Antiparasitic Chemotherapy for Human and Veterinary Use 3rd
... Successful vacuolar pathogens have developed sophisticated strategies to hijack the endomembrane system of host cells and evade antimicrobial responses. The protozoan parasite Leishmania, the causative agent of leishmaniases in humans, is particularly adept at transforming the macrophage into a hosp ...
... Successful vacuolar pathogens have developed sophisticated strategies to hijack the endomembrane system of host cells and evade antimicrobial responses. The protozoan parasite Leishmania, the causative agent of leishmaniases in humans, is particularly adept at transforming the macrophage into a hosp ...
Desmopressin Acetate Nasal Spray, 10 mcg per 0.1 mL
... 10 mcg of desmopressin acetate is equivalent to 40 IU. The change in structure of arginine vasopressin to desmopressin acetate has resulted in a decreased vasopressor action and decreased actions on visceral smooth muscle relative to the enhanced antiduretic activity, so that clinically effective an ...
... 10 mcg of desmopressin acetate is equivalent to 40 IU. The change in structure of arginine vasopressin to desmopressin acetate has resulted in a decreased vasopressor action and decreased actions on visceral smooth muscle relative to the enhanced antiduretic activity, so that clinically effective an ...
The influence of macrolide antibiotics on the uptake of organic
... Germany). Unlabeled telithromycin was obtained after extraction of Ketek® tablets (Sanofi-Aventis Deutschland GmbH, Bad Soden, Germany) using ethyl acetate and crystallization from ethyl acetate : hexane 8:2 (v/v). Purity was assayed by HPLC-UV to be > 99 %. The polyclonal antibodies pESL (König et ...
... Germany). Unlabeled telithromycin was obtained after extraction of Ketek® tablets (Sanofi-Aventis Deutschland GmbH, Bad Soden, Germany) using ethyl acetate and crystallization from ethyl acetate : hexane 8:2 (v/v). Purity was assayed by HPLC-UV to be > 99 %. The polyclonal antibodies pESL (König et ...
DILT-XR - Apotex
... 48%, and 69% with the 120, 240, 360, and 480 mg/day diltiazem groups, respectively. Similar findings were observed for standing systolic and diastolic blood pressures. The trough (24 hours after a dose) antihypertensive effect of Diltiazem Hydrochloride Extended-Release Capsules, USP (Once-a-day dos ...
... 48%, and 69% with the 120, 240, 360, and 480 mg/day diltiazem groups, respectively. Similar findings were observed for standing systolic and diastolic blood pressures. The trough (24 hours after a dose) antihypertensive effect of Diltiazem Hydrochloride Extended-Release Capsules, USP (Once-a-day dos ...
O F L O X A C IN O P H T H A L M IC S O L U T IO N U S P , 0 .3 %
... General: As with other anti-infectives, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs discontinue use and institute alternative therapy. Whenever clinical judgment dictates, the patient should be examined with the aid of magnification, ...
... General: As with other anti-infectives, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs discontinue use and institute alternative therapy. Whenever clinical judgment dictates, the patient should be examined with the aid of magnification, ...
Effects of a Novel Cholecystokinin (CCK)
... levels between 7.7 and 10.4 pM within 15 min of initiating the infusion. There were no statistically significant differences in plasma CCK concentrations achieved during CCK infusion between any of the drug or placebo treatments (overall treatment effect, P > 0.1). Baseline (average of -15- and 0-mi ...
... levels between 7.7 and 10.4 pM within 15 min of initiating the infusion. There were no statistically significant differences in plasma CCK concentrations achieved during CCK infusion between any of the drug or placebo treatments (overall treatment effect, P > 0.1). Baseline (average of -15- and 0-mi ...
The poster sessions are an important highlight of these conferences
... Abstract: DS is a multi-targeted TKI of BCR ABL and SRC w. significant activity in pts with CML CP resistant or intolerant of IM. Phase II trial to study efficacy and safety of DS in pts with previously untreated CML CP Methods: Preliminary objective was to estimate the proportion of pts attaining ...
... Abstract: DS is a multi-targeted TKI of BCR ABL and SRC w. significant activity in pts with CML CP resistant or intolerant of IM. Phase II trial to study efficacy and safety of DS in pts with previously untreated CML CP Methods: Preliminary objective was to estimate the proportion of pts attaining ...
SNOMED CT® UK Drug Extension Editorial Policy
... Refer to the SNOMED CT Release File Specification for a full explanation of how this identifier is structured. ...
... Refer to the SNOMED CT Release File Specification for a full explanation of how this identifier is structured. ...
PRODUCT MONOGRAPH Pr CILOXAN® 0.3% Ciprofloxacin
... Pregnancy: There are no adequate and well controlled studies of CILOXAN (Ciprofloxacin Hydrochloride) Ophthalmic Solution or Ointment in pregnant women. This drug should be used in pregnant women only if in the physician's opinion, the benefit clearly outweighs any potential unknown risks. ...
... Pregnancy: There are no adequate and well controlled studies of CILOXAN (Ciprofloxacin Hydrochloride) Ophthalmic Solution or Ointment in pregnant women. This drug should be used in pregnant women only if in the physician's opinion, the benefit clearly outweighs any potential unknown risks. ...
Model-based Analysis of the Effects of Thioridazine Enantiomers on the... Papillary Action Potential
... prolongation was not well described. Using the inverse method however, the model described the experimental data for the racemate with considerably greater accuracy. Simultaneous inhibition of IKr and ICaL provided a better explanation for the observed pattern of rate dependence than IKr inhibition ...
... prolongation was not well described. Using the inverse method however, the model described the experimental data for the racemate with considerably greater accuracy. Simultaneous inhibition of IKr and ICaL provided a better explanation for the observed pattern of rate dependence than IKr inhibition ...
Diltiazem Hydrochloride Extended-Release Capsules, USP
... measured at trough, for placebo, 60 mg, 120 mg, 240 mg, 360 mg, and 480 mg was 29, 40, 56, 51, 69, and 68 seconds, respectively. As doses of diltiazem were increased, overall angina frequency was decreased. Diltiazem, 180 mg once daily, or placebo was administered in a double-blind study to patients ...
... measured at trough, for placebo, 60 mg, 120 mg, 240 mg, 360 mg, and 480 mg was 29, 40, 56, 51, 69, and 68 seconds, respectively. As doses of diltiazem were increased, overall angina frequency was decreased. Diltiazem, 180 mg once daily, or placebo was administered in a double-blind study to patients ...
Methadone-Drug Interactions
... in terms of its presence and activity in the liver (Eap et al. 2002; Leavitt et al. 2000). This enzyme also is found in the gastrointestinal tract, so methadone metabolism actually can begin before the drug enters the circulatory system (Hardman et al. 1996). The amount of this enzyme in the intesti ...
... in terms of its presence and activity in the liver (Eap et al. 2002; Leavitt et al. 2000). This enzyme also is found in the gastrointestinal tract, so methadone metabolism actually can begin before the drug enters the circulatory system (Hardman et al. 1996). The amount of this enzyme in the intesti ...
Document
... mild sedative action and a feeling of well-being. • In the Middle Ages, stramonium was employed to drug victims prior to robbing • them. During this event, the victim appeared normal and was cooperative, though afterwards could usually not remember what ...
... mild sedative action and a feeling of well-being. • In the Middle Ages, stramonium was employed to drug victims prior to robbing • them. During this event, the victim appeared normal and was cooperative, though afterwards could usually not remember what ...
methotrexate - Cancer Care Ontario
... cumulative doses of methotrexate (may also occur with low oral doses), by concurrent cranial radiation and when methotrexate IT is used to treat meningeal tumour rather than for prophylaxis. Pulmonary toxicity can be immediate or delayed. It is not always fully reversible and may be fatal. Any use ...
... cumulative doses of methotrexate (may also occur with low oral doses), by concurrent cranial radiation and when methotrexate IT is used to treat meningeal tumour rather than for prophylaxis. Pulmonary toxicity can be immediate or delayed. It is not always fully reversible and may be fatal. Any use ...
NIDA Monograph 169 - pg. 83-104
... In nonlaboratory settings, social users of cocaine are sometimes able to control their drug intake so their patterns of use do not escalate to levels that would increase their risk of dependency and toxicity (Siegel 1984). This suggests that there may be factors in addition to the primary reinforcin ...
... In nonlaboratory settings, social users of cocaine are sometimes able to control their drug intake so their patterns of use do not escalate to levels that would increase their risk of dependency and toxicity (Siegel 1984). This suggests that there may be factors in addition to the primary reinforcin ...
Prescribing Information
... Serious and sometimes fatal hypersensitivity reactions have occurred with abacavir, a component of TRIZIVIR. These hypersensitivity reactions have included multi-organ failure and anaphylaxis and typically occurred within the first 6 weeks of treatment with abacavir (median time to onset was 9 days) ...
... Serious and sometimes fatal hypersensitivity reactions have occurred with abacavir, a component of TRIZIVIR. These hypersensitivity reactions have included multi-organ failure and anaphylaxis and typically occurred within the first 6 weeks of treatment with abacavir (median time to onset was 9 days) ...
Urinary Hydrocodone and Metabolite Distributions in
... noted that numerous mechanisms have been suggested to explain the observed sex differences and should not be discounted. These include, but are not limited to, higher estrogen concentrations in women, the relationship between analgesic and antianalgesic properties, psychological factors and genetic ...
... noted that numerous mechanisms have been suggested to explain the observed sex differences and should not be discounted. These include, but are not limited to, higher estrogen concentrations in women, the relationship between analgesic and antianalgesic properties, psychological factors and genetic ...
PRODUCT MONOGRAPH COMBIGAN®
... Precautions for considerations during use in this population. Patients using Systemic Beta-blockers: Results from pivotal trials indicate that the mean change from baseline IOP was significantly lower (p < 0.001) with COMBIGAN® than with either brimonidine tartrate alone or timolol maleate alone for ...
... Precautions for considerations during use in this population. Patients using Systemic Beta-blockers: Results from pivotal trials indicate that the mean change from baseline IOP was significantly lower (p < 0.001) with COMBIGAN® than with either brimonidine tartrate alone or timolol maleate alone for ...
Uses
... Side effects: (1) GIT problems. (2) Cholestatic jaundice: especially with Erythromycin Estolate [result from hypersensitivity reaction bile becomes granular in bile duct its flow back up into circulation]. (3) Ototoxicity: transient deafness [especially at doses]. (4) Erythromycin level ...
... Side effects: (1) GIT problems. (2) Cholestatic jaundice: especially with Erythromycin Estolate [result from hypersensitivity reaction bile becomes granular in bile duct its flow back up into circulation]. (3) Ototoxicity: transient deafness [especially at doses]. (4) Erythromycin level ...
Frequency, Type and Causes of Medication Errors in Pediatric
... Today, patient safety is deemed a very important issue for our healthcare system and health care providers(1) and in this regard medication errors are used as the index to assess patient safety in hospitals. Medication errors are one of the most common medical errors(2) and its incidence rate have b ...
... Today, patient safety is deemed a very important issue for our healthcare system and health care providers(1) and in this regard medication errors are used as the index to assess patient safety in hospitals. Medication errors are one of the most common medical errors(2) and its incidence rate have b ...
Ministerstvo zdravotnictva SR k d. k. s04544-oKCLP-2012
... ■ ■Key Points The most common cause of warfarin resistance is noncompliance. Others include poor absorption, high vitamin K intake, hypersensitivity to vitamin K, and rapid drug deactivation. Patient education is necessary to improve compliance and to mitigate adverse effects of warfarin therapy, re ...
... ■ ■Key Points The most common cause of warfarin resistance is noncompliance. Others include poor absorption, high vitamin K intake, hypersensitivity to vitamin K, and rapid drug deactivation. Patient education is necessary to improve compliance and to mitigate adverse effects of warfarin therapy, re ...
Levofloxacin 5 mg/mL in 5% Dextrose Injection
... Rupture of the shoulder, hand and Achilles tendons that required surgical repair or resulted in prolonged disability have been reported in patients receiving quinolones, including Levofloxacin. Levofloxacin should be discontinued if the patient experiences pain, inflammation or rupture of a tendon. ...
... Rupture of the shoulder, hand and Achilles tendons that required surgical repair or resulted in prolonged disability have been reported in patients receiving quinolones, including Levofloxacin. Levofloxacin should be discontinued if the patient experiences pain, inflammation or rupture of a tendon. ...
Important Drug Information
... To place an order, or if you have any questions, customers can contact Hospira directly by calling Customer Care at 1-877-946-7747 (Monday – Friday, 7AM-6PM CDT). Hospira will make reasonable attempts to fill your orders. Hospira will be closely monitoring the distribution of Doxorubicin Hydrochlori ...
... To place an order, or if you have any questions, customers can contact Hospira directly by calling Customer Care at 1-877-946-7747 (Monday – Friday, 7AM-6PM CDT). Hospira will make reasonable attempts to fill your orders. Hospira will be closely monitoring the distribution of Doxorubicin Hydrochlori ...
FOOD AND DRUG ADMINISTRATION, et al
... 44,986-92. FDA asserted that the four so-called "drug-like" uses are "predominant" or even "nearly exclusive," but it did not quantify those terms. FDA acknowledged that there are "nondrug" uses of tobacco products, but asserted that those uses are "secondary." n7 n7 FDA's initial jurisdictional ana ...
... 44,986-92. FDA asserted that the four so-called "drug-like" uses are "predominant" or even "nearly exclusive," but it did not quantify those terms. FDA acknowledged that there are "nondrug" uses of tobacco products, but asserted that those uses are "secondary." n7 n7 FDA's initial jurisdictional ana ...
Pharmacokinetics
Pharmacokinetics, sometimes abbreviated as PK (from Ancient Greek pharmakon ""drug"" and kinetikos ""moving, putting in motion""; see chemical kinetics), is a branch of pharmacology dedicated to determining the fate of substances administered externally to a living organism. The substances of interest include pharmaceutical agents, hormones, nutrients, and toxins. It attempts to discover the fate of a drug from the moment that it is administered up to the point at which it is completely eliminated from the body.Pharmacokinetics describes how the body affects a specific drug after administration through the mechanisms of absorption and distribution, as well as the chemical changes of the substance in the body (e.g. by metabolic enzymes such as cytochrome P450 or glucuronosyltransferase enzymes), and the effects and routes of excretion of the metabolites of the drug. Pharmacokinetic properties of drugs may be affected by elements such as the site of administration and the dose of administered drug. These may affect the absorption rate. Pharmacokinetics is often studied in conjunction with pharmacodynamics, the study of a drug's pharmacological effect on the body.A number of different models have been developed in order to simplify conceptualization of the many processes that take place in the interaction between an organism and a drug. One of these models, the multi-compartment model, gives the best approximation to reality; however, the complexity involved in using this type of model means that monocompartmental models and above all two compartmental models are the most-frequently used. The various compartments that the model is divided into are commonly referred to as the ADME scheme (also referred to as LADME if liberation is included as a separate step from absorption): Liberation - the process of release of a drug from the pharmaceutical formulation. See also IVIVC. Absorption - the process of a substance entering the blood circulation. Distribution - the dispersion or dissemination of substances throughout the fluids and tissues of the body. Metabolization (or biotransformation, or inactivation) – the recognition by the organism that a foreign substance is present and the irreversible transformation of parent compounds into daughter metabolites. Excretion - the removal of the substances from the body. In rare cases, some drugs irreversibly accumulate in body tissue.The two phases of metabolism and excretion can also be grouped together under the title elimination.The study of these distinct phases involves the use and manipulation of basic concepts in order to understand the process dynamics. For this reason in order to fully comprehend the kinetics of a drug it is necessary to have detailed knowledge of a number of factors such as: the properties of the substances that act as excipients, the characteristics of the appropriate biological membranes and the way that substances can cross them, or the characteristics of the enzyme reactions that inactivate the drug.All these concepts can be represented through mathematical formulas that have a corresponding graphical representation. The use of these models allows an understanding of the characteristics of a molecule, as well as how a particular drug will behave given information regarding some of its basic characteristics. Such as its acid dissociation constant (pKa), bioavailability and solubility, absorption capacity and distribution in the organism.The model outputs for a drug can be used in industry (for example, in calculating bioequivalence when designing generic drugs) or in the clinical application of pharmacokinetic concepts. Clinical pharmacokinetics provides many performance guidelines for effective and efficient use of drugs for human-health professionals and in veterinary medicine.