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Immunology Overview
Immunology Overview

... Defensins are cationic proteins 29-35 aa in length produced by neutrophils, epithelial cells of kidney and pancreas, and by paneth cells in the gut. They kill S. aureus, S. pneumoniae, E. coli, P. aeruginosa, and H. influenzae. They disrupt microbial membrane, block DNA, RNA, protein synthesis. Cath ...
Immune System - Trimble County Schools
Immune System - Trimble County Schools

... Evasion of Innate Immunity by Pathogens • Some pathogens avoid destruction by modifying their surface to prevent recognition or by resisting breakdown following phagocytosis • Tuberculosis (TB) is one such disease and kills more than a million people a year ...
PRESS RELEASE Swiss biotech starts breakthrough anti
PRESS RELEASE Swiss biotech starts breakthrough anti

... patient's own cells that are growing, dividing and spreading without control. The first generation immunotherapies (passive) are monoclonal antibodies that target one characterized component, such as a single antigen on the cancer cell membrane, and so hopefully destroy the cancer cell. A promising ...


... 10. (5 pts) NK cells, like CD8+ cytotoxic T-lymphocytes, can recognize and kill host cells infected by an intracellular pathogen using a unique granule-based mechanism. Describe how NK cells function in the presence of healthy vs. virally-infected host cells and how this granule-based system leads t ...
ASCIA SCID Pamphlet - Immune Deficiencies Foundation Australia
ASCIA SCID Pamphlet - Immune Deficiencies Foundation Australia

... healthy people are T cells (T lymphocytes), which are the most important cells in the immune system. One of the roles of T cells is to help another type of white blood cell (B cells) to produce antibodies. In SCID neither the T cells nor the B cells work properly. In fact, blood from SCID babies usu ...
Lymphatic & Immune Systems
Lymphatic & Immune Systems

... List examples of physical and chemical barriers to infection. Describe how an inflammatory response can be initiated. Explain the major activities of phagocytes and natural killer cells. Discuss the three main functions of the complement system. 13.3 Adaptive Immunity Describe the major steps in the ...
CHAPTER 17 ONTOGENY OF THE IMMUNE SYSTEM
CHAPTER 17 ONTOGENY OF THE IMMUNE SYSTEM

... In normal human adults, the generation of all cells of the hematopoietic system, with one important exception, is restricted to the bone marrow. We’ve already discussed this exception in Chapter 13; while B-cells (and most other blood cells) are produced within the bone marrow, mature T-cells are pr ...
IMMUNE SYSTEM
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... “Fine mucous-coated hairs” ~ inside nose traps particles when inhaled ~ stimulates sneezing reflex ...
Document
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... • MA.6.A.3.6 Construct and analyze tables, graphs, and equations to describe linear functions and other simple relations using both common language and algebraic notation. • HE.6.C.1.4 Recognize how heredity can affect personal health. • HE.6.C.1.8 Explain how body systems are impacted by hereditary ...
Immune System Interactive Physiology Worksheets
Immune System Interactive Physiology Worksheets

... mediators. These chemical mediators cause two key effects: • __________________, which causes redness and heat • ______________________, which causes swelling and, thus, pain 22. These chemical mediators activate cell adhesion molecules on endothelial cells. When neutrophils bind to these molecules, ...
Airgas template
Airgas template

... malignancies in both T- and B-lymphocytes, where Hodgkin malignancies originate in Bcells (a specific type called the Reed-Sternberg cell). Therefore, more immune function is lost in non-Hodgkin lymphoma, and the prognosis is ...
BS963 (Autoimmunity) 2011
BS963 (Autoimmunity) 2011

... There are over 80 types of autoimmune diseases. Many have overlapping symptoms. The most commonly cited complaints amongst autoimmune disease sufferers are fatigue, low-grade fever and sore muscles. Autoimmune diseases can affect any part of the body, including the nerves, muscles, endocrine system ...
Immunology. Understanding The Immune System. 2nd Edition Brochure
Immunology. Understanding The Immune System. 2nd Edition Brochure

... immunological synapse, B–lymphocyte subsets, dendritic cell–driving of CD–4 + T–cell subset activities, biology of the CD–4 + T–cell TH17 subset and regulatory T–cell, cross–presentation, mechanisms of tolerance induction, immunoediting and tumor camouflage and the connection between inflammation an ...
LAMIQ - Open Medicine
LAMIQ - Open Medicine

... 34 million people living with HIV, with Sub-Saharan Africa being the most heavily affected with 72% of new infections. From: WHO/UNAIDS, 2011 ...
Autoimmune diseases
Autoimmune diseases

... Bacteria and virus (Ag): are soluble proteins introduced into the host cell and stimulate reticuloendothelial system (spleen, lymph nodes, bone marrow) to produce Ab Anti bodies (Ab): are altered serum globulin molecules when brought in contact with protein or microbes (i.e. Antigen) their productio ...
Immunology Study of the components and function of the immune
Immunology Study of the components and function of the immune

... Macrophages Mononuclear phagocytic cells in tissue ...
Autoimmune T cells—not always the bad guys
Autoimmune T cells—not always the bad guys

... Autoimmune T cells—not always the bad guys Autoimmune attack of central nervous system (CNS) components is associated with devastating neurodegenerative diseases such as multiple sclerosis. Although autoimmune T cells are usually viewed as detrimental, Schwartz and colleagues report on page 49 of th ...
m5zn_6cef59fb9533e86
m5zn_6cef59fb9533e86

... line: external surface epithelium & membranes  Second line: inflammatory processes – antimicrobial proteins, phagocytes, etc. ...
35.3 Fighting Infectious Disease
35.3 Fighting Infectious Disease

... the flow of blood and fluids to the area. This causes allergy symptoms. ▶ Allergic reactions in the respiratory system can cause asthma, a dangerous chronic disease in which the air passages narrow and breathing becomes difficult. ▶ When the immune system makes a mistake and attacks the body’s own c ...
eprint_1_19626_1346
eprint_1_19626_1346

... by the green heme enzyme myeloperoxidase. It is thought that the bactericidal properties of HOCl are enough to kill bacteria phagocytosed by the neutrophil, but this may instead be step necessary for the activation of proteases. ...
Lesson 16 – Subtypes (Color Ink Saving)
Lesson 16 – Subtypes (Color Ink Saving)

Cellular Biology
Cellular Biology

... Ingest bacteria, dead cells, and cellular debris Cells are short lived and become a component of the purulent exudate ...
Lecture 19
Lecture 19

... when introduced into the body stimulates the production of specific antibodies (antibody generation) • Antibody (Ab) – A protein produced by B cells in response to recognition of an antigen – Protein made in response to exposure to bacteria and other pathogens, toxins, plant pollen and red blood cel ...
Types II and III: Antibody-Mediated and Antigen
Types II and III: Antibody-Mediated and Antigen

... Goodpasture syndrome is a rare disease that can involve rapidly progressive kidney failure along with lung disease. However, some forms of the disease involve just the lung or kidney, not both. Causes, incidence, and risk factors Goodpasture syndrome is an autoimmune disorder, a condition that occur ...
Antigens and Immunogens - Abdel
Antigens and Immunogens - Abdel

... Antigen is any agent capable of binding specifically to components of immune response such as lymphocytes and antibodies. The distinguishing between terms is necessary because there are many compounds that are capable of binding with components of immune system that have been induced specifically ag ...
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Immune system



The immune system is a system of many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. In many species, the immune system can be classified into subsystems, such as the innate immune system versus the adaptive immune system, or humoral immunity versus cell-mediated immunity.Pathogens can rapidly evolve and adapt, and thereby avoid detection and neutralization by the immune system; however, multiple defense mechanisms have also evolved to recognize and neutralize pathogens. Even simple unicellular organisms such as bacteria possess a rudimentary immune system, in the form of enzymes that protect against bacteriophage infections. Other basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants, such as plants and insects. These mechanisms include phagocytosis, antimicrobial peptides called defensins, and the complement system. Jawed vertebrates, including humans, have even more sophisticated defense mechanisms, including the ability to adapt over time to recognize specific pathogens more efficiently. Adaptive (or acquired) immunity creates immunological memory after an initial response to a specific pathogen, leading to an enhanced response to subsequent encounters with that same pathogen. This process of acquired immunity is the basis of vaccination.Disorders of the immune system can result in autoimmune diseases, inflammatory diseases and cancer.Immunodeficiency occurs when the immune system is less active than normal, resulting in recurring and life-threatening infections. In humans, immunodeficiency can either be the result of a genetic disease such as severe combined immunodeficiency, acquired conditions such as HIV/AIDS, or the use of immunosuppressive medication. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms. Common autoimmune diseases include Hashimoto's thyroiditis, rheumatoid arthritis, diabetes mellitus type 1, and systemic lupus erythematosus. Immunology covers the study of all aspects of the immune system.
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