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... Cytochrome c, well known for its role in mitochondrial respiration. Once released into the cytosol, cytochrome c binds to a protein called Apaf-1 (apoptosis-activating factor-1, homologous to Ced-4 in C. elegans), which forms a wheel-like hexamer that has been called the apoptosome. This complex is ...
The role of innate immunity in the induction of autoimmunity
The role of innate immunity in the induction of autoimmunity

... Perhaps the best evidence that bacterial DNA impacts on the normal immune system relates to the presence of antibodies to bacterial DNA in the serum of normal humans (Table 2). These anti-DNA differ in specificity from anti-DNA autoantibodies found in SLE sera, which bind the DNA backbone. In contras ...
ringworm of the body - Mid
ringworm of the body - Mid

... Diagnostic Findings Ringworm of the body presents as a ring-shaped pink patch with a scaly, raised border and a clear center. The lesions are usually 1/2 to 1 inch in size and may be mildly itchy. Cause Ringworm is a fungal infection of the skin, often transferred from pets or other children who hav ...
Management of Metabolic Side Effects of Antiretoviral Drugs
Management of Metabolic Side Effects of Antiretoviral Drugs

... transcriptase inhibitor and metabolic changes induced by protease inhibitor are all involved in the pathogenesis of lipodystrophy. Lipogenesis and lipolysis can be influenced by proinflammatory cytokines, such as tumour necrosis factor-alpha, that inhibit the former and stimulate the latter process ...
Intervention (Mild and Moderate Reactions)
Intervention (Mild and Moderate Reactions)

... 2. The cells which mediate immunity include lymphocytes and phagocytes. Lymphocytes recognize antigens on pathogens. Phagocytes internalize pathogens and degrade them 3. An Immune response consists of two phases. In the first phase, antigen activates specific lymphocytes that recognize it; in the ef ...
Age prevalence of H. pylori in Western countries
Age prevalence of H. pylori in Western countries

... – Significantly raised LFTs (x3), – Hypersensitivity to infliximab – Active TB – Pregnancy } avoid for 6 months after – Breast Feeding } stopping treatment • Cautions: – Previous TB – Hepatic Impairment – Renal Impairment – Heart Failure – Mouse allergies – > 14 weeks since last infusion ...
Biology – The Search for Better Health
Biology – The Search for Better Health

... the body will then instigate the third line of defence. The third line of defence is called the immune response and is a specific response. It involves the production of two different types of lymphocytes, B cells and T cells, which are specific to the invading particle. These lymphocytes work toget ...
EDITORIAL Hyperbaric oxygen as an adjunctive treatment for
EDITORIAL Hyperbaric oxygen as an adjunctive treatment for

... distinct group that is related closely to other zygomycetes such as Mucorales [3,4]. Zygomycosis has emerged as an increasingly common invasive mould infection, particularly among leukaemia patients and bone marrow transplant (BMT) recipients [5]. Zygomycetes are inherently resistant to most antifun ...
Age prevalence of H. pylori in Western countries
Age prevalence of H. pylori in Western countries

PRESENTATION - FINAL - Critical Path to TB Drug Regimens
PRESENTATION - FINAL - Critical Path to TB Drug Regimens

... # Bedaquline+clofaz – prolonged tissue levels after end of dosing period33 ...
HIV and Malnutrition: Effects on Immune System
HIV and Malnutrition: Effects on Immune System

C.5  Articles
C.5 Articles

... from patients with relapse tuberculosis had a higher concentration of antibodies and reacted with a greater variety of antigens (native culture filtrates of Mycobacterium tuberculosis H37Rv) than did sera from patients with newly acquired tuberculosis. Our data confirm the results of these previous ...
Toward An Understanding of Allergy and In
Toward An Understanding of Allergy and In

... antibody-synthesizing plasma cells Bacteria and bacterial toxins may that then produce antigen-specific immunoglobulins of different isotypes, called IgM, IgG, IgE, IgD and IgA. T-cells, on the Non-immune Mediated Reactions to Foods other hand, provide cell-mediat• Lactase deficiency (dairy) ➔ bloat ...
Autoimmune Disorders in Pregnancy
Autoimmune Disorders in Pregnancy

... • Can be proinflammatory or anti-inflammatory • T helper cell differentiation • Both types- counter-regulatory effects • Th1 cells proinflammatory • IL-2, interferon -Ύ which induce a cytotoxic response ...
2-3 Innate immunity 2016
2-3 Innate immunity 2016

... Macrophages are constitutively present in tissues and recognize microbes that enter these tissues and respond rapidly to these microbes. They initiate the immune response. •These cells are phagocytes (eliminate the pathogens) •Activate the innate immune response (by secreted proteins, called cytoki ...
LESSON 6 Your Immune System
LESSON 6 Your Immune System

... birth, antibodies pass from her body to her developing fetus. However, these immunities last only a few months. The baby’s immune system becomes active and produces antibodies on its own to fight pathogens. A vaccine causes the immune system to produce antibodies for certain diseases. This process i ...
Monoclonal Antibodies and Recombinant DNA Technology: Present
Monoclonal Antibodies and Recombinant DNA Technology: Present

PPT 55
PPT 55

... 1. Mechanism maintaining elevated neutralising IgG titres after infection? 2. ‘Persistent infection’ despite the high level of neutralising antibody? ...
Mechanism of increasing airway resistance In Asthma Airways are
Mechanism of increasing airway resistance In Asthma Airways are

... as the least provocation. Asthmatic smooth muscle also secretes a wide range of cytokines and growth factors that help sustain the chronic inflammatory response. Lungs over a period of years become hyperinflated and this further causes a narrowing of the airways. As lung tissue grows the chest cage ...
Preparation of Vaccines
Preparation of Vaccines

Neurons, Synapses, & Signaling
Neurons, Synapses, & Signaling

... defense by attacking pathogens or impeding their reproduction Interferon proteins provide innate defense, interfering with viruses and helping activate macrophages About 30 proteins make up the complement system, which causes lysis of invading cells and helps trigger inflammation ...
Approach to patient with cytopenia
Approach to patient with cytopenia

Burkitt`s Lymphoma
Burkitt`s Lymphoma

... lymphoma, which was very common in children in that region. This became known as Burkitt's lymphoma. Later research showed that B-lymphocytes in these children had been infected with the Epstein-Barr virus (or E-B virus). Epstein-Barr virus infections are known as glandular fever or infectious monon ...
New advances in the pathogenesis and treatment of ITP 2014 ASH
New advances in the pathogenesis and treatment of ITP 2014 ASH

... 2015 update on the pathogenesis and treatment of ITP Ming Hou Qilu Hospital, Shandong University ...
Immune System: Cytokines
Immune System: Cytokines

... cytokines notably TNFalpha, but also IL1 and IL6. These mediators induce the Acute Phase Response, which is a rapid systemic response which massively increases the concentration of many key serum proteins to aid the host defence response. C reactive protein (CRP) and Mannose binding protein are natu ...
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Immunosuppressive drug

For a list of immunosuppressive drugs, see the transplant rejection page.Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to: Prevent the rejection of transplanted organs and tissues (e.g., bone marrow, heart, kidney, liver) Treat autoimmune diseases or diseases that are most likely of autoimmune origin (e.g., rheumatoid arthritis, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's Disease, pemphigus, and ulcerative colitis). Treat some other non-autoimmune inflammatory diseases (e.g., long term allergic asthma control).A common side-effect of many immunosuppressive drugs is immunodeficiency, because the majority of them act non-selectively, resulting in increased susceptibility to infections and decreased cancer immunosurveillance. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, lipodystrophy, moon face, liver and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.Immunosuppressive drugs can be classified into five groups: glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs.
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