the nervous system, promote alertness and ...
... Psychoactive plants produce their effects by acting on the nervous system. In general they mimic, block, or affect the normal metabolism of neurotransmitters. They can be classified as stimulants, depressants, or hallucinogens. Stimulants excite portions of the nervous system, promote alertness and ...
PSYCHOPHARMACOLOGY
... Increasing data regarding effects on bipolar depression May carry lower risk during pregnancy compared to other anticonvulsants (further studies needed) Risk of dermatologic AE (including life threatening Stevens-Johnson syndrome Slow titration to avoid side effects) ...
... Increasing data regarding effects on bipolar depression May carry lower risk during pregnancy compared to other anticonvulsants (further studies needed) Risk of dermatologic AE (including life threatening Stevens-Johnson syndrome Slow titration to avoid side effects) ...
Erickson-DrugsHandout
... Readily available in drug market and inexpensive and relatively easy to make – recipes are obtainable on the internet Obtainable as clear and odorless liquid, gel, or powder which have a salty taste – however, taste is masked by ETOH which increases its clinical effects ...
... Readily available in drug market and inexpensive and relatively easy to make – recipes are obtainable on the internet Obtainable as clear and odorless liquid, gel, or powder which have a salty taste – however, taste is masked by ETOH which increases its clinical effects ...
Drug Information Summary - Nalbuphine
... mu antagonism and full kappa agonism. Both the partial mu antagonism and the kappa agonism are useful for opioid-induced itch (OII), a phenomenon which has both central and peripheral mechanisms. (The commonly used option, diphenhydramine or Benadryl, is sedating, and potentially dangerous in the el ...
... mu antagonism and full kappa agonism. Both the partial mu antagonism and the kappa agonism are useful for opioid-induced itch (OII), a phenomenon which has both central and peripheral mechanisms. (The commonly used option, diphenhydramine or Benadryl, is sedating, and potentially dangerous in the el ...
Drug Discovery Process
... •large groups of people (1,000-3,000) •to confirm its effectiveness •monitor side effects •compare it to commonly used treatments •Interactions (with other meds) •Multicenter trial – many docs; many hospitals ...
... •large groups of people (1,000-3,000) •to confirm its effectiveness •monitor side effects •compare it to commonly used treatments •Interactions (with other meds) •Multicenter trial – many docs; many hospitals ...
Anxiolytic, Sedative, and Hypnotic Drugs
... The binding increases the affinity of the GABA-A receptor for GABA, which in turn causes an increased frequency of chloride channel opening (since BDZ need GABA for their activity, a ceiling effect occurs with high doses). ...
... The binding increases the affinity of the GABA-A receptor for GABA, which in turn causes an increased frequency of chloride channel opening (since BDZ need GABA for their activity, a ceiling effect occurs with high doses). ...
Document
... BUT, large amounts of caffeine (7-8 cups) may cause irritability in the infant. • Ryu JE. Effect of maternal caffeine consumption on heart rate and sleep ...
... BUT, large amounts of caffeine (7-8 cups) may cause irritability in the infant. • Ryu JE. Effect of maternal caffeine consumption on heart rate and sleep ...
Brain Basics Powerpoint
... • connects rest of brain to spinal cord (lots of myelinated tracts) • life support functions (heart rate, respiration) – recall connection to the ...
... • connects rest of brain to spinal cord (lots of myelinated tracts) • life support functions (heart rate, respiration) – recall connection to the ...
Intoxicants
... A common feature: recreational drugs affect the reward circuit (mesolimbic system) in specific areas of the brain by increasing or prolonging the release of the neurotransmitter dopamine. You feel good when the nerve cells release a lot of dopamine. This can be caused by drugs, or by other pleasurab ...
... A common feature: recreational drugs affect the reward circuit (mesolimbic system) in specific areas of the brain by increasing or prolonging the release of the neurotransmitter dopamine. You feel good when the nerve cells release a lot of dopamine. This can be caused by drugs, or by other pleasurab ...
Intoxicants
... A common feature: recreational drugs affect the reward circuit (mesolimbic system) in specific areas of the brain by increasing or prolonging the release of the neurotransmitter dopamine. You feel good when the nerve cells release a lot of dopamine. This can be caused by drugs, or by other pleasurab ...
... A common feature: recreational drugs affect the reward circuit (mesolimbic system) in specific areas of the brain by increasing or prolonging the release of the neurotransmitter dopamine. You feel good when the nerve cells release a lot of dopamine. This can be caused by drugs, or by other pleasurab ...
Adrenergic Drugs - Nursing Pharmacology
... Rationale: Infiltration of an intravenous solution containing an adrenergic drug may lead to tissue necrosis from excessive vasoconstriction around the intravenous site. Phentolamine is often used for the treatment of infiltration, but the first thing the nurse must do is to stop the infusion of the ...
... Rationale: Infiltration of an intravenous solution containing an adrenergic drug may lead to tissue necrosis from excessive vasoconstriction around the intravenous site. Phentolamine is often used for the treatment of infiltration, but the first thing the nurse must do is to stop the infusion of the ...
Slide 1
... --Addiction has aspect of impulse control disorders and compulsive disorders --Impulsive acts preceded by tension or arousal followed by pleasure gratification or relief --Compulsive acts preceded by anxiety and stress followed by relief from stress --Addiction considered to shift from an impulsive ...
... --Addiction has aspect of impulse control disorders and compulsive disorders --Impulsive acts preceded by tension or arousal followed by pleasure gratification or relief --Compulsive acts preceded by anxiety and stress followed by relief from stress --Addiction considered to shift from an impulsive ...
Drug Abuse Fact Sheets
... superlabs, although it can also be made in small, illegal laboratories, where its production endangers the people in the labs, neighbors, and the environment. 3. Methamphetamine increases the release and blocks the reuptake of the brain chemical (or neurotransmitter) dopamine, leading to high levels ...
... superlabs, although it can also be made in small, illegal laboratories, where its production endangers the people in the labs, neighbors, and the environment. 3. Methamphetamine increases the release and blocks the reuptake of the brain chemical (or neurotransmitter) dopamine, leading to high levels ...
A. 4 Variability in drug response a. Define tachyphylaxis
... There are many gene defects described, the common ones being A- in 11% of blacks and variants in Eastern Mediterranean (Favism) and Chinese populations. G6PD activity falls in red cells with age, and cells with very low activity will haemolyse in the presence of an oxidant drug. Drugs inducing haemo ...
... There are many gene defects described, the common ones being A- in 11% of blacks and variants in Eastern Mediterranean (Favism) and Chinese populations. G6PD activity falls in red cells with age, and cells with very low activity will haemolyse in the presence of an oxidant drug. Drugs inducing haemo ...
Drugs Hanson 5
... with dependence, either physiological or psychological in nature; other times, it is used synonymously with the term drug abuse. A more accurate definition is the compulsive drug use despite negative ...
... with dependence, either physiological or psychological in nature; other times, it is used synonymously with the term drug abuse. A more accurate definition is the compulsive drug use despite negative ...
Bath Salts Alert
... can contain up to 500 mg. Taken orally, the bath salts are rapidly absorbed and produce a rush that peaks at 1.5 hours after ingestion and lasts for 3 to 4 hours. The physical effects of PABS include tachycardia, hypertension, arrhythmias, hyperthermia, seizures, stroke, myocardial infarction, and e ...
... can contain up to 500 mg. Taken orally, the bath salts are rapidly absorbed and produce a rush that peaks at 1.5 hours after ingestion and lasts for 3 to 4 hours. The physical effects of PABS include tachycardia, hypertension, arrhythmias, hyperthermia, seizures, stroke, myocardial infarction, and e ...
Pharmacologic Treatments - University of Kentucky | Medical Center
... • Dry eyes and mouth, rapid heart beat (do not use if heart disease), somnolence ...
... • Dry eyes and mouth, rapid heart beat (do not use if heart disease), somnolence ...
Drug-abuse poisoning: new substances in the 21st
... Symptoms sought by the consumer are euphoria, wellbeing, relaxation, drowsiness, impaired time perception and increased appetite, but are highly variable depending on the dose adsorbed (Table 1). Cannabis use is associated with an increased risk of cardiovascular disease, neurovascular disease or PA ...
... Symptoms sought by the consumer are euphoria, wellbeing, relaxation, drowsiness, impaired time perception and increased appetite, but are highly variable depending on the dose adsorbed (Table 1). Cannabis use is associated with an increased risk of cardiovascular disease, neurovascular disease or PA ...
File
... • Chloride influx is enhanced, and hyperpolarization occurs, resulting in paralysis and death of the worm. • The drug is given orally and does not readily cross the blood–brain barrier. ...
... • Chloride influx is enhanced, and hyperpolarization occurs, resulting in paralysis and death of the worm. • The drug is given orally and does not readily cross the blood–brain barrier. ...
NEUROPHARMACOLOGY
... (2) Although withdrawal syndrome is mild, craving is very compelling and long-lasting (a) anxiety, irratibility, decreased concentration (b) increased appetite ...
... (2) Although withdrawal syndrome is mild, craving is very compelling and long-lasting (a) anxiety, irratibility, decreased concentration (b) increased appetite ...
No Slide Title
... COMBINED CONDITIONS HIV, Hepatitis B and C infection Acquisitive / non acquisitive crime Markedly poor general health Markedly poor social and economic standing Markedly impaired mental health Significant isolation from sources of support ...
... COMBINED CONDITIONS HIV, Hepatitis B and C infection Acquisitive / non acquisitive crime Markedly poor general health Markedly poor social and economic standing Markedly impaired mental health Significant isolation from sources of support ...
Stimulant
Stimulants (also referred to as psychostimulants) are psychoactive drugs that induce temporary improvements in either mental or physical functions or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others. Due to their rendering a characteristic ""up"" feeling, stimulants are also occasionally referred to as ""uppers"". Depressants or ""downers"", which decrease mental and/or physical function, are in stark contrast to stimulants and are considered to be their functional opposites. Stimulants are widely used throughout the world as prescription medicines and without prescription both as legal substances and illicit substances of recreational use or abuse.