Inflammatory response: 1. Vascular reaction 2. Cellular reaction
... - induced by microbial products, IL-1, TNF 2. C-C chemokines (also called β-chemokines) (MCP-1, eotaxin, MIP-1, RANTES) - attract monocytes, eosinophils, basophils, lymphocytes (NOT neutrophils) - MCP-1 (monocyte chemoattractant protein) - MIP-1 (macrophage inflammatory protein) - RANTES (regulated ...
... - induced by microbial products, IL-1, TNF 2. C-C chemokines (also called β-chemokines) (MCP-1, eotaxin, MIP-1, RANTES) - attract monocytes, eosinophils, basophils, lymphocytes (NOT neutrophils) - MCP-1 (monocyte chemoattractant protein) - MIP-1 (macrophage inflammatory protein) - RANTES (regulated ...
393 KB - International Medical Press
... The innate immune receptors TLR7 and TLR8 recognize pathogen RNA and are able to induce an antiviral response. They are currently under investigation as targets for new antiviral drugs. TLR stimulatory drugs including CpG ODN or R848 have been shown to induce a robust activation of the innate immune ...
... The innate immune receptors TLR7 and TLR8 recognize pathogen RNA and are able to induce an antiviral response. They are currently under investigation as targets for new antiviral drugs. TLR stimulatory drugs including CpG ODN or R848 have been shown to induce a robust activation of the innate immune ...
d phenotype - a review
... common in blacks. In this case, the Ro/r genotype CDue/cde appears as the product of a deviant of gene Ro(cDe). Transmission of a gene for the weakened expression of D is less common in whites, but it is more common in the genotypes cDue/cde and cDue/cde as products of the deviants of genes R1 (Cde) ...
... common in blacks. In this case, the Ro/r genotype CDue/cde appears as the product of a deviant of gene Ro(cDe). Transmission of a gene for the weakened expression of D is less common in whites, but it is more common in the genotypes cDue/cde and cDue/cde as products of the deviants of genes R1 (Cde) ...
Funded Positions for PhD Students in Comparative Immunology
... amphibians with the Frog Virus 3 ranavirus, wherein distinct lineages of amphibian (Xenopus laevis) macrophages confer susceptibility and resistance to this infectious agent. In fact, the success of any given antimicrobial response often hinges on pertinent macrophage development and functional pola ...
... amphibians with the Frog Virus 3 ranavirus, wherein distinct lineages of amphibian (Xenopus laevis) macrophages confer susceptibility and resistance to this infectious agent. In fact, the success of any given antimicrobial response often hinges on pertinent macrophage development and functional pola ...
Inflammatory response to infectious pulmonary injury C. Delclaux , E. Azoulay *
... contact with the external environment. The upper and lower airways are repeatedly exposed to a multitude of airborne particles and microorganisms. Since these agents are frequently deposited on the surface of the respiratory tract, an elaborate system of defence mechanisms maintains the sterility of ...
... contact with the external environment. The upper and lower airways are repeatedly exposed to a multitude of airborne particles and microorganisms. Since these agents are frequently deposited on the surface of the respiratory tract, an elaborate system of defence mechanisms maintains the sterility of ...
The Immune System: The Mind-Body
... antigens and signal their presence. ••Helper T-cells: directing activities of macrophages and the proliferation of T- and B-cells. •• Natural killer cells: “ruthless destroyers” of cancerous and infected cells. ••B-cells: formation of antibodies with the special ability to fight bacterial infections ...
... antigens and signal their presence. ••Helper T-cells: directing activities of macrophages and the proliferation of T- and B-cells. •• Natural killer cells: “ruthless destroyers” of cancerous and infected cells. ••B-cells: formation of antibodies with the special ability to fight bacterial infections ...
Document
... In the process of going from G0 and entering into the cell cycle and proliferation, you have many things occur. You have changes in gene transcription, changes in the synthesis of proteins, so these are very early events that prepare the cell to enter G1 and progress to the cycle cell. The second im ...
... In the process of going from G0 and entering into the cell cycle and proliferation, you have many things occur. You have changes in gene transcription, changes in the synthesis of proteins, so these are very early events that prepare the cell to enter G1 and progress to the cycle cell. The second im ...
File
... Lymph nodes • Occur along lymphatic vessels • Connective tissue divides nodes into nodules, each of which contain B cells, T cells, and a sinus • As lymph passes through the sinuses, macrophages engulf pathogens in the lymph • Cancer cells can enter the lymph nodes and lymphatic vessels and move thr ...
... Lymph nodes • Occur along lymphatic vessels • Connective tissue divides nodes into nodules, each of which contain B cells, T cells, and a sinus • As lymph passes through the sinuses, macrophages engulf pathogens in the lymph • Cancer cells can enter the lymph nodes and lymphatic vessels and move thr ...
Rebounding: Good for the Lmph System by
... The rebounding motion stimulates all internal organs, moves the cerebral-spinal fluid and the aqueous fluid within the eyes (many people claim improved eyesight), and does wonders for the intestines. Many immune cells such as T-lymphocytes and macrophages are self-propelled by amoebic action. These ...
... The rebounding motion stimulates all internal organs, moves the cerebral-spinal fluid and the aqueous fluid within the eyes (many people claim improved eyesight), and does wonders for the intestines. Many immune cells such as T-lymphocytes and macrophages are self-propelled by amoebic action. These ...
Ms. Costello`s and Dr. Gocke`s PowerPoint slides
... cytokines and chemokines that pave the way for entry of other immune cells into the lesion site. ...
... cytokines and chemokines that pave the way for entry of other immune cells into the lesion site. ...
Steven A. Porcelli, M.D.
... In 2000, Dr. Porcelli was recruited to Einstein to be the Irene Diamond Associate Professor in Immunology, and was subsequently appointed the Murray and Evelyne Weinstock Chair in Microbiology and Immunology. Beginning in 2015, he was appointed Chair of the Department of Microbiology and Immunology. ...
... In 2000, Dr. Porcelli was recruited to Einstein to be the Irene Diamond Associate Professor in Immunology, and was subsequently appointed the Murray and Evelyne Weinstock Chair in Microbiology and Immunology. Beginning in 2015, he was appointed Chair of the Department of Microbiology and Immunology. ...
Drug Hypersensitivity Reactions: Classification and
... and minutes after oral drug uptake. Symptoms reach from simple local itch, local wheal-andflare reaction upon parenteral drug application, to acute bronchospasm and generalized urticaria and edema, preferentially periorbital, perioral or genital. More severe and complex reactions are called anaphyla ...
... and minutes after oral drug uptake. Symptoms reach from simple local itch, local wheal-andflare reaction upon parenteral drug application, to acute bronchospasm and generalized urticaria and edema, preferentially periorbital, perioral or genital. More severe and complex reactions are called anaphyla ...
Integrated Analysis of MicroRNA, mRNA, and Protein Expression
... observed may be due to the differences in cell population between the 4μm MultiOmyx section and the 10μm NanoString section, posttranscriptional regulation, and sample heterogeneity. • Cluster analysis of the mRNA nCounter results revealed two main clusters. Low expression cluster, expressing OX40, ...
... observed may be due to the differences in cell population between the 4μm MultiOmyx section and the 10μm NanoString section, posttranscriptional regulation, and sample heterogeneity. • Cluster analysis of the mRNA nCounter results revealed two main clusters. Low expression cluster, expressing OX40, ...
How to Interpret Hepatitis B Antibody and Viral Tests
... liver cells. When a lab test identifies the “e” antigen, it means the virus is actively replicating and the person usually has a large quantity of HBV-DNA in their bloodstream. Their blood and body fluids are usually more infectious, because of the high volume of virus, than someone who has develope ...
... liver cells. When a lab test identifies the “e” antigen, it means the virus is actively replicating and the person usually has a large quantity of HBV-DNA in their bloodstream. Their blood and body fluids are usually more infectious, because of the high volume of virus, than someone who has develope ...
Aalborg Universitet Molecular Pathogenesis of Spondyloarthritis Carlsen, Thomas Gelsing
... predominantly of the IgG3 subclass, antibodies against bacterial HSP60 are predominantly of the IgG1 subclass. Therefore, based on the ELISA results, crossreaction between bacterial and human HSP60 could not be supported as a pathogenic mechanism for SpA disease in our study. However, a weak correl ...
... predominantly of the IgG3 subclass, antibodies against bacterial HSP60 are predominantly of the IgG1 subclass. Therefore, based on the ELISA results, crossreaction between bacterial and human HSP60 could not be supported as a pathogenic mechanism for SpA disease in our study. However, a weak correl ...
Immunocontrol in dogs
... block fertilization primarily at the site of sperm–zona interaction. In reality, the underlying mechanism of immunocontraception is actually quite complex. Immunocontraception probably interferes with one or several mechanisms that cause a cascade of biochemical events leading to infertility. It has ...
... block fertilization primarily at the site of sperm–zona interaction. In reality, the underlying mechanism of immunocontraception is actually quite complex. Immunocontraception probably interferes with one or several mechanisms that cause a cascade of biochemical events leading to infertility. It has ...
Czytaj więcej - Instytut Mikroekologii
... immunoglobulins and secretory IgA production during the first weeks or months after birth (Allansmith et al. 1968, Gleeson et al. 1982). Studies in animals show that continuous acquisition of new bacterial strains in the microflora are required to keep the immune system in an activated state (Schro ...
... immunoglobulins and secretory IgA production during the first weeks or months after birth (Allansmith et al. 1968, Gleeson et al. 1982). Studies in animals show that continuous acquisition of new bacterial strains in the microflora are required to keep the immune system in an activated state (Schro ...
Evolution and Human Health - NAU jan.ucc.nau.edu web server
... – Selection to reproduce rapidly within individual hosts in order to avoid or overcome host defenses – Selection for transmission between host individuals Under this view, within-host selection is stronger and virulence does not enhance transmission to new host individuals Poliovirus normally infect ...
... – Selection to reproduce rapidly within individual hosts in order to avoid or overcome host defenses – Selection for transmission between host individuals Under this view, within-host selection is stronger and virulence does not enhance transmission to new host individuals Poliovirus normally infect ...
Cardiovascular System_Lecture IV - Medical
... the endothelial blood vessel lining is damaged), thrombin (primarily through PAR-1), ADP, with receptors expressed on white blood cells or the endothelial cells of the blood vessels, among other activators. Once activated, they release a number of different coagulation factors and platelet activatin ...
... the endothelial blood vessel lining is damaged), thrombin (primarily through PAR-1), ADP, with receptors expressed on white blood cells or the endothelial cells of the blood vessels, among other activators. Once activated, they release a number of different coagulation factors and platelet activatin ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.