this PDF file
... In this study we used different secretions ( vaginal secretion ,tonsillar tissue ,cerebrospinal fluid and appendix tissue ) .These secretions were obtained from different patients. Standard SIgA was used to determine which of these secretion was SIgA .from the result the appendix was showed high tit ...
... In this study we used different secretions ( vaginal secretion ,tonsillar tissue ,cerebrospinal fluid and appendix tissue ) .These secretions were obtained from different patients. Standard SIgA was used to determine which of these secretion was SIgA .from the result the appendix was showed high tit ...
Module 1 - BluWiki
... Reasons for Emergence and Maintenance of Infectious Diseases o What are some reasons why infectious diseases may emerge? Zoonosis MAY cross into human population (zoonotic infections are those which can be spread from vertebrate animals to humans) For example: rabies, salmonella, leishmaniasis ...
... Reasons for Emergence and Maintenance of Infectious Diseases o What are some reasons why infectious diseases may emerge? Zoonosis MAY cross into human population (zoonotic infections are those which can be spread from vertebrate animals to humans) For example: rabies, salmonella, leishmaniasis ...
Get - Wiley Online Library
... immune responses mediated by CD8+ and CD4+ T cells and in superior antitumour effects in vivo in cancer-bearing mice. Objectives The Ag-specific immune responses caused by intradermal (i.d.) injections of R9-PTD-containing protein Ags without DC preparation were investigated. We also investigated th ...
... immune responses mediated by CD8+ and CD4+ T cells and in superior antitumour effects in vivo in cancer-bearing mice. Objectives The Ag-specific immune responses caused by intradermal (i.d.) injections of R9-PTD-containing protein Ags without DC preparation were investigated. We also investigated th ...
Review Article Infectious diseases and autoimmunity
... Methodology: We searched PubMed, Cochrane, and Scopus without time limits for relevant articles. Results: In this review, we (i) describe the ways in which an infectious agent can initiate or exacerbate autoimmunity; (ii) discuss the evidence linking certain infectious agents to autoimmune diseases ...
... Methodology: We searched PubMed, Cochrane, and Scopus without time limits for relevant articles. Results: In this review, we (i) describe the ways in which an infectious agent can initiate or exacerbate autoimmunity; (ii) discuss the evidence linking certain infectious agents to autoimmune diseases ...
2007 - Charlotte, NC
... G. Perdew. Non-classical Mechanisms of Receptor-Mediated Transcription L. Jameson, et al. Physiologic Roles of the Nonclassical Estrogen Receptor Alpha Signaling Pathway T. Beischlag, et al. Combinatorial Control of Gene Expression by Diverse Classes of Aromatic Hydrocarbons and Estrogenic Compounds ...
... G. Perdew. Non-classical Mechanisms of Receptor-Mediated Transcription L. Jameson, et al. Physiologic Roles of the Nonclassical Estrogen Receptor Alpha Signaling Pathway T. Beischlag, et al. Combinatorial Control of Gene Expression by Diverse Classes of Aromatic Hydrocarbons and Estrogenic Compounds ...
Chapter I Overview of Immunology
... (2) Humoral factors Complement Lysozyme Interferons(IFN) C-reactive protein ...
... (2) Humoral factors Complement Lysozyme Interferons(IFN) C-reactive protein ...
Integrin E(CD103)7 influences cellular shape and
... localization of DETCs.12 Expression of ␣E(CD103)7 has been described on some CD4⫹CD25⫹13,14 and CD8⫹15,16 regulatory T cells (Treg). In several experimental models ␣E(CD103)7 is involved in guiding tissue localization of lymphocyte subsets in inflammatory conditions and/or allograft rejection.14,1 ...
... localization of DETCs.12 Expression of ␣E(CD103)7 has been described on some CD4⫹CD25⫹13,14 and CD8⫹15,16 regulatory T cells (Treg). In several experimental models ␣E(CD103)7 is involved in guiding tissue localization of lymphocyte subsets in inflammatory conditions and/or allograft rejection.14,1 ...
Flow cytometric analysis of CD55 and CD59 expression on blood
... Detection of PNH-type cells. Five mililiters of peripheral blood was collected from antecubital vein to a tube with EDTA anticoagulant. One-hundred microliter blood samples were immunostained in tubes with the following two-color combinations of monoclonal antibodies (Becton Dickinson): isotype cont ...
... Detection of PNH-type cells. Five mililiters of peripheral blood was collected from antecubital vein to a tube with EDTA anticoagulant. One-hundred microliter blood samples were immunostained in tubes with the following two-color combinations of monoclonal antibodies (Becton Dickinson): isotype cont ...
doc Immunology Notes From Book
... Pathophysiology: Integration of medicine with physiology. Many disease states are also physiology gone wrong. It is important for pathologists to understand and know physiology to deal with disease. Cells: Simplest structural units into which a complex multicellular organism can be divided and still ...
... Pathophysiology: Integration of medicine with physiology. Many disease states are also physiology gone wrong. It is important for pathologists to understand and know physiology to deal with disease. Cells: Simplest structural units into which a complex multicellular organism can be divided and still ...
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... Autoimmune diseases are characterized by the production of autoantibodies specific for selfantigens by activated B cells. However, the precise mechanism for the pathogenesis of autoimmunity remains unknown. Intravenous immunoglobulin (IVIg), which is manufactured from the pooled plasma of more than ...
... Autoimmune diseases are characterized by the production of autoantibodies specific for selfantigens by activated B cells. However, the precise mechanism for the pathogenesis of autoimmunity remains unknown. Intravenous immunoglobulin (IVIg), which is manufactured from the pooled plasma of more than ...
Definition of a Conserved Immunodominant Domain on Hepatitis C
... (where much smaller quantities of virus were incubated with antibody) were comparable, with IC50 values in this assay ranging from 0.03 to 1.1 g/ml. This is remarkable, since these two assays measure the neutralization of amounts of the 2a HCVcc genotype that differ by many orders of magnitude and, ...
... (where much smaller quantities of virus were incubated with antibody) were comparable, with IC50 values in this assay ranging from 0.03 to 1.1 g/ml. This is remarkable, since these two assays measure the neutralization of amounts of the 2a HCVcc genotype that differ by many orders of magnitude and, ...
Regulatory T cells control tolerogenic versus autoimmune response
... before sperm antibodies were detectable. We obtained unexpected results germane to the mechanism of Treg function and immune sequelae of vasectomy. First, vasectomized mice develop sperm-specific systemic tolerance despite sperm antigen presentation from an inflamed epididymis. Second, Treg depletion ...
... before sperm antibodies were detectable. We obtained unexpected results germane to the mechanism of Treg function and immune sequelae of vasectomy. First, vasectomized mice develop sperm-specific systemic tolerance despite sperm antigen presentation from an inflamed epididymis. Second, Treg depletion ...
The Role of CD2 Family Members in NK-Cell Regulation of B
... (NTB-A, SLAMF6), CD84 (SLAMF5), CRACC (CS1, SLAMF7), Ly9 (CD229), 2B4 (CD244), and CD48 [49]. The Sle1b cluster was introduced to a C57BL/6 background [50] in order to analyze its effects in a strain that does not exhibit autoimmunity. Interestingly, the presence of this interval alone was found to ...
... (NTB-A, SLAMF6), CD84 (SLAMF5), CRACC (CS1, SLAMF7), Ly9 (CD229), 2B4 (CD244), and CD48 [49]. The Sle1b cluster was introduced to a C57BL/6 background [50] in order to analyze its effects in a strain that does not exhibit autoimmunity. Interestingly, the presence of this interval alone was found to ...
Cytokines that Mediate and Regulate Immune Responses
... leukocytes that regulate a number of physiological and pathological functions including innate immunity, acquired immunity and a plethora of inflammatory responses. During the effector phases of natural and acquired immune responses, cytokines are produced from various sources such as immune and inf ...
... leukocytes that regulate a number of physiological and pathological functions including innate immunity, acquired immunity and a plethora of inflammatory responses. During the effector phases of natural and acquired immune responses, cytokines are produced from various sources such as immune and inf ...
The Role of CD2 Family Members in NK-Cell Regulation of B
... (NTB-A, SLAMF6), CD84 (SLAMF5), CRACC (CS1, SLAMF7), Ly9 (CD229), 2B4 (CD244), and CD48 [49]. The Sle1b cluster was introduced to a C57BL/6 background [50] in order to analyze its effects in a strain that does not exhibit autoimmunity. Interestingly, the presence of this interval alone was found to ...
... (NTB-A, SLAMF6), CD84 (SLAMF5), CRACC (CS1, SLAMF7), Ly9 (CD229), 2B4 (CD244), and CD48 [49]. The Sle1b cluster was introduced to a C57BL/6 background [50] in order to analyze its effects in a strain that does not exhibit autoimmunity. Interestingly, the presence of this interval alone was found to ...
The structural network of inflammation and cancer: Merits and
... help forecast the global effects on the cell [3–6]; and they can help in selecting drug targets which are not the direct ‘ailing’ dysfunctional protein [7,8]. Such drugs exploit conformational ensembles [9,10]; they may also make use of network dynamics [11]. Constructing the structural network of m ...
... help forecast the global effects on the cell [3–6]; and they can help in selecting drug targets which are not the direct ‘ailing’ dysfunctional protein [7,8]. Such drugs exploit conformational ensembles [9,10]; they may also make use of network dynamics [11]. Constructing the structural network of m ...
Chapter 7 Unimpaired immune functions in the absence of Mrp4 (Abcc4)
... was abundantly present within FVBwt skin, only few Mrp4 expressing cells were detected. In addition, no Mrp4 protein expression was detected on in vitro cultured FVBwt bone-marrow derived DC (BM-DC). DC migration from murine ear skin was unaltered between FVBwt and MRP4/5 dKO animals. The absence of ...
... was abundantly present within FVBwt skin, only few Mrp4 expressing cells were detected. In addition, no Mrp4 protein expression was detected on in vitro cultured FVBwt bone-marrow derived DC (BM-DC). DC migration from murine ear skin was unaltered between FVBwt and MRP4/5 dKO animals. The absence of ...
Host manipulation by cancer cells
... It is now well established that cancer development and progression represent an evolutionary process as Darwinian selection drives cancer cells along evolutionary landscapes, culminating in resistance to immune attack, malignant progression, metastasis [1], and even sometimes contagion (Box 1). For ...
... It is now well established that cancer development and progression represent an evolutionary process as Darwinian selection drives cancer cells along evolutionary landscapes, culminating in resistance to immune attack, malignant progression, metastasis [1], and even sometimes contagion (Box 1). For ...
Modeling Diabetes - Joseph M. Mahaffy
... cell divisions, to create effector cells (also called cytotoxic T-lymphocytes or CTL’s), which seek out and destroy target cells, which protects the host from this foreign invader. These CTL’s can be dangerous in the body, so are short-lived. Alternately, the activated T cell can issue a weaker res ...
... cell divisions, to create effector cells (also called cytotoxic T-lymphocytes or CTL’s), which seek out and destroy target cells, which protects the host from this foreign invader. These CTL’s can be dangerous in the body, so are short-lived. Alternately, the activated T cell can issue a weaker res ...
Major Histocompatibility Complex Class I Deficiency
... would protect from NK cell cytotoxicity Increased NK cell activity lead to auto-toxicity and tissue destruction ...
... would protect from NK cell cytotoxicity Increased NK cell activity lead to auto-toxicity and tissue destruction ...
Gene Therapy for Ovarian Cancer
... phase. This provides a mechanism for tumor selectivity. Great enthusiasm was generated by studies indicating the existence of "bystander" amplification mechanisms that cause cell death in nontransfected nearby cells.[24] Initial studies, in fact, indicated that it was enough to transfect 5% to 15% o ...
... phase. This provides a mechanism for tumor selectivity. Great enthusiasm was generated by studies indicating the existence of "bystander" amplification mechanisms that cause cell death in nontransfected nearby cells.[24] Initial studies, in fact, indicated that it was enough to transfect 5% to 15% o ...
- European Medical Journal
... therapy could have a beneficial effect during acute and non-acute asthma. The IgE reducing effect of OM-85 has been reported in human subjects and in animal models.27,28,33-35 Currently, the molecular mechanism by which OM-85 achieves a reduction in serum IgE remains speculative and needs further in ...
... therapy could have a beneficial effect during acute and non-acute asthma. The IgE reducing effect of OM-85 has been reported in human subjects and in animal models.27,28,33-35 Currently, the molecular mechanism by which OM-85 achieves a reduction in serum IgE remains speculative and needs further in ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.