Guaifenesin as a Treatment for Primary Dysmenorrhea
... used for years to promote expectoration of secretions in patients with pulmonary disease. The drug is derived from the resin of guaiacum trees and was introduced to European medicine in the 16th century as an analgesic.6 Guaifenesin is also used as a muscle relaxant in veterinary anesthesia to aid i ...
... used for years to promote expectoration of secretions in patients with pulmonary disease. The drug is derived from the resin of guaiacum trees and was introduced to European medicine in the 16th century as an analgesic.6 Guaifenesin is also used as a muscle relaxant in veterinary anesthesia to aid i ...
FORMULATION AND EVALUATION OF CARBAMAZEPINE EXTENDED RELEASE TABLET BY Research Article
... The objective of the present study was to design and develop the carbamazepine extended release tablet fabricated by controlled erosion technology. The core tablets were prepared by wet granulation technique using hydroxypropyl methyl cellulose E5 as hydrophilic matrix. The prepared core matrix tabl ...
... The objective of the present study was to design and develop the carbamazepine extended release tablet fabricated by controlled erosion technology. The core tablets were prepared by wet granulation technique using hydroxypropyl methyl cellulose E5 as hydrophilic matrix. The prepared core matrix tabl ...
Drug Metabolism and Variability among Patients in Drug Response
... members of a given population, but its distribution is continuous and unimodal. This suggests that multiple genes are involved in its regulation but that individual genetic factors play a minor role. Though constitutive variability is about fivefold, CYP3A activity is readily modulated by several fa ...
... members of a given population, but its distribution is continuous and unimodal. This suggests that multiple genes are involved in its regulation but that individual genetic factors play a minor role. Though constitutive variability is about fivefold, CYP3A activity is readily modulated by several fa ...
- pharma excipients
... effectively sustained release for 12 hrs with parameters such as floating lag time, buoyancy, and floating time in acceptable range. In-vitro drug release kinetics evaluated using the linear regression method was found to follow the Higuchi release kinetics equation. This suggests that fenugreek gum ...
... effectively sustained release for 12 hrs with parameters such as floating lag time, buoyancy, and floating time in acceptable range. In-vitro drug release kinetics evaluated using the linear regression method was found to follow the Higuchi release kinetics equation. This suggests that fenugreek gum ...
Konuray, A. O., 2008, Development of Tolerance and Dependence
... whose target of action is the brain. Although its use has decreased over the years, phenobarbital is still being prescribed to many patients. As a side effect, phenobarbital enhances the synthesis of its own metabolic enzymes in the liver. This enzyme induction problem causes increased tolerance to ...
... whose target of action is the brain. Although its use has decreased over the years, phenobarbital is still being prescribed to many patients. As a side effect, phenobarbital enhances the synthesis of its own metabolic enzymes in the liver. This enzyme induction problem causes increased tolerance to ...
Expanded Access Programs
... • General standards, as well as specific standards based on the size of population and seriousness of the disease • Requirements for obtaining access • Safeguards, including IRB review, informed consent, and reporting requirements to FDA ...
... • General standards, as well as specific standards based on the size of population and seriousness of the disease • Requirements for obtaining access • Safeguards, including IRB review, informed consent, and reporting requirements to FDA ...
Risks of Methadone use as Substitute Therapy for
... Unique characteristic of the person is also very important for evaluating a successful opiate substitution. For example, research has shown that opiate treatment will be more successful in patients who have a relatively low incidences of depression and anxiety, who are older and better educated, who ...
... Unique characteristic of the person is also very important for evaluating a successful opiate substitution. For example, research has shown that opiate treatment will be more successful in patients who have a relatively low incidences of depression and anxiety, who are older and better educated, who ...
Interaction of quinidine, disopyramide and
... ocular toxicity may produce symptoms such as blurred vision, halos, photophobia and secondary colour blindness [45]. Like chloroquine and hydroxychloroquine, quinidine is a quinoline derivative and is known to have ocular toxic side effects [44–48]. The studies by Zaidman [45] suggest that the drug ...
... ocular toxicity may produce symptoms such as blurred vision, halos, photophobia and secondary colour blindness [45]. Like chloroquine and hydroxychloroquine, quinidine is a quinoline derivative and is known to have ocular toxic side effects [44–48]. The studies by Zaidman [45] suggest that the drug ...
FY M.Pharm - ICT Mumbai
... Genetic basis of variation of pharmacokinetics Methods for pharmacogenomic profiling & study Pharmacokinetic Introduction to ADME and basic pharmacokinetic parameters like Volume of distribution, Elimination half life, Elimination rate constant, Clearance, Area under curve, Bioavailability, calc ...
... Genetic basis of variation of pharmacokinetics Methods for pharmacogenomic profiling & study Pharmacokinetic Introduction to ADME and basic pharmacokinetic parameters like Volume of distribution, Elimination half life, Elimination rate constant, Clearance, Area under curve, Bioavailability, calc ...
Guideline on clinical investigation of medicinal products in the
... available, another device may be used which is calibrated carefully in proportion to a mercury sphygmomanometer. Use of aneroid manometer is not recommended. Appropriate cuff size must be used to ensure accurate measurement. Both SBP and DBP should be recorded. The disappearance of sound (Korotkov p ...
... available, another device may be used which is calibrated carefully in proportion to a mercury sphygmomanometer. Use of aneroid manometer is not recommended. Appropriate cuff size must be used to ensure accurate measurement. Both SBP and DBP should be recorded. The disappearance of sound (Korotkov p ...
Inflammation and Drug Idiosyncrasy—Is There a Connection?
... al., 1984). Accordingly, although INH acetylation is likely to be causally involved in its hepatotoxicity, it appears that other factors are necessary to precipitate an idiosyncratic reaction in people. Similarly, frequent speculation about a specific immune response (e.g., antigen-antibody reaction ...
... al., 1984). Accordingly, although INH acetylation is likely to be causally involved in its hepatotoxicity, it appears that other factors are necessary to precipitate an idiosyncratic reaction in people. Similarly, frequent speculation about a specific immune response (e.g., antigen-antibody reaction ...
Because of a particular pharmaceutical solution`s use, it may be
... next to water. USP, is 94.9 to 96% C2H5OH by volume (i.e., v/v) ...
... next to water. USP, is 94.9 to 96% C2H5OH by volume (i.e., v/v) ...
INTENDED USE SUMMARY AMPHETAMINE (AMP 1,000
... Buprenorphine is a potent analgesic often used in the treatment of opioid addiction. The drug is sold under the trade names Subutex™, Buprenex™, Temgesic™ and Suboxone™, which contain Buprenorphine HCl alone or in combination with Naloxone HCl. Therapeutically, Buprenorphine is used as a substitutio ...
... Buprenorphine is a potent analgesic often used in the treatment of opioid addiction. The drug is sold under the trade names Subutex™, Buprenex™, Temgesic™ and Suboxone™, which contain Buprenorphine HCl alone or in combination with Naloxone HCl. Therapeutically, Buprenorphine is used as a substitutio ...
ARVO 2017 Annual Meeting Abstracts 160 Anti
... Purpose: There is a controversy on the use of long term dexamethasone in ophthalmology due to side effects, mainly intraocular pressure rise (IOP). The aim of this preclinical work was to evaluate the efficacy/risk balance of preservative free hydrocortisone. Modifications of IOP were examined after ...
... Purpose: There is a controversy on the use of long term dexamethasone in ophthalmology due to side effects, mainly intraocular pressure rise (IOP). The aim of this preclinical work was to evaluate the efficacy/risk balance of preservative free hydrocortisone. Modifications of IOP were examined after ...
הודעה על החמרה ( מידע בטיחות) בעלון לצרכן
... lithium, tramadol, tryptophan, buspirone, and St. John’s Wort [see Drug Interactions (7.1)]. Amphetamines and amphetamine derivatives are known to be metabolized, to some degree, by cytochrome P450 2D6 (CYP2D6) and display minor inhibition of CYP2D6 metabolism [see Clinical Pharmacology 12.3]. The p ...
... lithium, tramadol, tryptophan, buspirone, and St. John’s Wort [see Drug Interactions (7.1)]. Amphetamines and amphetamine derivatives are known to be metabolized, to some degree, by cytochrome P450 2D6 (CYP2D6) and display minor inhibition of CYP2D6 metabolism [see Clinical Pharmacology 12.3]. The p ...
In the scientific literature, which countries first appeared term
... controlled environment outside a living organism C. done by a computer or by using computer simulations D. learning process at the same place where it occurs (no moving object tracking to any special conditions in a special environment) E. means that events occurring outside the living organism ANSW ...
... controlled environment outside a living organism C. done by a computer or by using computer simulations D. learning process at the same place where it occurs (no moving object tracking to any special conditions in a special environment) E. means that events occurring outside the living organism ANSW ...
the file - General Practice
... determined by the individual capacity to tolerate symptoms or, more often, by their anticipation of unpleasant withdrawals. Clients may be reassured that they will suffer less withdrawal symptoms on a regime where the daily dose is reduced in small portions (range one-tenth to one-quarter) every for ...
... determined by the individual capacity to tolerate symptoms or, more often, by their anticipation of unpleasant withdrawals. Clients may be reassured that they will suffer less withdrawal symptoms on a regime where the daily dose is reduced in small portions (range one-tenth to one-quarter) every for ...
Use of textile biomaterials for the topic treatment of chronic venous
... about 40 – 50% troxerutin within the first 60 minutes, but after that a slower and more constant release was observed (about 0.5%/hour). The release of troxerutin chemically linked on the carboxymethyl dextran microparticles takes place much slower than the release of the drug physically included in ...
... about 40 – 50% troxerutin within the first 60 minutes, but after that a slower and more constant release was observed (about 0.5%/hour). The release of troxerutin chemically linked on the carboxymethyl dextran microparticles takes place much slower than the release of the drug physically included in ...
Campral - Allergan
... suicides) were infrequent overall, but were more common in Campral-treated patients than in patients treated with placebo (1.4% vs. 0.5% in studies of 6 months or less; 2.4% vs. 0.8% in year-long studies). Completed suicides occurred in 3 of 2272 (0.13%) patients in the pooled acamprosate group from ...
... suicides) were infrequent overall, but were more common in Campral-treated patients than in patients treated with placebo (1.4% vs. 0.5% in studies of 6 months or less; 2.4% vs. 0.8% in year-long studies). Completed suicides occurred in 3 of 2272 (0.13%) patients in the pooled acamprosate group from ...
Clinical pharmacology of facilities used at the diseases of
... D. palpitations and headache E. hypotension, dizziness 71. The mechanism by which digoxin causes a positive inotropic effect on heart tissue is by: A. increasing ATP hydrolysis B. stimulating the Na/K pump C. *increasing intracellular Na and Ca D. sensitizing the heart to catecholamines E. inhibitin ...
... D. palpitations and headache E. hypotension, dizziness 71. The mechanism by which digoxin causes a positive inotropic effect on heart tissue is by: A. increasing ATP hydrolysis B. stimulating the Na/K pump C. *increasing intracellular Na and Ca D. sensitizing the heart to catecholamines E. inhibitin ...
FORMULATION AND EVALUATION OF PULSATILE TABLET IN CAPSULE DEVICE Research Article
... Development of suitable chronotherapeutic oral dosage forms can be achieved using delayed and/or pulsatile technologies. A pulsatile release is characterized by proportioning drug concentration throughout 24-hour period (circadian rhythm) in synchrony with biological rhythm determinants of disease h ...
... Development of suitable chronotherapeutic oral dosage forms can be achieved using delayed and/or pulsatile technologies. A pulsatile release is characterized by proportioning drug concentration throughout 24-hour period (circadian rhythm) in synchrony with biological rhythm determinants of disease h ...
managing insomnia
... nitrazepam, are not usually recommended because they have a more prolonged action and may cause residual effects the following day.7 Adverse effects associated with benzodiazepine use include drowsiness and light headedness the next day, psychomotor impairment and amnesia. Although benzodiazepines a ...
... nitrazepam, are not usually recommended because they have a more prolonged action and may cause residual effects the following day.7 Adverse effects associated with benzodiazepine use include drowsiness and light headedness the next day, psychomotor impairment and amnesia. Although benzodiazepines a ...
Polysubstance dependence
A person with polysubstance dependence is psychologically addicted to being in an intoxicated state without a preference for one particular substance. Although any combination of three drugs can be used, studies have shown that alcohol is commonly used with another substance. This is supported by one study on polysubstance use that separated participants who used multiple substances into groups based on their preferred drug. The three substances were cocaine, alcohol, and heroin, which implies that those three are very popular. Other studies have found that opiates, cannabis, amphetamines, hallucinogens, inhalants and benzodiazepines are often used in combination as well. The results of a long-term or longitudinal study on substance use led the researchers to observe that excessively using or relying on one drug increased the probability of excessively using or relying on another drug.