PHS 398 (Rev. 9/04), Biographical Sketch Format Page
... von Herrath, M., B. Coon, D. Homann, T. Wolfe, L.G. Guidotti. Thymic tolerance to only one viral protein reduces lymphocytic choriomeningits virus-induced immunopathology and increases survival in perforindeficient mice. J. Virol. 73:5918-5925(1999) Homann, D., T. Dyrberg, J. Petersen, M.B.A. Oldsto ...
... von Herrath, M., B. Coon, D. Homann, T. Wolfe, L.G. Guidotti. Thymic tolerance to only one viral protein reduces lymphocytic choriomeningits virus-induced immunopathology and increases survival in perforindeficient mice. J. Virol. 73:5918-5925(1999) Homann, D., T. Dyrberg, J. Petersen, M.B.A. Oldsto ...
Understanding Autoimmune Disease – a review article for the layman
... Both T and B cells are derived from stem cells within the bone marrow. Immature T lymphocytes travel from the bone marrow to the thymus where they grow into mature T lymphocytes. This development includes proliferation, rearrangement of TCR genes and acquisition of the surface receptors and accessor ...
... Both T and B cells are derived from stem cells within the bone marrow. Immature T lymphocytes travel from the bone marrow to the thymus where they grow into mature T lymphocytes. This development includes proliferation, rearrangement of TCR genes and acquisition of the surface receptors and accessor ...
- Journal of Allergy and Clinical Immunology
... cytokines during immune-inflammatory processes. Chemokines are produced by a variety of cells, including stromal cells, epithelial cells, and all immune cells. These molecules are known to have functions other than chemotaxis, including regulation of inflammation, cellular proliferation, mucus produ ...
... cytokines during immune-inflammatory processes. Chemokines are produced by a variety of cells, including stromal cells, epithelial cells, and all immune cells. These molecules are known to have functions other than chemotaxis, including regulation of inflammation, cellular proliferation, mucus produ ...
Molecular and functional characterization of the immunoreceptors CD300d and CD300f
... Formerly, it was though that innate immunity recognized infective microbial in a nonspecifically manner; however, in the mid-1990s it was proved the existence of specific receptors that have evolved to detect components of foreign pathogens. Those receptors were called pattern recognition receptors ...
... Formerly, it was though that innate immunity recognized infective microbial in a nonspecifically manner; however, in the mid-1990s it was proved the existence of specific receptors that have evolved to detect components of foreign pathogens. Those receptors were called pattern recognition receptors ...
The Blood-Brain Barrier in NeuroAIDS
... Keywords: Blood-brain barrier, transporter, virus, HIV-1, AIDS, cytokine. INTRODUCTION The blood-brain barrier (BBB) is more than just a barrier which separates the central nervous system (CNS) from the blood. It is also a regulatory interface through which nutrients, xenobiotics, cytokines, immune ...
... Keywords: Blood-brain barrier, transporter, virus, HIV-1, AIDS, cytokine. INTRODUCTION The blood-brain barrier (BBB) is more than just a barrier which separates the central nervous system (CNS) from the blood. It is also a regulatory interface through which nutrients, xenobiotics, cytokines, immune ...
The Adaptive Immune System
... to T cells in peripheral lymphoid organs. In most cases, they recognize and phagocytose invading microbes or their products or fragments of infected cells at a site of infection and then migrate with their prey to a nearby lymph node; in other cases, they pick up microbes or their products directly ...
... to T cells in peripheral lymphoid organs. In most cases, they recognize and phagocytose invading microbes or their products or fragments of infected cells at a site of infection and then migrate with their prey to a nearby lymph node; in other cases, they pick up microbes or their products directly ...
as Adobe PDF - Edinburgh Research Explorer
... human body uses to distinguish between “self” and “non-self”. Foreign glycan patterns present on transplanted tissues, invading organisms, but also own diseased cells are recognized by soluble and cell membrane glycan receptors that activate innate immune response mechanisms. Given the fact that gly ...
... human body uses to distinguish between “self” and “non-self”. Foreign glycan patterns present on transplanted tissues, invading organisms, but also own diseased cells are recognized by soluble and cell membrane glycan receptors that activate innate immune response mechanisms. Given the fact that gly ...
Tissue specific HPV expression and downregulation of local
... CD4, CD8, CD16, CD1a, HLA-DR, and HLA-B7 mRNA levels in the tissues. DiVerentiation was determined by measuring involucrin, keratinocyte transglutaminase, as well as cytokeratins 10, 16, and 17. Proliferation markers such as PCNA and c-myc were also determined. Results: The transcription pattern of ...
... CD4, CD8, CD16, CD1a, HLA-DR, and HLA-B7 mRNA levels in the tissues. DiVerentiation was determined by measuring involucrin, keratinocyte transglutaminase, as well as cytokeratins 10, 16, and 17. Proliferation markers such as PCNA and c-myc were also determined. Results: The transcription pattern of ...
Supplement to Supplement to Rheumatology News
... a CTLA-4 fusion protein, was approved in 2005 for the treatment of RA, as this agent mediates interruption of T-cell stimulation during the pathogenesis of this autoimmune disease.5 Activated T cells proliferate and secrete other cytokines that induce further proliferation. When cytokines, such as T ...
... a CTLA-4 fusion protein, was approved in 2005 for the treatment of RA, as this agent mediates interruption of T-cell stimulation during the pathogenesis of this autoimmune disease.5 Activated T cells proliferate and secrete other cytokines that induce further proliferation. When cytokines, such as T ...
New Generation Vaccine Adjuvants
... Signal 0 – activation of the innate immune response Adjuvants contribute directly to all of these signals, but different adjuvants do this in different ways. Some adjuvants can be better defined as ‘delivery systems’, since they are particulate carriers to which antigens can be associated, to stabilize ...
... Signal 0 – activation of the innate immune response Adjuvants contribute directly to all of these signals, but different adjuvants do this in different ways. Some adjuvants can be better defined as ‘delivery systems’, since they are particulate carriers to which antigens can be associated, to stabilize ...
Growth Hormone Deficiency in Fungal Exposure
... Liiv, 2007). By age of 30 years, almost all patients with APECED produce pituitary autoantibodies and develop one or more major endocrine problems such as GHD, type 1 diabetes, hypothyroidism, hypoparathyroidism, adrenal failure, testicular failure, and ovarian failure (O’Dwyer et al., 2007; Liiv, 2 ...
... Liiv, 2007). By age of 30 years, almost all patients with APECED produce pituitary autoantibodies and develop one or more major endocrine problems such as GHD, type 1 diabetes, hypothyroidism, hypoparathyroidism, adrenal failure, testicular failure, and ovarian failure (O’Dwyer et al., 2007; Liiv, 2 ...
09-ACUTE INFLAMMATION.morphology, pptx
... complexes from the circulation. Deficiencies of the late components of the classical complement pathway (C5-C8) result in recurrent infections by Neisseria (gonococci, meningococci) but not by other microbes. ...
... complexes from the circulation. Deficiencies of the late components of the classical complement pathway (C5-C8) result in recurrent infections by Neisseria (gonococci, meningococci) but not by other microbes. ...
The role of lymph node sinus macrophages in host defense
... shown to directly target B cells to enhance humoral immune responses upon subsequent antigen challenge.46 These off-target effects should be taken into account when interpreting experimental results that make use of bisphosphonate-based preparations to study macrophage function. An alternative appro ...
... shown to directly target B cells to enhance humoral immune responses upon subsequent antigen challenge.46 These off-target effects should be taken into account when interpreting experimental results that make use of bisphosphonate-based preparations to study macrophage function. An alternative appro ...
Restoring the Balance of the Autonomic Nervous System as an
... on immune cells, is adaptive to environmental needs. In addition, immune function is regulated by peptide neurotransmitters that colocalize with NE, such as neuropeptide Y and adenosine triphosphate (ATP), as well, but their exact contribution to immune regulation remains to be unraveled (12). The r ...
... on immune cells, is adaptive to environmental needs. In addition, immune function is regulated by peptide neurotransmitters that colocalize with NE, such as neuropeptide Y and adenosine triphosphate (ATP), as well, but their exact contribution to immune regulation remains to be unraveled (12). The r ...
Red blood cells
... Exposure to fetal red blood cell antigens generally occurs during delivery, when bleeding takes place at the placenta and uterus. Such mixing of fetal and maternal blood can stimulate the mother’s immune system to produce anti-Rh antibodies, leading to ...
... Exposure to fetal red blood cell antigens generally occurs during delivery, when bleeding takes place at the placenta and uterus. Such mixing of fetal and maternal blood can stimulate the mother’s immune system to produce anti-Rh antibodies, leading to ...
CARBON NANOTUBES AS CARRIERS FOR DELIVERY OF BIOACTIVE AND THERAPEUTIC AGENTS: AN OVERVIEW Review Article
... some organic groups to the sidewalls and/or tips of the CNTs. Briefly, purified SWNTs and aniline are mixed together. Under the pressure from the mixing force, the outermost nanotubes from the bundle is librated and is exposed to the reactive agent. Thus, th ...
... some organic groups to the sidewalls and/or tips of the CNTs. Briefly, purified SWNTs and aniline are mixed together. Under the pressure from the mixing force, the outermost nanotubes from the bundle is librated and is exposed to the reactive agent. Thus, th ...
Cancer Immunotherapy - Society for Immunotherapy of Cancer
... Disclaimer: Information presented in Patient Resource Cancer Guide: Understanding Cancer Immunotherapy is not intended as a substitute for the advice given by your health care provider. The opinions expressed in Patient Resource Cancer Guide: Understanding Cancer Immunotherapy are those of the autho ...
... Disclaimer: Information presented in Patient Resource Cancer Guide: Understanding Cancer Immunotherapy is not intended as a substitute for the advice given by your health care provider. The opinions expressed in Patient Resource Cancer Guide: Understanding Cancer Immunotherapy are those of the autho ...
Licentiate thesis from the Department of Immunology,
... molecules can distinguish between invading pathogens and the body’s own cells. Traditionally, the immune responses raised to an invading pathogen are divided into innate immune responses and adaptive immune responses. The adaptive immunity is mediated by clonally distributed B and T cells and it exh ...
... molecules can distinguish between invading pathogens and the body’s own cells. Traditionally, the immune responses raised to an invading pathogen are divided into innate immune responses and adaptive immune responses. The adaptive immunity is mediated by clonally distributed B and T cells and it exh ...
Apoptotic Debris Accumulates on Hematopoietic Cells and
... (26). This indicates that activation of the immune system through FcgRs on hematopoietic cells, rather than the deposits of IgG-IC in the kidney, is important in lupus nephritis. Studies also show that IgG-ICs promote autoantibody secretion in a TLR-dependent manner, and they contribute to immune re ...
... (26). This indicates that activation of the immune system through FcgRs on hematopoietic cells, rather than the deposits of IgG-IC in the kidney, is important in lupus nephritis. Studies also show that IgG-ICs promote autoantibody secretion in a TLR-dependent manner, and they contribute to immune re ...
Chapter 2
... Upon cutaneous injury the wound healing process is initiated and starts with the formation of a blood clot (mainly consisting of fibrin, fibronectin and platelets) to prevent excessive blood loss. Cytokines and growth factors are released by platelets and injured skin resident cells in order to attr ...
... Upon cutaneous injury the wound healing process is initiated and starts with the formation of a blood clot (mainly consisting of fibrin, fibronectin and platelets) to prevent excessive blood loss. Cytokines and growth factors are released by platelets and injured skin resident cells in order to attr ...
Immuno-oncology: a policy action framework
... Balancing the need for increasing safety data and access to innovation Increasing regulatory requirements, particularly for safety data, may also result in delaying, or restricting, patients’ access to potentially beneficial innovations.21 As a result, patients, researchers and industry have called ...
... Balancing the need for increasing safety data and access to innovation Increasing regulatory requirements, particularly for safety data, may also result in delaying, or restricting, patients’ access to potentially beneficial innovations.21 As a result, patients, researchers and industry have called ...