Neutrophils in tuberculosis: heterogeneity shapes the way?
... Macrophages phagocyte apoptotic neutrophils by efferocytosis, which leads to several consequences, that is, removing neutrophils and preventing tissue injury, allowing macrophages to utilize neutrophil granule proteins for antimicrobial defense, and altering cytokine production by macrophages [40, 62 ...
... Macrophages phagocyte apoptotic neutrophils by efferocytosis, which leads to several consequences, that is, removing neutrophils and preventing tissue injury, allowing macrophages to utilize neutrophil granule proteins for antimicrobial defense, and altering cytokine production by macrophages [40, 62 ...
Innate immune responses of human tracheal epithelium to
... occurred in both columnar and basal cells. MyD88 (toll receptorassociated adapter), IL-1 receptor (IL1R)1, and TNF-␣ receptor (TNFR)1 were expressed in columnar and basal cells. ZO-1 was localized to tight junctions of columnar cells but not to basal cells. We infer the following. 1) Flagellin is ne ...
... occurred in both columnar and basal cells. MyD88 (toll receptorassociated adapter), IL-1 receptor (IL1R)1, and TNF-␣ receptor (TNFR)1 were expressed in columnar and basal cells. ZO-1 was localized to tight junctions of columnar cells but not to basal cells. We infer the following. 1) Flagellin is ne ...
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... murine studies to involve NF-κB activation and is once again characterised by the production of cytokines, such as IL-6, IL-1, and TNFα, resulting in both hepatic and systemic insulin resistance [36]. Mitochondrial ROS, induced by SFAs, appear to contribute to JNK activation and cellular insulin res ...
... murine studies to involve NF-κB activation and is once again characterised by the production of cytokines, such as IL-6, IL-1, and TNFα, resulting in both hepatic and systemic insulin resistance [36]. Mitochondrial ROS, induced by SFAs, appear to contribute to JNK activation and cellular insulin res ...
Wellness Foods Based on the Health Benefits of Fruit: Gold Kiwifruit
... were re-exposed to OVA in vitro(3). These results suggested that the gold kiwifruit puree enhanced both Th1 and Th2 type immune responses. Interestingly a concentrated juice made from gold kiwifruit had no effect on this weak immune response when fed to the mice at a similar dose. The two processed ...
... were re-exposed to OVA in vitro(3). These results suggested that the gold kiwifruit puree enhanced both Th1 and Th2 type immune responses. Interestingly a concentrated juice made from gold kiwifruit had no effect on this weak immune response when fed to the mice at a similar dose. The two processed ...
The effects of environmental mycobacteria on VLP and MVA based vaccines against tuberculosis
... has become since then the most widely administered vaccine globally. Later different local sub-strains of BCG evolved (by separate closed activity) such as BCG Connaught, Danish, Glaxo, Pasteur, and Tokyo, all of which contain differences in terms of genetic and antigenic composition (Behr, 2001, Oe ...
... has become since then the most widely administered vaccine globally. Later different local sub-strains of BCG evolved (by separate closed activity) such as BCG Connaught, Danish, Glaxo, Pasteur, and Tokyo, all of which contain differences in terms of genetic and antigenic composition (Behr, 2001, Oe ...
Approach to Patients With Suspected Hypersensitivity to Local
... These reactions are termed anaphylactoid reactions.13 Drugs that are thought to cause mast cell degranulation via anaphylactoid mechanisms include some opiates, muscle relaxants, vancomycin, and iodinated radiographic contrast media.14 In contrast, type IV hypersensitivity reactions are delayed-type ...
... These reactions are termed anaphylactoid reactions.13 Drugs that are thought to cause mast cell degranulation via anaphylactoid mechanisms include some opiates, muscle relaxants, vancomycin, and iodinated radiographic contrast media.14 In contrast, type IV hypersensitivity reactions are delayed-type ...
The level of monocyte turnover predicts disease progression in the
... Destruction of CD4⫹ T cells is considered to be the main cause of immunodeficiency resulting from HIV infection in humans as well as in the simian immunodeficiency virus (SIV)–infected macaque model of AIDS. However, the degree of CD4⫹ T-cell depletion does not always correlate with AIDS progression ...
... Destruction of CD4⫹ T cells is considered to be the main cause of immunodeficiency resulting from HIV infection in humans as well as in the simian immunodeficiency virus (SIV)–infected macaque model of AIDS. However, the degree of CD4⫹ T-cell depletion does not always correlate with AIDS progression ...
Licentiate thesis from the Department of Immunology,
... bacteria survive under low oxygen level and become drug-resistant. Under such a situation bacteria shut off protein synthesis and stop replication in the host. Three possible mechanisms have been suggested to be involved for the intracellular survival of bacteria (9-12). First, Voskuil et al demonst ...
... bacteria survive under low oxygen level and become drug-resistant. Under such a situation bacteria shut off protein synthesis and stop replication in the host. Three possible mechanisms have been suggested to be involved for the intracellular survival of bacteria (9-12). First, Voskuil et al demonst ...
ALS MediteK
... Severity varies from one patient to another. Young acne patients, males and patients with large white comedones prior to therapy are more susceptible to develop acne flare ups during isotretinoin therapy. It was observed that improvement occurs upon suspension of isotretinoin or reduction of the dos ...
... Severity varies from one patient to another. Young acne patients, males and patients with large white comedones prior to therapy are more susceptible to develop acne flare ups during isotretinoin therapy. It was observed that improvement occurs upon suspension of isotretinoin or reduction of the dos ...
How do red blood cells know when to die?
... high PS and low CD47 expression are comparable to apoptotic host cells, while those expressing very low levels of CD47 can be likened to foreign cells. Bearing these analogies in mind, we hypothesize the existence of two alternative pathways of RBC phagocytosis that entail different macrophage react ...
... high PS and low CD47 expression are comparable to apoptotic host cells, while those expressing very low levels of CD47 can be likened to foreign cells. Bearing these analogies in mind, we hypothesize the existence of two alternative pathways of RBC phagocytosis that entail different macrophage react ...
Giuliana Magri Characterization of natural killer cell response to human cytomegalovirus
... induction of apoptosis via TRAIL (TNF-related apoptosis-inducing ligand) or engagement of the Fas receptor on the target cell surface via the Fas ligand17. NK cells have also been shown to display regulatory capabilities, which are mediated by various cytokines, such as interferon-γ (IFN-γ), tumor n ...
... induction of apoptosis via TRAIL (TNF-related apoptosis-inducing ligand) or engagement of the Fas receptor on the target cell surface via the Fas ligand17. NK cells have also been shown to display regulatory capabilities, which are mediated by various cytokines, such as interferon-γ (IFN-γ), tumor n ...
Antibodies Targeting Hsa and PadA Prevent Platelet - Serval
... GPIb␣ allows rapid loss and formation of new interactions between platelets and the immobilized bacteria, leading to platelets rolling over the microorganisms. This process, which slows down platelets from the high shear stress experienced in the bloodstream, is then followed by the interaction of P ...
... GPIb␣ allows rapid loss and formation of new interactions between platelets and the immobilized bacteria, leading to platelets rolling over the microorganisms. This process, which slows down platelets from the high shear stress experienced in the bloodstream, is then followed by the interaction of P ...
Mediated by Heat Shock Factor-1 (HSF1) Protective Stress
... Recently, HSF1⫺/⫺ mice have provided additional insight into the biological role of HSF1. HSF1⫺/⫺ mice generally survive to adulthood, but there is some embryonic lethality mediated by defects in the chorioallantoic placenta that is dependent on the background genotype (39). HSF1⫺/⫺ females are also ...
... Recently, HSF1⫺/⫺ mice have provided additional insight into the biological role of HSF1. HSF1⫺/⫺ mice generally survive to adulthood, but there is some embryonic lethality mediated by defects in the chorioallantoic placenta that is dependent on the background genotype (39). HSF1⫺/⫺ females are also ...
Chapter 15 The Lymphatic System and Immunity
... • Second stage—inactive B cell develops into activated B cell – Initiated by inactive B cell’s contact with antigens, which bind to its surface antibodies, plus signal chemicals from T cells – Activated B cell, by dividing repeatedly, forms two clones of cells—plasma (effector) cells and memory cell ...
... • Second stage—inactive B cell develops into activated B cell – Initiated by inactive B cell’s contact with antigens, which bind to its surface antibodies, plus signal chemicals from T cells – Activated B cell, by dividing repeatedly, forms two clones of cells—plasma (effector) cells and memory cell ...
Establishment of immunohistochemical double staining
... switch motif will affect signaling pathways downstream upon ligand binding. Activation of PD1 results in cytokine downregulation, inhibition of proliferation and induction of apoptosis in CD8+ presenting T-‐ cells ...
... switch motif will affect signaling pathways downstream upon ligand binding. Activation of PD1 results in cytokine downregulation, inhibition of proliferation and induction of apoptosis in CD8+ presenting T-‐ cells ...
Curriculum Vitae
... 19. Sette A, Grey H, Oseroff C, Peters B, Moutaftsi M, Crotty S, Assarsson E, Greenbaum J, Kim Y, Kolla R, Tscharke D, Koelle D, Johnson RP, Blum J, Head S, Sidney J. Definition of epitopes and antigens recognized by vaccinia specific immune responses: their conservation in variola virus sequences, ...
... 19. Sette A, Grey H, Oseroff C, Peters B, Moutaftsi M, Crotty S, Assarsson E, Greenbaum J, Kim Y, Kolla R, Tscharke D, Koelle D, Johnson RP, Blum J, Head S, Sidney J. Definition of epitopes and antigens recognized by vaccinia specific immune responses: their conservation in variola virus sequences, ...
Airway Inflammation and Bronchial Remodelling in - (BORA)
... plastics manufacturing. It is estimated that as many as 5% of workers exposed to diisocyanates develop asthma, which may persist indefinitely even in the absence of continued exposure [4]. Clinically, diisocyanate asthma displays similar manifestations to allergic asthma induced by high molecular wei ...
... plastics manufacturing. It is estimated that as many as 5% of workers exposed to diisocyanates develop asthma, which may persist indefinitely even in the absence of continued exposure [4]. Clinically, diisocyanate asthma displays similar manifestations to allergic asthma induced by high molecular wei ...
Lung interstitial macrophages alter dendritic Research article
... DCs. Phagocytosis was determined by flow cytometry evaluation of FITC-labeled dextran uptake. Although lung DCs were able to take up dextran, only IMs and AMs displayed strong phagocytic activity (Figure 1H). To assess their ability to induce T cell proliferation, IMs, AMs, and lung DCs were loaded ...
... DCs. Phagocytosis was determined by flow cytometry evaluation of FITC-labeled dextran uptake. Although lung DCs were able to take up dextran, only IMs and AMs displayed strong phagocytic activity (Figure 1H). To assess their ability to induce T cell proliferation, IMs, AMs, and lung DCs were loaded ...
In vitro characterisation and expansion of human regulatory T cells
... results are excellent, with patient survival rates greater than 90% one year after surgery, but there are several problems with the long term acceptance and the use of immunosuppressive drugs causing infections, organ failure and cancer. Hematopoietic Stem Cells Transplantation (HSCT) is an establis ...
... results are excellent, with patient survival rates greater than 90% one year after surgery, but there are several problems with the long term acceptance and the use of immunosuppressive drugs causing infections, organ failure and cancer. Hematopoietic Stem Cells Transplantation (HSCT) is an establis ...
Carbohydrate profiling reveals a distinctive role for
... Antigen-presenting cells (APCs), such as dendritic cells (DCs) and macrophages (MØ), are the key players in the initiation and control of innate and adaptive immune responses. In order to perform their function, both DCs and MØ are equipped with a full array of specialized receptors, including adhes ...
... Antigen-presenting cells (APCs), such as dendritic cells (DCs) and macrophages (MØ), are the key players in the initiation and control of innate and adaptive immune responses. In order to perform their function, both DCs and MØ are equipped with a full array of specialized receptors, including adhes ...
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[NOTE: if using this form [bracketed] text is guidance
... 23. L. Shen, M.L. Lang and W.F. Wade. (2000). The Ins and Outs of Getting In: Structures and Signals that enhance BCR or Fc receptor-mediated antigen presentation. (Review) Immunopharmacology 49: 227-240. 24. M.L. Lang, S. Yadati, E.S. Seeley, T. Nydam, T.K. Wade, J.L. Gabriel, G.R. Yeaman, G.B. k B ...
... 23. L. Shen, M.L. Lang and W.F. Wade. (2000). The Ins and Outs of Getting In: Structures and Signals that enhance BCR or Fc receptor-mediated antigen presentation. (Review) Immunopharmacology 49: 227-240. 24. M.L. Lang, S. Yadati, E.S. Seeley, T. Nydam, T.K. Wade, J.L. Gabriel, G.R. Yeaman, G.B. k B ...
probiotics – identification and ways of action
... probiotics, leads to reduced secretion of TH1 (lymphocyte involved in an enhanced immune response), IL12 (interleukin which is naturally produced by dendritic cells), TNFα (inflammatory cytokine) and IFN-γ (cytokine that is critical for innate and adaptive immunity) which are responsible for the ons ...
... probiotics, leads to reduced secretion of TH1 (lymphocyte involved in an enhanced immune response), IL12 (interleukin which is naturally produced by dendritic cells), TNFα (inflammatory cytokine) and IFN-γ (cytokine that is critical for innate and adaptive immunity) which are responsible for the ons ...
Thèse de doctorat
... of the microenvironment. Concurrently, molecular classifications of tumors have proposed taxonomies within cancers that define groups of patients with different prognoses and are associated with response to treatments. Recent evidence suggest that the phenotype of the malignant cell is a critical de ...
... of the microenvironment. Concurrently, molecular classifications of tumors have proposed taxonomies within cancers that define groups of patients with different prognoses and are associated with response to treatments. Recent evidence suggest that the phenotype of the malignant cell is a critical de ...