BLOOD
... • Antibodies are plasma proteins that bind to specific antigens to inhibit or destroy them. • People do not produce antibodies for the antigen on their red blood cell surface. If they did, the antibodies would attach to the antigens and cause the blood to clump. This clumping is called agglutination ...
... • Antibodies are plasma proteins that bind to specific antigens to inhibit or destroy them. • People do not produce antibodies for the antigen on their red blood cell surface. If they did, the antibodies would attach to the antigens and cause the blood to clump. This clumping is called agglutination ...
Solid Organ Transplantation
... Immunosuppression: In addition to drugs, polyclonal sera are prepared by immunization of animals with human lymphocytes to produce anti-lymphocyte serum (ALS). ALS is used to treat the incidence of rejection or as induction therapy shortly after transplantation (Thymoglobulin). Furthermore, murine m ...
... Immunosuppression: In addition to drugs, polyclonal sera are prepared by immunization of animals with human lymphocytes to produce anti-lymphocyte serum (ALS). ALS is used to treat the incidence of rejection or as induction therapy shortly after transplantation (Thymoglobulin). Furthermore, murine m ...
Resistance is futile … The Immune System and HIV
... The HIV virus is enclosed by multiple layers Capsid the outer protein coat made of the protein p24 The level of p24 protein is an indicator of the amount of HIV virus in the blood ...
... The HIV virus is enclosed by multiple layers Capsid the outer protein coat made of the protein p24 The level of p24 protein is an indicator of the amount of HIV virus in the blood ...
Neurons, Synapses, & Signaling
... Antibodies do not kill pathogens; instead they mark pathogens for destruction In neutralization, antibodies bind to viral surface proteins preventing infection of a host cell Antibodies may also bind to toxins in body fluids and prevent them from entering body cells ...
... Antibodies do not kill pathogens; instead they mark pathogens for destruction In neutralization, antibodies bind to viral surface proteins preventing infection of a host cell Antibodies may also bind to toxins in body fluids and prevent them from entering body cells ...
Course 19
... In the end, the immune defenses are overwhelmed, and the resulting profound state of immunosuppression leaves the patient open to unchecked infections by pathogens that normally would not be the slightest problem for a person with an intact immune system. Sadly, these "opportunistic" infections can ...
... In the end, the immune defenses are overwhelmed, and the resulting profound state of immunosuppression leaves the patient open to unchecked infections by pathogens that normally would not be the slightest problem for a person with an intact immune system. Sadly, these "opportunistic" infections can ...
J.P. Morgan Healthcare Conference 2017
... This presentation and the accompanying oral presentation contain forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. All statements other than statements of historical facts contained in this presentation, including statemen ...
... This presentation and the accompanying oral presentation contain forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. All statements other than statements of historical facts contained in this presentation, including statemen ...
Document
... • Several ducts into the prostatic urethra • Surrounded by smooth muscle • Secretions • Citrate • Enzymes (fibrinolysin, hyaluronidase, acid phosphatase) • Prostate specific antigen (PSA) • activate sperm ...
... • Several ducts into the prostatic urethra • Surrounded by smooth muscle • Secretions • Citrate • Enzymes (fibrinolysin, hyaluronidase, acid phosphatase) • Prostate specific antigen (PSA) • activate sperm ...
The Interferons
... Increased major histocompatibility complex (MHC) antigen expression, leading to enhanced activation of lymphocytes via antigen presentation ...
... Increased major histocompatibility complex (MHC) antigen expression, leading to enhanced activation of lymphocytes via antigen presentation ...
An infectious disease
... Possible environmental reservoirs include contaminated water sources. The source of H.pylori is not yet known. ...
... Possible environmental reservoirs include contaminated water sources. The source of H.pylori is not yet known. ...
- Zaharoff Laboratory
... are Food and Drug Administration approved for the treatment of chronic hepatitis B and C, AIDS-related Kaposi’s sarcoma, malignant melanoma, follicular lymphoma, chronic myeloid leukemia, and hairy cell leukemia. Although initially identified for their antiviral properties (8), the type I IFNs are p ...
... are Food and Drug Administration approved for the treatment of chronic hepatitis B and C, AIDS-related Kaposi’s sarcoma, malignant melanoma, follicular lymphoma, chronic myeloid leukemia, and hairy cell leukemia. Although initially identified for their antiviral properties (8), the type I IFNs are p ...
Protocol
... best characterized inflammasome contains the NLR protein NLRP3, the adaptor protein ASC, and the cysteine protease caspase-1. Activation of this complex leads to the processing and the release of the pro-inflammatory cytokine IL-1β in order to initiate and propagate the inflammatory response. NLRP3 ...
... best characterized inflammasome contains the NLR protein NLRP3, the adaptor protein ASC, and the cysteine protease caspase-1. Activation of this complex leads to the processing and the release of the pro-inflammatory cytokine IL-1β in order to initiate and propagate the inflammatory response. NLRP3 ...
chapter 6
... interaction between cancer cells (uninfected cancer cells and infected cancer cells) with ratio dependent functional response between them. We consider a more realistic type of functional response involving measure of immune response to suppress interaction among oncolytic virus and cancer cells. Fu ...
... interaction between cancer cells (uninfected cancer cells and infected cancer cells) with ratio dependent functional response between them. We consider a more realistic type of functional response involving measure of immune response to suppress interaction among oncolytic virus and cancer cells. Fu ...
The Immune System in Occupational Disease
... components to the cytosol by an unknown mechanism. The released contents and molecules generated during this process contribute to NLRP3/ASC/caspase-1 inflammasome activation, which in turn processes the proforms of IL-1 family members to active forms. Either IL-1 family member cytokines or the prod ...
... components to the cytosol by an unknown mechanism. The released contents and molecules generated during this process contribute to NLRP3/ASC/caspase-1 inflammasome activation, which in turn processes the proforms of IL-1 family members to active forms. Either IL-1 family member cytokines or the prod ...
How do Immunologists Study Disease?
... Years later that “particle” was determined to be a retrovirus and was named in her honor – Friend Virus. The virus was not named for its qualities as was HIV, Human Immunodefiency Virus, the cause of AIDS. Friend virus causes disease much the way its close relative HIV does only FV has a different v ...
... Years later that “particle” was determined to be a retrovirus and was named in her honor – Friend Virus. The virus was not named for its qualities as was HIV, Human Immunodefiency Virus, the cause of AIDS. Friend virus causes disease much the way its close relative HIV does only FV has a different v ...
causes of cell injury
... Cell Recognition: membrane antigens allow the body to recognize its own cells and tolerate them; other cells are attacked by the immune system. Receptor Function: compounds that interact with the cell such as chemical mediators, hormones and drugs do so at specific points called receptors. Cell Adhe ...
... Cell Recognition: membrane antigens allow the body to recognize its own cells and tolerate them; other cells are attacked by the immune system. Receptor Function: compounds that interact with the cell such as chemical mediators, hormones and drugs do so at specific points called receptors. Cell Adhe ...
Autograft Monocytes: The Bad Humors of Autologous Peripheral
... IL-6 and IL-10 has been positively correlated with the CD14+ HLADR low/neg cells [25]. Specifically in APHSCT, two immunosuppressive cytokine produced by MDSCs/TAM had been identified from the autograft absolute monocyte count (A-AMC) collected during stem cell collection: IL-10 and TNF-α. Singh et ...
... IL-6 and IL-10 has been positively correlated with the CD14+ HLADR low/neg cells [25]. Specifically in APHSCT, two immunosuppressive cytokine produced by MDSCs/TAM had been identified from the autograft absolute monocyte count (A-AMC) collected during stem cell collection: IL-10 and TNF-α. Singh et ...
enref_20 - LWW.com
... despite the data showing efficacy of human MSCs in treating inflammation in mice; many investigators have questioned the rationale of using human cells in immunocompetent mice (12). In the following section, we will briefly provide the advantages and disadvantages of modeling human vs mice MSCs in ...
... despite the data showing efficacy of human MSCs in treating inflammation in mice; many investigators have questioned the rationale of using human cells in immunocompetent mice (12). In the following section, we will briefly provide the advantages and disadvantages of modeling human vs mice MSCs in ...
Document
... Chemokines are a family of chemotactic cytokines that orchestrate the immune response, ranging from homing of immune cells to areas of inflammation to activation of immune cells. The family is divided into four subfamilies based on their molecular structure and chemokines activate G-protein coupled ...
... Chemokines are a family of chemotactic cytokines that orchestrate the immune response, ranging from homing of immune cells to areas of inflammation to activation of immune cells. The family is divided into four subfamilies based on their molecular structure and chemokines activate G-protein coupled ...
The role of autoantibodies in health and disease
... considers that clearance of dying cells is one of the most important responsibilities of the immune system, which is required to prevent uncontrolled inflammation and autoimmunity. The authors shown that IgM-NAA recognizes apoptotic cells, enhance phagocytic clearance of dying cells and suppress inn ...
... considers that clearance of dying cells is one of the most important responsibilities of the immune system, which is required to prevent uncontrolled inflammation and autoimmunity. The authors shown that IgM-NAA recognizes apoptotic cells, enhance phagocytic clearance of dying cells and suppress inn ...
Division in Response to Rechallenge Cutting Edge: Asymmetric
... Abbreviations used in this article: LCMV, lymphocytic choriomeningitis virus; LCMVarm, lymphocytic choriomeningitis virus Armstrong; LMgp33, Listeria monocytogenes expressing gp33–41; MTOC, microtubule-organizing center; p.i., postinfection; PKC-z, protein kinase C-z; WT, wild-type. Copyright Ó 2012 ...
... Abbreviations used in this article: LCMV, lymphocytic choriomeningitis virus; LCMVarm, lymphocytic choriomeningitis virus Armstrong; LMgp33, Listeria monocytogenes expressing gp33–41; MTOC, microtubule-organizing center; p.i., postinfection; PKC-z, protein kinase C-z; WT, wild-type. Copyright Ó 2012 ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.