FasL on human nucleus pulposus cells prevents angiogenesis in
... Abstract: The intervertebral disc is the largest avascular organ in the human body. However, with the progress of intervertebral disc degeneration (IDD), the disc tends to be vascularized increasingly via angiogenesis. It is well established that both human nucleus pulposus (NP) cells and vascular e ...
... Abstract: The intervertebral disc is the largest avascular organ in the human body. However, with the progress of intervertebral disc degeneration (IDD), the disc tends to be vascularized increasingly via angiogenesis. It is well established that both human nucleus pulposus (NP) cells and vascular e ...
immunology syllabus 2013 - The University of Texas Medical School
... c) The major portion of the essay should be devoted towards discussion of the immunologic implications and principles of the case. Describe in as much detail as possible the normal immune mechanisms to combat this infectious agent and how they affect the course of infection (e.g. Macrophages phagoc ...
... c) The major portion of the essay should be devoted towards discussion of the immunologic implications and principles of the case. Describe in as much detail as possible the normal immune mechanisms to combat this infectious agent and how they affect the course of infection (e.g. Macrophages phagoc ...
Reliability of Rabbit Monoclonal Antibodies
... the greater affinity of rabbit monoclonal antibodies than mouse monoclonal equivalents, and, therefore, these antibodies may be effectively used at higher dilutions and, in some cases, without the need for heat-induced antigen retrieval.17 A recent article suggested that this increased sensitivity r ...
... the greater affinity of rabbit monoclonal antibodies than mouse monoclonal equivalents, and, therefore, these antibodies may be effectively used at higher dilutions and, in some cases, without the need for heat-induced antigen retrieval.17 A recent article suggested that this increased sensitivity r ...
Xenopus laevis Antiviral Immunity in the Amphibian Innate T Cells
... http://www.jimmunol.org/content/195/2/576.full#ref-list-1 Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription ...
... http://www.jimmunol.org/content/195/2/576.full#ref-list-1 Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription ...
Uchanska-Ziegler, B., Loll, B., Fabian, H., Hee, CS, Saenger, W
... Robert Koch-Institut, P 25, Nordufer 20, 13353 Berlin, Germany ...
... Robert Koch-Institut, P 25, Nordufer 20, 13353 Berlin, Germany ...
LFA-1 is required for retention of effector CD8 T cells in mouse lungs
... circulation remain unchanged in E-, P-, or L-selectin genedisrupted mice.11,14 The smaller diameter of the pulmonary capillaries allows close contact between neutrophils and capillary endothelium. Neutrophils have to deform and elongate in order to pass through the capillary segments, which possibly ...
... circulation remain unchanged in E-, P-, or L-selectin genedisrupted mice.11,14 The smaller diameter of the pulmonary capillaries allows close contact between neutrophils and capillary endothelium. Neutrophils have to deform and elongate in order to pass through the capillary segments, which possibly ...
Are mesenchymal stromal cells immune cells? Open Access Martin J Hoogduijn
... phenotypes and different functions [4,5]. Cell isolation procedures can, therefore, affect the cellular composition of MSC cultures. Culture conditions can have a further impact on the phenotype and function of MSCs [6]. This may affect study outcomes. Therefore, some care should be taken in compari ...
... phenotypes and different functions [4,5]. Cell isolation procedures can, therefore, affect the cellular composition of MSC cultures. Culture conditions can have a further impact on the phenotype and function of MSCs [6]. This may affect study outcomes. Therefore, some care should be taken in compari ...
Latent Infection with Cytomegalovirus Is Associated with Poor
... virus respond as well as the young. Hence, advanced chronological age plays a role in depressed responses to influenza but only in concert with CMV infection. Our data also suggest that contrary to the widely accepted concept, a more late-differentiated CD4 compartment is not detrimental but is asso ...
... virus respond as well as the young. Hence, advanced chronological age plays a role in depressed responses to influenza but only in concert with CMV infection. Our data also suggest that contrary to the widely accepted concept, a more late-differentiated CD4 compartment is not detrimental but is asso ...
Module 4 Lecture 3 Plant hormones
... amylase and other germination-initiating enzymes is light. Thus the photoactivation is achieved by phytochrome in its Pfr form. GA stimulates the production of numerous enzymes, notably a-amylase, in germinating cereal grains. ...
... amylase and other germination-initiating enzymes is light. Thus the photoactivation is achieved by phytochrome in its Pfr form. GA stimulates the production of numerous enzymes, notably a-amylase, in germinating cereal grains. ...
Distribution and expression profiles of dendritic cell subpopulations
... Our study showed that the large numbers of CD11c+ cDCs were observed in NMI- and MI-TCC compared with that in control. Similarly, the number of IL-23p19+ cells also increased in bladder cancer. In accordance with this finding, previous studies demonstrated that the abundance of CD11c+ DCs were proba ...
... Our study showed that the large numbers of CD11c+ cDCs were observed in NMI- and MI-TCC compared with that in control. Similarly, the number of IL-23p19+ cells also increased in bladder cancer. In accordance with this finding, previous studies demonstrated that the abundance of CD11c+ DCs were proba ...
NS1 antigen ELISA
... Dengue fever caused by dengue virus (DENV), a member of Flaviviridae leads to large global disease burden. Detection of immunoglobulin M (IgM) and nucleic acid to DENV, and virus isolation have been used for laboratory diagnostic assays for dengue. Nonstructural 1 (NS1) antigen which releases from D ...
... Dengue fever caused by dengue virus (DENV), a member of Flaviviridae leads to large global disease burden. Detection of immunoglobulin M (IgM) and nucleic acid to DENV, and virus isolation have been used for laboratory diagnostic assays for dengue. Nonstructural 1 (NS1) antigen which releases from D ...
B Lymphocytes in Cancer Immunology
... undergo activation-induced cell death in response to BCR cross-linking. In contrast, naïve B cells proliferate upon antigen activation. Unlike naïve cells, transitional and prenaïve B cells also undergo spontaneous apoptosis when placed in culture without exogenous stimulatory signals. This predispo ...
... undergo activation-induced cell death in response to BCR cross-linking. In contrast, naïve B cells proliferate upon antigen activation. Unlike naïve cells, transitional and prenaïve B cells also undergo spontaneous apoptosis when placed in culture without exogenous stimulatory signals. This predispo ...
Chapter 1 General introduction and outine of the thesis
... in response to the chemotactic stimuli1. These cells scavenge the wound for pathogens and produce cytokines that attract Mφ1. Then, the neutrophils undergo apoptosis as Mφ start to enter the wound area after approximately two days1. Mφ dispose the wound of dead cells, including neutrophils, resolve ...
... in response to the chemotactic stimuli1. These cells scavenge the wound for pathogens and produce cytokines that attract Mφ1. Then, the neutrophils undergo apoptosis as Mφ start to enter the wound area after approximately two days1. Mφ dispose the wound of dead cells, including neutrophils, resolve ...
B cell fate following immunization: from memory B cells to plasma cells
... Most approved successful human vaccines induce neutralizing antibody titers maintained above a given threshold for long-term protection against potential pathogen exposure. The pathogens targeted by these vaccines are antigenically stable and the relevant epitopes are immunogenic. In contrast, HIV-1 ...
... Most approved successful human vaccines induce neutralizing antibody titers maintained above a given threshold for long-term protection against potential pathogen exposure. The pathogens targeted by these vaccines are antigenically stable and the relevant epitopes are immunogenic. In contrast, HIV-1 ...
Glycosylation and Fc Receptors
... prevents unwanted immune responses against commensal bacteria or other perceived antigens encountered in a normal diet. SIgA is extensively N- and O-linked glycosylated (see Fig. 2). Both IgA1 and IgA2 contain two N-linked sites per H chain, one in the Ca2 domain (Asn263) and one in the C-terminal r ...
... prevents unwanted immune responses against commensal bacteria or other perceived antigens encountered in a normal diet. SIgA is extensively N- and O-linked glycosylated (see Fig. 2). Both IgA1 and IgA2 contain two N-linked sites per H chain, one in the Ca2 domain (Asn263) and one in the C-terminal r ...
One Step Hepatitis B Surface Antigen Test Strip
... 1. The HBsAg One Step Hepatitis B Surface Antigen Test Strip (Serum/Plasma) is for in vitro diagnostic use only. This test should be used for the detection of HBsAg in serum or plasma specimen. Neither the quantitative value nor the rate of HBsAg concentration can be determined by this qualitative t ...
... 1. The HBsAg One Step Hepatitis B Surface Antigen Test Strip (Serum/Plasma) is for in vitro diagnostic use only. This test should be used for the detection of HBsAg in serum or plasma specimen. Neither the quantitative value nor the rate of HBsAg concentration can be determined by this qualitative t ...
Do bacteria have a role in asthma development? EDITORIAL
... and Moraxella catarralis can be found in ,20% of wheezing children [7]. Mycoplasma pneumoniae and Chlamydia pneumoniae were identified in 5–25% of children with asthma exacerbations [8]. A significantly greater reduction in asthma symptoms and a larger improvement from baseline lung function was fou ...
... and Moraxella catarralis can be found in ,20% of wheezing children [7]. Mycoplasma pneumoniae and Chlamydia pneumoniae were identified in 5–25% of children with asthma exacerbations [8]. A significantly greater reduction in asthma symptoms and a larger improvement from baseline lung function was fou ...
PATHOGENESIS OF AN EMERGING PATHOGEN – CRIMEAN
... CCHF pathogenesis is probably derived from a complex interaction between the virus and host cells. So far few studies have investigated the contribution of what seems to be the main players: endothelial cells and immune cells. Endothelial cells (ECs) are the likely focal point of pathogenesis since ...
... CCHF pathogenesis is probably derived from a complex interaction between the virus and host cells. So far few studies have investigated the contribution of what seems to be the main players: endothelial cells and immune cells. Endothelial cells (ECs) are the likely focal point of pathogenesis since ...
blood powerpoint 2
... • In 1910, identification of the ABO blood antigen gene explained the observed blood type incompatibilities • Today there are 31 different genes known to contribute to the surface features of RBCs determining compatibility between blood types ...
... • In 1910, identification of the ABO blood antigen gene explained the observed blood type incompatibilities • Today there are 31 different genes known to contribute to the surface features of RBCs determining compatibility between blood types ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.