Endothelial Nitric Oxide Synthase - Arteriosclerosis, Thrombosis
... Another consequence of this hypothesis is that the eNOS enzyme should have a Janus face, which allows the enzyme to switch from the coupled to the uncoupled mode when it encounters infectious agents—from cardiovascular homeostasis to host defense. Indeed, activation and endothelial deposition of the ...
... Another consequence of this hypothesis is that the eNOS enzyme should have a Janus face, which allows the enzyme to switch from the coupled to the uncoupled mode when it encounters infectious agents—from cardiovascular homeostasis to host defense. Indeed, activation and endothelial deposition of the ...
Slide
... MHC class I in human is called HLA I (Human Leukocyte Antigen) (in mouse H-2). Every normal (heterozygous) human expresses six different MHC class I molecules on every cell, containing α-chains derived from the two alleles of HLA-A, HLA-B, HLA-C genes that inherited from the parents. MHC genes are t ...
... MHC class I in human is called HLA I (Human Leukocyte Antigen) (in mouse H-2). Every normal (heterozygous) human expresses six different MHC class I molecules on every cell, containing α-chains derived from the two alleles of HLA-A, HLA-B, HLA-C genes that inherited from the parents. MHC genes are t ...
Antibody Conjugates with Unnatural Amino Acids
... cell. For example, the Methanococcus jannaschii tRNATyr/TyrRS pair has been engineered to recognize several different uAAs in Escherichia coli.37−39 Thus, the genetic requirements for producing a recombinant protein in a host cell are genes for (i) an engineered tRNA, (ii) an engineered tRNA syntheta ...
... cell. For example, the Methanococcus jannaschii tRNATyr/TyrRS pair has been engineered to recognize several different uAAs in Escherichia coli.37−39 Thus, the genetic requirements for producing a recombinant protein in a host cell are genes for (i) an engineered tRNA, (ii) an engineered tRNA syntheta ...
Immuno-oncology: a policy action framework
... Balancing the need for increasing safety data and access to innovation Increasing regulatory requirements, particularly for safety data, may also result in delaying, or restricting, patients’ access to potentially beneficial innovations.21 As a result, patients, researchers and industry have called ...
... Balancing the need for increasing safety data and access to innovation Increasing regulatory requirements, particularly for safety data, may also result in delaying, or restricting, patients’ access to potentially beneficial innovations.21 As a result, patients, researchers and industry have called ...
study of the human humoral immune response against rotavirus
... A better understanding of the frequencies of antigen-specific mBc subsets and their association with serological memory –defined as the persistence of Abs levels in the absence of the antigen [30]– is also important to identify valuable correlates of protection for vaccines [31, 32]. The mechanisms ...
... A better understanding of the frequencies of antigen-specific mBc subsets and their association with serological memory –defined as the persistence of Abs levels in the absence of the antigen [30]– is also important to identify valuable correlates of protection for vaccines [31, 32]. The mechanisms ...
The molecular mechanisms of TLR
... IL10, IL6, IL12 and IL23, which are several fold higher in dendritic cells (DCs) stimulated with combinatorial TLR ligands compared with single stimulations.6,7 Some in vivo experiments also support the notion that TLRs collaborate. For example, Tlr2−/− and Tlr9−/− mice are more susceptible than the ...
... IL10, IL6, IL12 and IL23, which are several fold higher in dendritic cells (DCs) stimulated with combinatorial TLR ligands compared with single stimulations.6,7 Some in vivo experiments also support the notion that TLRs collaborate. For example, Tlr2−/− and Tlr9−/− mice are more susceptible than the ...
Peptide Vaccine: Progress and Challenges
... A successful vaccine must induce a strong and long memory humoral and cellular immune response, but more importantly, protect against the disease being targeted. Therefore, it is important to evaluate whether the peptide immunogen can induce ―protective‖ T-cell and B-cell immunity. The earliest pept ...
... A successful vaccine must induce a strong and long memory humoral and cellular immune response, but more importantly, protect against the disease being targeted. Therefore, it is important to evaluate whether the peptide immunogen can induce ―protective‖ T-cell and B-cell immunity. The earliest pept ...
Thyroid Glossary - YOUR THYROID And YOU
... to Graves' disease. Autoantibodies to the thyroid stimulating hormone receptor are present in more than 90 percent of people with Graves disease. Tumor - An abnormal growth. Tumors may be benign or malignant by cell type. U.S. - (Ultrasound ) A procedure in which high-energy sound waves are bounced ...
... to Graves' disease. Autoantibodies to the thyroid stimulating hormone receptor are present in more than 90 percent of people with Graves disease. Tumor - An abnormal growth. Tumors may be benign or malignant by cell type. U.S. - (Ultrasound ) A procedure in which high-energy sound waves are bounced ...
Thesis - KI Open Archive
... KIR via bidirectional promoters (32). This multifaceted system endows humans with complex and unique KIR repertoires, comprising NK cells expressing 0, 1, 2 or more KIRs. Expression of KIRs has been determined to largely follow the product rule (%KIR-A+KIR-B+ = %KIR-A+ x %KIR-B+) (33). At steady sta ...
... KIR via bidirectional promoters (32). This multifaceted system endows humans with complex and unique KIR repertoires, comprising NK cells expressing 0, 1, 2 or more KIRs. Expression of KIRs has been determined to largely follow the product rule (%KIR-A+KIR-B+ = %KIR-A+ x %KIR-B+) (33). At steady sta ...
cross-talk between human nk cells and macrophages
... Natural killer (NK) cells are important effectors of innate immune responses providing cellular immunity against tumor-transformed and virally-infected cells. The existence of cross-talks between NK cells and myeloid cells, in particular dendritic cells, is well established, but information on the c ...
... Natural killer (NK) cells are important effectors of innate immune responses providing cellular immunity against tumor-transformed and virally-infected cells. The existence of cross-talks between NK cells and myeloid cells, in particular dendritic cells, is well established, but information on the c ...
KUOPION YLIOPISTON JULKAISUJA C. LUONNONTIETEET JA YMPÄRISTÖTIETEET 264
... The bioactive form of vitamin D, 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the nuclear receptor superfamily expressed in many cell types, and modulates a variety of biological functions. 1α,25(OH)2D3 is essential for bo ...
... The bioactive form of vitamin D, 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the nuclear receptor superfamily expressed in many cell types, and modulates a variety of biological functions. 1α,25(OH)2D3 is essential for bo ...
Induction of tolerance in autoimmune diseases by hematopoietic
... pathogen epitopes and self-proteins, and occasional isolation of an infectious agent in affected tissue. An infection could precipitate an autoimmune disease by breaking self-tolerance through molecular mimicry,98,99 determinant or epitope spreading,100,101 or bystander activation.102 Molecular mimi ...
... pathogen epitopes and self-proteins, and occasional isolation of an infectious agent in affected tissue. An infection could precipitate an autoimmune disease by breaking self-tolerance through molecular mimicry,98,99 determinant or epitope spreading,100,101 or bystander activation.102 Molecular mimi ...
Chapter 13 - IARC Publications
... B-cells their specificity. When B-cells are activated by antigen binding, they proliferate and redifferentiate into antibody-producing cells. The endpoint in this secondary differentiation is the plasma cell, which in essence is a cellular factory for making antibodies. Several other receptors are e ...
... B-cells their specificity. When B-cells are activated by antigen binding, they proliferate and redifferentiate into antibody-producing cells. The endpoint in this secondary differentiation is the plasma cell, which in essence is a cellular factory for making antibodies. Several other receptors are e ...
Asthma, inflammation and anti-inflammatory treatments: Controlling
... Inflammation is a vital part of the immune response, but it is very much a double edged sword. Excessive inflammation and hyperactive inflammatory response is the primary cause of immune dysfunctions such as asthma. The immune cells of patients suffering from immune system dysfunctions such as asth ...
... Inflammation is a vital part of the immune response, but it is very much a double edged sword. Excessive inflammation and hyperactive inflammatory response is the primary cause of immune dysfunctions such as asthma. The immune cells of patients suffering from immune system dysfunctions such as asth ...
Novel therapeutic targets in primary biliary cirrhosis
... animal models have highlighted how T cells and B cells might be relevant to liver injury (reviewed elsewhere38). On the basis of data from both animal models and human studies, a disease model has been developed in which a combination of environmental triggers39–42 in genetically predisposed hosts12 ...
... animal models have highlighted how T cells and B cells might be relevant to liver injury (reviewed elsewhere38). On the basis of data from both animal models and human studies, a disease model has been developed in which a combination of environmental triggers39–42 in genetically predisposed hosts12 ...
Microbes in Colon Cancer and Inflammatory Bowel Disease
... elements that are secondarily increased in obesity that have been proposed to participate in the pathogenesis of CRC. Chronic low-grade inflammation with persistent activation of the nuclear transcription factor NK-kB may result in transcription of genes that promote tumorigenesis in visceral adipos ...
... elements that are secondarily increased in obesity that have been proposed to participate in the pathogenesis of CRC. Chronic low-grade inflammation with persistent activation of the nuclear transcription factor NK-kB may result in transcription of genes that promote tumorigenesis in visceral adipos ...
Human Monoclonal Antibody Reactivity With
... eplet-bearing antigens that share a given self-configuration of amino acids, which is critical for the binding with antibody. Thus, there seems to be an autoreactive component of the alloantibody response to some HLA mismatches. These findings might be viewed in context with current concepts of anti ...
... eplet-bearing antigens that share a given self-configuration of amino acids, which is critical for the binding with antibody. Thus, there seems to be an autoreactive component of the alloantibody response to some HLA mismatches. These findings might be viewed in context with current concepts of anti ...
Immune response to human papillomavirus after
... mucosal and systemic infection. The rapid presence of viral particles in the bloodstream allows the immune system to recognize and mount a rapid and strong response directed against the pathogen, including both the secretion of high levels of circulating antibodies able to neutralize and control the ...
... mucosal and systemic infection. The rapid presence of viral particles in the bloodstream allows the immune system to recognize and mount a rapid and strong response directed against the pathogen, including both the secretion of high levels of circulating antibodies able to neutralize and control the ...
Investigating the Mechanisms of Massage Efficacy
... Th1 differentiated cell line and are considered proinflammatory.19–21 Those associated with the M2 phenotype derive from Th2 differentiated cells and are considered antiinflammatory.19–21 Additional T helper cell pathways have been identified, but for this communication, we focus on the well-establishe ...
... Th1 differentiated cell line and are considered proinflammatory.19–21 Those associated with the M2 phenotype derive from Th2 differentiated cells and are considered antiinflammatory.19–21 Additional T helper cell pathways have been identified, but for this communication, we focus on the well-establishe ...
Page 1 of 200 - Gamma Delta Conference 2016
... and γδ T cells, and have roles in human cancer and autoimmunity, but self-lipid antigens presented by CD1c to the T cell receptors of these cells remain poorly understood. We determined a new CD1c crystal structure at 2.4 Å revealing an extended ligand binding potential of the antigen groove and a s ...
... and γδ T cells, and have roles in human cancer and autoimmunity, but self-lipid antigens presented by CD1c to the T cell receptors of these cells remain poorly understood. We determined a new CD1c crystal structure at 2.4 Å revealing an extended ligand binding potential of the antigen groove and a s ...
