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Case Studies for Studying the Immune System
Case Studies for Studying the Immune System

... Case Studies for Studying the Immune System Lesson One: Teacher reviews the concepts and vocabulary of the immune system. Lesson Two: Students create a concept map from a selection of the words below. Lesson Two: Teacher gives each pair of students a case from the list below. 1. Students analyze the ...
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File

Ralph Steinman and dendritic cells
Ralph Steinman and dendritic cells

... collect and process antigens for presentation on MHC molecules to T lymphocytes. DCs also sense the environment via innate receptors for inflammatory mediators, for damaged cells or for microbial products, and then direct an appropriate adaptive immune response from the T cells reactive with the pre ...
cell is smallest unit of life - life is made out of very complex
cell is smallest unit of life - life is made out of very complex

... The antigen binds to a receptor or antibody on the immune cell and stimulates the cell. The part of the antigen molecule to which the antibody binds is called the epitope. could be pieces of the invador A stimulated cell can make new antibodies ==> ANTIbody GENerator. Antibody: - a protein known as ...
HST.035 Homework Assignment #2
HST.035 Homework Assignment #2

... Can result in hives/rash because of vasodilation and increased vascular permeability Can result in wheezing because of bronchoconstriction in the lungs Is mediated by Fc-specific activation of neutrophils ...
3 pharmacy B cells
3 pharmacy B cells

... replication and growth ...
The Adaptive Immune Response T
The Adaptive Immune Response T

... rearrangement of antigen receptor genes is the product of RAG-1 and RAG-2 (recombination activating genes); inherited defects in RAG proteins result in a failure to generate mature lymphocytes. Whereas each T cell expresses TCR molecules of one specificity, collectively, the full complement of T cel ...
Chapter 7 Cytokines
Chapter 7 Cytokines

... 2. Take part in adaptive immunity ...
STUDI PENGGUNAAN ANTIBIOTIKA PADA PASIEN TUMOR OTAK
STUDI PENGGUNAAN ANTIBIOTIKA PADA PASIEN TUMOR OTAK

... including its type, dose, route, duration of administration, and frequency in patients with brain tumors of which trepanation-excision of the tumor performed. Result. This study was conducted retrospectively from period of January to December 2010. In this study, we studied the clinical data of 30 p ...
PLoS Pathog
PLoS Pathog

Feline Infectious Anemia - Bardstown Veterinary Clinic
Feline Infectious Anemia - Bardstown Veterinary Clinic

... For this reason it is very common for the infection can be missed during these screenings. The most effective way to diagnose this condition is to either see the evidence on a blood smear performed in the veterinary clinic and conformation through a specialized test called a PCR. Once the diagnosis ...
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Syllbus File - Al-Hussein Bin Talal University
Syllbus File - Al-Hussein Bin Talal University

... 2. To learn about the composition and features of innate immunity and acquired immunity 3. To be familiar with the basic function of immunity 4. To learn about clonal selection theory 5. To learn about the brief history and recent developments in immunology, and its status in medicine [Contents] 1. ...
Final Immunology Overview
Final Immunology Overview

... o Realize that if you miss that first line of defense, you’ll be very susceptible to infections and in some cases there’s not very much that can be done. They’ll live on antibiotics their entire lives and will have serious problems as a result of their defect. Questions about the innate immune respo ...
Kuby Immunology 6/e - Dr. Jennifer Capers
Kuby Immunology 6/e - Dr. Jennifer Capers

SUPPLEMENT/ANCILLARY TITLE
SUPPLEMENT/ANCILLARY TITLE

... hidden internal membrane phospholipid molecule called phosphatidylserine on their surface. ___ 21. Many fevers result from exposure to certain bacteria, which release endogenous pyrogen molecules that in turn stimulate leukocytes to release chemicals known as endotoxins. ___ 22. Interferons are poly ...
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slide_3

disease emergence and re-emergence
disease emergence and re-emergence

... • Types of Parasites: – Protozoa: Single-celled, microscopic organisms that can perform all necessary functions of metabolism and reproduction. Some protozoa are free-living, while others parasitize other organisms for their nutrients and life cycle. • The morphology of protozoa varies widely and in ...
B. True or False/Edit
B. True or False/Edit

... hidden internal membrane phospholipid molecule called phosphatidylserine on their surface. ___ 21. Many fevers result from exposure to certain bacteria, which release endogenous pyrogen molecules that in turn stimulate leukocytes to release chemicals known as endotoxins. ___ 22. Interferons are poly ...
Eicosanoids as pro- and anti- inflammatory mediators (Block
Eicosanoids as pro- and anti- inflammatory mediators (Block

... Description: Eicosanoids are potent pro- and anti-inflammatory mediators, which are produced by cells of the adaptive and non-adaptive immune systems but also by somatic cells of vertebrates. This seminar is intended to give an overview on biosynthesis and biological implications of eicosanoids in r ...
B CELLS Memory B cells
B CELLS Memory B cells

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... 42. The ______________________________________________________________ is designed to protect against microscopic organisms (bacteria, viruses) and foreign substances which enter an organism from outside its body. The immune system also protects from many cancer cells which arise within our bodies w ...
Allen.Presentatie.2012.MWI
Allen.Presentatie.2012.MWI

... • Neutrokine- identified as member of TNF ligand superfamily of cytokines • All 8 members of superfamily are involved in regulation of cell proliferation, activation and differentiation • Neutrokine-: expressed in various cells/organs • Potentially useful for diagnosis, prevention or treatment of ...
Engineered T Cells for HIV/AIDS
Engineered T Cells for HIV/AIDS

... Rationale for Selection of CCR5 ZFN Target for Gene Modification Therapy • Primary HIV-1 coreceptor • People carrying mutations of both CCR5 alleles (homozygotes for CCR5 delta 32 deletion) are resistant for HIV infection (1% of Caucasian population • No adverse effects of the mutation in humans fo ...
Chapter 15 Immune response(Ir)
Chapter 15 Immune response(Ir)

... • The first antibodies produced in a humoral immune response are IgM, but activated B cells subsequently undergo isotype switching or class switching to secrete antibodies of different isotypes: IgG, IgA, and IgE. Isotype switching does not affect antibody specificity significantly. • Occurred wh ...
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Cancer immunotherapy



Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.
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