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Cells of the immune system
Cells of the immune system

... Antigen: material (from a pathogen) that induces an immune response Innate (natural) immunity: rapid, non specific immune response Adaptive (acquired) immunity: slower, specific immune response Leukocytes: blood cells Lymphocytes: specialized blood cells that mediate adaptive immunity (e.g. T and B ...
Yr 7 Cells, Tissues and Organs Topic vocabulary list
Yr 7 Cells, Tissues and Organs Topic vocabulary list

... Yr 7 Cells, Tissues and Organs Topic vocabulary list One of the most challenging aspects about science is learning the vocabulary. Understanding and being able to use the correct words to explain your ideas and answer questions is the key to good progression in science. Below are the most common wor ...
Chapter 12 Infectious Diseases
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... 35. Answers may vary. A vaccine contains either a dead pathogen or a nontoxic component of a pathogen, such as part of a bacterial cell wall or the coating of a virus. When injected into a person, the vaccine provokes an immune response. The injected person’s body produces white blood cells, prote ...
AMS_PowerPoint_Haematopoietic_2
AMS_PowerPoint_Haematopoietic_2

... Deficiency of red cells or haemoglobin, results from excessive loss (blood loss anaemia), increased destruction (haemolytic anaemia), or impaired production of red blood cells (iron deficiency, megaloblastic, and aplastic anaemia. 2. Blood loss anaemia is characterised by loss of ironcontaining red ...
THE T CELL RECEPTOR (TCR)
THE T CELL RECEPTOR (TCR)

... may present peptide antigens to T cells. 2. Naïve T cells that encounter antigens in the absence of costimulators become anergic. 3. Microbes or innate immune cytokines stimulate expression of costimulators on APCs. 4. Costimulators are recognized by their receptors on T cells and provide the second ...
1 Table S1. Pathway/Function Gene Symbol Fold Change Function
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... Mediator of cell division, Macrophage activation by LPS ...
Clinical Microbiology
Clinical Microbiology

... Immunological techniques-detection of antigens or serum antibodies in specimens by the various procedures discussed in chapter 33 Bacteriophage typing-the host range specificities of bacteriophages are dependent upon surface receptors on the particular bacteria; therefore, this can be a reliable met ...
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To study humoral and cellular immune response

...  Adoptive transfer of JEV-immune T cells protected mice from subsequent virus challenge (Mathur et al., 1983; Murali-Krishna et al., 1996). Tcell influencing Antibody  CD4+T helper cell ,played an essential part in the maintenance of an effective antibody response necessary to combat the infection ...
Lecture on Innate Immunity and Inflammation
Lecture on Innate Immunity and Inflammation

... • Many cell types produce small amounts of type 1 interferons upon infection • There is a dendritic cell subtype (“plasmacytoid dendritic cell”; “natural interferon-producing cell”) that produces 100-1000x more interferon upon contact with viruses, does not need a productive infection. • Also produc ...
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lecture_clinical-immunology-1

MLAB 1315- Hematology Fall 2007 Keri Brophy
MLAB 1315- Hematology Fall 2007 Keri Brophy

... which then become coated with antibody and are destroyed in the baby’s RES. This could be associated with ABO or Rh incompatibility. It can be severe and treatment would consist of an exchange transfusion of the newborn. ...
Chapter 22
Chapter 22

... antibodies, are antigens, of which molecular weights could be as large as Mr = 10,000 or more. A small molecule may become antigenic upon binding with other molecules. For example, Haptens are small molecules capable of combining with larger molecules to stimulate adaptive immune response. Two types ...
Immune system and Cancer
Immune system and Cancer

... Internal defenses - inflammation - triggered by disruption of body tissue - prevents spread of damage - disposes of cell debris and pathogens ...
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... 2. Agranulocytes: lack obvious granules, have kidney-shaped or round nuclei. a. Lymphocytes: have very large spherical nuclei with small rim of cytoplasm. - most found in lymph nodes, spleen, marrow. - participate in immune response, T-lymphocytes in cell- mediated immunity, B- lymphocytes in humora ...
Immune Reconstitution - UCLA Center for World Health
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... regiment combines three or more different drugs. Can virus be cleared by HAART and why? HAART regiments can reduce the amount of active virus and in some case can lower the number of virus until it is undetectable by current blood testing techniques. However, usual HAART treatment cannot clear HIV i ...
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... 9–34 Explain why expression of CD40 ligand by TFH cells is important in the boundary area of primary follicles in secondary lymphoid tissue as it relates to the targeted delivery of secreted cytokines to the B-cell surface. 9–35 Which of the following is a characteristic of follicular dendritic cell ...
Lymphoid cells: Cells of the adaptive immune system
Lymphoid cells: Cells of the adaptive immune system

... Function of the thymus: T lymphocytes become activated following the recognition of an antigenic peptide, which is presented to the T lymphocyte on a major histocompatability complex (MHC) molecule by an antigen presenting cell (APC). The antigen presenting cell is usually a dendritic cell, although ...
svhs advanced biology - Sonoma Valley High School
svhs advanced biology - Sonoma Valley High School

... Contrast interstitial fluid with lymph. Describe what causes lymph fluid to enter lymphatic capillaries. Explain how the circulatory system and its vessels differ from the lymphatic system and its vessels. Describe the role of lymph nodes found in various areas of the body. Explain what metastasis m ...
Virotherapy
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... • Virotherapy is a relatively young field that shows great promise to help or even replace chemotherapy. • Potentially, you may be able to treat cancer with as little as a series of injections with little to no side effects. ...
Immune Responses to Infectious Diseases
Immune Responses to Infectious Diseases

... However the phagocytic activity is strictly dependent on the size of the pathogens [15]. This is well demonstrated with respect to the host defense against helminths, in which phagocytosis by macrophages or neutrophils are prevented by the parasite size. This restriction demands a different strategy ...
the scientific sessions
the scientific sessions

... ...
Pattern recognition by primary and secondary response of an
Pattern recognition by primary and secondary response of an

Chapter3 - sshsanatomy
Chapter3 - sshsanatomy

... Occupies the central portion of the cell Nuclear substance is known as nucleoplasm Nuclear membrane is called nuclear envelope Cell membrane seems to be extension of the ER The non-membranous nucleolus is in the nucleus, it contains the nucleic acid RNA instead of DNA • Functions in control and regu ...
Blood/Immunity Lab - University of Missouri
Blood/Immunity Lab - University of Missouri

... Blood Typing & RBC Antigens • Antigens present on RBC surface specify blood type (A and B) **many more antigens have been identified, and typing is going towards “gene chips” • Major antigen group – Type A blood has only A antigens – Type B has only B antigens – Type AB has both A & B antigens • AB ...
Basic Concepts of Immunology
Basic Concepts of Immunology

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Polyclonal B cell response



Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.
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