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Understanding the interaction between psychosocial stress
Understanding the interaction between psychosocial stress

... outcomes in immune-related disorders such as viral infections, chronic autoimmune diseases and tumors. Experimental evidence in humans supporting these observations was, however, lacking. Studies published in the last 2 decades in Brain, Behavior and Immunity and other journals have demonstrated tha ...
Immunological studies on Swine Influenza Virus in  Massimiliano Baratelli
Immunological studies on Swine Influenza Virus in Massimiliano Baratelli

... Additionally, T cells epitopes were empirically identified. Proteins M1 and NP of a human IAV were selected as target and thus dissected by using overlapping peptides and functional methods (IFN and proliferation responses) until finding T cells epitopes. The tests were performed using cells from ...
Recruitment of regulatory T cells is correlated with hypoxia
Recruitment of regulatory T cells is correlated with hypoxia

... Introduction: Basal-like breast cancers behave more aggressively despite the presence of a dense lymphoid infiltrate. We hypothesised that immune suppression in this subtype may be due to T regulatory cells (Treg) recruitment driven by hypoxia-induced up-regulation of CXCR4 in Treg. Methods: Immunop ...
Challenges and strategies: The immune responses in gene therapy
Challenges and strategies: The immune responses in gene therapy

... products are never made in the hosts resulting from either complete gene mutation or absent expression, so an entirely new protein could be considered as ‘‘foreign’’ by the host immune system. Protein replacement gene therapy for some genetic diseases, which are caused by the absence of a functional ...
Lecture 09
Lecture 09

... Childhood Immunizations in US and the World The HERD effect Are they safe? FDA approval process The thrimersoal debate Vaccine manufacture How are vaccines made? Challenges for vaccine development ...
Lymphatic System
Lymphatic System

... connective tissue that surrounds them. Lymphatic vessels leading to the node (afferent vessels) and (efferent vessels) leading out of the node. The inside of the lymph node is divided into lymph nodules. The nodules are the structural units of the lymph nodes. Lymph sinuses are found in the lymph no ...
Ângela França and Nuno Cerca* Plasma is the main regulator of S
Ângela França and Nuno Cerca* Plasma is the main regulator of S

... and nucleic acids with DAPI (Sigma, MO, USA), as detailed elsewhere (Cerca 2012). Biofilm images were acquired using an OlympusTM FluoView FV1000 (Lisboa, Portugal) microscope. Biofilms were observed using a 60 × water-immersion objective (60 ×/ 1.2 W). Images were taken, with 1024 × 1024 resolution ...
Surfactant proteins and the inflammatory and immune response in
Surfactant proteins and the inflammatory and immune response in

oral graft versus host disease
oral graft versus host disease

... those seen in oral lichen planus), mucosal erosion-desquamation-ulceration, xerostomia, and pain. However, many of these changes can also be caused by pre HSCT chemoradiotherapy conditioning, post-HSCT drugs, or infections. Generally, the oral manifestations of cGVHD are clinically similar to those ...
The Lymphatic System
The Lymphatic System

... without it neither the circulatory system nor the immune system would function can be thought of as an accessory to the circulatory system it helps the circulatory system to do its job the two systems are directly connected together it consists of fluid derived from plasma =lymph and white blood cel ...
Structural and functional aspects of factor viii in the initiation of the
Structural and functional aspects of factor viii in the initiation of the

Doctoral thesis from the Department of Immunology, the Wenner-Gren Institute,... University, Stockholm, Sweden
Doctoral thesis from the Department of Immunology, the Wenner-Gren Institute,... University, Stockholm, Sweden

... Manifestations of disease varied significantly from young children to adolescence to adults. Apparently, young children do not show classical symptoms of TB and that lead to difficulties in diagnosis and treatment. On the other hand, adult individuals show more clear symptoms in advanced pulmonary T ...
Production and Immunodiagnostic Applications of Antihuman Light
Production and Immunodiagnostic Applications of Antihuman Light

... V«„, V,M1> V,1V) and five Vx (Vx„ Vx]l/V, Vxl„, V xlv , V xvl ) subgroups.8 Five mice were immunized with each protein: 6- to 8-week-old pathogen-free, female Balb/c mice were injected intraperitoneally (IP) every 2 to 4 weeks with 100 n% of the immunogen emulsified in 0.2 mL of either complete Freu ...
Epithelial barrier and dendritic cell function in the intestinal mucosa
Epithelial barrier and dendritic cell function in the intestinal mucosa

determining the innate and adaptive immune responses to vesicular
determining the innate and adaptive immune responses to vesicular

... The goal of this research project is to determine the response of dendritic cells and T cells to vesicular stomatitis virus (VSV) vectors that express flagellin. VSV is currently in clinical trials as a recombinant vaccine vector against heterologous antigens (1). Incorporating flagellin gene into t ...
New Insights on the Pathogenesis of Invasive Cryptococcus neoformans
New Insights on the Pathogenesis of Invasive Cryptococcus neoformans

... proven beneficial against Cn in mice. This oligonucleotide is based on bacterial nucleotides shown to activate the immune response to several pathogens. CpG enhances the survival time and decreases the brain and lung fungal burdens of mice infected with Cn. The effect is via the Th1 response, as the ...
Class II MHC
Class II MHC

... during parturition and subsequently developed antibodies to these antigens. More recently, they are produced by monoclonal .antibody technology ...
The Tissue Level of Organization
The Tissue Level of Organization

Chapter 4 Lecture
Chapter 4 Lecture

... Inclusions, secretory vesicles, and other cytoplasmic components are shed in the process. The gland cell then undergoes growth and repair before it releases additional secretions. Cells burst, releasing cytoplasmic contents Cells produce secretion, increasing in size ...
stem cells
stem cells

... Inclusions, secretory vesicles, and other cytoplasmic components are shed in the process. The gland cell then undergoes growth and repair before it releases additional secretions. Cells burst, releasing cytoplasmic contents Cells produce secretion, increasing in size ...
Regeneration or scarring: An immunologic perspective
Regeneration or scarring: An immunologic perspective

... Stelnicki et al. (1999) have reviewed data showing that genes involved in patterning embryonic skin, including genes required for normal development of limbs, jaws, and axial skeleton, are differentially expressed during fetal but not adult skin wounds. Given the multiplicity of cytokine signals in ...
Rheumatoid arthritis is an autoimmune disease that causes chronic
Rheumatoid arthritis is an autoimmune disease that causes chronic

... liver reactions that have occurred with the licensed 100mg dose, and in some cases the reactions have been associated with short term use (less than one month).  Dr June Raine, Director of Vigilance and Risk Management of Medicines at the MHRA said, “The MHRA carefully reviewed the latest evidence, ...
Document
Document

... Patients who are always hypocomplementemic regardless of clinical disease activity may have an underlying complement deficiency! ...
Inhibitory receptors on myeloid cells: New targets for therapy?
Inhibitory receptors on myeloid cells: New targets for therapy?

... in his description of receptors that suppress activation of natural killer (NK) cells (Lanier, 1998). The “classical” view of inhibitory receptors is that these receptors inhibit cell activation in trans, contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and bind phosphatases for their ...
μMACS™ Epitope Tag Protein Isolation Kits
μMACS™ Epitope Tag Protein Isolation Kits

... protein, this protein is described as being “epitope-tagged” and can be detected by an epitope specific antibody.1,2 It is important that the addition of a tag sequence does not affect the function, intracellular transport, modification or location of the target protein. The use of epitope tags of o ...
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Adoptive cell transfer

Adoptive cell transfer (ACT) is the transfer of cells into a patient; as a form of cancer immunotherapy. The cells may have originated from the patient him- or herself and then been altered before being transferred back, or, they may have come from another individual. The cells are most commonly derived from the immune system, with the goal of transferring improved immune functionality and characteristics along with the cells back to the patient. Transferring autologous cells, or cells from the patient, minimizes graft-versus-host disease (GVHD) or what is more casually described as tissue or organ rejection.
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