Polynucleotide Phosphorylase and Mitochondrial
... can promote reduction of arsenate (AsV) into the more toxic arsenite (AsIII) because they convert AsV into an arsenylated product in which the arsenic is more reducible by glutathione (GSH) or other thiols to AsIII than in inorganic AsV. We have also shown that mitochondria can rapidly reduce AsV in ...
... can promote reduction of arsenate (AsV) into the more toxic arsenite (AsIII) because they convert AsV into an arsenylated product in which the arsenic is more reducible by glutathione (GSH) or other thiols to AsIII than in inorganic AsV. We have also shown that mitochondria can rapidly reduce AsV in ...
metalloids 109 - Technical Learning College
... is quite large, requiring a major effort to bring it under control. Employee health and safety, as well as that of the public, depend upon careful application of federal and state regulations and safe working procedures. This manual will cover general laws, regulations, required procedures and work ...
... is quite large, requiring a major effort to bring it under control. Employee health and safety, as well as that of the public, depend upon careful application of federal and state regulations and safe working procedures. This manual will cover general laws, regulations, required procedures and work ...
EVALUATION OF HEAVY METALS IN AYURVEDIC MEDICINES
... used worldwide.2 Ayurvedic medicines are primarily composed of herbs, minerals, metals and animal products.3 These are included in either purely herbal or rasa shastra products. Rasa shastra is an ancient practice where metals like lead, mercury, iron and zinc etc, are processed and added to herbs. ...
... used worldwide.2 Ayurvedic medicines are primarily composed of herbs, minerals, metals and animal products.3 These are included in either purely herbal or rasa shastra products. Rasa shastra is an ancient practice where metals like lead, mercury, iron and zinc etc, are processed and added to herbs. ...
Forensic Toxicology: General Consideration By
... body through any route (Inhalation, Ingestion, surface absorption etc) will produce ill-health or death by its action which is due to its physical chemical or physiological properties. Eg: alphose, sulphuric acid, arsenic etc. Drug (WHO 1996): “Drug is any substance or product that is used or intend ...
... body through any route (Inhalation, Ingestion, surface absorption etc) will produce ill-health or death by its action which is due to its physical chemical or physiological properties. Eg: alphose, sulphuric acid, arsenic etc. Drug (WHO 1996): “Drug is any substance or product that is used or intend ...
Chelation in Metal Intoxication
... reach the sites of metal storage, retain chelating ability at the pH of body fluids and the property of forming metal complexes that are less toxic than the free metal ion (Figure 2). Figure 2. Characteristics of an ideal chelating agent for better chelation of heavy metals. ...
... reach the sites of metal storage, retain chelating ability at the pH of body fluids and the property of forming metal complexes that are less toxic than the free metal ion (Figure 2). Figure 2. Characteristics of an ideal chelating agent for better chelation of heavy metals. ...
Group 15: The Nitrogen Family
... Red phosphorus is an amorphous solid. It is more stable and explodes at temperatures higher than those of white phosphorus. It is still, however, dangerously reactive. Both forms of phosphorus are insoluble in water and can be interconverted with various applications of heat, pressure, and light. Th ...
... Red phosphorus is an amorphous solid. It is more stable and explodes at temperatures higher than those of white phosphorus. It is still, however, dangerously reactive. Both forms of phosphorus are insoluble in water and can be interconverted with various applications of heat, pressure, and light. Th ...
Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis
... Arsenic trioxide is a documented environmental toxicant and a potent chemotherapeutic agent, which has been used therapeutically for decades[1]. Besides being an anticancer drug against acute promyelocytic leukemia (APL), arsenic trioxide has also been proved as an effective compound that can inhibi ...
... Arsenic trioxide is a documented environmental toxicant and a potent chemotherapeutic agent, which has been used therapeutically for decades[1]. Besides being an anticancer drug against acute promyelocytic leukemia (APL), arsenic trioxide has also been proved as an effective compound that can inhibi ...
Principles of Toxicology
... b. They are constituents of organic compounds. c. We have evolved mechanism (like many other organism) for combating metal poisoning. d. Humans have a protein called metalothionine (which binds metals and prevents them from producing damage to cells). XXVI. ARSENIC POISONING [S26] a. Arsenic poisoni ...
... b. They are constituents of organic compounds. c. We have evolved mechanism (like many other organism) for combating metal poisoning. d. Humans have a protein called metalothionine (which binds metals and prevents them from producing damage to cells). XXVI. ARSENIC POISONING [S26] a. Arsenic poisoni ...
Detoxification of Metals – Biochelation
... The link formed between the metal and the chelating agent is of coordinate nature which is generally similar to covalent type but the major difference is that both electrons forming the link are supplied by the binding atom, the resulting compound is called metal complex or coordinate compound. A si ...
... The link formed between the metal and the chelating agent is of coordinate nature which is generally similar to covalent type but the major difference is that both electrons forming the link are supplied by the binding atom, the resulting compound is called metal complex or coordinate compound. A si ...
Arsenic in Cancer Treatment: Challenges for Application of Realgar
... when researchers at the Institute of Hematology, Chinese Academy of Sciences (Beijing) noted that an herbal formula prescribed by Chinese doctors appeared to be producing good results in many APL patients. A modified version of the traditional formula, which includes both indigo and REA with Salvia ...
... when researchers at the Institute of Hematology, Chinese Academy of Sciences (Beijing) noted that an herbal formula prescribed by Chinese doctors appeared to be producing good results in many APL patients. A modified version of the traditional formula, which includes both indigo and REA with Salvia ...
Arsenic translocation in rice cultivation and its implication for human
... it on to the vacuoles, and this is due to the characteristics of the root cell tonoplast (Rascio and Navari-Izzo, 2011). The root absorbs As as AsV and AsIII. Arsenate penetrates because it is highly similar to the Pi transporters that belong to the PHT1 family (Ali et al., 2009). The plasma membran ...
... it on to the vacuoles, and this is due to the characteristics of the root cell tonoplast (Rascio and Navari-Izzo, 2011). The root absorbs As as AsV and AsIII. Arsenate penetrates because it is highly similar to the Pi transporters that belong to the PHT1 family (Ali et al., 2009). The plasma membran ...
File
... • Occupational exposure to arsenic occurs in the manufacture of pesticides, herbicides, and other agricultural products. • Arsenic contaminated drinking water. ...
... • Occupational exposure to arsenic occurs in the manufacture of pesticides, herbicides, and other agricultural products. • Arsenic contaminated drinking water. ...
Print this article - Research in Pharmaceutical Sciences
... favorable to the activities. Enzymatic screening results showed that compound (Fig. 6), comprising all of these features, was the most active inhibitor against the 20S human proteasome at less than a 2 nM level, as active as the marketed drug bortezomib (15). Interest in dipeptide boronic acids of t ...
... favorable to the activities. Enzymatic screening results showed that compound (Fig. 6), comprising all of these features, was the most active inhibitor against the 20S human proteasome at less than a 2 nM level, as active as the marketed drug bortezomib (15). Interest in dipeptide boronic acids of t ...
Possible Roles of Plant Sulfurtransferases in Detoxification of
... Abstract: Plants and animals have evolved various potential mechanisms to surmount the adverse effects of heavy metal toxicity. Plants possess low molecular weight compounds containing sulfhydryl groups (-SH) that actively react with toxic metals. For instance, glutathione (γ-Glu-Cys-Gly) is a sulfu ...
... Abstract: Plants and animals have evolved various potential mechanisms to surmount the adverse effects of heavy metal toxicity. Plants possess low molecular weight compounds containing sulfhydryl groups (-SH) that actively react with toxic metals. For instance, glutathione (γ-Glu-Cys-Gly) is a sulfu ...
The Effect of Arsenic on Liver Tissue of Experimental Animals
... resources used for this review were obtained from published work in several peer review journals. ALT activity has shown an increase of 6.03%, 13.61% and 27.75% at different doses of exposure and the AST has shown also an increase of 9.04%, 16.32% and 38.08% at different doses in fishes. The GDH act ...
... resources used for this review were obtained from published work in several peer review journals. ALT activity has shown an increase of 6.03%, 13.61% and 27.75% at different doses of exposure and the AST has shown also an increase of 9.04%, 16.32% and 38.08% at different doses in fishes. The GDH act ...
IOSR Journal of Biotechnology and Biochemistry (IOSR-JBB)
... distributed semi- metallic element occurring in various compounds in the crust of the earth is considered one of the most significant hazards in the environment. Arsenic has been used since ancient times as a therapeutic agent. It is a promising drug for patients with relapsed acute promyelocytic Le ...
... distributed semi- metallic element occurring in various compounds in the crust of the earth is considered one of the most significant hazards in the environment. Arsenic has been used since ancient times as a therapeutic agent. It is a promising drug for patients with relapsed acute promyelocytic Le ...
arsenic trioxide - Cancer Care Ontario
... information (for health professionals) contained in the Drug Formulary (the "Formulary") is intended for healthcare providers and is to be used for informational purposes only. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects o ...
... information (for health professionals) contained in the Drug Formulary (the "Formulary") is intended for healthcare providers and is to be used for informational purposes only. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects o ...
Advances in Environmental Biology
... Serum levels of MDA significantly increased in the rats exposed to sodium arsenite (p<0.05), but arsenic treated groups did not show a significant increase in MDA content of kidney (Table 1,2). A significant decreasing was obtained after plant extract treatment in serum MDA. Arsenic increased serum ...
... Serum levels of MDA significantly increased in the rats exposed to sodium arsenite (p<0.05), but arsenic treated groups did not show a significant increase in MDA content of kidney (Table 1,2). A significant decreasing was obtained after plant extract treatment in serum MDA. Arsenic increased serum ...
LC/MS/MS and GC/MS Applications in Testing Illicit Substances
... substances to improve athletic performance • Androgenic- from the Greek word andros “man” and genein “to produce” androgens are responsible for development and maintenance of male sex characteristics • Anabolic- from the Greek word anabole “to build up” constructive metabolism aka anabolism ...
... substances to improve athletic performance • Androgenic- from the Greek word andros “man” and genein “to produce” androgens are responsible for development and maintenance of male sex characteristics • Anabolic- from the Greek word anabole “to build up” constructive metabolism aka anabolism ...
Brain Storming at CSIR
... Arsenic is a deadly toxic metalloid. The element is itself is not soluble in water. It remains in combination with other elements. Arsenic disrupts ATP production. Inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation. Highly toxic as well as carcin ...
... Arsenic is a deadly toxic metalloid. The element is itself is not soluble in water. It remains in combination with other elements. Arsenic disrupts ATP production. Inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation. Highly toxic as well as carcin ...
Selective Zinc Finger Protein Oxidation and Arsenic Carcinogenesis
... Cysteine oxidation induced by reactive oxygen species (ROS) on redox sensitive targets such as zinc finger proteins plays a critical role in redox signaling and subsequent biological outcomes. Evidence from our lab and others demonstrates that arsenic inhibits DNA repair at low, non-cytotoxic concen ...
... Cysteine oxidation induced by reactive oxygen species (ROS) on redox sensitive targets such as zinc finger proteins plays a critical role in redox signaling and subsequent biological outcomes. Evidence from our lab and others demonstrates that arsenic inhibits DNA repair at low, non-cytotoxic concen ...
Forensic Toxicology
... Normal level of 1-3% in body (up to 10% in smokers) Fatal level at autopsy considered to be >50% for a healthy middle-aged male CO prevents Oxygen binding to hemoglobin (red blood cells) Leads to suffocation CO victims have “cherry pink color” ...
... Normal level of 1-3% in body (up to 10% in smokers) Fatal level at autopsy considered to be >50% for a healthy middle-aged male CO prevents Oxygen binding to hemoglobin (red blood cells) Leads to suffocation CO victims have “cherry pink color” ...
The Effects of Arsenic Toxicity in PLHC-1 Cell Line
... Xin-Mei Liu, Jian-Zhong Shao, Li-Xin Xian, Xian-Yong Chen. Cytotoxic Effect and Apoptosis Induction of Atrazine in a Grass Carp (Ctenopharyngodon idellus) Cell Line. WILEY InterScience. 2006. 80-89. Zigang D. The Molecular Mechanisms of Arsenic-Induced Cell Transformation and Apoptosis. Environmenta ...
... Xin-Mei Liu, Jian-Zhong Shao, Li-Xin Xian, Xian-Yong Chen. Cytotoxic Effect and Apoptosis Induction of Atrazine in a Grass Carp (Ctenopharyngodon idellus) Cell Line. WILEY InterScience. 2006. 80-89. Zigang D. The Molecular Mechanisms of Arsenic-Induced Cell Transformation and Apoptosis. Environmenta ...
arsenic removal by controlled biological iron oxidation reactions
... sulfate from aqueous streams. These technologies find their origin in the exploration of microorganisms involved in the global sulfur cycle. Currently, several sulfur cycle biotechnologies are applied successfully at full-scale. The sulfur cycle is closely linked with the iron cycle, and also the la ...
... sulfate from aqueous streams. These technologies find their origin in the exploration of microorganisms involved in the global sulfur cycle. Currently, several sulfur cycle biotechnologies are applied successfully at full-scale. The sulfur cycle is closely linked with the iron cycle, and also the la ...
Arsenic biochemistry
Arsenic biochemistry refers to biochemical processes that can use arsenic or its compounds, such as arsenate. Arsenic is a moderately abundant element in Earth's crust, and although many arsenic compounds are often considered highly toxic, a wide variety of organoarsenic compounds are produced biologically and various organic and inorganic arsenic compounds are metabolized by numerous organisms. This pattern is general for other related elements, including selenium, which can exhibit both beneficial and deleterious effects. Arsenic biochemistry has become topical since many toxic arsenic compounds are found in some aquifers, potentially affecting many millions of people via biochemical processes.