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Unit VI: Immunity and Diseases
Unit VI: Immunity and Diseases

... Allergens – any substance that causes an allergic reaction Antibodies – a protein produced by B-cells in response to the presence of an antigen (bacterium or virus) Antigens – a protein on the surface of a pathogen that stimulates the production of antibodies Autoimmune disease – a chronic disease w ...
Malaria Drugs and Vaccine
Malaria Drugs and Vaccine

... RTS,S/AS02A is generated against CSP, the most abundant cell surface protein during the malaria parasite's infectious sporozoite stage ...
Malaria Drugs and Vaccine
Malaria Drugs and Vaccine

... RTS,S/AS02A is generated against CSP, the most abundant cell surface protein during the malaria parasite's infectious sporozoite stage ...
Structures external to the Cell Wall:
Structures external to the Cell Wall:

... Flagella may be classified according to there arrangement as follow: 1- Monotrichous (single polar flagellum). 2- Lophotrichous (tuft of polar flagella). 3- Perituichous (flagella distributed over the cell). 4- Amphitrichous (one flagellum at each side of cell). ...
Structures external to the Cell Wall
Structures external to the Cell Wall

... Flagella may be classified according to there arrangement as follow: 1- Monotrichous (single polar flagellum). 2- Lophotrichous (tuft of polar flagella). 3- Perituichous (flagella distributed over the cell). 4- Amphitrichous (one flagellum at each side of cell). ...
Chapter 4: Cell Injury, Aging, and Death Test Bank MULTIPLE
Chapter 4: Cell Injury, Aging, and Death Test Bank MULTIPLE

... Viruses are able to enter the host cell and use host metabolic processes to survive and replicate. Viruses do not produce toxins. Viruses do not directly produce free radicals, although these can be produced indirectly by the immune response that follows viral infection. Both viruses and bacteria pr ...
( R.PM) for 5 minutes. Then serum separate and incubate at 56 ºC
( R.PM) for 5 minutes. Then serum separate and incubate at 56 ºC

... Serological tests: mean the measurement of antigen-antibody interaction for detection of the causes of disease. Antibodies (immunoglobulins ):are large Y-shaped proteins. They are used by the immune system to identify and neutralize foreign objects like bacteria and viruses. The basic structure of a ...
Cloning`s Historical Timeline
Cloning`s Historical Timeline

... Johann Friedrick Miescher extracts what comes to be known as DNA from the ...
328 Comparative evolutionary analysis of IL6 in lagomorphs F
328 Comparative evolutionary analysis of IL6 in lagomorphs F

... amino acid extension has four more cysteine residues. The inferred phylogeny for the IL6 gene is in agreement with what has been accepted for the mammals and lagomorphs. Conclusions: Our results indicate that in the ancestral of the Oryctolagus genus, (approximately 2 million years ago), a single mu ...
PowerPoint Presentation - Cell-Mediated Immunity
PowerPoint Presentation - Cell-Mediated Immunity

... The professional Antigen Presenting Cells (APCs) • Three types of APC are found in the lymph nodes: – Dendritic cells -- constitutively express MHC I and MHC II (can stimulate both CD4+ and CD8+ T cells) as well as B7 (the co-stimulatory signal). Antigen presentation appears to be the sole purpose ...
Sheldon Biology Semester I Review Sheet
Sheldon Biology Semester I Review Sheet

... 1. Can require ATP to move a substance through a carrier transmembrane protein from an area of high to low concentration. See picture in the right hand corner of this page. 2. Can be referring to endo/exocytosis…. Where a fluid or a solid is taken in by “in pocketing” and being surrounded by the mem ...
Information processing in immune systems: Clonal selection versus
Information processing in immune systems: Clonal selection versus

... The Erdos and Renyi theory thus predicts a phase transition: once the connectivity exceeds one idiotypic connection per clone, most clones suddenly become interconnected. Note that if the connectivity of the idiotypic network were to be lower, a large proportion of the clones would not be connected ...
Cytokines
Cytokines

... system depends in a large part on interleukins, And rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial ...
Forensic Serology
Forensic Serology

... Serum – a liquid that separates clotted blood Antibodies – proteins in the blood that tag, destroy, or neutralize bacteria, viruses, or harmful toxins, producing an immune response Antigens – foreign substances in the body capable of causing disease (the presence triggers an immune response Agglutin ...
Modelling the regulation of immunoglobulin class switching
Modelling the regulation of immunoglobulin class switching

... the Ig gene with one of the downstream "constant" region gene segments (1). Much is known about molecular pathways that carry out the recombination process (1) and the transcriptional networks that control them and the subsequent differentiation into Ig producing plasma cells (2). However, very litt ...
Transcript
Transcript

... II. Lysosomes [S 48] a. Lysosomes have many hydrogen pumps that are continually pumping hydrogens into the lysosome. i. All of digestive enzymes are active at low PH. A. This is important because you do not want these proteins active everywhere else in the cell. III. Lysosomes [S 49] a. On EM’s lyso ...
inverse relationship between net electric charge on the antigen and
inverse relationship between net electric charge on the antigen and

... charge . These findings indicated that it is possible to distinguish between thymocytes on the basis of their capacity to react with more acidic or more basic surfaces and that a population of thymus-derived cells may recognize immunogens on the basis of their overall electrical charge . In the pres ...
Age-related autoimmunity Open Access
Age-related autoimmunity Open Access

... the elderly [12]. By contrast, many studies have shown that Tregs (both in animal models and humans) are expanded in the elderly. This results in increased suppression of T cell immune responses and the prevention of autoimmune diseases, but increases susceptibility to infectious diseases and cancer ...
Document
Document

... How does the body build immunity? • Once a body has found a pathogen, the body produces memory cells. • Memory cells are T cells and B cells that remember specific pathogens. • A vaccination is a substance prepared from killed or weakened pathogens that is introduced into the body to produce immunit ...
Ch 7 Powerpoint
Ch 7 Powerpoint

Posters Abstracts
Posters Abstracts

... The stochastic nature of the recombination machinery giving rise to TCRs ensures that there is a distinct and largely non-overlapping repertoire of receptors in different genetically identical individuals. Furthermore, the frequency of each TCR is not uniform even in the resting repertoire. Charting ...
Allergy and Immune Disorders
Allergy and Immune Disorders

... Allergy-hypersensitivity to one or more substances  Acquired through exposures to substances  Allergist-physician that specializes and treats allergies  Immunity is based on the ability of the body to recognize foreign proteins ...
41475 - Cell Signaling Technology
41475 - Cell Signaling Technology

... Background: The nucleosome, made up of four core histone proteins (H2A, H2B, H3, and H4), is the primary building block of chromatin. Originally thought to function as a static scaffold for DNA packaging, histones have now been shown to be dynamic proteins, undergoing multiple types of post-translat ...
Histology of the mucosal lymphatic tissues The lymphoid system is
Histology of the mucosal lymphatic tissues The lymphoid system is

... Lamina propria displays numerous lymphoid nodules (capped by M cells) and lymphoid cells. It does not form villi but possess shallow crypts with some goblet cells, surface columnar cells and numerous enteroendocrine cells. Muscularis mucosa is composed of an inner circular and outer longitudinal lay ...
CELL TRANSPORT WORKSHEET
CELL TRANSPORT WORKSHEET

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Polyclonal B cell response



Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.
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