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Movement Disorders Induced by Gastrointestinal Drugs: Two
Movement Disorders Induced by Gastrointestinal Drugs: Two

... initial positive benefits, in the absence of adverse effects, the nizatidine dosage was increased to 300 mg twice a day. Within 4 days after this dosage increase, the patient started pacing and could not sit still. Mild Parkinsonism was also present. Concern for these extrapyramidal symptoms led to ...
525_08_lecture5
525_08_lecture5

... •CNS stimulation (lower doses) •hypertension (lower doses), insomnia •activation of psychoses •Hypotension (higher doses) •Cardiac depression (higher doses) ...
File
File

... • Guidelines for drug names – Active component in single word – When two or more components, list principal, active ingredient first – Use of common stems for drug groups ...
Benzodiazepines
Benzodiazepines

... can cause addiction is because they create tolerance. As a patient becomes more tolerant to the effects of benzodiazepines, larger doses are needed to achieve the intended effect (such as better sleep or less anxiety). Tolerance can contribute to an addiction. People who stop using benzodiazepines c ...
File
File

... relieves pain by acting in the CNS or on peripheral pain mechanisms, without significantly altering the consciousness – Opioids and NSAIDS • Narcotics Those drugs which possess both an analgesic (pain relieving) and sedative properties. ...
3,4-Methylenedioxymethamphetamine Produces Glycogenolysis
3,4-Methylenedioxymethamphetamine Produces Glycogenolysis

... weight cutoff and 210-␮m outside diameter) for the striatum was 4.5 mm in length. On the day of the dialysis experiment, the probe was connected to an infusion pump set to deliver glucose-free Dulbecco’s phosphate-buffered saline containing 1.2 mM CaCl2 at a rate of 1.8 ␮l/min. After a 2-h equilibra ...
A case for psilocybin
A case for psilocybin

... mystical experiences associated with psilocybin serve as a measure of adequate drug effects rather than mediating an antidepressant and/or anxiolytic effect. Perhaps future studies could shed some light on this relationship by employing other drugs, such Salvinorin A and other kappa opioid receptor ...
3,4-Methylenedioxymethamphetamine Produces Glycogenolysis
3,4-Methylenedioxymethamphetamine Produces Glycogenolysis

... and 10 ␮l of glucose-6-phosphate dehydrogenase (0.2 mg/ml) were then added, and the tubes were vortexed and incubated at room temperature for 30 min. The fluorescence was again measured. The difference in the fluorescence values was corrected for sample, reagent, and enzyme blank. Glycogen values ar ...
Toxicities of Drugs Used in the Management of Fever
Toxicities of Drugs Used in the Management of Fever

... either alone or in combination with other active drugs [1]. Although episodic use of these agents at appropriate doses for the treatment of fever or analgesia is relatively safe, this safety profile may be compromised in certain at-risk populations. In addition, because many products contain several ...
Ma Huang (Ephedrae Herba): Setting the Record Straight
Ma Huang (Ephedrae Herba): Setting the Record Straight

... output and blood pressure, and decreases renal perfusion. Ephedrine use is contraindicated in patients on certain prescription drugs such as norepinephrine-dopamine reuptake inhibitors (NDRIs) like bupropion, monoamine oxidase inhibitors (MAOI) like phenelzine, and betablockers like propranolol. In ...
Document
Document

... Absorption from the GI tract is negligible ...
3-1General Properties of Drugs
3-1General Properties of Drugs

... Drugs do not perform any new functions on a tissue or organ in the body; they only modify existing functions. Drugs in general exert multiple actions rather than a single effect. Drug action results from a physiochemical interaction between the drug and a molecule in the body. ...
Mecamylamine (Inversine )
Mecamylamine (Inversine )

... indications.8 The principal focus of research on other clinical indications largely involves mecamylamine’s potent blockade of brain nicotinic receptors at doses that do not have a significant effect on parasympathetic function (2.5–10 mg/day).9 Potential indications currently under investigation in ...
MDMA (Ecstasy) - cloudfront.net
MDMA (Ecstasy) - cloudfront.net

... What does MDMA do to the brain? MDMA affects the brain by increasing the activity of at least three neurotransmitters (the chemical messengers of brain cells): serotonin, dopamine, and norepinephrine.5 Like other amphetamines, MDMA causes these neurotransmitters to be released from their storage si ...
Anaesthetic Drugs
Anaesthetic Drugs

... unconsciousness Many reflexes  (airway, gag, CN) Awareness +/- NMJ paralysis ...
Lithium Toxicity - Medical Place Pharmacy Chatham
Lithium Toxicity - Medical Place Pharmacy Chatham

... Background on Lithium • Has been used since the 1870s. – Initially used to gout ...
Adreno-cortico-steroids, Inhibitors, and Antagonists
Adreno-cortico-steroids, Inhibitors, and Antagonists

... ➨ The degree and duration of suppression depends on the dose and duration of therapy. ➨ It takes at least 2-3 months for the pituitary and adrenals to become responsive, after chronic steroid therapy is discontinued. ➨ If therapy is to be stopped corticoid dosage should be tapered slowly (ACTH admin ...
PGXL-Multidrug-report-example-11172014
PGXL-Multidrug-report-example-11172014

... COMT Result: Val/Val High activity: COMT is an enzyme that degrades dopamine and norepinephrine, primarily in the prefrontal cortex. The Val allele has higher enzymatic activity resulting in higher dopamine degradation and lower dopamine concentrations as compared to the Met allele. Lower prefrontal ...
Endocrine aspects of anabolic steroids
Endocrine aspects of anabolic steroids

... glands appears to be dose-related: Increasing testosterone beyond the physiological range in normal men results in further increases in the sebum excretion rate. Consequently AAS users tend to suffer from severe acne. One of the more serious problems associated with anabolic steroid abuse is the inv ...
Regulations for the Veterinary Hospital Pharmacy Philip J. Seibert
Regulations for the Veterinary Hospital Pharmacy Philip J. Seibert

... Most veterinary use of human-labeled drug products occurs in non-food animal practice (companion, sporting, exotic, etc.). Many diseases of pets and other non-food animals cannot be treated in accordance with current standards of veterinary practice without the use of humanlabeled drugs because appr ...
MOTM SALVINORIN A MAGIC MINT
MOTM SALVINORIN A MAGIC MINT

... receptors, each favoured by different opiates; heroin and morphine bind to the mu receptors, for example. The kappa receptors occur in areas like the brain and spinal cord. An agonist is a molecule that binds to a receptor and produces a response. ...
An Overview of Setting Occupational Exposure Limits
An Overview of Setting Occupational Exposure Limits

... In the therapeutic dose/safety factor approach, the lowest recommended therapeutic dose of the drug is identified. This therapeutic dose then is divided by a safety factor. A safety factor of 100 usually is suggested because it can be thought of as a factor of 10 for adjusting a therapeutic effectiv ...
Drug Effecting Platelet Function
Drug Effecting Platelet Function

... function causing prolongation of the bleeding time. The mechanisms behind the antiplatelet effects of drugs are described below. Drugs that cause thrombocytopenia are not discussed. Fig. 1 Mechanisms of platelet activation & aggregation and sites of action of inhibitory drugs ...
( + )-amphetamine produce different types of circling in rats
( + )-amphetamine produce different types of circling in rats

... that both drugs act differently on hindleg stepping in unilateral43 lesioned rats. Anyhow, the present data imply that the effects under discussion are mediated via diffe~'ent substrates within the brain, viz. a suggestion that fits in with earlier reported data 43. As mentioned, apomorphine and (+) ...
Profile of female patients seeking in-patient treatment for
Profile of female patients seeking in-patient treatment for

... prescription drugs was pain followed by stress/anxiety in our study as also reported earlier23,24. Almost 60 per cent of women in the current study had a co-occurring psychiatric disorder. The common conditions were depression, cluster B personality trait/ disorder and somatoform disorder. This ra ...
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Stimulant



Stimulants (also referred to as psychostimulants) are psychoactive drugs that induce temporary improvements in either mental or physical functions or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others. Due to their rendering a characteristic ""up"" feeling, stimulants are also occasionally referred to as ""uppers"". Depressants or ""downers"", which decrease mental and/or physical function, are in stark contrast to stimulants and are considered to be their functional opposites. Stimulants are widely used throughout the world as prescription medicines and without prescription both as legal substances and illicit substances of recreational use or abuse.
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