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Слайд 1 - sechenov.ru
Слайд 1 - sechenov.ru

... TYPE II : humoral antibodies participate directly in injuring cells by predisposing them to phagocytosis or lysis. TYPE III : immune complex diseases in which humoral antibodies bind antigen and activate complement; the fractions of complement then attract neutrophils, which produce tissue damage. T ...
Slide 1
Slide 1

... c. allows macrophages to destroy the complex d. changes shape so complement can lysis e. initiates release of mediators ...
immune_07
immune_07

... c. allows macrophages to destroy the complex d. changes shape so complement can lysis e. initiates release of mediators ...
Monoclonal antibodies-anticancer therapy
Monoclonal antibodies-anticancer therapy

... Monoclonal antibodies for cancer treatment Three mechanisms that could be responsible for the cancer treatment. A. mAbs act directely when binding to a cancer specific antigens and induce immunological response to cancer cells. Such as inducing cancer cell apoptosis, inhibiting growth, or interferi ...
Chapter 43 Power Point notes
Chapter 43 Power Point notes

...  Antigen – any foreign molecule that is specifically recognized by lymphocytes and elicits a response from them  2 main types of lymphocytes  B lymphocytes (B cells)  T lymphocytes (T cells)  Both circulate through the blood and lymph and are concentrated in the spleen, lymph nodes, and other l ...
a. active site is covered (toxin)
a. active site is covered (toxin)

File - Classes with Mrs. Sheetz
File - Classes with Mrs. Sheetz

... • Histamine: a chemical which initiates the inflammatory response; causes blood vessels to dilate, increases blood flow to area • Phagocytes (macrophages & neutrophils): engulf and remove pathogens ...
How can your immune system malfunction?
How can your immune system malfunction?

... allergic reactions? ...
Indices of Tolerance
Indices of Tolerance

... This study concludes that by using the bioassays & biomarkers listed above, the presence of transplantation tolerance in kidney transplant patients may be clearly identified (high specificity & sensitivity). This tentative “fingerprint” of clinical transplantation tolerance now needs to be tested an ...
Immunology for Surgeons: The Basics 101
Immunology for Surgeons: The Basics 101

... other cytokines, namely TNF and CSF; deficiency --> SCID IL-3: hematopoetic growth factor IL-4: inhibits macrophages IL-6: inhibits TNF IL-8: neutrophil chemokine IL-10: inhibits monocytes/macrophages and antiinflammatory IL-4, 6, and 10 are “inhibitory” cytokines ...
Lymphatic System
Lymphatic System

... » Attack baby’s RBC’s- hemolytic disease of newborn » Can affect subsequent Rh pos pregnancies – Pevent by giving Rh neg mom anti-Rh immunoglobulins in an injection ...
IMMUNE EFFECTOR MECHANISMS
IMMUNE EFFECTOR MECHANISMS

... and IgG or IgM and are deposited in tissue – Immune complexes fix complement (releasing C3a, C5a), resulting in mast cell degranulation and attraction of neutrophils – Inflammatory response can aid in clearing bacteria – Complement activation, release of neutrophil lysosomal contents can cause tissu ...
Immune System Disorders
Immune System Disorders

... vigorous overreaction of the immune system to a previously encountered antigen. Mast cells are immune cells involved in allergic responses, they are non- motile, found around blood vessels, in connective tissue and in the lungs. Mast cells release active agents such as Histamine, which cause contrac ...
abcellera announces successful completion of collaboration for the
abcellera announces successful completion of collaboration for the

... both a very enjoyable and a productive partnership. We are grateful for DARPA’s support and it has been an honor to be of service in this important and forward-looking initiative led by Colonel Dan Wattendorf to bolster rapid pandemic response and biodefense.” said Dr. Hansen. For more information o ...
Autoimmune Diseases
Autoimmune Diseases

... UVB=> flares of both cutaneous and internal organ lupus (some antigens, like Ro, La, RNP, but not chromatin antigens and other nuclear components are translocated to keratinocyte cell surface, favorising the immune response); decrease DNA methylation and induces gene expression; increase expression ...
Immunology in Head and Neck Cancer
Immunology in Head and Neck Cancer

... • Active immunotherapy – administer agents that activate immune reaction – goal is to stimulate areas responsible for antitumor immunity ...
Fig 1.1
Fig 1.1

... cells responsible for innate immunity and lymphocytes responsible for specific immunity. The guardian cells of the innate immune system form the first line of defence against infection and can digest pathogens or vaccine particles and use these to activate lymphocytes. In addition they produce chemi ...
Figure 1.1 The human immune system All blood cells originally
Figure 1.1 The human immune system All blood cells originally

... guardian cells responsible for innate immunity and lymphocytes responsible for specific immunity. The guardian cells of the innate immune system form the first line of defence against infection and can digest pathogens or vaccine particles and use these to activate lymphocytes. In addition they prod ...
Immunity & Abnormal Responses
Immunity & Abnormal Responses

... – Group of inactive plasma proteins, part of non-specific immunity – Especially active against invading bacteria – When activated, system compliments action of antibodies by; – Destruction of target cell membranes – Attracts phagocytes (chemotaxis) – Stimulates & enhances phagocytosis – Stimulates i ...
The Immune System
The Immune System

... Virus attaches to the CD4+ protein on Thelper cells and destroys them Decreased T-helper cell count makes the patient prone to opportunistic infections, malignancies not normally seen in patients with intact immune systems, and direct ...
Nature Communications: CNIC researchers define the key role of a
Nature Communications: CNIC researchers define the key role of a

... immune system, such as autoimmune diseases and graft-versus-host disease after tissue transplantation. The results are published in Nature Communications. Lymphocytes play essential roles in the immune response through their ability to recognize and respond to specific foreign antigens. Antigen-medi ...
Typical violations of immunobiological supervision 1. The main
Typical violations of immunobiological supervision 1. The main

... forms of violation of immunity? a) hypotrophy of thymus; b) lymphadenopathy; + c) immunodeficiency states; + d) pathological tolerance; e) lymphocytic leukemia; + f) reaction of "graft-versus-host disease." 18. What is one of the important differences between antigen-presenting cells of the immune s ...
REVIEW QUESTIONS – CHAPTER 26
REVIEW QUESTIONS – CHAPTER 26

30_Extracellular bact BA
30_Extracellular bact BA

... MHC class II molecules with α:β T-cell receptors and CD28 co-stimulatory molecules in the absence of antigenic peptides ...
File
File

< 1 ... 431 432 433 434 435 436 437 438 439 ... 450 >

Immunosuppressive drug

For a list of immunosuppressive drugs, see the transplant rejection page.Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to: Prevent the rejection of transplanted organs and tissues (e.g., bone marrow, heart, kidney, liver) Treat autoimmune diseases or diseases that are most likely of autoimmune origin (e.g., rheumatoid arthritis, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's Disease, pemphigus, and ulcerative colitis). Treat some other non-autoimmune inflammatory diseases (e.g., long term allergic asthma control).A common side-effect of many immunosuppressive drugs is immunodeficiency, because the majority of them act non-selectively, resulting in increased susceptibility to infections and decreased cancer immunosurveillance. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, lipodystrophy, moon face, liver and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.Immunosuppressive drugs can be classified into five groups: glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs.
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