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AFSC Amniotic Fluid Stem Cell Expansion
AFSC Amniotic Fluid Stem Cell Expansion

... We found that human amniotic fluid stem cells could be expanded more than 100 fold over three passages in PRIME-XV™ AFSC Expansion Medium. In addition, hAFSCs were able to sustain the expression markers of stem cells, such as CD29, CD44, CD73, CD90, CD105, and SSEA-4, as well as transcription factor ...
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... Viral virulence, like bacterial virulence, is under polygenic control. The susceptibility of a particular cell to viral infection depends mainly on the presence of cellular receptors. Hence, cells resistant to a virus may be susceptible to its extracted nucleic acid. Cultivation may markedly alter t ...
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... framework is simpler. In vertebrates, various organs are involved, while all the molecules determining invertebrate stress response are harboured into the immunocyte. In other words, the prototypical response in invertebrates appears to be concentrated into a single, multifunctional cell, representi ...
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immune-mediated anemia

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... widespread use. In vitro transfection of Vγ9Vδ2-T with CD1d could overcome this hurdle and thereby pave the way for future clinical assessment of the potential superiority of CD1d+ Vγ9Vδ2-T cells over moDCs with respect to iNKTbased immunotherapeutic approaches (Fig. 1A). Finally, Vγ9Vδ2-T cells are ...
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Human PDX-1/IPF1 Antibody

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Polyclonal B cell response



Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.
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