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basicprinciplesofimmunesystem
basicprinciplesofimmunesystem

... Cells involved in specific immune system The entire cells of specific immune system derive from pluripotent “stem cells” in bone marrow & develop through hematopoeisis process. They differentiate into 2 lineages : 1. myeloid lineage  produce phagocytes and other blood cells. 2. lymphoid lineage ...
PRESS RELEASE 2011-10-03 The 2011 Nobel Prize in Physiology or Medicine
PRESS RELEASE 2011-10-03 The 2011 Nobel Prize in Physiology or Medicine

... We live in a dangerous world. Pathogenic microorganisms (bacteria, virus, fungi, and parasites) threaten us continuously but we are equipped with powerful defense mechanisms (please see figures on page 5). The first line of defense, innate immunity, can destroy invading microorganisms and trigger in ...
BOSY_DEFENCE__ARISTO_
BOSY_DEFENCE__ARISTO_

... (after infection) • to localize & destroy the pathogens • phagocytes involve in phagocytosis – to engulf and digest the pathogens ...
tuberculin-type hypersensitivity
tuberculin-type hypersensitivity

Document
Document

... accelerates tissue repair, and inhibits the reproduction of bacteria and viruses. V. General Aspects of Specific Immunity A. The immune system consists of widely distributed cells that recognize foreign substances and act to neutralize or destroy them. 1. Two characteristics that distinguish immunit ...
Adaptive immune response
Adaptive immune response

... pathogen injected to elicit an immune response  Bestow immunity without disease; primary response  Booster shots (secondary response); intensify response  Shortcomings – adverse reactions & the immunity is less durable (poor memory) & has less cell mediated ...
How Immunity Evolved
How Immunity Evolved

... specificities, which are clonally distributed on immune cells (T and B lymphocytes)  plasticity • The specificity of the receptors expressed on each lymphocyte is not predetermined, and neither is the response that can be induced in lymphocytes upon ligation of their receptors by antigen  ambiguit ...
Composition of Blood
Composition of Blood

... • RBCs are flattened biconcave discs – Shape provides increased surface area for diffusion – Lack nuclei & mitochondria – Each RBC contains 280 million hemoglobins – transport oxygen specialised to do this also carry some CO2 ...
Biol 155 Human Physiology
Biol 155 Human Physiology

IB280 SEMINAR Dr. France-Isabelle Auzanneau, Professor, Department of Chemistry, University of Guelph
IB280 SEMINAR Dr. France-Isabelle Auzanneau, Professor, Department of Chemistry, University of Guelph

... Professor, Department of Chemistry, University of Guelph Tumor Associated Carbohydrate antigens: Synthetic chemistry and molecular modelling studies Carbohydrates constitute the most abundant class of natural products. In addition to being a source of energy, numerous oligo- and poly- saccharides ha ...
LSU Neuroscience Center of Excellence Health Sciences
LSU Neuroscience Center of Excellence Health Sciences

... The role of immune cells in repair of the central nervous system (CNS) has been a subject of controversy for decades. We recognized that innate immune cells (macrophages/microglia) play an essential part in CNS recovery from axotomy. Subsequently, we found that T cells recognizing CNS-specific antig ...
IgM Humoral immune response to thymus
IgM Humoral immune response to thymus

... c. quantitatively and qualitatively different (faster, stronger and more efficient) ...
7th Lecture
7th Lecture

...  The T- cell antigen receptor (TCR) recognizes and binds proteolytically processed short peptide fragments (antigens) bound to self major histocompatibility complex (MHC) molecules on the surface of an APC  There are two major classes of MHC molecules that present different types of antigens to di ...
Alissa Pharma
Alissa Pharma

... “ We believe that, in the case of solid tumors, targeted radionuclide therapy is likely to be most effective when used in combination with other treatment modalities. The high expression of ferritin in pancreatic cancer suggests that this is a promising target and we plan to pursue preclinical studi ...
Adaptive immunity
Adaptive immunity

... molecules that mediate resistance to infections . Immune response :- the coordinated reaction of immune cells and molecules to infectious microbes. Immunology :- is the study of the immune system and its responses to invading pathogens. The physiologic function of the immune system is to prevent inf ...
PPT - Fat Tuesday Productions
PPT - Fat Tuesday Productions

... The activated T cells reach the epidermis within about 48 hours and they begin releasing cytokines, which recruits more T cells and causes dermatitis. This picture shows severe dermatitis caused by poison ivy. ...
B cell
B cell

... Antigenicity 抗原性: the ability to combine specifically with Ab and/or cell-surface receptors (Ig/TCR) ...
IMMUNITY MEDIATED BY B LYMPHOCYTES AND ANTIBODIES
IMMUNITY MEDIATED BY B LYMPHOCYTES AND ANTIBODIES

... * Proteins of classic pathway named with capital “C” followed by a numeral (C1, C2, C3…..C9) * Cleavage fragments named as parent followed by lower case letter * “a” for smaller fragment (C3a) * “b” for larger fragment (C3b) ...
antigen recognition by b-cell and t
antigen recognition by b-cell and t

T cells…
T cells…

The Immune System - Phillips Scientific Methods
The Immune System - Phillips Scientific Methods

study_guide_2007_hazbun - Welcome to people.pharmacy
study_guide_2007_hazbun - Welcome to people.pharmacy

... 1. Know the machinery of the immune system: Tissues, cells and blood proteins (e.g., complement) of the Immune System (IS) -know who are phagogcytes, APCs, killer cells (both CD8 and NK cells), helper cells (Th1 and Th2) 2. How do we classify the immune system? Innate and Adaptive Immunity a. -know ...
Antibody Structure and B Cell Diversity
Antibody Structure and B Cell Diversity

... * Transmembrane proteins * Transport M and D to B cell surface * Communication of antigen binding to inside of B cell * Tails interact with intracellular signaling molecules ...
Chapter 11: Immunological Responses to Microbes
Chapter 11: Immunological Responses to Microbes

Immune Responses to Extracellular Bacteria Infection by
Immune Responses to Extracellular Bacteria Infection by

... listeriolysin O (LLO), which lyses the vacuolar membrane and activates nuclear factor-kB (NF-kB)-mediated transcription of innate immune-response genes, such as CC-chemokine ligand 2 (CCL2). b | The CCL2 that is produced then induces the recruitment of circulating monocytes that express CC-chemokine ...
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Immunosuppressive drug

For a list of immunosuppressive drugs, see the transplant rejection page.Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to: Prevent the rejection of transplanted organs and tissues (e.g., bone marrow, heart, kidney, liver) Treat autoimmune diseases or diseases that are most likely of autoimmune origin (e.g., rheumatoid arthritis, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's Disease, pemphigus, and ulcerative colitis). Treat some other non-autoimmune inflammatory diseases (e.g., long term allergic asthma control).A common side-effect of many immunosuppressive drugs is immunodeficiency, because the majority of them act non-selectively, resulting in increased susceptibility to infections and decreased cancer immunosurveillance. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, lipodystrophy, moon face, liver and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.Immunosuppressive drugs can be classified into five groups: glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs.
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