cell biology of cancer
... pharmacology was observed using the Chou-Talalay combination index method. Such results suggested that B-I09 can decelerate the growth of CLL either as a single agent or in combination with ibrutinib. Our finding in synergism may be important because B-I09 may help ibrutinib to achieve higher cytoto ...
... pharmacology was observed using the Chou-Talalay combination index method. Such results suggested that B-I09 can decelerate the growth of CLL either as a single agent or in combination with ibrutinib. Our finding in synergism may be important because B-I09 may help ibrutinib to achieve higher cytoto ...
Contribution of Choline
... utilize different mechanisms to maintain close association with host cells. In addition to specific receptor-ligand interactions, the physicochemical properties of bacterial surfaces can modulate the affinity of pathogens for host cells (8, 12, 16). There are more than 90 pneumococcal serotypes, eac ...
... utilize different mechanisms to maintain close association with host cells. In addition to specific receptor-ligand interactions, the physicochemical properties of bacterial surfaces can modulate the affinity of pathogens for host cells (8, 12, 16). There are more than 90 pneumococcal serotypes, eac ...
Systemically dispersed innate IL-13–expressing cells in type 2
... to track IL-4–secreting cells in vivo without the need for restimulation. Whether assessed at rest, after IL-25 challenge, or during the course of N. brasiliensis infection, however, we were unable to document significant human CD2 expression on lineage-negative cells from 4get × KN2 mice, despite ou ...
... to track IL-4–secreting cells in vivo without the need for restimulation. Whether assessed at rest, after IL-25 challenge, or during the course of N. brasiliensis infection, however, we were unable to document significant human CD2 expression on lineage-negative cells from 4get × KN2 mice, despite ou ...
Immune response and virus population composition: HIV as a case
... until the final stages of the disease, whereas the highly prolific (high-k) SI variants appear only when the immune system is severely impaired (Ercoli et al. 1997). To avoid this difficulty, Callaway et al. (1999) postulate that a transition from the NSI to the prolific SI phenotype is due to the h ...
... until the final stages of the disease, whereas the highly prolific (high-k) SI variants appear only when the immune system is severely impaired (Ercoli et al. 1997). To avoid this difficulty, Callaway et al. (1999) postulate that a transition from the NSI to the prolific SI phenotype is due to the h ...
EBV infection B cells and lymphomagenesis
... Source: R Kuppers; Nature reviews immunology; 2003 ...
... Source: R Kuppers; Nature reviews immunology; 2003 ...
Specification sheet
... Sodium azide (NaN3) is a toxic chemical and is present as an antimicrobial agent in Reagent A. The concentration in these products is not classified as hazardous. However, the build-ups of sodium azide may react with lead and copper plumbing to form highly explosive metal azides. Flush any disposed ...
... Sodium azide (NaN3) is a toxic chemical and is present as an antimicrobial agent in Reagent A. The concentration in these products is not classified as hazardous. However, the build-ups of sodium azide may react with lead and copper plumbing to form highly explosive metal azides. Flush any disposed ...
KIDNEY DAMAGE IN AUTOIMMUNE DISEASES
... depositions along the GBM. However, most patients also have circulating anti-GBM antibodies in their plasma detected by enzyme-linked immunosorbent assay (ELISA) or Western blotting. The majority of these antibodies are of the IgG1 subtype, with only few IgG4 antibodies. Very rarely, patients have n ...
... depositions along the GBM. However, most patients also have circulating anti-GBM antibodies in their plasma detected by enzyme-linked immunosorbent assay (ELISA) or Western blotting. The majority of these antibodies are of the IgG1 subtype, with only few IgG4 antibodies. Very rarely, patients have n ...
A c a d
... significantly lower rates of infection and resultant mortality than men. This significant difference in the inflammatory response of women compared with that of men has long been noted27. This heightened inflammatory response is advantageous in response to infection and sepsis but is unfavourable in ...
... significantly lower rates of infection and resultant mortality than men. This significant difference in the inflammatory response of women compared with that of men has long been noted27. This heightened inflammatory response is advantageous in response to infection and sepsis but is unfavourable in ...
Human Intestinal Epithelial Cells in Innate Immunity
... survival of the individual. The intestinal mucosal surface is lined by a single layer of epithelial cells. In humans it covers an area of over 100 m2 that is continuously exposed to different antigens in the form of food constituents, commensal microflora, episodic pathogens, and to noxious compound ...
... survival of the individual. The intestinal mucosal surface is lined by a single layer of epithelial cells. In humans it covers an area of over 100 m2 that is continuously exposed to different antigens in the form of food constituents, commensal microflora, episodic pathogens, and to noxious compound ...
QuickTime™ and a TIFF (Uncompressed) decompressor QuickTime
... Inflam Bowel Dis 2010 [Epub ahead of print] ...
... Inflam Bowel Dis 2010 [Epub ahead of print] ...
Meningitis_Prince
... endemic areas, military recruits, and those exposed to certain types of outbreaks, e.g., those in schools (college freshmen). There is currently no effective vaccine against type B - which has an antigenic structure much like host neuronal tissue and hence, is not especially antigenic. STREPTOCOCCUS ...
... endemic areas, military recruits, and those exposed to certain types of outbreaks, e.g., those in schools (college freshmen). There is currently no effective vaccine against type B - which has an antigenic structure much like host neuronal tissue and hence, is not especially antigenic. STREPTOCOCCUS ...
Nieuwste middelen
... Generation of hybridomas (fusion of mice spleen/lymph node cells with SP2/0 MM cells) Testing of 42 anti-CD38 mAbs in CDC assays only one mAb was capable to induce CDC this antibody was selected for further testing=daratumumab VU University Medical Center Amsterdam The Netherlands ...
... Generation of hybridomas (fusion of mice spleen/lymph node cells with SP2/0 MM cells) Testing of 42 anti-CD38 mAbs in CDC assays only one mAb was capable to induce CDC this antibody was selected for further testing=daratumumab VU University Medical Center Amsterdam The Netherlands ...
Microbiology
... Susceptibility: lack of resistance to a disease Immunity: ability to ward off disease Innate immunity: defenses against any pathogen Adaptive immunity: immunity or resistance to a specific pathogen ...
... Susceptibility: lack of resistance to a disease Immunity: ability to ward off disease Innate immunity: defenses against any pathogen Adaptive immunity: immunity or resistance to a specific pathogen ...
Helminth infections: The structure trans
... namely IL4R-α and further helps B-cells to produce antibodies to fight against the infection. IL4 and IL4R-α is a critical link between interdependence of B and T cells in protective immunity. In our laboratory we investigated the structure of mesenteric lymph node during HP infection. We compared ...
... namely IL4R-α and further helps B-cells to produce antibodies to fight against the infection. IL4 and IL4R-α is a critical link between interdependence of B and T cells in protective immunity. In our laboratory we investigated the structure of mesenteric lymph node during HP infection. We compared ...
Innate immune memory: implications for development of pediatric
... been thought that they do not confer specificity or immunological memory to the innate host defense. Remarkably, the last few years of research have dramatically changed the dogma of innate immunity being “non-specific”. Indeed, the different classes of pattern recognition receptors (PRRs) such as t ...
... been thought that they do not confer specificity or immunological memory to the innate host defense. Remarkably, the last few years of research have dramatically changed the dogma of innate immunity being “non-specific”. Indeed, the different classes of pattern recognition receptors (PRRs) such as t ...
... to determine the context of these signals. Efficiency is important for T cells for several reasons: T cell receptors (TCRs) must be able to recognize a few activating peptide-MHC (pMHC) complexes (∼10) in a sea of selfpMHC on the surface of an antigen-presenting cell (APC). Furthermore, the differenc ...
Immunoproteomics: the Key to Discovery of New Vaccine Antigens
... previously identified, and/or associated with virulence, including flagellin and flagellar hook associated protein, OmpA and BipB, confirming the capacity for patient serum to identify potential vaccine candidates. Although BipB was previously shown not to prolong survival of challenged mice [25], a ...
... previously identified, and/or associated with virulence, including flagellin and flagellar hook associated protein, OmpA and BipB, confirming the capacity for patient serum to identify potential vaccine candidates. Although BipB was previously shown not to prolong survival of challenged mice [25], a ...
PowerPoint 프레젠테이션
... for preservation and biochemical fixation • It imparts intrinsic tissue stability (biodegradation resistance) and reduces the antigenicity of the material. • Recent reports have suggested a detrimental role of aldehyde-induced intra- and intermolecular collagen cross-linkages in initiating tissue mi ...
... for preservation and biochemical fixation • It imparts intrinsic tissue stability (biodegradation resistance) and reduces the antigenicity of the material. • Recent reports have suggested a detrimental role of aldehyde-induced intra- and intermolecular collagen cross-linkages in initiating tissue mi ...
An Overview of Autoimmune Disorders
... tackle and destroy the ill causing particles [6-8]. Immunity is a mechanism working out to eliminate and destroy the foreign particles or antigens to sustain the health and longevity of the host [9-12]. Antigens can be cancerous cells, parasites, bacteria, fungi, virus, etc. To destroy these antigen ...
... tackle and destroy the ill causing particles [6-8]. Immunity is a mechanism working out to eliminate and destroy the foreign particles or antigens to sustain the health and longevity of the host [9-12]. Antigens can be cancerous cells, parasites, bacteria, fungi, virus, etc. To destroy these antigen ...
The HMG-Co-A reductase inhibitor, atorvastatin, promotes a
... MHC class II transactivator (CIITA) is the master regulator of MHC II expression in antigen presenting cells CIITA has multiple promoter regions, with pIV being predominant in epithelial cells and pI predominant in bone marrow derived cells. A previous study reported that statins suppressed IFN-gamm ...
... MHC class II transactivator (CIITA) is the master regulator of MHC II expression in antigen presenting cells CIITA has multiple promoter regions, with pIV being predominant in epithelial cells and pI predominant in bone marrow derived cells. A previous study reported that statins suppressed IFN-gamm ...
Molecular and Electrophysiological Evidence for a GABAC Receptor
... micrographs of the rat pituitary. As shown in Fig. 3A, immunoreactivity was found on anterior lobe cells. No significant immunolabeling was observed in the neurointermediate lobe. To identify 1-expressing cells, among the various types of adenohypophyseal cells, successive staining experiments were ...
... micrographs of the rat pituitary. As shown in Fig. 3A, immunoreactivity was found on anterior lobe cells. No significant immunolabeling was observed in the neurointermediate lobe. To identify 1-expressing cells, among the various types of adenohypophyseal cells, successive staining experiments were ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.