(Rev. 9/04), Biographical Sketch Format Page
... Chase, D.L., Pepper, J.S., and Koelle, M.R. (2004). Mechanism of extrasynaptic dopamine signaling in C. elegans. Nature Neurosci, 7, 1096-1103. Hess, H.A., Röper J.C., Grill, S.W., and Koelle, M.R. (2004). RGS-7 Completes a ReceptorIndependent Heterotrimeric G Protein Cycle to Asymmetrically Regulat ...
... Chase, D.L., Pepper, J.S., and Koelle, M.R. (2004). Mechanism of extrasynaptic dopamine signaling in C. elegans. Nature Neurosci, 7, 1096-1103. Hess, H.A., Röper J.C., Grill, S.W., and Koelle, M.R. (2004). RGS-7 Completes a ReceptorIndependent Heterotrimeric G Protein Cycle to Asymmetrically Regulat ...
lec31_2013 - Andrew.cmu.edu
... Secretion of glucagon from the - cells in the pancreas occurs when blood glucose levels are low. This also leads to the phosphorylation of many enzymes. Secretion of insulin from the -cells ...
... Secretion of glucagon from the - cells in the pancreas occurs when blood glucose levels are low. This also leads to the phosphorylation of many enzymes. Secretion of insulin from the -cells ...
Unit 10 web
... All naturally occurring -amino acids, except glycine (R=H), are chiral and the ‘L’ stereoisomer. ...
... All naturally occurring -amino acids, except glycine (R=H), are chiral and the ‘L’ stereoisomer. ...
Gene Section USP15 (ubiquitin specific peptidase 15) Atlas of Genetics and Cytogenetics
... USP15. For example, USP15 was one of twelve DUBs identified from an siRNA screen that impact on the hepatocyte growth factor (HGF)-dependent cell scattering response in non-small cell lung cancer and pancreatic cancer cells (Buus et al., 2009). A number of specific USP15 substrates have also been de ...
... USP15. For example, USP15 was one of twelve DUBs identified from an siRNA screen that impact on the hepatocyte growth factor (HGF)-dependent cell scattering response in non-small cell lung cancer and pancreatic cancer cells (Buus et al., 2009). A number of specific USP15 substrates have also been de ...
7.06 Cell Biology EXAM #3 KEY
... You are studying signal peptidase in yeast. In yeast, a single gene encodes signal peptidase, and its gene product is a soluble protein localized to the lumen of the ER. (a, 4 pts) Would you expect that signal peptidase itself is synthesized with a signal sequence? If yes, which enzyme would remove ...
... You are studying signal peptidase in yeast. In yeast, a single gene encodes signal peptidase, and its gene product is a soluble protein localized to the lumen of the ER. (a, 4 pts) Would you expect that signal peptidase itself is synthesized with a signal sequence? If yes, which enzyme would remove ...
Peroxisomes - University of California San Diego
... These proteins have one or more sequences (mPTSs) that direct them to the peroxisomal membrane with the correct topology. Although a dozen or so mPTSs have been defined in several yeast and mammalian peroxisomal membrane proteins (PMPs), they have no simple consensus sequence. The PMP receptor(s), t ...
... These proteins have one or more sequences (mPTSs) that direct them to the peroxisomal membrane with the correct topology. Although a dozen or so mPTSs have been defined in several yeast and mammalian peroxisomal membrane proteins (PMPs), they have no simple consensus sequence. The PMP receptor(s), t ...
Cloning of a cDNA Encoding a Plasma Membrane
... membrane (protein) was isolated by two-phase partitioning. The final yield of protein was too low to permit accurate quantitation; however, when comparing the density of known amounts of Coomassie blue-stained BSA with that of the protein, we estimated a recovery of ~4 to 8 u.g. Initial N-terminal s ...
... membrane (protein) was isolated by two-phase partitioning. The final yield of protein was too low to permit accurate quantitation; however, when comparing the density of known amounts of Coomassie blue-stained BSA with that of the protein, we estimated a recovery of ~4 to 8 u.g. Initial N-terminal s ...
Slide 1
... A target cell is defined by its ability to bind selectively a given hormone via a receptor ...
... A target cell is defined by its ability to bind selectively a given hormone via a receptor ...
COMMUNICATION Two categories of mammalian galactose
... The monosaccharide-binding profiles of the asialoglycoprotein receptor and Kupffer cell receptor are similar: both show a marked preference for GalNAc over galactose. In contrast, the rat macrophage galactose lectin exhibits no preference for GalNAc over galactose (Iobst and Drickamer, 1996). Bindin ...
... The monosaccharide-binding profiles of the asialoglycoprotein receptor and Kupffer cell receptor are similar: both show a marked preference for GalNAc over galactose. In contrast, the rat macrophage galactose lectin exhibits no preference for GalNAc over galactose (Iobst and Drickamer, 1996). Bindin ...
Wellness- lesson 03- Proteins
... decides how the body will function and what biological materials will be produced. In other words, each cell has a little brain that is very aware of what our bodies need at any given time. Pretty amazing, huh? ...
... decides how the body will function and what biological materials will be produced. In other words, each cell has a little brain that is very aware of what our bodies need at any given time. Pretty amazing, huh? ...
An RNA-binding domain in the viral haemorrhagic septicaemia virus
... then digested with 50 U RNase T1 for 15 min at 37 °C. RNA–protein complexes were run on 15 % SDS–PAGE gels, which were then stained with Coomassie blue, dried and autoradiographed. Superimposing the stained gel (Fig. 3 a) and resulting autoradiograph (Fig. 3 b) clearly indicated that the B protein i ...
... then digested with 50 U RNase T1 for 15 min at 37 °C. RNA–protein complexes were run on 15 % SDS–PAGE gels, which were then stained with Coomassie blue, dried and autoradiographed. Superimposing the stained gel (Fig. 3 a) and resulting autoradiograph (Fig. 3 b) clearly indicated that the B protein i ...
File - Wk 1-2
... glucose enters the beta cells of the pancreas via GLUT2 transporters glucose is then phosphorylated by glucokinase, which traps it inside the cell, and is further metabolized to create ATP ↑ ATP causes ATP-gated K channel to close ↑ K+ ions inside the cell depolarizes the membrane and cause ...
... glucose enters the beta cells of the pancreas via GLUT2 transporters glucose is then phosphorylated by glucokinase, which traps it inside the cell, and is further metabolized to create ATP ↑ ATP causes ATP-gated K channel to close ↑ K+ ions inside the cell depolarizes the membrane and cause ...
Protein folding
... competition in which typically more than 100 different “target sequences” (of proteins whose structures are known but not yet publicly available) are made available to a community that numbers more than 150 research groups around the world. ...
... competition in which typically more than 100 different “target sequences” (of proteins whose structures are known but not yet publicly available) are made available to a community that numbers more than 150 research groups around the world. ...
Regulation of ion channels
... positive (depolarizes) in response to a stimulus – action potential • Action potential coincides with a brief increases in permeabilities of membrane to Na+ and K+ • Flow of Na+ out of cell depolarizes membrane; subsequent flow of K+ out of cell repolarizes and slightly hyperpolarizes membrane • Act ...
... positive (depolarizes) in response to a stimulus – action potential • Action potential coincides with a brief increases in permeabilities of membrane to Na+ and K+ • Flow of Na+ out of cell depolarizes membrane; subsequent flow of K+ out of cell repolarizes and slightly hyperpolarizes membrane • Act ...
Proteins
... • Excess protein cannot be stored and is converted into glucose or fat for later use. • Athletes who are highly trained for endurance activities may need to exceed the RDA for protein. ...
... • Excess protein cannot be stored and is converted into glucose or fat for later use. • Athletes who are highly trained for endurance activities may need to exceed the RDA for protein. ...
Functional decorations: post-translational modifications and heart
... controlled without the need to synthesize new protein or degrade the existing pool. Such activity must be energetically favorable for the cell. PTMs can be broadly classed into three groups: enzymatic, in which the addition and subtraction of the modification is regulated by proteins; chemical, in w ...
... controlled without the need to synthesize new protein or degrade the existing pool. Such activity must be energetically favorable for the cell. PTMs can be broadly classed into three groups: enzymatic, in which the addition and subtraction of the modification is regulated by proteins; chemical, in w ...
Physiology of the neuromuscular junction
... identical α (alpha) subunits, one β (beta), one δ (delta) and one ε (epsilon) subunit. In the foetus a γ (gamma) subunit replaces the ε. These different proteins are each coded by a different gene and synthesised within the muscle cells. The whole receptor spans the muscle cell membrane projecting p ...
... identical α (alpha) subunits, one β (beta), one δ (delta) and one ε (epsilon) subunit. In the foetus a γ (gamma) subunit replaces the ε. These different proteins are each coded by a different gene and synthesised within the muscle cells. The whole receptor spans the muscle cell membrane projecting p ...
EF-Tu PROTEIN DOMAINS
... adaptation to various living conditions. Furthermore, since all known EF-Tu proteins are composed of three distinct domains, they can also serve as suitable models for the understanding of domain organization in proteins. One of the main research projects of the Department of Gene Expression at the ...
... adaptation to various living conditions. Furthermore, since all known EF-Tu proteins are composed of three distinct domains, they can also serve as suitable models for the understanding of domain organization in proteins. One of the main research projects of the Department of Gene Expression at the ...
Non-linear optimization
... Learning the kernel matrix with semidefinite programming G.R.G.Lanckrit et. al, 2004 Kernel-based data fusion and its application to protein function prediction in yeast G.R.G.Lanckrit et. al, 2004 Machine learning using Hyperkernels C.S.Ong, A.J.Smola, 2003 Semidefinite optimization ...
... Learning the kernel matrix with semidefinite programming G.R.G.Lanckrit et. al, 2004 Kernel-based data fusion and its application to protein function prediction in yeast G.R.G.Lanckrit et. al, 2004 Machine learning using Hyperkernels C.S.Ong, A.J.Smola, 2003 Semidefinite optimization ...
Document
... – Is a cofactor for certain enzymes including, amine oxidase, copperdependent superoxide dismutase, cytochrome oxidase, tyrosinase – It is excess can cause problems because it can oxidize proteins and lipids, bind to nucleic acids and enhance the production of free ...
... – Is a cofactor for certain enzymes including, amine oxidase, copperdependent superoxide dismutase, cytochrome oxidase, tyrosinase – It is excess can cause problems because it can oxidize proteins and lipids, bind to nucleic acids and enhance the production of free ...
Document
... Competition of Ligand-binding Chains of Different Receptors for a Common Subunit Can Produce Antagnistic Effects between Cytokines ...
... Competition of Ligand-binding Chains of Different Receptors for a Common Subunit Can Produce Antagnistic Effects between Cytokines ...
Chapt. 10: Protein Sorting, Transport: Endoplasmic Reticulum, Golgi
... Posttranslation translocation (more common in yeast): • Proteins synthesized on free ribosomes • Signal sequences recognized by receptors on translocon (not need SRP) • Hsp70 chaperones keep polypeptide chains unfolded so can enter translocon • Hsp70 chaperone in ER (BiP) acts as ratchet to pull pol ...
... Posttranslation translocation (more common in yeast): • Proteins synthesized on free ribosomes • Signal sequences recognized by receptors on translocon (not need SRP) • Hsp70 chaperones keep polypeptide chains unfolded so can enter translocon • Hsp70 chaperone in ER (BiP) acts as ratchet to pull pol ...
G protein–coupled receptor
G protein–coupled receptors (GPCRs), also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times.G protein–coupled receptors are found only in eukaryotes, including yeast, choanoflagellates, and animals. The ligands that bind and activate these receptors include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters, and vary in size from small molecules to peptides to large proteins. G protein–coupled receptors are involved in many diseases, and are also the target of approximately 40% of all modern medicinal drugs. Two of the United States's top five selling drugs (Hydrocodone and Lisinopril) act by targeting a G protein–coupled receptor. The 2012 Nobel Prize in Chemistry was awarded to Brian Kobilka and Robert Lefkowitz for their work that was ""crucial for understanding how G protein–coupled receptors function."". There have been at least seven other Nobel Prizes awarded for some aspect of G protein–mediated signaling.There are two principal signal transduction pathways involving the G protein–coupled receptors: the cAMP signal pathway and the phosphatidylinositol signal pathway. When a ligand binds to the GPCR it causes a conformational change in the GPCR, which allows it to act as a guanine nucleotide exchange factor (GEF). The GPCR can then activate an associated G protein by exchanging its bound GDP for a GTP. The G protein's α subunit, together with the bound GTP, can then dissociate from the β and γ subunits to further affect intracellular signaling proteins or target functional proteins directly depending on the α subunit type (Gαs, Gαi/o, Gαq/11, Gα12/13).