Immune Response and Interventions
... specific pathogens studied in the programme “Infection Research”; (3) development of strategies to strengthen effector T cells and T cell-dependent B cell responses or to modulate Tregs. Research aim 2: Unravel the immune evasion mechanisms operative during infection Pathogens have developed various ...
... specific pathogens studied in the programme “Infection Research”; (3) development of strategies to strengthen effector T cells and T cell-dependent B cell responses or to modulate Tregs. Research aim 2: Unravel the immune evasion mechanisms operative during infection Pathogens have developed various ...
Acquired Immunodeficiency Syndrome: AIDS
... opportunistic agents, such as Pneumocystis carinii, which causes PCP or P. carinii pneumonia, as well as other rare opportunistic infections. Opportunistic agents are microorganisms that healthy individuals can harbor with no ill consequences but that cause disease in those with impaired immune func ...
... opportunistic agents, such as Pneumocystis carinii, which causes PCP or P. carinii pneumonia, as well as other rare opportunistic infections. Opportunistic agents are microorganisms that healthy individuals can harbor with no ill consequences but that cause disease in those with impaired immune func ...
What`s in your DNA?
... (CLIA) of 1988 as qualified to perform high complexity clinical testing. The New York Blood Center has been approved by the New York State Department of Health to perform these tests under its current Clinical Laboratory Permit. • These results are intended to predict a blood group antigen profile i ...
... (CLIA) of 1988 as qualified to perform high complexity clinical testing. The New York Blood Center has been approved by the New York State Department of Health to perform these tests under its current Clinical Laboratory Permit. • These results are intended to predict a blood group antigen profile i ...
Paracrine effects of TLR4-polarised mesenchymal stromal cells are
... In summary, Ti and colleagues show that LPS modulates the secretome of umbilical MSCs. he authors demonstrate that EVs secreted by LPS-treated MSCs are anti-inlammatory and immunomodulatory. hey further suggest that these efects are at least partly mediated by EV miRNA cargo. Finally, this study sug ...
... In summary, Ti and colleagues show that LPS modulates the secretome of umbilical MSCs. he authors demonstrate that EVs secreted by LPS-treated MSCs are anti-inlammatory and immunomodulatory. hey further suggest that these efects are at least partly mediated by EV miRNA cargo. Finally, this study sug ...
Adaptive Immunity from Prokaryotes to Eukaryotes
... immunity in plants. According to Luke and O’Neill (2011), “Every organism has to contend with the risk of infection. To cope, organisms have evolved two types of immune responses: the more recent “adaptive” system, found only in vertebrates; and the more ancient “innate” system, which is present in ...
... immunity in plants. According to Luke and O’Neill (2011), “Every organism has to contend with the risk of infection. To cope, organisms have evolved two types of immune responses: the more recent “adaptive” system, found only in vertebrates; and the more ancient “innate” system, which is present in ...
GRANULOMATOUS DISEASES
... Granulomatous inflammation is a distinctive pattern of chronic inflammation characterized by aggregates of activated macrophages that assume an Epithelioid appearance. Granulomas are encountered in certain specific pathologic states; consequently, recognition of the granulomatous pattern is importan ...
... Granulomatous inflammation is a distinctive pattern of chronic inflammation characterized by aggregates of activated macrophages that assume an Epithelioid appearance. Granulomas are encountered in certain specific pathologic states; consequently, recognition of the granulomatous pattern is importan ...
Enumeration of autoreactive helper T lymphocytes in uveitis.
... patients had active disease and were assayed within several weeks of establishing a diagnosis. Figure 2 shows a representative tetanus and S-antigen limiting-dilution analysis for a patient (22) with VK.H disease. In this example, the S-antigen-specific response was observed with a frequency of 42 h ...
... patients had active disease and were assayed within several weeks of establishing a diagnosis. Figure 2 shows a representative tetanus and S-antigen limiting-dilution analysis for a patient (22) with VK.H disease. In this example, the S-antigen-specific response was observed with a frequency of 42 h ...
B Lymphocytes in Cancer Immunology
... and PDL2: CD273) [14]. In addition, some human B cells stimulated by IL-21 together with TLR or BCR agonists express granzyme B [30] and may thereby kill through perforin-mediated mechanisms typically associated with cytotoxic CD8+ T cells or NK cells [31]. ...
... and PDL2: CD273) [14]. In addition, some human B cells stimulated by IL-21 together with TLR or BCR agonists express granzyme B [30] and may thereby kill through perforin-mediated mechanisms typically associated with cytotoxic CD8+ T cells or NK cells [31]. ...
30-01-12 ALLERGY: • GALECTIN-9: A SUPPRESSOR OF FOOD
... Although DCs are the key APCs for the initiation of CD4+ T cell activation, B cells are required for subsequent activation and memory generation. ...
... Although DCs are the key APCs for the initiation of CD4+ T cell activation, B cells are required for subsequent activation and memory generation. ...
PDF file - Robinson Lab
... even when the donor was seropositive unless viral infection erupted [41]. Deliberate vaccination of donors pretransplant with a protein recall antigen, such as tetanus toxoid [42], or neoantigen KLH [43], could demonstrate adoptive B cell transfer but antibody development still required recipient re ...
... even when the donor was seropositive unless viral infection erupted [41]. Deliberate vaccination of donors pretransplant with a protein recall antigen, such as tetanus toxoid [42], or neoantigen KLH [43], could demonstrate adoptive B cell transfer but antibody development still required recipient re ...
Novocastra™ Liquid Mouse Monoclonal Antibody Thyroid
... The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient’s clinical history and other diagnostic tests by a qualified pathologist. Antibodies from Leica Biosystems Newcas ...
... The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient’s clinical history and other diagnostic tests by a qualified pathologist. Antibodies from Leica Biosystems Newcas ...
Immunology of HIV - Infectious Diseases
... • IgG response is ubiquitous - basis of diagnosis • Most people do make neutralizing Abs against their own virus • BUT only work against the virus that was there a few months ago - not the one that is there today • Failure of infused “cocktail” to impact infection for more than a few days ...
... • IgG response is ubiquitous - basis of diagnosis • Most people do make neutralizing Abs against their own virus • BUT only work against the virus that was there a few months ago - not the one that is there today • Failure of infused “cocktail” to impact infection for more than a few days ...
HIV & AIDS
... HIV-RNA is reverse transcribed The product DNA is integrated into the host genome ...
... HIV-RNA is reverse transcribed The product DNA is integrated into the host genome ...
Self Antigens Expressed by Solid Tumors Do Not Efficiently
... of splenic mononuclear cells). These CTLs are responsible for rapid virus elimination occurring within z10 d and give rise to a long-term protective CTL memory (25–27). This strong CTL response was well suited for an in vivo model of tumor immunotherapy. The two transgenic lines were crossed to obta ...
... of splenic mononuclear cells). These CTLs are responsible for rapid virus elimination occurring within z10 d and give rise to a long-term protective CTL memory (25–27). This strong CTL response was well suited for an in vivo model of tumor immunotherapy. The two transgenic lines were crossed to obta ...
Virus interactions with endocytic pathways in macrophages and
... highly active endocytic processes [for reviews, see for example 7, 12]. This allows them to not only engulf and digest invading pathogens, but also present the products on their cell surface to T lymphocytes using major histocompatibility complex (MHC) molecules [reviewed in 11, 13]. T cells themsel ...
... highly active endocytic processes [for reviews, see for example 7, 12]. This allows them to not only engulf and digest invading pathogens, but also present the products on their cell surface to T lymphocytes using major histocompatibility complex (MHC) molecules [reviewed in 11, 13]. T cells themsel ...
35-2 Defense Against Infection PowerPoint
... Although cytotoxic T cells are helpful in the immune system, they make the acceptance of organ transplants difficult. When an organ is transplanted from one person to another, the normal response of the recipient’s immune system would be to recognize it as nonself. T cells and proteins would damage ...
... Although cytotoxic T cells are helpful in the immune system, they make the acceptance of organ transplants difficult. When an organ is transplanted from one person to another, the normal response of the recipient’s immune system would be to recognize it as nonself. T cells and proteins would damage ...
Slide 1
... Widespread flu-like illness is expected over the next several months, with H1N1 flu intermingling with seasonal (“regular”) flu during 2009-10. Based on current information from health officials, H1N1-specific testing will not be routinely available, so it is unlikely that health professionals will ...
... Widespread flu-like illness is expected over the next several months, with H1N1 flu intermingling with seasonal (“regular”) flu during 2009-10. Based on current information from health officials, H1N1-specific testing will not be routinely available, so it is unlikely that health professionals will ...
research presentation - University of Saskatchewan
... Dendritic cells (DC) are a family of professional antigen (Ag) presenting cells (APC), considered by many to be the central APC for induction of primary immune responses. Their abilities to process and present various types of antigens are unmatched in this context. The decision of whether or not en ...
... Dendritic cells (DC) are a family of professional antigen (Ag) presenting cells (APC), considered by many to be the central APC for induction of primary immune responses. Their abilities to process and present various types of antigens are unmatched in this context. The decision of whether or not en ...
The Lymphatic System
... Nonspecific responses block the entry and spread of disease-causing agents. ...
... Nonspecific responses block the entry and spread of disease-causing agents. ...
Crustacean hematopoiesis and the astakine cytokines.
... This cell type is rare in P. leniusculus but more common in marine crustaceans5, and so far, no molecular marker is available to identify this cell type. The number and proportion of different hemocyte types varies a great deal among crustaceans and is influenced by various environmental conditions6 ...
... This cell type is rare in P. leniusculus but more common in marine crustaceans5, and so far, no molecular marker is available to identify this cell type. The number and proportion of different hemocyte types varies a great deal among crustaceans and is influenced by various environmental conditions6 ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.