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DNA
DNA

...  ___DNA___ is a _polymer_ made of _repeating_ subunits called _nucleotides_ (the monomer).  _Nucleotides_ have three parts: a simple __sugar__, a _phosphate_ __group__, and a _nitrogenous_ ___base___.  In DNA there are ___four___ possible _nucleotides_ , each containing one of these four bases.  ...
docx
docx

... A mixture-detection algorithm determined by Roche Molecular Systems was used to facilitate detection of p53 mutations in heterogeneous samples. The algorithm utilized a sample with wild-type p53 sequence as a reference, which was hybridized and scanned under identical conditions to samples with unkn ...
Studies on Chlamydomonas Chloroplast Transformation: Foreign
Studies on Chlamydomonas Chloroplast Transformation: Foreign

... modulate gene expression in chloroplasts. Recently, Sanford and co-workers (Klein et al., 1987) have developed a DNA transfer technique that relies upon bombardment of recipient cells with high-velocity tungsten microprojectiles coated with DNA. Using this delivery system, Klein et al. (1988) have m ...
LP 6 Chromosome abnormalities
LP 6 Chromosome abnormalities

AP BIO Lab 7: Genetics of Drosophila
AP BIO Lab 7: Genetics of Drosophila

... to keep track of which cross you have received. This will aid in determining expected results as well as allow your instructor to identify any problems you may be having and to help correct them. 5. Immobilize the parental generation of your cross and observe the flies under a stereomicroscope. If, ...
Unusual mutations in high functioning fragile X males
Unusual mutations in high functioning fragile X males

... FMR protein at quantities sufficient to prevent intellectual deficits.15 We report on two further cases of nonretarded males with full mutations who were by segregation analysis classified as normal transmitting males and were the founders of large fragile X families. Both were expected to carry pre ...
Geneticseasy
Geneticseasy

... dominant to white fur. I would like to know which genotype my bunny is. So I mated him with a white bunny and came out with all brown bunnies. What genotype is my bunny? Show the cross to prove it!!!! ...
Mutation Is Random
Mutation Is Random

... The tendency is for students to revert back to the idea that there are differences in rate among genes because some genes are more important than others. Once students have a general idea, they should try to draw a graph that summarizes their perspective. For example, if their idea is that genes var ...
grade 12 life sciences learner notes
grade 12 life sciences learner notes

... arranged in any order with a purine attached to a pyrimidine. The combination of nitrogenous bases is the code system for the messages from the DNA. A weak hydrogen bond holds the complementary nitrogenous bases together. This occurs as follows:  Adenine always only joins to Thymine  Guanine alway ...
Chromosome Theory
Chromosome Theory

... The Lyon Hypothesis Having extra chromosomes causes problems (i.e., Downs Syndrome)  Men have only one X chromosome and they are normal (at least they think so)  Women have two X chomosomes and they are normal  Mary Lyon proposed that the extra dosage of X chromosome that women have is compensat ...
Meiosis - DiBiasioScience
Meiosis - DiBiasioScience

... • Prophase 1: Each chromosome dupicates and remains closely associated. These are called sister chromatids. Crossing-over can occur during the latter part of this stage. • Metaphase 1: Homologous chromosomes align at the equatorial plate. • Anaphase 1: Homologous pairs separate with sister chromatid ...
Supercoils in plant DNA: nucleoid
Supercoils in plant DNA: nucleoid

... higher order organization of nuclear DNA in plants have been conducted. Plants share many common features with the other eukaryotes, but there are also many peculiarities distinguishing them. For example, they possess unusually large genomes, highly variable in size and organization from species to ...
Chromosome number 2
Chromosome number 2

... ◦ iii.Individuals with fragile X syndrome have 200 to 1,300 copies, indicating that tandem amplification of this sequence is tolerated until a threshold number of copies is reached. ◦ iv.Amplification of CGG repeats occurs only in females, perhaps during a slipped mispairing process during DNA repli ...
Ii.
Ii.

...  Iii. Nondisjunction occurs in mitosis (result is somatic cells with unusual chromosome complements). ...
Low chromosome number angiosperms
Low chromosome number angiosperms

Combining Whole-exome and RNA-Seq Data Improves the Quality
Combining Whole-exome and RNA-Seq Data Improves the Quality

... KRAS mutations not found in pancreatic models with high mouse stroma content (5) ...
Wendy Weisz has Down syndrome.
Wendy Weisz has Down syndrome.

... The gene causing the cry has been located in band 15.3. This would explain why some babies with other features of the syndrome do not have the characteristic cry and some babies have the cry but not the other characteristics.  In most cases the deletion is spontaneous and no specific cause can be i ...
Characterization of Two ENU-Induced Mutations Affecting Mouse
Characterization of Two ENU-Induced Mutations Affecting Mouse

... Using a large-scale ENU mutagenesis screen, we have identified two novel mutations, Skm1 and Skm2, that result in congenital spinal deformities in mice. The genes underlying these new ENU-derived mutants have previously been associated with skeletal abnormalities in both mice and humans, and thus ser ...
BMI 731 Chapter1: SNP Analysis
BMI 731 Chapter1: SNP Analysis

Meiosis - Lamont High
Meiosis - Lamont High

... • This process is known as synapsis • During this time the chromosomes are so close together that crossing over can occur • This leads to genetic variation since sections of the DNA are exchanged mixing maternal and paternal genes ...
Resolvase OsGEN1 Mediates DNA Repair by
Resolvase OsGEN1 Mediates DNA Repair by

... recombination during meiosis (Saito et al., 2012, 2013). Mutational analysis reveals that GEN-1’s function in DNA damage signaling is separated from its role in DNA repair. GEN-1 promotes germ cell cycle arrest and apoptosis via a pathway parallel to canonical DNA damage response pathways and acts r ...
The Importance of the TSHR-gene in Domestic Chicken Hanna Johnsen
The Importance of the TSHR-gene in Domestic Chicken Hanna Johnsen

... (Jensen, 2006). Traits of this domesticated phenotype include behavioral changes such as reduced fear response, increased sociability and reduced anti-predator response. Changes in appearance such as altered fur and plumage colors, body size and growth are usually traits that come with domestication ...
DNA-dependent protein kinase in nonhomologous end joining: a
DNA-dependent protein kinase in nonhomologous end joining: a

... DNA double-strand breaks (DSBs) can be accidentally introduced in cells by the action of ionizing radiation or certain reactive radicals. These agents have the ability to initiate a series of chemical reactions that ultimately sever the DNA backbone, resulting in chromosome breakage and fragmentatio ...
Lgi1 null mutant mice exhibit myoclonic seizures
Lgi1 null mutant mice exhibit myoclonic seizures

... amplitudes of mEPSCs were similar between mutant and wildtype mice, suggesting the LGI1 mutation did not alter the density and response of postsynaptic receptors (n ¼ 12, P . 0.05; Fig. 6A and C). Remarkably, however, the frequency of mEPSCs was dramatically increased in the mutant mice (n ¼ 12, P , ...
Unit 3
Unit 3

... The word fraternal comes from a word meaning “brother.” Fraternal twins are like any brothers and sisters, except that they are born on the same day. They each have some the same genes as their parents. But they do not share an identical genetic makeup. Fraternal twins may resemble each other, but t ...
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Mutagen



In genetics, a mutagen is a physical or chemical agent that changes the genetic material, usually DNA, of an organism and thus increases the frequency of mutations above the natural background level. As many mutations can cause cancer, mutagens are therefore also likely to be carcinogens. Not all mutations are caused by mutagens: so-called ""spontaneous mutations"" occur due to spontaneous hydrolysis, errors in DNA replication, repair and recombination.
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