Activation of dendritic cells: translating innate into adaptive immunity
... than to a direct effect of the PAMP on DCs [22]. But, if inflammation induced by PAMPs is sufficient to activate DCs, why do these cells also express TLRs and, more pointedly, what is the significance of the lack of TLR expression by specific DC subtypes? The answer is unclear at present but it is l ...
... than to a direct effect of the PAMP on DCs [22]. But, if inflammation induced by PAMPs is sufficient to activate DCs, why do these cells also express TLRs and, more pointedly, what is the significance of the lack of TLR expression by specific DC subtypes? The answer is unclear at present but it is l ...
RITUXIMAB - International Waldenstrom`s Macroglobulinemia
... We have all heard of rituximab and many of us have been treated with it. But how does it work? Why does it work well for some of us but poorly or not at all for others? And what “new and improved” versions of rituximab are on the horizon? Rituximab was developed by Idec Pharmaceuticals and initially ...
... We have all heard of rituximab and many of us have been treated with it. But how does it work? Why does it work well for some of us but poorly or not at all for others? And what “new and improved” versions of rituximab are on the horizon? Rituximab was developed by Idec Pharmaceuticals and initially ...
Immunostimulating activity of maysin i
... immune response, macrophages play an important role in regulating innate and adaptive immune responses by producing various types of cytokines and chemokines and secreting cytotoxic and inflammatory molecules, such as NO and reactive oxygen species (ROS) (7, 8). The tumor necrosis factors-α (TNF-α), ...
... immune response, macrophages play an important role in regulating innate and adaptive immune responses by producing various types of cytokines and chemokines and secreting cytotoxic and inflammatory molecules, such as NO and reactive oxygen species (ROS) (7, 8). The tumor necrosis factors-α (TNF-α), ...
Abbreviations - Danish Medical Bulletin
... Healthy individuals as well as MS patients have systemically circulating myelinreactive T cells, but in MS patients the cells are more activated, and they are only found intrathecally in MS patients [Zhang et al. 1994; Lovett-Racke et al. 1998; Burns et al. 1999; Bielekova et al. 2004]. The question ...
... Healthy individuals as well as MS patients have systemically circulating myelinreactive T cells, but in MS patients the cells are more activated, and they are only found intrathecally in MS patients [Zhang et al. 1994; Lovett-Racke et al. 1998; Burns et al. 1999; Bielekova et al. 2004]. The question ...
Cough, fever and weight loss in a young male
... The prognosis is quite poor with a median survival of 14 months. The cause of death is usually from respiratory failure or sepsis. Transformation into high-grade lymphoma occurs in 13–49%. Less than 10% of cases resolve spontaneously [4, 8]. Previously, lymphomatoid granulomatosis was treated with i ...
... The prognosis is quite poor with a median survival of 14 months. The cause of death is usually from respiratory failure or sepsis. Transformation into high-grade lymphoma occurs in 13–49%. Less than 10% of cases resolve spontaneously [4, 8]. Previously, lymphomatoid granulomatosis was treated with i ...
Glossary of terms that may be used in breast cancer clinical trial
... effects on tissue, cells, living experimental animals, or humans. Biobank – A repository of tissue and blood samples that can be used for genetic research. Biomarker – A cellular or molecular indicator of exposure, health effects, or susceptibility. Biopsy – Removal of a small piece of living tissue ...
... effects on tissue, cells, living experimental animals, or humans. Biobank – A repository of tissue and blood samples that can be used for genetic research. Biomarker – A cellular or molecular indicator of exposure, health effects, or susceptibility. Biopsy – Removal of a small piece of living tissue ...
Immunity
... negative bacterial and viral cultures, soft, non-tender lymph nodes, recognition of self and recognition of foreign proteins - are the defining characteristics of immunity or what constitutes immunity. The antecedents are events or incidents that must be in play in order for immunity to exist. The a ...
... negative bacterial and viral cultures, soft, non-tender lymph nodes, recognition of self and recognition of foreign proteins - are the defining characteristics of immunity or what constitutes immunity. The antecedents are events or incidents that must be in play in order for immunity to exist. The a ...
Harnessing Their Therapeutic Potential Natural IgM in Immune
... The B-lineage compartment includes at least three distinct mature B cell subsets: B-1 that constitutively produce nIg, which is most often IgM, but can be IgG and IgA isotypes; marginal zone B cells that are responsible for responses to encapsulated organisms and their nonprotein Ags; and B-2 cells ...
... The B-lineage compartment includes at least three distinct mature B cell subsets: B-1 that constitutively produce nIg, which is most often IgM, but can be IgG and IgA isotypes; marginal zone B cells that are responsible for responses to encapsulated organisms and their nonprotein Ags; and B-2 cells ...
immediate and delayed hypersensitivity to gluten
... that have been used synonymously to refer to a disease process affecting the small bowel and characterized by gastrointestinal symptoms and malabsorption. However, since 1966 scientific evidence has been accumulated demonstrating that gluten sensitivity can exist even in the absence of enteropathy. ...
... that have been used synonymously to refer to a disease process affecting the small bowel and characterized by gastrointestinal symptoms and malabsorption. However, since 1966 scientific evidence has been accumulated demonstrating that gluten sensitivity can exist even in the absence of enteropathy. ...
The role of Fc–Fc R interactions in IgG-mediated microbial
... selective binding to the inhibitory FcRIIb is necessary for optimal activity of agonistic anti-CD40 mAbs (Li and Ravetch, 2011). In the context of infectious diseases, Fc–FcR inter actions readily amplify the in vivo protective activity of neutralizing antibodies through opsonization and clearanc ...
... selective binding to the inhibitory FcRIIb is necessary for optimal activity of agonistic anti-CD40 mAbs (Li and Ravetch, 2011). In the context of infectious diseases, Fc–FcR inter actions readily amplify the in vivo protective activity of neutralizing antibodies through opsonization and clearanc ...
chapter 5 complement
... adaptive immune response which it generates (depending on its degree of immunogenicity and the isotype distribution of the resulting antibodies) and possible previous exposures of the immune system to the same or similar pathogens (immunological memory). Overall, the opsonizing and inflammatory effe ...
... adaptive immune response which it generates (depending on its degree of immunogenicity and the isotype distribution of the resulting antibodies) and possible previous exposures of the immune system to the same or similar pathogens (immunological memory). Overall, the opsonizing and inflammatory effe ...
Host defence mechanisms against bacterial aggression in
... of patients may be more susceptible to periodontitis because they are unable to produce a high-affinity antibody response to the dominant bacterial antigens (21). The antibody response to specific characteristics of bacterial virulence appears to be critical for the resolution or non-progression of ...
... of patients may be more susceptible to periodontitis because they are unable to produce a high-affinity antibody response to the dominant bacterial antigens (21). The antibody response to specific characteristics of bacterial virulence appears to be critical for the resolution or non-progression of ...
Immune disorders
... between the donor and the recipient. Immunosuppression is needed in most transplant situations cyclosporin • suppresses T-cells but does not kill them • has no effect on B-cells • leaves most parts of the immune system intact ...
... between the donor and the recipient. Immunosuppression is needed in most transplant situations cyclosporin • suppresses T-cells but does not kill them • has no effect on B-cells • leaves most parts of the immune system intact ...
Immuun nr 3 2015 - Dutch Society for Immunology
... the UK and ‘Sport Immunologie’ is unofficially used in Germany, but is nonexistent in The Netherlands. Exercise physiologist Richard Jaspers PhD of the VU University Amsterdam: “Human Movement Sciences teach cardiology, orthopaedia and exercise physiology. Maastricht also focuses on nutrition and Ni ...
... the UK and ‘Sport Immunologie’ is unofficially used in Germany, but is nonexistent in The Netherlands. Exercise physiologist Richard Jaspers PhD of the VU University Amsterdam: “Human Movement Sciences teach cardiology, orthopaedia and exercise physiology. Maastricht also focuses on nutrition and Ni ...
Additional file 2 Virological and immunological responses to
... of weights to adjust for informative censoring; adding covariates for high baseline viral load and coinfection with hepatitis B or C). The definition of virologic failure used in this trial is not suitable for our data – because patients followed for longer in our study are less likely to fail to su ...
... of weights to adjust for informative censoring; adding covariates for high baseline viral load and coinfection with hepatitis B or C). The definition of virologic failure used in this trial is not suitable for our data – because patients followed for longer in our study are less likely to fail to su ...
1 Principles of Vaccination
... not cause disease such as may occur with the “wild” form of the organism. When a live attenuated vaccine does cause “disease,” it is usually much milder than the natural disease and is referred to as an adverse reaction. The immune response to a live attenuated vaccine is virtually identical to that ...
... not cause disease such as may occur with the “wild” form of the organism. When a live attenuated vaccine does cause “disease,” it is usually much milder than the natural disease and is referred to as an adverse reaction. The immune response to a live attenuated vaccine is virtually identical to that ...
Diagnosis
... - Based on the appearance of the skin. - There are no special blood tests or diagnostic procedures. - A skin biopsy (or scraping) may be needed to rule out other disorders and to confirm the diagnosis. - When the plaques are scraped, one can see pinpoint bleeding from the skin below (Auspitz's sign) ...
... - Based on the appearance of the skin. - There are no special blood tests or diagnostic procedures. - A skin biopsy (or scraping) may be needed to rule out other disorders and to confirm the diagnosis. - When the plaques are scraped, one can see pinpoint bleeding from the skin below (Auspitz's sign) ...
gene therapy for severe combined immunodeficiency
... into the patients in the absence of preconditioning. The results obtained from the first five patients have recently been reported in the scientific literature.6 To date, 10 infants in total have now been treated, with good immunological reconstitution in all but one, in whom the graft appears to ha ...
... into the patients in the absence of preconditioning. The results obtained from the first five patients have recently been reported in the scientific literature.6 To date, 10 infants in total have now been treated, with good immunological reconstitution in all but one, in whom the graft appears to ha ...
immune system
... offender, enclosing it in a vesicle called a phagosome before breaking down the contents with hydrolytic enzymes. The remains are presented (so-called antigen presentation) to other specialised immune cells that initiate a more targeted immune response. Inflammation: When the receptors of cells in ...
... offender, enclosing it in a vesicle called a phagosome before breaking down the contents with hydrolytic enzymes. The remains are presented (so-called antigen presentation) to other specialised immune cells that initiate a more targeted immune response. Inflammation: When the receptors of cells in ...