faculty fac - Molecular and Cellular Physiology
... Our laboratory investigates microcirculatory function and the changes that occur during inflammatory diseases such as diabetes, hypercholesterolemia, and inflammatory bowel disease. Exchange of molecules (such as water, nutrients, and metabolites) occurs between plasma and tissue at the level of the ...
... Our laboratory investigates microcirculatory function and the changes that occur during inflammatory diseases such as diabetes, hypercholesterolemia, and inflammatory bowel disease. Exchange of molecules (such as water, nutrients, and metabolites) occurs between plasma and tissue at the level of the ...
Understanding the CBC
... Basophils Basophils have a role in the body’s immune response, by releasing histamine and heparin. Their small numbers increase during the healing process or when there is an alteration in bone marrow ...
... Basophils Basophils have a role in the body’s immune response, by releasing histamine and heparin. Their small numbers increase during the healing process or when there is an alteration in bone marrow ...
CS12 Herpes Simplex Virus_Presentation
... • Although HSV-1 and HSV-2 have many antigens in common, the glycoprotein G (gG) antigen is unique to each type; thus, gG1 is found only on HSV-1, and gG2 is found only on HSV-2. • ELISA based test can be used to detect type-specific IgG antibodies (sensitivity around 90%). • Western Blot • PCR ...
... • Although HSV-1 and HSV-2 have many antigens in common, the glycoprotein G (gG) antigen is unique to each type; thus, gG1 is found only on HSV-1, and gG2 is found only on HSV-2. • ELISA based test can be used to detect type-specific IgG antibodies (sensitivity around 90%). • Western Blot • PCR ...
The Human Intervertebral Disc
... • Should NOT provoke immune response6 • Need to keep cells within nucleus.13 • Identify ideal cell amount: prevent oxygen deprivation and over-pressurization6,14 ...
... • Should NOT provoke immune response6 • Need to keep cells within nucleus.13 • Identify ideal cell amount: prevent oxygen deprivation and over-pressurization6,14 ...
The effect of the sympathetic nervous system on the production of
... monocyte/macrophage direction, while in case of the other two celltypes, immunmodulant effect of isoproterenol could not be shown. • The other stimulus was the aspecific immunological inductor PMA. Its choice was justified by that we tried to follow the change of immunmodulation during differentiati ...
... monocyte/macrophage direction, while in case of the other two celltypes, immunmodulant effect of isoproterenol could not be shown. • The other stimulus was the aspecific immunological inductor PMA. Its choice was justified by that we tried to follow the change of immunmodulation during differentiati ...
BCCA Protocol Summary for Treatment of Relapsed/Refractory
... including palpitations and lightheadedness or a new onset of dyspnea. If atrial fibrillation persists, evaluate the risk vs. benefit of continuing treatment and consider a dose reduction. 7. Lymphocytosis: Has been reported, usually occurring within the first few weeks of therapy and resolving by 8- ...
... including palpitations and lightheadedness or a new onset of dyspnea. If atrial fibrillation persists, evaluate the risk vs. benefit of continuing treatment and consider a dose reduction. 7. Lymphocytosis: Has been reported, usually occurring within the first few weeks of therapy and resolving by 8- ...
Multiple Sclerosis Is an Inflammatory T-Cell–Mediated - Direct-MS
... antiglomerular basement membrane disease, and idiopathic thrombocytopenic purpura. In these situations, the pathogenic potential of autoantibodies can be demonstrated by passive transfer of immune serum to animals. Although antibodies directed against selfantigens have been identified in MS, passive ...
... antiglomerular basement membrane disease, and idiopathic thrombocytopenic purpura. In these situations, the pathogenic potential of autoantibodies can be demonstrated by passive transfer of immune serum to animals. Although antibodies directed against selfantigens have been identified in MS, passive ...
Kineta Scientists Present Novel Antiviral Research Findings at
... SEATTLE, WA, October 3, 2011 – Today, Kineta scientists will present new findings from the company’s antiviral drug development program – vaccine adjuvants of the Retinoic Acid Inducible Gene I (RIG-I), at the Fifth Annual International Society for Vaccines, Global Congress, in Seattle. Research sci ...
... SEATTLE, WA, October 3, 2011 – Today, Kineta scientists will present new findings from the company’s antiviral drug development program – vaccine adjuvants of the Retinoic Acid Inducible Gene I (RIG-I), at the Fifth Annual International Society for Vaccines, Global Congress, in Seattle. Research sci ...
Scancell Presentation
... Scancell’s ImmunoBody® platform, in combination with electroporation, has set a new standard for T cell activation SCIB1 shrinks and even destroys tumours in patients with inoperable metastatic melanoma SCIB1 prevents disease recurrence and prolongs overall survival in patients with fully rese ...
... Scancell’s ImmunoBody® platform, in combination with electroporation, has set a new standard for T cell activation SCIB1 shrinks and even destroys tumours in patients with inoperable metastatic melanoma SCIB1 prevents disease recurrence and prolongs overall survival in patients with fully rese ...
Correlation between viral load and levels of CD8 T cells
... battle HIV, as with other infections • After acute HIV infection, immune system remains persistently activated in most people • The T10 marker is now called CD38 and is used to measure immune activation • Levels of CD38 measured on immune cells called CD8 T cells correlate with pace of disease progr ...
... battle HIV, as with other infections • After acute HIV infection, immune system remains persistently activated in most people • The T10 marker is now called CD38 and is used to measure immune activation • Levels of CD38 measured on immune cells called CD8 T cells correlate with pace of disease progr ...
Cellular immunotherapy for refractory hematological malignancies
... purposeful rejection of donor cells so as to elicit a potent immune reaction that appears to break host tumor tolerance. Methods/design: The trial is a FDA and institutional Rhode Island Hospital/The Miriam Hospital IRB approved Phase I/II study to determine the efficacy and safety of haploidentical ...
... purposeful rejection of donor cells so as to elicit a potent immune reaction that appears to break host tumor tolerance. Methods/design: The trial is a FDA and institutional Rhode Island Hospital/The Miriam Hospital IRB approved Phase I/II study to determine the efficacy and safety of haploidentical ...
PPT Version - OMICS International
... their KS becomes serious enough to be fatal. African KS appearing in young children are the most serious. Left untreated, these forms can result in death in a few short years. Despite the fact that it is associated with AIDS, AIDS-related KS is most commonly treatable and not fatal. ...
... their KS becomes serious enough to be fatal. African KS appearing in young children are the most serious. Left untreated, these forms can result in death in a few short years. Despite the fact that it is associated with AIDS, AIDS-related KS is most commonly treatable and not fatal. ...
Eicosanoids: an emerging role in dendritic cell biology
... actions of cyclooxygenase (COX) and lipoxygenase (LO) enzymes, respectively. Disordered activation of PLA2, LO, and COX enzymes have been implicated in many inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel diseases. PLA2 is activated by PLA2-activating protein and LO by 5-l ...
... actions of cyclooxygenase (COX) and lipoxygenase (LO) enzymes, respectively. Disordered activation of PLA2, LO, and COX enzymes have been implicated in many inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel diseases. PLA2 is activated by PLA2-activating protein and LO by 5-l ...
Document
... respiratory and urogenital tracts). Mucosal surfaces are the portal of entry of many pathogens. SIgA is produced excessively at mucosal surfaces and is the predominant class of Ig found in human external secretions and in tears. IgA are glycoproteins and one of five classes of Ab. Ab classes are def ...
... respiratory and urogenital tracts). Mucosal surfaces are the portal of entry of many pathogens. SIgA is produced excessively at mucosal surfaces and is the predominant class of Ig found in human external secretions and in tears. IgA are glycoproteins and one of five classes of Ab. Ab classes are def ...
Disease mechanism: Unravelling Wiskott–Aldrich syndrome
... There is no obvious explanation for the findings described above, but we might infer that WASp plays a role in at least two (or more) signaling pathways. In fact, the carboxy-terminal portion of WASp contains several sites predicted to bind Src homology 3 (SH3) domains, and the SH3-containing adapto ...
... There is no obvious explanation for the findings described above, but we might infer that WASp plays a role in at least two (or more) signaling pathways. In fact, the carboxy-terminal portion of WASp contains several sites predicted to bind Src homology 3 (SH3) domains, and the SH3-containing adapto ...
The expression of fetal oncogene 5T4 in CTCs
... expression in a small cohort of samples from patients with NSCLC. We obtained matched primary tumor and blood samples, with the blood being obtained prior to resection of the primary tumor. The expression of 5T4 was found to be robust and measurable in both the FFPE tumors and CTCs. However, we obse ...
... expression in a small cohort of samples from patients with NSCLC. We obtained matched primary tumor and blood samples, with the blood being obtained prior to resection of the primary tumor. The expression of 5T4 was found to be robust and measurable in both the FFPE tumors and CTCs. However, we obse ...
White Blood Cells
... • As a result of increased blood flow, there will be more white blood cells, specifically monocytes and neutrophils, attracted to the injury site. The macrophages in the dermis release cytokines. A cytokine is a chemical which recruits more white blood cells to the injury site. The increased blood ...
... • As a result of increased blood flow, there will be more white blood cells, specifically monocytes and neutrophils, attracted to the injury site. The macrophages in the dermis release cytokines. A cytokine is a chemical which recruits more white blood cells to the injury site. The increased blood ...
Understing the word Scientific Literacy by the example of Immune
... knowledge. If we take story number one as an example for this definition, it will make more sense to understand the definition of scientific literacy. It proves that this definition is too narrow because everybody has knowledge that immune system helps to fight against disease. I think this informat ...
... knowledge. If we take story number one as an example for this definition, it will make more sense to understand the definition of scientific literacy. It proves that this definition is too narrow because everybody has knowledge that immune system helps to fight against disease. I think this informat ...
Cytokines
... bone marrow. The common chain is the signal transducing part of the IL-7 receptor. Thus, only non-functional immature B cells are present in the blood. The common chain is needed for early steps in the differentiation of the precursor to T cells and NK cells. This may relate to a need for IL-7 f ...
... bone marrow. The common chain is the signal transducing part of the IL-7 receptor. Thus, only non-functional immature B cells are present in the blood. The common chain is needed for early steps in the differentiation of the precursor to T cells and NK cells. This may relate to a need for IL-7 f ...
BIOE 301 - Rice University
... – Kill invaders – Signal other immune cells – Present antigen to adaptive immune system ...
... – Kill invaders – Signal other immune cells – Present antigen to adaptive immune system ...
Slide 1
... As a result of pathogen- or chemical-induced membrane damage (DAMPS; including: ssRNA, dsRNA, and CpG DNA, and endogenous nucleotides), or contact with a pathogen (PAMPS; including: LPS, bacterial peptidoglycans, bacterial flagellin, envelope proteins from viruses and hemagglutinin protein) a varie ...
... As a result of pathogen- or chemical-induced membrane damage (DAMPS; including: ssRNA, dsRNA, and CpG DNA, and endogenous nucleotides), or contact with a pathogen (PAMPS; including: LPS, bacterial peptidoglycans, bacterial flagellin, envelope proteins from viruses and hemagglutinin protein) a varie ...
immunology - Chapter..
... of antibodies: IgA, IgD, IgE, IgG, and IgM – Differences in length and sugars of heavy chain • Only two isotypes of light chain – kappa () and lambda () – Each antibody has either or chains • The antigen binding site is composed of two variable domains (VH and VL) – Constant domain of light ch ...
... of antibodies: IgA, IgD, IgE, IgG, and IgM – Differences in length and sugars of heavy chain • Only two isotypes of light chain – kappa () and lambda () – Each antibody has either or chains • The antigen binding site is composed of two variable domains (VH and VL) – Constant domain of light ch ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.