LMP1 signaling can replace CD40 signaling in B cells in vivo and
... LMP1, binds directly to TRAF 6.7,11 Conversely, LMP1, but not CD40, binds to the tumor necrosis factor receptor–associated death domain protein (TRADD) and receptor-interacting protein (RIP).12 The most striking difference between LMP1 and CD40 is that LMP1 constitutively signals independently of li ...
... LMP1, binds directly to TRAF 6.7,11 Conversely, LMP1, but not CD40, binds to the tumor necrosis factor receptor–associated death domain protein (TRADD) and receptor-interacting protein (RIP).12 The most striking difference between LMP1 and CD40 is that LMP1 constitutively signals independently of li ...
prolongation of allograft survival in ccr7
... T-cell and APC migration to secondary lymphoid organs during the initiation of the immune response. We demonstrate that CCR7 deficiency extends skin and heart allograft survival but cannot ultimately prevent allograft rejection. Supporting the proposed mechanism of a defect in T-cell and APC recircu ...
... T-cell and APC migration to secondary lymphoid organs during the initiation of the immune response. We demonstrate that CCR7 deficiency extends skin and heart allograft survival but cannot ultimately prevent allograft rejection. Supporting the proposed mechanism of a defect in T-cell and APC recircu ...
experimental oncology and molecular medicine department
... of the immune system, the extracellular matrix, and transforming tissues, following the hypothesis that the evolving microenvironment is crucial for the fate of incipient tumors and might therefore offer new therapeutic targets within stroma components. Taking advantage of knock out and transgenic m ...
... of the immune system, the extracellular matrix, and transforming tissues, following the hypothesis that the evolving microenvironment is crucial for the fate of incipient tumors and might therefore offer new therapeutic targets within stroma components. Taking advantage of knock out and transgenic m ...
EMERGING ROLES FOR CYSTEINE PROTEASES IN HUMAN
... development. The ability of macrophages and other cells to mobilize elastolytic cysteine proteases to their surfaces under specialized conditions may also lead to accelerated collagen and elastin degradation at sites of inflammation in diseases such as atherosclerosis and emphysema. The development ...
... development. The ability of macrophages and other cells to mobilize elastolytic cysteine proteases to their surfaces under specialized conditions may also lead to accelerated collagen and elastin degradation at sites of inflammation in diseases such as atherosclerosis and emphysema. The development ...
Licentiate thesis from the Department of Immunology,
... been explored in the control of intracellular infections especially chlamydial respiratory infection, and chronic infections induced by actinomycetes (26, 27). While the role of antibody in protection against TB is uncertain, several mechanisms of action mediated by antibody are considered, which co ...
... been explored in the control of intracellular infections especially chlamydial respiratory infection, and chronic infections induced by actinomycetes (26, 27). While the role of antibody in protection against TB is uncertain, several mechanisms of action mediated by antibody are considered, which co ...
Cerebrospinal fluid neopterin: an informative biomarker of central
... Neopterin is a biochemical product of the guanosine triphosphate pathway that is both cell-restricted and inducible by immune-inflammatory stimuli. It is produced primarily in monocyte/macrophage and related cells and the most important stimuli are interferons, especially Th1-type cytokine interfero ...
... Neopterin is a biochemical product of the guanosine triphosphate pathway that is both cell-restricted and inducible by immune-inflammatory stimuli. It is produced primarily in monocyte/macrophage and related cells and the most important stimuli are interferons, especially Th1-type cytokine interfero ...
The Cnidaria, Past, Present and Future
... Nuclear factor kappa light chain of activated B cells Pathogen/microbe-associated molecular pattern Phenoloxidase/prophenoloxidase Pathogen recognition receptor Reactive oxygen species Surface mucus layer Superoxide dismutase Transforming growth factor beta Toll/interleukin-1 receptor Toll-like rece ...
... Nuclear factor kappa light chain of activated B cells Pathogen/microbe-associated molecular pattern Phenoloxidase/prophenoloxidase Pathogen recognition receptor Reactive oxygen species Surface mucus layer Superoxide dismutase Transforming growth factor beta Toll/interleukin-1 receptor Toll-like rece ...
THE LYMPHATIC SYSTEM AND LYMPHOID TISSUE
... be a vehicle for the spread (metastasis) of disease. When cancer cells enter the lymphatic vessels, they travel to other parts of the body, where they may establish new tumors. Along the way, some cancer cells become lodged in the lymph nodes. In breast cancer, the degree of invasion of nearby lymph ...
... be a vehicle for the spread (metastasis) of disease. When cancer cells enter the lymphatic vessels, they travel to other parts of the body, where they may establish new tumors. Along the way, some cancer cells become lodged in the lymph nodes. In breast cancer, the degree of invasion of nearby lymph ...
Provenge, Common name - Autologous peripheral blood
... test results will not be available at the time of infusion. If the sterility results become positive for microbial contamination after Provenge has been approved for infusion, the marketing authorisation holder will notify the treating physician and may request additional information from the physic ...
... test results will not be available at the time of infusion. If the sterility results become positive for microbial contamination after Provenge has been approved for infusion, the marketing authorisation holder will notify the treating physician and may request additional information from the physic ...
Amino acid-derived hormones
... Most lipid hormones are derived from cholesterol, so they are structurally similar to it . The primary class of lipid hormones in humans is the steroid hormones. Chemically, these hormones are usually ketones or alcohols; their chemical names will end in "-ol" for alcohols or "-one" for ketones. Exa ...
... Most lipid hormones are derived from cholesterol, so they are structurally similar to it . The primary class of lipid hormones in humans is the steroid hormones. Chemically, these hormones are usually ketones or alcohols; their chemical names will end in "-ol" for alcohols or "-one" for ketones. Exa ...
Artificial Immune Systems
... Why is it that engineers are attracted to the immune system for inspiration? The immune system exhibits several properties that engineers recognise as being desirable in their systems. [Timmis & Andrews 2007, Timmis et al. 2008a, de Castro & Timmis 2002a] have identified these as: Distribution and s ...
... Why is it that engineers are attracted to the immune system for inspiration? The immune system exhibits several properties that engineers recognise as being desirable in their systems. [Timmis & Andrews 2007, Timmis et al. 2008a, de Castro & Timmis 2002a] have identified these as: Distribution and s ...
Recent developments in basophil research
... efficient in taking up, processing and presenting antigens to naïve T cells. They provide peptides via ...
... efficient in taking up, processing and presenting antigens to naïve T cells. They provide peptides via ...
Normocytic Anemia
... serum protein electrophoresis: IgG kappa monoclonal protein with depression of IgA, IgM and polyclonal IgG. Bone marrow investigation: excessive number of plasma cells Skeletal survey: numerous lytic lesions in the axial skeleton and cranium. ...
... serum protein electrophoresis: IgG kappa monoclonal protein with depression of IgA, IgM and polyclonal IgG. Bone marrow investigation: excessive number of plasma cells Skeletal survey: numerous lytic lesions in the axial skeleton and cranium. ...
the role of intestinal epithelial cells and the regulation
... function of IEC in regulating intestinal homeostasis and inflammation. Importantly, down-regulation of pIgR expression was a common feature in human IBD and mouse models of experimental colitis. One molecule of pIgR is consumed for every molecule of SIgA transported, thus high expression of pIgR is ...
... function of IEC in regulating intestinal homeostasis and inflammation. Importantly, down-regulation of pIgR expression was a common feature in human IBD and mouse models of experimental colitis. One molecule of pIgR is consumed for every molecule of SIgA transported, thus high expression of pIgR is ...
Distribution of macrophages in the human fallopian tubes: an
... cycle. Circulating ovarian sex steroids may regulate these cyclic changes; however, the mechanism of action of these steroids (direct or indirect via growth factors and cytokines) remains largely unknown. In animals, Abe et al. [1] and Steinhauer et al. [28] showed that the goat and canine oviducts ...
... cycle. Circulating ovarian sex steroids may regulate these cyclic changes; however, the mechanism of action of these steroids (direct or indirect via growth factors and cytokines) remains largely unknown. In animals, Abe et al. [1] and Steinhauer et al. [28] showed that the goat and canine oviducts ...
Immunology and Immunopathogenesis of Malaria
... This high burden of mortality falls heavily on sub-Saharan Africa, where over 90% of these deaths are thought to occur, and 5% of children die before the age of 5 years. The death toll from malaria is still growing, with malariaspecific mortality in young African children estimated to have doubled du ...
... This high burden of mortality falls heavily on sub-Saharan Africa, where over 90% of these deaths are thought to occur, and 5% of children die before the age of 5 years. The death toll from malaria is still growing, with malariaspecific mortality in young African children estimated to have doubled du ...
this PDF file - Smart Science Technology
... circulating monocytes infiltrate tissues they get transformed into macrophages. The tissue macrophages not only eliminate encountered pathogens through phagocytosis but also process and present the foreign antigens via MHC molecules to lymphocytes causing lymphocyte activation [4]. Phagocytosis by m ...
... circulating monocytes infiltrate tissues they get transformed into macrophages. The tissue macrophages not only eliminate encountered pathogens through phagocytosis but also process and present the foreign antigens via MHC molecules to lymphocytes causing lymphocyte activation [4]. Phagocytosis by m ...
Distinct lines of chickens express different splenic cytokine profiles
... the 2 lines after Salmonella Enteritidis infection (Van Hermert et al., 2006). Heterophils isolated from Salmonella Enteritidis-resistant broiler lines expressed significantly less transforming growth factor (TGF) β1 mRNA than heterophils isolated from Salmonella Enteritidis-susceptible lines (Swagg ...
... the 2 lines after Salmonella Enteritidis infection (Van Hermert et al., 2006). Heterophils isolated from Salmonella Enteritidis-resistant broiler lines expressed significantly less transforming growth factor (TGF) β1 mRNA than heterophils isolated from Salmonella Enteritidis-susceptible lines (Swagg ...
Function of the Drosophila TGF-a homolog Spitz is controlled by Star
... Star nulls are haploinsuf®cient dominant mutations with a rough eye phenotype indicates that Star is genetically dose sensitive and suggests that Star function may be quantitatively limiting on the Spitz signal during eye development (Harris et al., 1976; Mayer and NuÈsslein-Volhard, 1988). Finally, ...
... Star nulls are haploinsuf®cient dominant mutations with a rough eye phenotype indicates that Star is genetically dose sensitive and suggests that Star function may be quantitatively limiting on the Spitz signal during eye development (Harris et al., 1976; Mayer and NuÈsslein-Volhard, 1988). Finally, ...