17
... Moreover, the branched structures of dendrimers may also impede their passage through small pores, such as those of the glomerular filtration barrier, and, thus, a dendrimer may be eliminated more slowly than a linear polymer with the same molar mass (12–14). Despite these significant potential bene ...
... Moreover, the branched structures of dendrimers may also impede their passage through small pores, such as those of the glomerular filtration barrier, and, thus, a dendrimer may be eliminated more slowly than a linear polymer with the same molar mass (12–14). Despite these significant potential bene ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... The elderly population (≥65 years) is the fastest growing part of the population. Co-existing diseases and progressive decline in the functional capacity of organs make elderly patients vulnerable for per-operative complications5.Neuraxial blockade is known to reduce mortality by one third along wit ...
... The elderly population (≥65 years) is the fastest growing part of the population. Co-existing diseases and progressive decline in the functional capacity of organs make elderly patients vulnerable for per-operative complications5.Neuraxial blockade is known to reduce mortality by one third along wit ...
EA_QA194.4_BisphosPPI - Specialist Pharmacy Service
... Medicines Q&As 1.48) but not any fracture or hip fracture. It should be noted that the information on patients included in the study was incomplete and adjustments for confounders were not reported. (39, 40) A nested case control study using information from the GPRD (1987-2003), concluded that lon ...
... Medicines Q&As 1.48) but not any fracture or hip fracture. It should be noted that the information on patients included in the study was incomplete and adjustments for confounders were not reported. (39, 40) A nested case control study using information from the GPRD (1987-2003), concluded that lon ...
Filling two-piece hard gelatin capsules with liquids
... evident in Figure 1, which compares the in vitro dissolution profiles of triamterene when formulated with different solubilizing excipients [13]. Formulating drug compounds in liquid or semi-solid excipients is also used to target lymphatic transport [14] or to circumvent the impact of transporters ...
... evident in Figure 1, which compares the in vitro dissolution profiles of triamterene when formulated with different solubilizing excipients [13]. Formulating drug compounds in liquid or semi-solid excipients is also used to target lymphatic transport [14] or to circumvent the impact of transporters ...
NEEDLE FREE INJECTION SYSTEM: A REVIEW Review Article
... typically air, CO2 or nitrogen) fluid through a small orifice, these devices created a high pressure stream that could easily penetrate the skin, subcutaneous tissue and underlying shallow muscle in order to deliver the vaccine in a fraction of a second. One major problem to needle free injections h ...
... typically air, CO2 or nitrogen) fluid through a small orifice, these devices created a high pressure stream that could easily penetrate the skin, subcutaneous tissue and underlying shallow muscle in order to deliver the vaccine in a fraction of a second. One major problem to needle free injections h ...
PARTICLE COATING, TASTE MASKING & PELLETIZATION
... Requires post treatment and waste processing increases cost An innovative method to replace the wet coating process is to directly coat fine particles on target particles (dry particle coating) using strong mechanical forces. DRY PARTICLE COATING:Dry particle coating is used to create new-gene ...
... Requires post treatment and waste processing increases cost An innovative method to replace the wet coating process is to directly coat fine particles on target particles (dry particle coating) using strong mechanical forces. DRY PARTICLE COATING:Dry particle coating is used to create new-gene ...
Archives of Medical Research
... Animal body weight gain in the AIA model is considered as a good index of both anti-inflammatory activity and positive immune effect (8) when testing anti-inflammatory drugs. This effect appears to be related to a decrease in prostaglandin synthesis as well as in cytokine production (23). Our result ...
... Animal body weight gain in the AIA model is considered as a good index of both anti-inflammatory activity and positive immune effect (8) when testing anti-inflammatory drugs. This effect appears to be related to a decrease in prostaglandin synthesis as well as in cytokine production (23). Our result ...
Pres. - Virology Education
... EC90) that is specific to HIV prevention is required during the window of time that HIV needs to establish an infection. ...
... EC90) that is specific to HIV prevention is required during the window of time that HIV needs to establish an infection. ...
Loteprednol etabonate - Therapeutic Goods Administration
... and that this settling could not occur within the in use period. Thus, the chemical and physical data provided support an unopened shelf life of 2 years when stored below 25°C (15 months for the 2.5 mL volume product) and an opened shelf life of 4 weeks. The additional conditions “Do not freeze”, “S ...
... and that this settling could not occur within the in use period. Thus, the chemical and physical data provided support an unopened shelf life of 2 years when stored below 25°C (15 months for the 2.5 mL volume product) and an opened shelf life of 4 weeks. The additional conditions “Do not freeze”, “S ...
DESCRIPTION Naftifine Hydrochloride Cream, 1% contains the
... carcinogenic potential of Naftifine Hydrochloride Cream, 1% have not been performed. In vitro and animal studies have not demonstrated any mutagenic effect or effect on fertility. Pregnancy: Teratogenic Effects: Pregnancy Category B: Reproduction studies have been performed in rats and rabbits (via ...
... carcinogenic potential of Naftifine Hydrochloride Cream, 1% have not been performed. In vitro and animal studies have not demonstrated any mutagenic effect or effect on fertility. Pregnancy: Teratogenic Effects: Pregnancy Category B: Reproduction studies have been performed in rats and rabbits (via ...
Piracetam (NootropilIV)
... • The solution for injection will be administered intravenously over several minutes. • The solution for infusion will be administered continuously at the recommended daily dose over a 24-hour period. Recommended daily doses are provided below by indication. Symptomatic treatment of psycho-organic s ...
... • The solution for injection will be administered intravenously over several minutes. • The solution for infusion will be administered continuously at the recommended daily dose over a 24-hour period. Recommended daily doses are provided below by indication. Symptomatic treatment of psycho-organic s ...
Australian Public Assessment Report for loteprednol etabonate Proprietary Product Name: Lotemax
... and that this settling could not occur within the in use period. Thus, the chemical and physical data provided support an unopened shelf life of 2 years when stored below 25°C (15 months for the 2.5 mL volume product) and an opened shelf life of 4 weeks. The additional conditions “Do not freeze”, “S ...
... and that this settling could not occur within the in use period. Thus, the chemical and physical data provided support an unopened shelf life of 2 years when stored below 25°C (15 months for the 2.5 mL volume product) and an opened shelf life of 4 weeks. The additional conditions “Do not freeze”, “S ...
ranitidine oral
... excluded. Increases in blood alcohol concentrations have been noted in some studies in healthy individuals receiving ranitidine or some other H2 antagonists concomitantly with alcohol; however, conflicting data exist, which may be related to the effects of various patient-specific factors (e.g., gen ...
... excluded. Increases in blood alcohol concentrations have been noted in some studies in healthy individuals receiving ranitidine or some other H2 antagonists concomitantly with alcohol; however, conflicting data exist, which may be related to the effects of various patient-specific factors (e.g., gen ...
... gives yellow color in alkaline solution. The increase in absorbance due to its formation is directly proportional to alkaline phosphate (ALKP) activity. Estimation of total bilirubin (TB)23 involved the reaction of bilirubin with diazotized sulphanic acid to form an azocompound, the color of which i ...
Homocysteine: a promising biomarker of folate antagonist
... recently described by Casey aet al. [30]. They showed that inhibition of isoprenylcysteine carboxyl methyltransferase, which is responsible for carboxylmethylation of a G-protein Ras and its accurate localization into the cell membrane, is a critical component of antiproliferative action of methotre ...
... recently described by Casey aet al. [30]. They showed that inhibition of isoprenylcysteine carboxyl methyltransferase, which is responsible for carboxylmethylation of a G-protein Ras and its accurate localization into the cell membrane, is a critical component of antiproliferative action of methotre ...
Zopiclone is a drug with very similar effects
... Zopiclone is prescribed in tablet form, either as zopiclone or under the brand name Zimovane, which along with zolpidem (brand name Stilnoct) and zaleplon (brand name Sonata), are known as ‘Z drugs’ – that is, sleeping pills which begin with the letter ’z’. Zopiclone tablets go by the street names o ...
... Zopiclone is prescribed in tablet form, either as zopiclone or under the brand name Zimovane, which along with zolpidem (brand name Stilnoct) and zaleplon (brand name Sonata), are known as ‘Z drugs’ – that is, sleeping pills which begin with the letter ’z’. Zopiclone tablets go by the street names o ...
Archive 2014
... From the Editorial In-Charge It gives me immense pleasure to be a part of the beautiful journey that made ’The Nest 2013-2014’, with the theme ETHICS. The job of the editors is a daunting task and I am really very thankful to my team - Sahana Ray, Ankita Satoor and Dipali Nagila who worked with dedi ...
... From the Editorial In-Charge It gives me immense pleasure to be a part of the beautiful journey that made ’The Nest 2013-2014’, with the theme ETHICS. The job of the editors is a daunting task and I am really very thankful to my team - Sahana Ray, Ankita Satoor and Dipali Nagila who worked with dedi ...
Dept. of Quality Assurance
... widely used technique called swab testing. Clean wet, swabs are applied to areas that have been cleaned and an extract of that swab is analyzed to show the effectiveness of that cleaning. Swab testing, however, is expensive and time consuming, but sampling does not represent the entire part of equip ...
... widely used technique called swab testing. Clean wet, swabs are applied to areas that have been cleaned and an extract of that swab is analyzed to show the effectiveness of that cleaning. Swab testing, however, is expensive and time consuming, but sampling does not represent the entire part of equip ...
Coccidiosis or Coccidiasis?
... • They allow some coccidiosis to occur. • The level of coccidiosis allowed has a minimal adverse effect on flock performance. • The low-grade cycling of coccidia is commonly referred to as a “leakage” and it allows a gradual development of immunity. • The coccidia are not under selection pressure an ...
... • They allow some coccidiosis to occur. • The level of coccidiosis allowed has a minimal adverse effect on flock performance. • The low-grade cycling of coccidia is commonly referred to as a “leakage” and it allows a gradual development of immunity. • The coccidia are not under selection pressure an ...
Rapanofal Package Insert
... and hematocrit. Large numbers of Heinz bodies can lead to hemolytic anemia.5,6 In one study in cats, treatment with propofol once a day for 3 days led to a marked increase in Heinz bodies. Treatment for 5 or more consecutive days resulted in generalized malaise and/or facial edema; clinical signs of ...
... and hematocrit. Large numbers of Heinz bodies can lead to hemolytic anemia.5,6 In one study in cats, treatment with propofol once a day for 3 days led to a marked increase in Heinz bodies. Treatment for 5 or more consecutive days resulted in generalized malaise and/or facial edema; clinical signs of ...
Medicated Chewing Gum: A Novel Drug Delivery
... was filed in 1869 (Conway et al., 2003). The gum was intended as dentifrices but it has never been marketed. The first Medicated chewing gum “Aspergum” was launched in 1928. This chewing gum is still available and contains acetylsalicylic acid. Another commercially available medicated chewing gum is ...
... was filed in 1869 (Conway et al., 2003). The gum was intended as dentifrices but it has never been marketed. The first Medicated chewing gum “Aspergum” was launched in 1928. This chewing gum is still available and contains acetylsalicylic acid. Another commercially available medicated chewing gum is ...
NOROXIN TABLETS (NORFLOXACIN)
... 30 mL/min/1.73 m2 is similar to that in healthy volunteers. In patients with creatinine clearance rates equal to or less than 30 mL/min/1.73 m2, the renal elimination of norfloxacin decreases so that the effective serum half-life is 6.5 hours. In these patients, alteration of dosage is necessary (se ...
... 30 mL/min/1.73 m2 is similar to that in healthy volunteers. In patients with creatinine clearance rates equal to or less than 30 mL/min/1.73 m2, the renal elimination of norfloxacin decreases so that the effective serum half-life is 6.5 hours. In these patients, alteration of dosage is necessary (se ...
Frequently Asked Questions
... Carbopol® polymers are efficient tablet binders. Formulations comprising Carbopol® polymers generally do not require an additional binder to be used. In the case of wet granulation formulations, it is recommended to incorporate the polymer in the powder blend (0.5 - 3.0% w/w) versus adding it as an ...
... Carbopol® polymers are efficient tablet binders. Formulations comprising Carbopol® polymers generally do not require an additional binder to be used. In the case of wet granulation formulations, it is recommended to incorporate the polymer in the powder blend (0.5 - 3.0% w/w) versus adding it as an ...
semester 4 grading period 2 study guide File
... control inflammation in the body. Corticosteroids are not the same as the anabolic steroids that are often linked with illegal use in sports. Anabolic steroids (anabolic-androgenic steroids) are synthetic versions of the male hormone testosterone. They are a class of drugs that are legally available ...
... control inflammation in the body. Corticosteroids are not the same as the anabolic steroids that are often linked with illegal use in sports. Anabolic steroids (anabolic-androgenic steroids) are synthetic versions of the male hormone testosterone. They are a class of drugs that are legally available ...
Pharmacokinetics
Pharmacokinetics, sometimes abbreviated as PK (from Ancient Greek pharmakon ""drug"" and kinetikos ""moving, putting in motion""; see chemical kinetics), is a branch of pharmacology dedicated to determining the fate of substances administered externally to a living organism. The substances of interest include pharmaceutical agents, hormones, nutrients, and toxins. It attempts to discover the fate of a drug from the moment that it is administered up to the point at which it is completely eliminated from the body.Pharmacokinetics describes how the body affects a specific drug after administration through the mechanisms of absorption and distribution, as well as the chemical changes of the substance in the body (e.g. by metabolic enzymes such as cytochrome P450 or glucuronosyltransferase enzymes), and the effects and routes of excretion of the metabolites of the drug. Pharmacokinetic properties of drugs may be affected by elements such as the site of administration and the dose of administered drug. These may affect the absorption rate. Pharmacokinetics is often studied in conjunction with pharmacodynamics, the study of a drug's pharmacological effect on the body.A number of different models have been developed in order to simplify conceptualization of the many processes that take place in the interaction between an organism and a drug. One of these models, the multi-compartment model, gives the best approximation to reality; however, the complexity involved in using this type of model means that monocompartmental models and above all two compartmental models are the most-frequently used. The various compartments that the model is divided into are commonly referred to as the ADME scheme (also referred to as LADME if liberation is included as a separate step from absorption): Liberation - the process of release of a drug from the pharmaceutical formulation. See also IVIVC. Absorption - the process of a substance entering the blood circulation. Distribution - the dispersion or dissemination of substances throughout the fluids and tissues of the body. Metabolization (or biotransformation, or inactivation) – the recognition by the organism that a foreign substance is present and the irreversible transformation of parent compounds into daughter metabolites. Excretion - the removal of the substances from the body. In rare cases, some drugs irreversibly accumulate in body tissue.The two phases of metabolism and excretion can also be grouped together under the title elimination.The study of these distinct phases involves the use and manipulation of basic concepts in order to understand the process dynamics. For this reason in order to fully comprehend the kinetics of a drug it is necessary to have detailed knowledge of a number of factors such as: the properties of the substances that act as excipients, the characteristics of the appropriate biological membranes and the way that substances can cross them, or the characteristics of the enzyme reactions that inactivate the drug.All these concepts can be represented through mathematical formulas that have a corresponding graphical representation. The use of these models allows an understanding of the characteristics of a molecule, as well as how a particular drug will behave given information regarding some of its basic characteristics. Such as its acid dissociation constant (pKa), bioavailability and solubility, absorption capacity and distribution in the organism.The model outputs for a drug can be used in industry (for example, in calculating bioequivalence when designing generic drugs) or in the clinical application of pharmacokinetic concepts. Clinical pharmacokinetics provides many performance guidelines for effective and efficient use of drugs for human-health professionals and in veterinary medicine.