Monoclonal antibodies to equine arteritis virus proteins identify the
... MAb 17F5 probe. Thus these neutralizing MAbs may also be GL-specific. In this report we described the production and characterization of MAbs to the N and GL proteins of EAV. We determined definitively the protein specificities of these MAbs with VVRs expressing EAV proteins, including two new VVRs ...
... MAb 17F5 probe. Thus these neutralizing MAbs may also be GL-specific. In this report we described the production and characterization of MAbs to the N and GL proteins of EAV. We determined definitively the protein specificities of these MAbs with VVRs expressing EAV proteins, including two new VVRs ...
PARADOXICAL EFFECTS OF IMMUNE CELLS ON THE INFLAMMATION
... urban areas and northern climates (Loftus, Jr. & Sandborn, 2002;Hanauer, 2006). There are two major types of IBD, Crohn‘s and ulcerative colitis, both of which have an unknown etiology. Ulcerative colitis results in characteristic ulceration of the colon and rectum and typically involves only the in ...
... urban areas and northern climates (Loftus, Jr. & Sandborn, 2002;Hanauer, 2006). There are two major types of IBD, Crohn‘s and ulcerative colitis, both of which have an unknown etiology. Ulcerative colitis results in characteristic ulceration of the colon and rectum and typically involves only the in ...
- Royal College of Surgeons
... system is a major barrier to transplantation. Here we have a setting where a foreign HLA protein can be recognised by a patient's recipient T-cells in its intact form. So if you bear with me, the donor antigen presenting cell in blue, is within the kidney when it is first transplanted. It is express ...
... system is a major barrier to transplantation. Here we have a setting where a foreign HLA protein can be recognised by a patient's recipient T-cells in its intact form. So if you bear with me, the donor antigen presenting cell in blue, is within the kidney when it is first transplanted. It is express ...
Characterization of Critical Reagents for Ligand Binding Assays
... Ligand binding assays are utilized throughout the large molecule drug development process. However their robustness, accuracy and reproducibility depend on the quality of critical reagents. The unique characteristics of these reagents are crucial to assay performance, and require careful characteriz ...
... Ligand binding assays are utilized throughout the large molecule drug development process. However their robustness, accuracy and reproducibility depend on the quality of critical reagents. The unique characteristics of these reagents are crucial to assay performance, and require careful characteriz ...
BLOOD PHYSIOLOGY
... ④ Monocyte Its body is large, diameter about 15~30 µm without granule Function: ...
... ④ Monocyte Its body is large, diameter about 15~30 µm without granule Function: ...
O-Linked Glycoproteins - Sigma
... O-linked glycans to attract and bind bacterial carbohydrate binding receptors. Many bacterial pathogens express adhesins, carbohydraterecognition proteins specific for cell surface O-glycan structures that function as receptors for binding and infecting host cells. The adhesins bind to the mucin sur ...
... O-linked glycans to attract and bind bacterial carbohydrate binding receptors. Many bacterial pathogens express adhesins, carbohydraterecognition proteins specific for cell surface O-glycan structures that function as receptors for binding and infecting host cells. The adhesins bind to the mucin sur ...
Microbial recognition and evasion of host immunity
... 2012). Recognition of non-self molecules is an important first step towards an effective immune response and is enabled by pattern-recognition receptors (PRRs) in the host cells. These PRRs are able to recognize microbe-associated molecular patterns (MAMPs), which are also often referred to as patho ...
... 2012). Recognition of non-self molecules is an important first step towards an effective immune response and is enabled by pattern-recognition receptors (PRRs) in the host cells. These PRRs are able to recognize microbe-associated molecular patterns (MAMPs), which are also often referred to as patho ...
Antibody-Directed Phototherapy (ADP)
... the tumour only, sparing side effects in surrounding normal tissues, including those in which the target is expressed. On-target toxicity is often a major drug development issue. Additionally, when compared to ADCs that contain well established chemotherapy drugs, ADP is not immuno-suppressive as it ...
... the tumour only, sparing side effects in surrounding normal tissues, including those in which the target is expressed. On-target toxicity is often a major drug development issue. Additionally, when compared to ADCs that contain well established chemotherapy drugs, ADP is not immuno-suppressive as it ...
Pro5® Pentamer Applications
... ProImmune’s Human CD1d tetramer can detect NKT cells from non-human primates R-PE labeled human CD1d tetramers used to stain PBMCs from rhesus macaque monkeys. PBMCs were pre-stimulated with RGI-2001 (liposomal α-GalCer, a ligand for NKT cells) for 3 days. Data shown is gated on live, CD3 positive ...
... ProImmune’s Human CD1d tetramer can detect NKT cells from non-human primates R-PE labeled human CD1d tetramers used to stain PBMCs from rhesus macaque monkeys. PBMCs were pre-stimulated with RGI-2001 (liposomal α-GalCer, a ligand for NKT cells) for 3 days. Data shown is gated on live, CD3 positive ...
The Key Enzyme of the Sialic Acid Metabolism Is Involved in
... Sialic acid (Sia) belongs to a family of nine carbon amino sugars with more than 50 members. Sia is expressed as terminal sugars on glycoproteins on the cell surface and on secreted glycoproteins and involved in many biological interactions [1]. The precursor for all Sia is N-acetylneuraminic acid ( ...
... Sialic acid (Sia) belongs to a family of nine carbon amino sugars with more than 50 members. Sia is expressed as terminal sugars on glycoproteins on the cell surface and on secreted glycoproteins and involved in many biological interactions [1]. The precursor for all Sia is N-acetylneuraminic acid ( ...
Protozoan Parasite Glycosylphosphatidylinositol Anchors from a
... T. cruzi- and parasite-derived glycolipids Green monkey kidney-derived LLC-MK2 cells (American Type Culture Collection, Manassas, VA) were grown at 37°C in DMEM (Life Technologies, Grand Island, NY) containing 5% heat-inactivated FBS, 40 g of gentamicin sulfate/ml, 0.3% sodium bicarbonate in a 5% C ...
... T. cruzi- and parasite-derived glycolipids Green monkey kidney-derived LLC-MK2 cells (American Type Culture Collection, Manassas, VA) were grown at 37°C in DMEM (Life Technologies, Grand Island, NY) containing 5% heat-inactivated FBS, 40 g of gentamicin sulfate/ml, 0.3% sodium bicarbonate in a 5% C ...
Cross–reactivity of antibodies against microbial proteins to
... induces myocardial damage with reactive T- and B-lymphocytes, and there are shared epitopes between the M protein and the cardiac myosin (5-7) . A similar mechanism has been described for Epstein-Barr viral infection and hemolytic anemia (8). In our effort to determine the role of mycobacterial infe ...
... induces myocardial damage with reactive T- and B-lymphocytes, and there are shared epitopes between the M protein and the cardiac myosin (5-7) . A similar mechanism has been described for Epstein-Barr viral infection and hemolytic anemia (8). In our effort to determine the role of mycobacterial infe ...
Immune Profiling by High Throughput Sequencing of B and T Cell
... Killer T cells, marked by the surface expression of CD8, recognize short peptides (~8-10 amino acids) presented on the surface of cells by human leukocyte antigen (HLA) Class I molecules(1). Helper T cells, marked by the surface expression of CD4, recognize longer peptides (~12-16 nucleotides) prese ...
... Killer T cells, marked by the surface expression of CD8, recognize short peptides (~8-10 amino acids) presented on the surface of cells by human leukocyte antigen (HLA) Class I molecules(1). Helper T cells, marked by the surface expression of CD4, recognize longer peptides (~12-16 nucleotides) prese ...
pO 2
... of, relating to, undergoing, or being a change in the shape and activity of a protein (as an enzyme) that results from combination with another substance at a point other than the chemically active site ...
... of, relating to, undergoing, or being a change in the shape and activity of a protein (as an enzyme) that results from combination with another substance at a point other than the chemically active site ...
Protein_Structure_Final_Powerpoint
... Protein organization determines folding patterns that affect function. Amino acid side chains are in part responsible for protein folding Molecular interactions determine tertiary and quaternary structures DNA mutations can affect protein function Unconserved regions are predicted to serve as key si ...
... Protein organization determines folding patterns that affect function. Amino acid side chains are in part responsible for protein folding Molecular interactions determine tertiary and quaternary structures DNA mutations can affect protein function Unconserved regions are predicted to serve as key si ...
Memmler`s The Human Body in Health and Disease 11th
... What is contained in the lysosome that joins the phagocytic vesicle? ...
... What is contained in the lysosome that joins the phagocytic vesicle? ...
Gene Section ELAVL1 (ELAV (embryonic lethal, abnormal vision,
... skeletal muscle, is frequently seen in patients with chronic diseases such as cancer. The bioactive gas nitric oxide has been identified as an important player in cancer-induced cachexia because NO is directly involved in the loss of MyoD mRNA (a key factor needed for the myogenic process, which is ...
... skeletal muscle, is frequently seen in patients with chronic diseases such as cancer. The bioactive gas nitric oxide has been identified as an important player in cancer-induced cachexia because NO is directly involved in the loss of MyoD mRNA (a key factor needed for the myogenic process, which is ...
Entire conference report by Dr Ros Vallings
... IL-2 is down. The symptoms fit the criteria for a diagnosis of CFS. 3 Q-fever groups were studied and there were differences in the frequency of carriage of HLA-DR B1*11 and of IFN-Á. 35% were positive in the post-Q-fever syndrome group, and the levels were low in the controls and Q-fever recovered ...
... IL-2 is down. The symptoms fit the criteria for a diagnosis of CFS. 3 Q-fever groups were studied and there were differences in the frequency of carriage of HLA-DR B1*11 and of IFN-Á. 35% were positive in the post-Q-fever syndrome group, and the levels were low in the controls and Q-fever recovered ...
Raulet, D. H. and N. Guerra. 2009. Oncogenic stress sensed by the immune system: role of natural killer cell receptors. Nat Rev Immunol 9:568-580.
... these cases transformation depends on direct infection of the pre-malignant cell3. Examples that are relevant to human disease include cervical carcinoma, some lymphomas and Kaposi’s sarcoma. In these instances, the transformed cell may express non-self antigens encoded by the pathogen that can be t ...
... these cases transformation depends on direct infection of the pre-malignant cell3. Examples that are relevant to human disease include cervical carcinoma, some lymphomas and Kaposi’s sarcoma. In these instances, the transformed cell may express non-self antigens encoded by the pathogen that can be t ...
Studies on the development of a vaccine against Mycobacterium sp.
... PPD injection, ceasing only after degradation of the antigen. The innate immune response, the first line of defense against pathogenic microbes, plays a critical role during mycobacterial infection. Toll-like receptor 2 (TLR2) which exists on the surface of the phagocyte recognizes pathogen-associat ...
... PPD injection, ceasing only after degradation of the antigen. The innate immune response, the first line of defense against pathogenic microbes, plays a critical role during mycobacterial infection. Toll-like receptor 2 (TLR2) which exists on the surface of the phagocyte recognizes pathogen-associat ...
Lennert et al
... Anaplasia larger cell type* * Remain Altercation for adding anaplasia larger cell type HD and omiting Lymphocyte depletion type HD ...
... Anaplasia larger cell type* * Remain Altercation for adding anaplasia larger cell type HD and omiting Lymphocyte depletion type HD ...
... ing immunohistochemical techniques should use a panel of antibodies that recognize at least two different epitopes of Pgp 170 to minimize false-positive results [22]. MRK16 (Valbiotech, Paris, France), an immunoglobulin (Ig)G2a antibody, is specific for the class I isoform (MDR1) of human P-glycopro ...
Production of Reactive Oxygen Species, Alteration of
... (KCN), a powerful inhibitor of mitochondrial cytochrome c oxidase. Residual oxygen consumption (6 and 3 natoms min⫺1 mg⫺1 cell protein in control and 4-h PCD cells, respectively) was observed after addition of KCN, probably because of the cyanideinsensitive alternative oxidase activity (Vanlerberghe ...
... (KCN), a powerful inhibitor of mitochondrial cytochrome c oxidase. Residual oxygen consumption (6 and 3 natoms min⫺1 mg⫺1 cell protein in control and 4-h PCD cells, respectively) was observed after addition of KCN, probably because of the cyanideinsensitive alternative oxidase activity (Vanlerberghe ...
The amphioxus immune system
... Even if the structure of the amphioxus vascular system has been extensively studied, free blood cells have not been clearly identified. Only Rhodes and coworkers (1982) described by electron microscope the presence in the perivisceral coelom of free cells able to phagocyte and similar to specialized ...
... Even if the structure of the amphioxus vascular system has been extensively studied, free blood cells have not been clearly identified. Only Rhodes and coworkers (1982) described by electron microscope the presence in the perivisceral coelom of free cells able to phagocyte and similar to specialized ...
Polyclonal B cell response
Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.In the course of normal immune response, parts of pathogens (e.g. bacteria) are recognized by the immune system as foreign (non-self), and eliminated or effectively neutralized to reduce their potential damage. Such a recognizable substance is called an antigen. The immune system may respond in multiple ways to an antigen; a key feature of this response is the production of antibodies by B cells (or B lymphocytes) involving an arm of the immune system known as humoral immunity. The antibodies are soluble and do not require direct cell-to-cell contact between the pathogen and the B-cell to function.Antigens can be large and complex substances, and any single antibody can only bind to a small, specific area on the antigen. Consequently, an effective immune response often involves the production of many different antibodies by many different B cells against the same antigen. Hence the term ""polyclonal"", which derives from the words poly, meaning many, and clones (""Klon""=Greek for sprout or twig); a clone is a group of cells arising from a common ""mother"" cell. The antibodies thus produced in a polyclonal response are known as polyclonal antibodies. The heterogeneous polyclonal antibodies are distinct from monoclonal antibody molecules, which are identical and react against a single epitope only, i.e., are more specific.Although the polyclonal response confers advantages on the immune system, in particular, greater probability of reacting against pathogens, it also increases chances of developing certain autoimmune diseases resulting from the reaction of the immune system against native molecules produced within the host.