Lesson 2 * The Body*s Defenses
... can spread from one person to another only if body fluids from an infected person come in contact with those of an uninfected person. You cannot get HIV, the virus that causes AIDS, by hugging someone infected with the virus. ...
... can spread from one person to another only if body fluids from an infected person come in contact with those of an uninfected person. You cannot get HIV, the virus that causes AIDS, by hugging someone infected with the virus. ...
BSC 589 Independent Studies (3 Credit Hours) – Fall 2012
... de Visser, K.E., Eichten, A., and Coussens, L.M. 2006. Paradoxical roles of the immune system during cancer development. Nat Rev Cancer 6:24-37. DeNardo, D.G., and Coussens, L.M. 2007. Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells durin ...
... de Visser, K.E., Eichten, A., and Coussens, L.M. 2006. Paradoxical roles of the immune system during cancer development. Nat Rev Cancer 6:24-37. DeNardo, D.G., and Coussens, L.M. 2007. Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells durin ...
Lecture 8: The Development and Survival of Lymphocytes (
... Lecture 8: The Development and Survival of Lymphocytes (based on lecture by Dr. Barbara Birshtein) ...
... Lecture 8: The Development and Survival of Lymphocytes (based on lecture by Dr. Barbara Birshtein) ...
Lycera and Celgene Announce an Exclusive
... including Lycera's first-in-class RORgamma agonists for cancer immunotherapy, and clinicalstage candidate, LYC-30937, being studied for inflammatory bowel disease (IBD) NEW YORK and ANN ARBOR, Mich., June 9, 2015 /PRNewswire/ -- Lycera Corp., a privately held biopharmaceutical company developing bre ...
... including Lycera's first-in-class RORgamma agonists for cancer immunotherapy, and clinicalstage candidate, LYC-30937, being studied for inflammatory bowel disease (IBD) NEW YORK and ANN ARBOR, Mich., June 9, 2015 /PRNewswire/ -- Lycera Corp., a privately held biopharmaceutical company developing bre ...
Immunogeno: Protective mechanism for Rift Valley fever in the
... during RVFV epidemics but, until now several studies have been concentrated on the response of the innate immune particularly based on signal interferon system than the response of the adaptive immune and cell mediated humoral immune. The available information on the immune response related to RVFV ...
... during RVFV epidemics but, until now several studies have been concentrated on the response of the innate immune particularly based on signal interferon system than the response of the adaptive immune and cell mediated humoral immune. The available information on the immune response related to RVFV ...
Ref. Infectious agents or immunomodulatory molecules Host cell
... immunostimulatory chemicals [4]. Cells were exposed to heat-killed E. coli, S. aureus and Bordatella pertussis bacteria for six, twelve, or twenty-four hours and five to seven time-points were collected. Additional experiments were done using live virulent B. pertussis, avirulent strains, and LPS fr ...
... immunostimulatory chemicals [4]. Cells were exposed to heat-killed E. coli, S. aureus and Bordatella pertussis bacteria for six, twelve, or twenty-four hours and five to seven time-points were collected. Additional experiments were done using live virulent B. pertussis, avirulent strains, and LPS fr ...
Viruses and host defenses
... IL6-like cytokine three chemokines interferon regulatory factor D-type cyclin G-protein coupled receptor ...
... IL6-like cytokine three chemokines interferon regulatory factor D-type cyclin G-protein coupled receptor ...
RhoGTPases — NODes for effector-triggered immunity in
... pathogenic potential of microbes and provides evidence that one strategy involves NOD1, which monitors the activation state of the RhoGTPases that are targeted by virulence effectors produced by pathogenic microbes. Interestingly, their findings reveal striking similarities with previous observation ...
... pathogenic potential of microbes and provides evidence that one strategy involves NOD1, which monitors the activation state of the RhoGTPases that are targeted by virulence effectors produced by pathogenic microbes. Interestingly, their findings reveal striking similarities with previous observation ...
Lecture notes
... Cytokines produced by T helper cells are particularly important in regulating immune responses. Different Th cells preferentially produce different cytokines that drive different types of immune response. Th1 cells produce cytokines like IFN- that activates macrophages, and IL-2 that activates T ce ...
... Cytokines produced by T helper cells are particularly important in regulating immune responses. Different Th cells preferentially produce different cytokines that drive different types of immune response. Th1 cells produce cytokines like IFN- that activates macrophages, and IL-2 that activates T ce ...
Type III Hypersensitivity
... Antibodies were produced before antiserum was eliminated. The binding of antibodies to antiserum forms immune complexes The deposition of IC causes serum sick: fever, chills, rash, arthritis ...
... Antibodies were produced before antiserum was eliminated. The binding of antibodies to antiserum forms immune complexes The deposition of IC causes serum sick: fever, chills, rash, arthritis ...
Resisting infection Cellular Defenses: Leukocytes
... dsRNA structures are NOT normal in healthy cells; they are good targets for selectively toxic antiviral activity Ultimately: Interferon-induced antiviral proteins help block viral replication in the uninfected cell ...
... dsRNA structures are NOT normal in healthy cells; they are good targets for selectively toxic antiviral activity Ultimately: Interferon-induced antiviral proteins help block viral replication in the uninfected cell ...
FDA approves Roche`s cancer immunotherapy TECENTRIQ
... The most common side effects (≥ 20%) in patients with metastatic non-small cell lung cancer were fatigue, decreased appetite, dyspnea (shortness of breath), cough, nausea, musculoskeletal pain, and constipation. Nine patients (6.3%) who were treated with TECENTRIQ experienced either pulmonary embol ...
... The most common side effects (≥ 20%) in patients with metastatic non-small cell lung cancer were fatigue, decreased appetite, dyspnea (shortness of breath), cough, nausea, musculoskeletal pain, and constipation. Nine patients (6.3%) who were treated with TECENTRIQ experienced either pulmonary embol ...
... Choice A: Why are IgG molecules good at physical blocking of pathogens, but IgM is more proficient at agglutination of pathogens. Choice B: Why is IgM particularly good at activating complement while most forms of IgG are not. Choice C: How do Fc receptors enhance pathogen destruction by either macr ...
HYPERSENSITIVITY REACTIONS The immune system is required
... asthma, which is triggered by allergen-induced activation of submucosal mast cells in the lower airways. This can lead within seconds to bronchial constriction and an increased secretion of mucus into the airways, making breathing more difficult by trapping inhaled air in the lungs. Patients with al ...
... asthma, which is triggered by allergen-induced activation of submucosal mast cells in the lower airways. This can lead within seconds to bronchial constriction and an increased secretion of mucus into the airways, making breathing more difficult by trapping inhaled air in the lungs. Patients with al ...
BIOL212ImmuneSystemNotes
... In neutralization, antibodies bind to viral surface proteins preventing infection of a host cell Antibodies may also bind to toxins in body fluids and prevent them from entering body cells In opsonization, antibodies bind to antigens on bacteria creating a target for macrophages or neutrophils, trig ...
... In neutralization, antibodies bind to viral surface proteins preventing infection of a host cell Antibodies may also bind to toxins in body fluids and prevent them from entering body cells In opsonization, antibodies bind to antigens on bacteria creating a target for macrophages or neutrophils, trig ...
Document
... The importance of immune regulation • To avoid excessive lymphocyte activation and tissue damage during normal protective responses against infections • To prevent inappropriate reactions against self antigens (“self-tolerance”) • Failure of control mechanisms is the underlying cause of immune-medi ...
... The importance of immune regulation • To avoid excessive lymphocyte activation and tissue damage during normal protective responses against infections • To prevent inappropriate reactions against self antigens (“self-tolerance”) • Failure of control mechanisms is the underlying cause of immune-medi ...
BIO 401
... signal sequences consist of short sequences, which are repeated many times. Be familiar with the role played by certain cytokines to promote preferential class switching to certain constant genes. If you are familiar with question 2 then you will get this question right! 13. Know why it is that any ...
... signal sequences consist of short sequences, which are repeated many times. Be familiar with the role played by certain cytokines to promote preferential class switching to certain constant genes. If you are familiar with question 2 then you will get this question right! 13. Know why it is that any ...
Animal Diseases
... Release chemicals that can induce the production of more white blood cells to help fight disease ...
... Release chemicals that can induce the production of more white blood cells to help fight disease ...
IMMUNITY
... • Triggered when allergen interacts with free IgE • Allergens can be ingested in foods, injected, inhaled, absorbed – Systemic response, such as anaphylaxis – Localized response, such as asthma, more common ...
... • Triggered when allergen interacts with free IgE • Allergens can be ingested in foods, injected, inhaled, absorbed – Systemic response, such as anaphylaxis – Localized response, such as asthma, more common ...
Establishment of a Plasma Cell Culture and Analysis of Expression of... Olaide Adekanbi, Tim Weeden, Michele Youd IMD Discovery, Genzyme Corporation Introduction
... Plasma cells are a part of the human body’s humoral immune response. During an active humoral immune response, B cells, a subset of white blood cells, differentiate into antibody secreting cells after they have become stimulated by an antigen. In various autoimmune disorders, defective plasma cells ...
... Plasma cells are a part of the human body’s humoral immune response. During an active humoral immune response, B cells, a subset of white blood cells, differentiate into antibody secreting cells after they have become stimulated by an antigen. In various autoimmune disorders, defective plasma cells ...
26.1 Organs, Tissues, and Cells of the Immune System (cont.)
... • The complement system consists of a variety of blood plasma proteins. • When activated by the presence of pathogens, these proteins amplify the immune response. • Complement proteins also form a membrane attack complex that contributes to the lysis of pathogens. ...
... • The complement system consists of a variety of blood plasma proteins. • When activated by the presence of pathogens, these proteins amplify the immune response. • Complement proteins also form a membrane attack complex that contributes to the lysis of pathogens. ...
Novel Cytokines in Infection and Immunity
... Cytokines are hormones of the immune system. Cytokine-targeting represents a major triumph in immunology scientifically, clinically and commercially. There is therefore considerable interest in discovering novel cytokines. I will illustrate the pleiotropic role of some of the novel cytokines by focu ...
... Cytokines are hormones of the immune system. Cytokine-targeting represents a major triumph in immunology scientifically, clinically and commercially. There is therefore considerable interest in discovering novel cytokines. I will illustrate the pleiotropic role of some of the novel cytokines by focu ...
Cells of the Immune System-I
... 1. Innate immune cells are derived from Bone Marrow. 2. Their primary function is to identify and kill microbes. Antigen-presenting cells (APCs) additionally function to present Ag to and activate lymphocytes. 3. Innate immune cells recognize the common microbial ...
... 1. Innate immune cells are derived from Bone Marrow. 2. Their primary function is to identify and kill microbes. Antigen-presenting cells (APCs) additionally function to present Ag to and activate lymphocytes. 3. Innate immune cells recognize the common microbial ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.