JV Poster Barcelona 2012
... Figure 3: Effects of bio-isosteric analogues of MK-801 on extinction of contextual freezing in a fearconditioning paradigm. (A) During recall of memory extinction trials, the percentage of time spent in freezing was decreased in mice treated with QXX at a dose of 5 mg/kg, with IPAC-5 and with dimebo ...
... Figure 3: Effects of bio-isosteric analogues of MK-801 on extinction of contextual freezing in a fearconditioning paradigm. (A) During recall of memory extinction trials, the percentage of time spent in freezing was decreased in mice treated with QXX at a dose of 5 mg/kg, with IPAC-5 and with dimebo ...
Невротрансмитери в ЦНС
... Glutamate is the excitatory amino acid transmitter in the CNS. It acts at NMDA (N-methyl-D-aspartate) and other receptors. NMDA receptors are involved in the development of adaptive responses that modulate synaptic transmission, known as synaptic plasticity.These responses have a role in both physi ...
... Glutamate is the excitatory amino acid transmitter in the CNS. It acts at NMDA (N-methyl-D-aspartate) and other receptors. NMDA receptors are involved in the development of adaptive responses that modulate synaptic transmission, known as synaptic plasticity.These responses have a role in both physi ...
John F. MacDonald 2014 - Canadian Association for Neuroscience
... excitatory amino acids such as glutamate, a decision that proved to be a turning point in cellular neuroscience. Although with his typical humility John often quipped that he made the decision to study excitatory amino acids because ‘no one else was doing this’, the move was nonetheless prescient as ...
... excitatory amino acids such as glutamate, a decision that proved to be a turning point in cellular neuroscience. Although with his typical humility John often quipped that he made the decision to study excitatory amino acids because ‘no one else was doing this’, the move was nonetheless prescient as ...
Synaptic Transmission Lecture
... • NO PORE, but binding can initiate: • 2nd messenger system • Other products could open ion channels • Modulate enzyme activity • Regulate ion channels in membrane • Initiate gene transcription/translation ...
... • NO PORE, but binding can initiate: • 2nd messenger system • Other products could open ion channels • Modulate enzyme activity • Regulate ion channels in membrane • Initiate gene transcription/translation ...
Nerve impulses and Synapses Electro
... depends not so much on the chemistry of the transmitter, than on the properties of the receptors it binds to. • It’s not the key that matters, but the door that is being unlocked. ...
... depends not so much on the chemistry of the transmitter, than on the properties of the receptors it binds to. • It’s not the key that matters, but the door that is being unlocked. ...
Cellular and Molecul..
... • The sense of smell remained the most enigmatic of our senses until recently • Our lives are apparently dominated by the visual sense, but often smells trigger much deeper emotional responses • All living organisms can detect and identify chemical substances in their environment • Humans can recogn ...
... • The sense of smell remained the most enigmatic of our senses until recently • Our lives are apparently dominated by the visual sense, but often smells trigger much deeper emotional responses • All living organisms can detect and identify chemical substances in their environment • Humans can recogn ...
Hypothalamic/Pituitary Axis
... Steroids transport via carrier proteins – why? Movement through plasma membrane into cytoplasm of target Interaction with specific receptors Binding to response elements in target genes Influence on transcription ...
... Steroids transport via carrier proteins – why? Movement through plasma membrane into cytoplasm of target Interaction with specific receptors Binding to response elements in target genes Influence on transcription ...
1 OVERVIEW OF EXTRACELLULAR SIGNALING A. Steps of
... OVERVIEW OF EXTRACELLULAR SIGNALING A. Steps of extracellular communication 1. synthesis of signaling molecule 2. Release of signaling molecule 3. Transport of the signal to the target cell 4. Detection of the signal by a specific receptor protein 5. Change in cellular metabolism or gene expression ...
... OVERVIEW OF EXTRACELLULAR SIGNALING A. Steps of extracellular communication 1. synthesis of signaling molecule 2. Release of signaling molecule 3. Transport of the signal to the target cell 4. Detection of the signal by a specific receptor protein 5. Change in cellular metabolism or gene expression ...
BIO 330 Cell Biology Lecture Outline Spring 2011 Chapter 14
... IP3 leads to increased intracellular Ca2+ DAG leads to PKC activation 3. Nitric oxide D. Transduction of signals via subunits of G proteins III. Protein Kinase-Associated Receptors A. Tyrosine vs. serine/threonine kinases B. Growth factors bind protein-kinase associated receptors C. Receptor tyro ...
... IP3 leads to increased intracellular Ca2+ DAG leads to PKC activation 3. Nitric oxide D. Transduction of signals via subunits of G proteins III. Protein Kinase-Associated Receptors A. Tyrosine vs. serine/threonine kinases B. Growth factors bind protein-kinase associated receptors C. Receptor tyro ...
Are You suprised ?
... G protein-coupled receptors (GPCRs) are the largest class of molecules involved in signal transduction across membranes, and represent major drug targets in all clinical areas. The serotonin1A receptor is an important neurotransmitter receptor of the GPCR superfamily and is implicated in the generat ...
... G protein-coupled receptors (GPCRs) are the largest class of molecules involved in signal transduction across membranes, and represent major drug targets in all clinical areas. The serotonin1A receptor is an important neurotransmitter receptor of the GPCR superfamily and is implicated in the generat ...
Heterodimers of G protein
... • This association may alter the function of both receptors, yielding a distinct functional unit ...
... • This association may alter the function of both receptors, yielding a distinct functional unit ...
Harvard-MIT Division of Health Sciences and Technology HST.131: Introduction to Neuroscience
... • K+ and Cl- channels will hyperpolarize or shunt depolarizing responses • Do not take Vm past threshold ...
... • K+ and Cl- channels will hyperpolarize or shunt depolarizing responses • Do not take Vm past threshold ...
5-8_PathEvByCertainTransmitter_SomorjaiD
... receptors, which are called the NMDA receptor and the non-NMDA receptor. These receptors all contain glutamate-binding sites. Once glutamate binds to the receptor, glutamate “excites” the cells by causing positive ions to flow into the cell, increasing the cell’s electrical charge. The increased cha ...
... receptors, which are called the NMDA receptor and the non-NMDA receptor. These receptors all contain glutamate-binding sites. Once glutamate binds to the receptor, glutamate “excites” the cells by causing positive ions to flow into the cell, increasing the cell’s electrical charge. The increased cha ...
Gene Description Function Score
... action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon gr ...
... action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon gr ...
John Ferguson MacDonald John Ferguson MacDonald, who died
... His interest in glutamate led John to examine mechanisms related to glutamate’s potentially noxious action: excessive depolarization and Ca2+ influx via NMDARs result in the death of nerve cells, for example following brain ischemia, when large amounts of glutamate are released from neurons and glia ...
... His interest in glutamate led John to examine mechanisms related to glutamate’s potentially noxious action: excessive depolarization and Ca2+ influx via NMDARs result in the death of nerve cells, for example following brain ischemia, when large amounts of glutamate are released from neurons and glia ...
John Ferguson MacDonald
... His interest in glutamate led John to examine mechanisms related to glutamate’s potentially noxious action: excessive depolarization and Ca2+ influx via NMDARs result in the death of nerve cells, for example following brain ischemia, when large amounts of glutamate are released from neurons and glia ...
... His interest in glutamate led John to examine mechanisms related to glutamate’s potentially noxious action: excessive depolarization and Ca2+ influx via NMDARs result in the death of nerve cells, for example following brain ischemia, when large amounts of glutamate are released from neurons and glia ...
Plasticity, Hippocampal Place Cells, and Cognitive Maps
... Amaral and Witter). The hippocampal slice, circled in the lower left figure, is expanded to show the trisynaptic circuit. At the top right, a single cornu ammonis 1 (CA1) pyramidal neuron and the hippocampal synapse are shown. Axons from CA3 pyramidal neurons form glutamatergic synapses on CA1 neuro ...
... Amaral and Witter). The hippocampal slice, circled in the lower left figure, is expanded to show the trisynaptic circuit. At the top right, a single cornu ammonis 1 (CA1) pyramidal neuron and the hippocampal synapse are shown. Axons from CA3 pyramidal neurons form glutamatergic synapses on CA1 neuro ...
Types of neurons - Brigham Young University
... Some Drugs work on receptors Some drugs are shaped like neurotransmitters Antagonists : fit the receptor but poorly and block the NT e.g. beta blockers ...
... Some Drugs work on receptors Some drugs are shaped like neurotransmitters Antagonists : fit the receptor but poorly and block the NT e.g. beta blockers ...
NMDA receptor
The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function.The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is named this because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations with a reversal potential near 0 mV. A property of the NMDA receptor is its voltage-dependent activation, a result of ion channel block by extracellular Mg2+ & Zn2+ ions. This allows the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell to be voltage-dependent.Calcium flux through NMDARs is thought to be critical in synaptic plasticity, a cellular mechanism for learning and memory. The NMDA receptor is distinct in two ways: first, it is both ligand-gated and voltage-dependent; second, it requires co-activation by two ligands: glutamate and either D-serine or glycine.The activity of the NMDA receptor is affected by many psychoactive drugs such as phencyclidine (PCP), alcohol (ethanol) and dextromethorphan (DXM). The anaesthetic effects of the drugs ketamine and nitrous oxide are partially because of their effects on NMDA receptor activity.