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Hannah Akuffo Publications 1990 to 1999
Hannah Akuffo Publications 1990 to 1999

... Mingarini K, Ingemarsson K, Opoku N, Akuffo HO. A simple dot blot assay adaptable for field use in the diagnosis of onchocerciasis: preparation of an adult worm antigen fraction which enhances sensitivity and specificity. Trans R Soc Trop Med Hyg. 1994 MayJun;88(3):303-6. 36. Wolday D, Akuffo H, Bri ...
The Role and Immunobiology of Eosinophils in the Respiratory
The Role and Immunobiology of Eosinophils in the Respiratory

... First described by Charles B. Carrington in the New England Journal of Medicine in 1969, chronic eosinophilic pneumonia (CEP) is a rare disorder, with many reports of this illness being limited to case studies [26, 27]. Though the exact etiology is unknown, the disease is often associated with a hig ...
RCAI Annual Report 2011 (PDF 34.1M)
RCAI Annual Report 2011 (PDF 34.1M)

... between ThPOK and Runx in the helper/killer lineage choice ...
Full-Text PDF
Full-Text PDF

Mucosal Vaccines: Where Do We Stand?
Mucosal Vaccines: Where Do We Stand?

Is lipid signaling through cannabinoid 2 receptors part of a protective
Is lipid signaling through cannabinoid 2 receptors part of a protective

... Neurodegenerative disorders (multiple sclerosis, Parkinson‘s, Huntington‘s, and Alzheimer’s diseases, amyotrophic lateral sclerosis) and pain . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
Cyst Infections in Patients with Autosomal Dominant
Cyst Infections in Patients with Autosomal Dominant

... cysts with an inflammatory wall and presence of pus. Patient 3 is 69-yr-old man who undergoes hemodialysis. He has a history of ADPKD complicated by several episodes of liver cyst infections documented by positive blood cultures. He received a 2-yr prophylactic antibiotic treatment (ciprofloxacin), ...
Crosstalk between cancer and immune cells: role of
Crosstalk between cancer and immune cells: role of

... such as IL-10, IL-6 and VEGF, which are crucial for both tumour growth and immunosuppression, activate STAT3 to create an efficient ‘feedforward’ mechanism to ensure increased STAT3 activity both in tumour cells and in tumour-associated immune cells. In normal cells, and under physiological conditio ...
Development of an Antigen-independent Affinity Assay to Study the
Development of an Antigen-independent Affinity Assay to Study the

... FcγRs are expressed on all immune competent cells and most cells co-express activating and inhibiting receptors. It is generally accepted that NK cells, platelets and B-cells are exceptions to this as the two former only express activating receptors while the latter only express the inhibiting recep ...
Micro Chapter 13 [4-20
Micro Chapter 13 [4-20

...  If not, innate immunity still can opsonize it, especially by complement that bind to the bacteria when there’s no antibodies, to opsonize o Complement binding is more efficient against some strains than others, make some more or less virulent  Also, C reactive protein (CRP) reacts with phosphoryl ...
Recent Advances in Understanding Immunity
Recent Advances in Understanding Immunity

... abortus lipoproteins Omp16 and Omp19 induced the production of pro- and anti-inflammatory cytokines in THP1 cell line and this cell activation is TLR2-dependent. Brucella Omp19 lipoprotein also has been found to induce the expression of IL-12 and other pro-inflammatory cytokines and up-regulation of ...
Generation of Monoclonal Antibodies to Cryptic Collagen Sites by
Generation of Monoclonal Antibodies to Cryptic Collagen Sites by

... The extracellular matrix (ECM) plays a fundamental role in the regulation of normal and pathological processes. The most abundantly expressed component found in the ECM is collagen. Triple helical collagen is known to be highly resistant to proteolytic cleavage except by members of the matrix metall ...
How is the STAT3 pathway activated?
How is the STAT3 pathway activated?

... Summary STAT3 is a cytokine and growth factor activated transcription factor  STAT3 has a wide range of functions, both anti and pro inflammatory depending on the tissue and physiological context STAT3 is also involved in disease states, such as asthma, colitis, and cancer STAT3 can suppress an ...
Micro Chapter 12 [4-20
Micro Chapter 12 [4-20

...  Treatment of strep within 9 days can prevent acute rheumatic fever, by preventing a full immune response to be mounted  People who develop acute rheumatic fever have to take prophylactic antibiotics well into adulthood or for life to prevent another strep infection that would worsen the heart dam ...
Intestinal Dendritic Cells Specialize to Activate Transforming Growth
Intestinal Dendritic Cells Specialize to Activate Transforming Growth

Phage therapy: awakening a sleeping giant
Phage therapy: awakening a sleeping giant

Pathogenesis of the Helicobacter Induced Mucosal Disease: A
Pathogenesis of the Helicobacter Induced Mucosal Disease: A

... wild type mice. On the other hand, a host that is resistant to Helicobacter develops an infection that is followed by a Th2 response sparing the mucosa from severe ...
Treg and CTLA-4: Two intertwining pathways to
Treg and CTLA-4: Two intertwining pathways to

... sequencing project [52] to determine the causal mutation in the scurfy mouse, an animal presenting with a severe lymphoproliferative syndrome [53]. The Foxp3 gene was pinpointed as the culprit, and it was shown that a frameshift mutation in scurfy mice resulted in a product lacking the carboxy-termi ...
Molecular Studies of T Cell Recognition and Cross
Molecular Studies of T Cell Recognition and Cross

... Intracellular pathogens are recognized by a specialized subset of lymphocytes known as CD8+ T cells. Pathogen recognition by CD8+ T cells occurs through binding of T cell receptors (TCR) to processed antigens in complex with major histocompatibility complex (MHC) class I proteins. TCR engagement of ...
the avian thrombocyte is a specialized immune cell
the avian thrombocyte is a specialized immune cell

FUNGAL PHASE REMEDIES - Dr. Karin Wagstaff : Doctor of
FUNGAL PHASE REMEDIES - Dr. Karin Wagstaff : Doctor of

... antigenic when coupled with a large molecular carrier such as a protein. ...
International Society for Biological Therapy of Cancer 24th Annual
International Society for Biological Therapy of Cancer 24th Annual

... Steven A. Rosenberg*. *Surgery Branch, National Cancer Institute, Bethesda, MD; w Department of Pathology, Laboratory Medicine, Abramson Cancer Research Institute, School of Medicine, University of Pennsylvania, Philadelphia, PA. Vascular endothelial growth factor (VEGF) plays an important role in v ...
The State of Melanoma Research
The State of Melanoma Research

View PDF - e-Science Central
View PDF - e-Science Central

... marker used most commonly for studying autophagy. Little is known of the third major step in autophagy. The last major step is lysosome degradation. A broad spectrum of viruses induces the formation and accumulation of autophagosomes or autophagy-related vesicles, causing cell death, which activates ...
ABSTRACT Title of Document:
ABSTRACT Title of Document:

... Also special thanks to Ken– your door was always open and several times you went out of your way to help me, which I greatly appreciate – also thank you for the rides to Ultimate Frisbee games! I would also like to acknowledge all of my lab mates in the Briken lab. Amro, my classmate, your support a ...
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Immunosuppressive drug

For a list of immunosuppressive drugs, see the transplant rejection page.Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to: Prevent the rejection of transplanted organs and tissues (e.g., bone marrow, heart, kidney, liver) Treat autoimmune diseases or diseases that are most likely of autoimmune origin (e.g., rheumatoid arthritis, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's Disease, pemphigus, and ulcerative colitis). Treat some other non-autoimmune inflammatory diseases (e.g., long term allergic asthma control).A common side-effect of many immunosuppressive drugs is immunodeficiency, because the majority of them act non-selectively, resulting in increased susceptibility to infections and decreased cancer immunosurveillance. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, lipodystrophy, moon face, liver and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.Immunosuppressive drugs can be classified into five groups: glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs.
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