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Chapter 15: Nonspecific Immunity
Chapter 15: Nonspecific Immunity

The Cell
The Cell

... from surface to interior  constructed from three types of ...
Lab - TeacherWeb
Lab - TeacherWeb

... many different types of antibodies and hormones. Cell receptors are very specific, this means that each receptor will only fit together and receive messages from one chemical messenger. Many chemicals will bind to the cell receptors. Here are some examples: The male hormone testosterone will bind to ...
Cells and Organs
Cells and Organs

The Immune System
The Immune System

...  Gives immune system time to respond ...
Lymphoid System I: Peripheral System, Lymph Node
Lymphoid System I: Peripheral System, Lymph Node

... Your acquired immune system is made of B and T cells, each specific for a single antigen. B and T cells are born in the bone marrow and then matured in the primary lymph organs (bone marrow and thymus respectively). They then circulate in the blood as naïve lymphocytes. Having never “seen” their ant ...
e. None of the above
e. None of the above

... 10. Prior exposure to the cowpox (vaccinia) virus increase one's chances of survival during subsequent exposure to smallpox because a. The cowpox has an adjuvant effect. ...
Endocrinology 5b – Adrenal steroids, anti-inflammatory and
Endocrinology 5b – Adrenal steroids, anti-inflammatory and

... lymphocytic leukaemia.To reduce cerebral oedema in patients with brain tumours. – As a component of anti-emetic treatment with chemotherapy – To elevate mood in terminally ill subjects – To mature the foetal lung for pre-term birth in pregnancy by increasing surfactant cell maturation Mode of Action ...
Cell Parts Vocab ONLY
Cell Parts Vocab ONLY

... Stack of membranes in cells that modifies, sorts, and packages proteins from the ER for transport ...
Teaching Slides
Teaching Slides

... HIV (a retrovirus) attacks helper T cells by binding with their cell receptor (CD4) This impacts both the Humoral and Cell Mediated responses ...
STRUCTURE AND FUNCTION OF THE BLOOD AND THE IMMUNE
STRUCTURE AND FUNCTION OF THE BLOOD AND THE IMMUNE

... • know and understand the mechanisms involved in the functions and regulation of the blood and the immune system, using the language of Immunology, Physiology, Biochemistry, Molecular Biology and Cell Biology - this will allow students at a later stage to understand the mechanisms of disease • under ...
anatomy of the immune system passive immunity
anatomy of the immune system passive immunity

... • after ingesting a foreign invader, they “wear” pieces of it called antigens on their cell membrane receptors – this tells other types of immune system cells what to look for – Is an antigen presenting cell ...
Organelles
Organelles

... The Golgi Complex is responsible for the packaging of proteins in the cell. The Golgi is a curved membrane stack resembling a stack of pancakes. The Golgi bodies package proteins produced in the ribosome and transport them via the ...
File - Mrs. LeCompte
File - Mrs. LeCompte

... Tight Junctions = Intercellular junctions that hold cells together tightly enough to block transport of substances through the intercellular space. ...
Exam 2A key
Exam 2A key

... a) the shape of the antibody with at least two binding regions. b) disulfide bridges between the antigens. c) complement that makes the affected cells sticky. d) bonds between class I and class II MHC molecules. e) denaturation of the antibodies. 16. Naturally acquired passive immunity would include ...
Exam 2B key
Exam 2B key

Kuby Immunology 6/e
Kuby Immunology 6/e

... ○ P-selectin (platelet) is stored in granule in endothelial cell ○ Upon activation, granule fuses with membrane so that p-selectin is expressed ...
Everyday our bodies are under attack. While invisible to the naked
Everyday our bodies are under attack. While invisible to the naked

... system cells and molecules at an infected of injured site. This immune response is good for the body, and is designed to promote healing. The clearest example of this process at work can be viewed when an individual cuts his or her finger. The initial swelling and redness (inflammation) indicates th ...
Monoclonal Antibodies
Monoclonal Antibodies

... antibodies linked to enzyme – Test region: contains polyclonal anti-HCG antibodies, which will bind to HCG molecules bound to monoclonal anti-HCG antibodies. Also contains dye molecules which will be activated if monoclonal antibodies bind to polyclonal anti-HCG antibodies – Control region: contains ...
Monoclonal Antibodies
Monoclonal Antibodies

... antibodies linked to enzyme – Test region: contains polyclonal anti-HCG antibodies, which will bind to HCG molecules bound to monoclonal anti-HCG antibodies. Also contains dye molecules which will be activated if monoclonal antibodies bind to polyclonal anti-HCG antibodies – Control region: contains ...
Specificity of primary and secondary responses
Specificity of primary and secondary responses

... a. The lag (latent) phase is the period from the initial exposure of immunogen to the time of detection of antibodies (In humans the average time of lag phase is about one week). During this lag phase specific T cells and B cells are activated by their contact with immunogen. b. The exponential phas ...
cells of the immune system
cells of the immune system

... The WBC of the immune system work together through a variety of complex interactions to defend the host. These interactions are essential and have evolved to rid the body of pathogens and other foreign substances. There are two sites at which pathogens may be located: 1. Extracellular sites 2. Intra ...
Cytotoxic Hypersensitivity
Cytotoxic Hypersensitivity

... Clinically, the most important form of DTH, since it causes many of the pathological effects in diseases which involve T cell-mediated immunity Maximal at 14 days Continual release of cytokines Leads to accumulation of large numbers of macrophages Granulomas can also arise from persistence of “indig ...
Dr. JL Jarry
Dr. JL Jarry

... Have antigen specific receptors on their surface Antigen binds with receptor This stimulates the B-cell to undergo clonal expansion B-cells divide into plasma cells Plasma cells mass-produce antibodies Antibodies circulate, find antigens, bind to them, and mark them for latter destruction • The dest ...
Cytokines
Cytokines

...  sIgA inhibit mucosal adhesion of viruses (defense against respiratory viruses and enteroviruses)  neutralizing IgG and IgM antibodies activate the classical pathway of complement, that is able to lyse certain viruses  opsonized viral particles are phagocytosed  IgA and IgG have preventive effec ...
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Polyclonal B cell response



Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.
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