PHYSICo chemicaL PROPERTIES
... (metabolized). The substances that result from metabolism (metabolites) may be inactive, or they may be similar to or different from the original drug in therapeutic activity or toxicity. Some drugs, called prodrugs, are administered in an inactive form, which is metabolized into an active form. ...
... (metabolized). The substances that result from metabolism (metabolites) may be inactive, or they may be similar to or different from the original drug in therapeutic activity or toxicity. Some drugs, called prodrugs, are administered in an inactive form, which is metabolized into an active form. ...
Annex 4 EPI Forms v4
... Cured: An MDR TB patient who has completed the treatment according to programme protocol and has at least five consecutive negative cultures from samples collected at least 30 days apart. If only one positive culture is reported during that time, and there is no concomitant clinical evidence of dete ...
... Cured: An MDR TB patient who has completed the treatment according to programme protocol and has at least five consecutive negative cultures from samples collected at least 30 days apart. If only one positive culture is reported during that time, and there is no concomitant clinical evidence of dete ...
Serotonin-Norepinephrine Reuptake Inhibitors
... As with the SSRIs, abrupt discontinuation of SNRImedication usually leads to a discontinuation syndrome which could include states of anxiety and further symptoms. It is therefore recommended to slowly taper down the dose under the supervision of a psychopharmacologist when discontinuing SNRIs. Anti ...
... As with the SSRIs, abrupt discontinuation of SNRImedication usually leads to a discontinuation syndrome which could include states of anxiety and further symptoms. It is therefore recommended to slowly taper down the dose under the supervision of a psychopharmacologist when discontinuing SNRIs. Anti ...
First experience of effectiveness and safety of bedaquiline for 18
... cardiologist) once she was discharged; however, there were occasional periods where, due to financial or transportation problems, the patient failed to attend for ECG appointment, which is reflected in occasional periods of several weeks between ECGs in figure 1. From a pre-treatment baseline of 411 ...
... cardiologist) once she was discharged; however, there were occasional periods where, due to financial or transportation problems, the patient failed to attend for ECG appointment, which is reflected in occasional periods of several weeks between ECGs in figure 1. From a pre-treatment baseline of 411 ...
Neuroleptics
... “Atypical” – derivatives of indole, benzodiazepine – they cause those negative reactions very rarely ...
... “Atypical” – derivatives of indole, benzodiazepine – they cause those negative reactions very rarely ...
Substance abuse in pregnancy
... Some studies indicate that heavy users may have offspring with smaller head circumference. There may be a trend towards decrease in birthweight. As with other substances, there are likely confounding variables. Pregnant persons who use marijuana are also more likely to drink alcohol and smoke cigare ...
... Some studies indicate that heavy users may have offspring with smaller head circumference. There may be a trend towards decrease in birthweight. As with other substances, there are likely confounding variables. Pregnant persons who use marijuana are also more likely to drink alcohol and smoke cigare ...
Antidepressant Drugs
... • Studies have found that effective blockage of serotonin reuptake by SSRIs and the speed with which they treat depression are not correlated • SSRIs tend not to be effective for severe depression • There is no evidence that depressed people have disordered serotonin systems ...
... • Studies have found that effective blockage of serotonin reuptake by SSRIs and the speed with which they treat depression are not correlated • SSRIs tend not to be effective for severe depression • There is no evidence that depressed people have disordered serotonin systems ...
Atypical Antipsychotics in the Treatment of MDD
... Prolongs the vocational disability, an increasing risk for chronification of the current illness episode. The length of the current untreated episode of illness may be the strongest predictor of overall short-term and long-term outcome in major depression.*1 The slow response of antidepressant tre ...
... Prolongs the vocational disability, an increasing risk for chronification of the current illness episode. The length of the current untreated episode of illness may be the strongest predictor of overall short-term and long-term outcome in major depression.*1 The slow response of antidepressant tre ...
HISTORY OF DRUGS IN THE LAST CENTURY Did drugs travel by
... History repeats itself with false marketing and misinformation; after World War II, Methadone was promoted as the "cure" for Heroin addiction. Cocaine is promoted as "not physically addictive"! In 1960, a Harvard PhD and Psychology ushered LSD into the new generation. Originally formulated as a "cur ...
... History repeats itself with false marketing and misinformation; after World War II, Methadone was promoted as the "cure" for Heroin addiction. Cocaine is promoted as "not physically addictive"! In 1960, a Harvard PhD and Psychology ushered LSD into the new generation. Originally formulated as a "cur ...
DEA Letter Detailing US Analog Problems in 1998 (PDF
... Schedule I or 11which produces a stimulant, depressant or hallucinogenic effect substantially similar to or greater than that produced by a Schedule I or 11controlled substance. The definition of amphetamine-like analogues would extend to substances such as ephedrine, pseudoephedrine, epinephrine, f ...
... Schedule I or 11which produces a stimulant, depressant or hallucinogenic effect substantially similar to or greater than that produced by a Schedule I or 11controlled substance. The definition of amphetamine-like analogues would extend to substances such as ephedrine, pseudoephedrine, epinephrine, f ...
club drugs: an approach to review the hazard in indian scenario
... drugs are from newspaper articles; hence there is an urgent need for verified, authentic research data. With technological advancement and particularly the information technology sector coming up in a big way in India suddenly there is a neo-rich young generation. This is often coupled with the need ...
... drugs are from newspaper articles; hence there is an urgent need for verified, authentic research data. With technological advancement and particularly the information technology sector coming up in a big way in India suddenly there is a neo-rich young generation. This is often coupled with the need ...
Companion Diagnostics Points to Consider
... Design Changes KEY ISSUE: When CoDx used to identify a distinct group of patients, the pharma sponsor needs to ensure that the same patient population can be identified after drug approval. Changes to test can change enrollment patterns • Changing the cut-off, measuring range or any test parameter ...
... Design Changes KEY ISSUE: When CoDx used to identify a distinct group of patients, the pharma sponsor needs to ensure that the same patient population can be identified after drug approval. Changes to test can change enrollment patterns • Changing the cut-off, measuring range or any test parameter ...
RAPID AMPHETAMINE TEST STRIP
... Amphetamines are a class of potent sympathomimetic agents with therapeutic applications. The most common amphetamines are d-amphetamine and d/l-amphetamine. Amphetamines are central nervous stimulants that cause the neurotransmitters epinephrine, norepinephrine and dopamine to be released into the b ...
... Amphetamines are a class of potent sympathomimetic agents with therapeutic applications. The most common amphetamines are d-amphetamine and d/l-amphetamine. Amphetamines are central nervous stimulants that cause the neurotransmitters epinephrine, norepinephrine and dopamine to be released into the b ...
Beyond the ABCs - Alcohol
... pancreas, lung, urinary tract, and breast. term used to describe the fact that heavy users may experience anxiety and even panic when Blood and muscle alcohol is not available. In this case, the reacAnemia is common in people who abuse alcohol. Abnormally large red blood cells (mean tion results not ...
... pancreas, lung, urinary tract, and breast. term used to describe the fact that heavy users may experience anxiety and even panic when Blood and muscle alcohol is not available. In this case, the reacAnemia is common in people who abuse alcohol. Abnormally large red blood cells (mean tion results not ...
Introduction to Drug Metabolism
... hypertension, is metabolized by CYP2D6 to 4hydroxydebrisoquine • Remarkable interindividual variation in pharmacological effect of the drug • Urine of volunteers given debrisoquine was examined for presence of 4hydroxydebrisoquine – One subject had a very low conversion of parent drug to metabolite ...
... hypertension, is metabolized by CYP2D6 to 4hydroxydebrisoquine • Remarkable interindividual variation in pharmacological effect of the drug • Urine of volunteers given debrisoquine was examined for presence of 4hydroxydebrisoquine – One subject had a very low conversion of parent drug to metabolite ...
Chapter 19
... to arrive in the U.S. as cocaine hydrochloride. It is now available as freebase crack cocaine. It acts by preventing the reabsorption of dopamine. This leaves high levels of dopamine to stimulate the pleasure centers of the brain. The effect is short-lived and its use is quickly followed by depressi ...
... to arrive in the U.S. as cocaine hydrochloride. It is now available as freebase crack cocaine. It acts by preventing the reabsorption of dopamine. This leaves high levels of dopamine to stimulate the pleasure centers of the brain. The effect is short-lived and its use is quickly followed by depressi ...
Neuro-Science Outline
... “Addiction” refers to behaviors that are compulsive, partially out of control or worse, and often escalating in severity and intensity” cannabinoid Use Begets More endocannabinoids begets more Cannabinoid Receptors Research has shown that small doses of cannabinoids from cannabis can signal the body ...
... “Addiction” refers to behaviors that are compulsive, partially out of control or worse, and often escalating in severity and intensity” cannabinoid Use Begets More endocannabinoids begets more Cannabinoid Receptors Research has shown that small doses of cannabinoids from cannabis can signal the body ...
Ocular Pharmacology
... o Topical medications read the aqueous, iris, ciliary body, penetration past the lens is minimal o Melanin binding can influence the pharmacologic effect of drugs Atropine o Ointments or gels improve precorneal retention of the drug o Ointments can be administered at the same time, however you mus ...
... o Topical medications read the aqueous, iris, ciliary body, penetration past the lens is minimal o Melanin binding can influence the pharmacologic effect of drugs Atropine o Ointments or gels improve precorneal retention of the drug o Ointments can be administered at the same time, however you mus ...
Pharmacologic Treatment of Acute Major Depression and Dysthymia
... the day, nearly every day; markedly diminished interest or pleasure in most activities most of the day; significant weight loss or gain or appetite disturbance; insomnia or hypersomnia; psychomotor agitation or retardation; inappropriate guilt; diminished ability to think or concentrate, or indecisi ...
... the day, nearly every day; markedly diminished interest or pleasure in most activities most of the day; significant weight loss or gain or appetite disturbance; insomnia or hypersomnia; psychomotor agitation or retardation; inappropriate guilt; diminished ability to think or concentrate, or indecisi ...
Detox regimens for party drugs
... addictive or are safer in some way than ‘classic’ drugs of abuse such as cocaine or heroin(Winstock & Mitcheson, 2012). In part this view is held and reinforced by the lack of knowledge on such substances and the dearth of academic literature on their management. However it is clear that these drugs ...
... addictive or are safer in some way than ‘classic’ drugs of abuse such as cocaine or heroin(Winstock & Mitcheson, 2012). In part this view is held and reinforced by the lack of knowledge on such substances and the dearth of academic literature on their management. However it is clear that these drugs ...
IN VITRO ACECLOFENAC SODIUM FOR PERIODONTITIS Research Article
... associated periodontitis, and necrotizing periodontitis2. A site-specific system aims at delivering the therapeutic agent at sufficient levels inside the pocket and at the same time minimizing the side effects associated with systemic drug administration4. In conventional mode of drug administration ...
... associated periodontitis, and necrotizing periodontitis2. A site-specific system aims at delivering the therapeutic agent at sufficient levels inside the pocket and at the same time minimizing the side effects associated with systemic drug administration4. In conventional mode of drug administration ...
1. NAME AND ADRESS OF MARKETING
... seriously ill patients who often have multiple risk factors for the development of the events. (6) Brugada-type ECG - elevated ST-segment and coved T-wave in ECG. (7) Rapidly progressive cardiac failure (in some cases with fatal outcome) in adults. The cardiac failure in such cases was usually unres ...
... seriously ill patients who often have multiple risk factors for the development of the events. (6) Brugada-type ECG - elevated ST-segment and coved T-wave in ECG. (7) Rapidly progressive cardiac failure (in some cases with fatal outcome) in adults. The cardiac failure in such cases was usually unres ...
Child Psychiatric Medications 101
... Neurobiologic systems involved in the etiology and pathogenesis of the symptoms (e.g., specific neurotransmitter systems) ...
... Neurobiologic systems involved in the etiology and pathogenesis of the symptoms (e.g., specific neurotransmitter systems) ...
The pitfalls in Life Style Drugs
... Effective, for short term (7-12 weeks) but not for long term (26 weeks) Effective providing that the individual is really willing to cut smoking - in which case he does not need any drug treatment The spontaneous quit rate for smokers, (people who just decide to quit smoking), can be raised up to 25 ...
... Effective, for short term (7-12 weeks) but not for long term (26 weeks) Effective providing that the individual is really willing to cut smoking - in which case he does not need any drug treatment The spontaneous quit rate for smokers, (people who just decide to quit smoking), can be raised up to 25 ...
Polysubstance dependence
A person with polysubstance dependence is psychologically addicted to being in an intoxicated state without a preference for one particular substance. Although any combination of three drugs can be used, studies have shown that alcohol is commonly used with another substance. This is supported by one study on polysubstance use that separated participants who used multiple substances into groups based on their preferred drug. The three substances were cocaine, alcohol, and heroin, which implies that those three are very popular. Other studies have found that opiates, cannabis, amphetamines, hallucinogens, inhalants and benzodiazepines are often used in combination as well. The results of a long-term or longitudinal study on substance use led the researchers to observe that excessively using or relying on one drug increased the probability of excessively using or relying on another drug.