SouthernHybridization - University of Hawaii
... • Detect PDI protein in wild type plants. • In mutant plants, determine the effect of the T-DNA insert on the expression of the PDI gene through movement or deletion of PDI protein band. ...
... • Detect PDI protein in wild type plants. • In mutant plants, determine the effect of the T-DNA insert on the expression of the PDI gene through movement or deletion of PDI protein band. ...
Lecture Notes of Seminario Interdisciplinare di Matematica Vol. 9
... The conformational search of the global minimum energy surface of a protein from the amino acid sequence is one of the challenging problems in bioinformatics. In recent years, several optimization approaches to solve this problem have appeared in the literature. The most common approach is to model ...
... The conformational search of the global minimum energy surface of a protein from the amino acid sequence is one of the challenging problems in bioinformatics. In recent years, several optimization approaches to solve this problem have appeared in the literature. The most common approach is to model ...
Jasmita_presen_nov3
... Energetically best ranked ligand placements in target site (s) Each placement has variable conformations ...
... Energetically best ranked ligand placements in target site (s) Each placement has variable conformations ...
Protein Secondary Structure Prediction
... the coordinates of residues. Tertiary Structure is the native state, or folded form, of a single protein chain. This form is also called the functional form. Tertiary structure of a protein includes the coordinates of its residues in three dimensional space. Quaternary Structure is the structure of ...
... the coordinates of residues. Tertiary Structure is the native state, or folded form, of a single protein chain. This form is also called the functional form. Tertiary structure of a protein includes the coordinates of its residues in three dimensional space. Quaternary Structure is the structure of ...
Antibody Sampler Kit MAP Kinase Activation
... Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases that include three major MAPKs: p38, JNK, and ERK. These MAPKs are involved in many cellular programs such as cell proliferation, differentiation, motility, and death. Upon stimulation, the MA ...
... Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases that include three major MAPKs: p38, JNK, and ERK. These MAPKs are involved in many cellular programs such as cell proliferation, differentiation, motility, and death. Upon stimulation, the MA ...
Proteins
... Significance of Protein Conformation • Small change in 1o structure – can change protein’s conformation and function ...
... Significance of Protein Conformation • Small change in 1o structure – can change protein’s conformation and function ...
Application of recombinant DNA technology in protein expression
... Dense particles, containing precipitated proteins. Their formation depends on protein synthesis rate, growth conditions. Advantages: proteolysis resistant, big yield, relatively pure, easy to separate. Disadvantages: inactive product requires in vitro refolding and renaturation ...
... Dense particles, containing precipitated proteins. Their formation depends on protein synthesis rate, growth conditions. Advantages: proteolysis resistant, big yield, relatively pure, easy to separate. Disadvantages: inactive product requires in vitro refolding and renaturation ...
Cloning, Characterization, and Expression of a G-Protein
... of hydrophobicity that could be transmembrane domains. There were several domains that had particularly high homology to the rat NPY receptor; these areas closely correlated with the hydrophobic, and thus possibly the transmembrane, domains. In addition to the seven transmembrane domains, GRL104 has ...
... of hydrophobicity that could be transmembrane domains. There were several domains that had particularly high homology to the rat NPY receptor; these areas closely correlated with the hydrophobic, and thus possibly the transmembrane, domains. In addition to the seven transmembrane domains, GRL104 has ...
The Plasma Membrane
... It is fluid because the phospholipid molecules move within the membrane. Proteins in the membrane that move among the phospholipids create the mosaic pattern. ...
... It is fluid because the phospholipid molecules move within the membrane. Proteins in the membrane that move among the phospholipids create the mosaic pattern. ...
Genetic threading (Power point)
... purified protein molecules (1014) to grow a crystal and protein needs to crystallize NMR method applicable to proteins of small and average size, which do not crystallize Both methods are expensive and give coherent results on the same protein, proving to be correct Structure of many important prote ...
... purified protein molecules (1014) to grow a crystal and protein needs to crystallize NMR method applicable to proteins of small and average size, which do not crystallize Both methods are expensive and give coherent results on the same protein, proving to be correct Structure of many important prote ...
Leukaemia Section t(9;22)(q34;q11) in ANLL Atlas of Genetics and Cytogenetics
... which allows unregulated proliferation of leukaemic progenitors. ...
... which allows unregulated proliferation of leukaemic progenitors. ...
The Guanine Nucleotide–Binding Switch in Three Dimensions
... an NH2-terminal extension necessary for insertion into and interaction with the membrane. Ran has an elongated COOH-terminal element crucial for its function in nuclear transport (9, 10). G␣ proteins with a molecular mass of 40 to 45 kD have several extensions to and insertions into the G domain, on ...
... an NH2-terminal extension necessary for insertion into and interaction with the membrane. Ran has an elongated COOH-terminal element crucial for its function in nuclear transport (9, 10). G␣ proteins with a molecular mass of 40 to 45 kD have several extensions to and insertions into the G domain, on ...
O. Ugur Sezerman Sabanci University MDBF 34056 Orhanli
... Meydan C., Yörükoğlu D., Küçükural A., Sezerman U., “Discovery of biomarkers for hexachlorobenzene toxicity using population based methods on gene expression data”, Lecture Notes in Computer Science, Vol.5265,412-423, 2008. Kallempudi S., Gül Ö., Başağa H., Sezerman U., Gurbuz Y.,“Label-free biosens ...
... Meydan C., Yörükoğlu D., Küçükural A., Sezerman U., “Discovery of biomarkers for hexachlorobenzene toxicity using population based methods on gene expression data”, Lecture Notes in Computer Science, Vol.5265,412-423, 2008. Kallempudi S., Gül Ö., Başağa H., Sezerman U., Gurbuz Y.,“Label-free biosens ...
- Wiley Online Library
... The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target ...
... The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target ...
Application of SVM to predict membrane protein types
... Elrod (1999a) during constructing the working data sets. ...
... Elrod (1999a) during constructing the working data sets. ...
Plant Molecular Biology
... 2003). DRP5 proteins do not contain an N-terminal signal peptide for plastid targeting. Instead, they are recruited to the cytosolic side of the chloroplast division site to form a ring in the late stage of chloroplast division. DRP5A shares only 20% sequence identity with DRP5B (ARC5) and it is unk ...
... 2003). DRP5 proteins do not contain an N-terminal signal peptide for plastid targeting. Instead, they are recruited to the cytosolic side of the chloroplast division site to form a ring in the late stage of chloroplast division. DRP5A shares only 20% sequence identity with DRP5B (ARC5) and it is unk ...
Education Professional Experience and Appointments
... 2. Lezon TR, Shrivastava IH, Yang Z and Bahar I. Elastic network models for biomolecular dynamics: Theory and application to membrane proteins and viruses, in Handbook on Biological Networks. Edited by Boccaletti S, Latora V and Moreno Y. World Scientific, 2009. 3. Zomot E, Bakan A, Shrivastava IH, ...
... 2. Lezon TR, Shrivastava IH, Yang Z and Bahar I. Elastic network models for biomolecular dynamics: Theory and application to membrane proteins and viruses, in Handbook on Biological Networks. Edited by Boccaletti S, Latora V and Moreno Y. World Scientific, 2009. 3. Zomot E, Bakan A, Shrivastava IH, ...
Programming Languages for Biology
... – many thousand of molecules interact in complex series of reactions to perform some function (called a pathway) • e.g., lactose interacting with a receptor triggers a series of actions to create the enzyme capable of breaking it down into usable form ...
... – many thousand of molecules interact in complex series of reactions to perform some function (called a pathway) • e.g., lactose interacting with a receptor triggers a series of actions to create the enzyme capable of breaking it down into usable form ...
Mesoderm induction
... - ectopic expression of nodal on right side randomizes location of the heart - nodal is involved in determining left-right asymmetry in mice, frogs, chicken & zebrafish ...
... - ectopic expression of nodal on right side randomizes location of the heart - nodal is involved in determining left-right asymmetry in mice, frogs, chicken & zebrafish ...
Gene Section CCDC6 (coiled-coil domain containing 6) Atlas of Genetics and Cytogenetics
... H4-PDGFRB. In a single case analyzed the translocation was found to be complex at the molecular level. Abnormal protein Contains the leucine zipper of H4 and the entire tyrosine kinase domain and transmembrane domain of PDGFRB. ...
... H4-PDGFRB. In a single case analyzed the translocation was found to be complex at the molecular level. Abnormal protein Contains the leucine zipper of H4 and the entire tyrosine kinase domain and transmembrane domain of PDGFRB. ...
Feedstuffs for Cattle
... of a ruminant. • The reticulum is second stomach compartment of a ruminant. It is also called a honeycomb. • The omasum is the third division of the stomach of a ruminant. It is also called manyplies. • The abomasum is the fourth stomach compartment (true stomach) of a ruminant. ...
... of a ruminant. • The reticulum is second stomach compartment of a ruminant. It is also called a honeycomb. • The omasum is the third division of the stomach of a ruminant. It is also called manyplies. • The abomasum is the fourth stomach compartment (true stomach) of a ruminant. ...
Mitogen-activated protein kinases and cardiomyocyte hypertrophy
... MAPK pathways, as well as MKK4 activating JNKs and p38 MAPKs [Fig.1]. Also, specific activation of p38α by adenovirusdelivered constitutively active MKK3β has been shown to result in potent inhibition of the activity of ERK1,2 and its upstream activator MEK1,2 [13]. There are also contradictonary re ...
... MAPK pathways, as well as MKK4 activating JNKs and p38 MAPKs [Fig.1]. Also, specific activation of p38α by adenovirusdelivered constitutively active MKK3β has been shown to result in potent inhibition of the activity of ERK1,2 and its upstream activator MEK1,2 [13]. There are also contradictonary re ...
G protein–coupled receptor
G protein–coupled receptors (GPCRs), also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times.G protein–coupled receptors are found only in eukaryotes, including yeast, choanoflagellates, and animals. The ligands that bind and activate these receptors include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters, and vary in size from small molecules to peptides to large proteins. G protein–coupled receptors are involved in many diseases, and are also the target of approximately 40% of all modern medicinal drugs. Two of the United States's top five selling drugs (Hydrocodone and Lisinopril) act by targeting a G protein–coupled receptor. The 2012 Nobel Prize in Chemistry was awarded to Brian Kobilka and Robert Lefkowitz for their work that was ""crucial for understanding how G protein–coupled receptors function."". There have been at least seven other Nobel Prizes awarded for some aspect of G protein–mediated signaling.There are two principal signal transduction pathways involving the G protein–coupled receptors: the cAMP signal pathway and the phosphatidylinositol signal pathway. When a ligand binds to the GPCR it causes a conformational change in the GPCR, which allows it to act as a guanine nucleotide exchange factor (GEF). The GPCR can then activate an associated G protein by exchanging its bound GDP for a GTP. The G protein's α subunit, together with the bound GTP, can then dissociate from the β and γ subunits to further affect intracellular signaling proteins or target functional proteins directly depending on the α subunit type (Gαs, Gαi/o, Gαq/11, Gα12/13).